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The effectiveness of lasers in the treatment of cutaneous conditions such as vascular disorders, hirsutism, acne, and scarring has been widely reported, but many of these reports are simply case series or small, non-randomised trials. As a result, the evidence base for much of the laser treatment currently carried out is small. This problem is compounded by the fact that there is a significant lack of reproducible, objective outcome measures available to assess the results of treatment. Therefore, there is a need to develop reliable and objective outcome measures and to improve the results of laser treatment. The studies included in this thesis focus on both of these aspects in relation to capillary vascular malformations (CMs), hirsutism, ablative laser resurfacing and acne vulgaris. The following studies were completed: the effect of increased ambient temperature on capillary vascular malformations; Capillary Vascular Malformation Response to Increased Ambient Temperature is Dependant on Anatomical Location; the Effect of Increased Ambient Temperature on Pulsed Dye Laser Treatment of Capillary Vascular Malformations; comparison of Pulsed dye, Alexandrite, KTP and Nd:YAG Lasers and Lumina IPL for the Treatment of Capillary Vascular Malformations; Laser Hair Removal in Women with Polycystic Ovary Syndrome (PCOS); a Randomised, Split-Face Comparison of Facial Hair Removal with the GentleLase Alexandrite Laser and Lumina Intense Pulsed Light Syndrome; assessment of the depth of CO₂ laser ablation; and Treating Acne Vulgaris with Intense Pulsed Light: A Randomised, Split-Face Control Study.

Dissertation submitted in partial compliance with the requirements for the Master's Diploma in Technology: Homoeopathy, Technikon Natal, 1994. / The purpose of the study was to determine the efficacy of simillimum treatment and Natrum muriaticum and Rhus toxicodendron on the treatment of recurrent cutaneous Herpes Simplex I with reference to patients response to treatment and patients perception of the effectiveness of treatment in order to determine the efficacy of the treatment methods in the management of recurrent Herpes Simplex I attacKS. Thirty one patients with recurrent cutaneous Herpes Simplex I were admitted to the study if they suffered from frequently recurring cutaneous Herpes Simplex lat least three times a year.Patients were recruited by means of advert ising in local newspapers, shoppi ng centres and libraries. Age group was 5-65 years. After an initial consultation including a case history and physical examination, a double-blind, random procedure ensured that the 31 patients were allocated to one of the two experimental groups.One group recei ved simillimum treatment and the other group received Natrum muriaticum and Rhus toxicodendron for a period of five months.Treatment only started at the beginning of a recurrent attaCK. At the time of recurrence details of the HSV llesion were obtained and a patient perception questionnaire / M

Class of 2012 Abstract / Specific Aims: To perform a pilot survey assessing the user benefit perceived by University of Arizona students regarding topical photoprotectants and their ability to prevent solar skin damage, including sunburn and carcinogenesis. In addition, to analyze the data obtained from the survey to identify incongruence between the FDA defined indication for the OTC sun protectants and the anticipated benefit expressed by University of Arizona students. Methods: An anonymous, paper based questionnaire consisting of four demographic questions and ten questions pertaining to sunscreen knowledge and use was distributed to students at the beginning of a full class. Questionnaires that were not at least ninety percent complete were excluded. All available students in the college of pharmacy in years one, two, and three were invited to participate. Main Results: Based on the survey analysis, 75% of pharmacy students have insufficient knowledge of FDA-approved use and guidelines for this class of OTC drugs. Conclusions: A need for training/instructional measures that aim at increasing adequate drug competency and consumer counseling skills has been identified in the area of FDA-regulated sunscreen products. An opportunity for an increased involvement of professional pharmacists in optimizing consumers' sunscreen selection and use has been identified.

MA (Fine Art), Faculty of the Humanities, University of the Witwatersrand, 2011

by Tsu Yun-Huang Stephen. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1992. / Includes bibliographical references (leaves 87-95). / ACKNOWLEDGEMENT --- p.1 / ABSTRACT --- p.2 / INTRODUCTION --- p.4 / Chapter SECTION 1: --- LITERATURE REVIEW --- p.5 / Chapter 1.1 --- Sensory ending in mammalian skin --- p.7 / Chapter 1.2 --- The slowly adapting type I mechanoreceptor --- p.7 / Chapter 1.3 --- The slowly adapting type II mechanoreceptor --- p.8 / Chapter 1.4 --- The role of the Merkel cell --- p.12 / Chapter 1.5 --- Hair cells as an analogy --- p.13 / Chapter 1.6 --- Molecular mechanism of SAI mechanotransduction --- p.14 / Chapter 1.7 --- Calcium influx and transmitter release --- p.17 / Chapter 1.8 --- Calcium homeostasis --- p.17 / Chapter 1.9 --- Substances that affect Calcium influx --- p.18 / Chapter "a," --- Inorganic ions --- p.18 / Chapter "b," --- Neomycin --- p.20 / Chapter "c," --- Verapamil --- p.20 / Chapter "d," --- Bay K8644 --- p.21 / Chapter 1.10 --- Modulators of intracellular calcium stores --- p.21 / Chapter 1.11 --- Caffeine and cAMP --- p.22 / Chapter 1.12 --- The mitochondria and NaN3 --- p.23 / Chapter SECTION 2: --- METHODS --- p.24 / Chapter 2.1 --- The Nerve Skin In Vitro Preparation --- p.25 / Chapter 2.2 --- Synthetic Interstitual Fluid --- p.25 / Chapter 2.3 --- Localised superfusion --- p.26 / Chapter 2.4 --- Nerve Chamber Perfusion --- p.26 / Chapter 2.5 --- Mechanical Stimulation and Experiment Control --- p.29 / Chapter 2.6 --- Data analysis --- p.29 / Chapter SECTION 3: --- RESULTS --- p.32 / Chapter 3.1 --- Viability of the Preparation --- p.33 / Chapter 3.2 --- Effects of Neomycin --- p.38 / Chapter 3.3 --- Effects of Magnesium --- p.47 / Chapter 3.4 --- Effects of Verapamil --- p.52 / Chapter 3.5 --- Effects of Bay-K-8644 --- p.58 / Chapter 3.6 --- Effects of Caffeine --- p.62 / Chapter 3.7 --- Effects of NaN3 --- p.69 / Chapter SECTION 4. --- DISCUSSION AND CONCLUSION / Chapter 4.1 --- Reliability of data obtained from the present in vitro preparation --- p.75 / Chapter 4.2 --- Comparison of the role of calcium in SAI and SA II receptors --- p.76 / Chapter 4.3 --- Synaptic link between Merkel cell and afferent nerve fibre? --- p.83 / Chapter SECTION5. --- REFERENCES --- p.87