Made available in DSpace on 2014-10-09T12:32:39Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:10:04Z (GMT). No. of bitstreams: 1 03303.pdf: 2739006 bytes, checksum: 37fea580dbe76269b12b7bdf94c093e8 (MD5) / Tese (Doutoramento) / IPEN/T / Instituto de Biociencias, Universidade de Sao Paulo - IB/USP

Made available in DSpace on 2014-10-09T12:26:01Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:10:21Z (GMT). No. of bitstreams: 1 11286.pdf: 1748953 bytes, checksum: b3436199d19a611450828efa997fb05d (MD5) / Dissertacao (Mestrado) / IPEN/D / Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

Made available in DSpace on 2014-10-09T12:32:20Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:10:29Z (GMT). No. of bitstreams: 1 01537.pdf: 1505528 bytes, checksum: 79b06b0cf173671eeb859566744153c3 (MD5) / Dissertacao (Mestrado) / IPEN/D / Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

M.Tech. (Homoeopathy) / Please refer to full text to view abstract

The effects of scaling a cavity with respect to a fixed incoming boundary layer thickness on its flow dynamics and control was studied experimentally. Three cavity models with constant length-to-depth ratio of 5 and length-to-width ratio of 2 and with corresponding linear dimensions in the ratio 0.5 : 1 : 2 were tested at freestream Mach number 0.71. Additionally, the 0.5 and 1 scale models were tested at freestream Mach number of 0.85. The experiments involved timeaveraged pressure measurements, unsteady pressure measurements, and PIV measurements. Time-averaged pressure measurements made at the floor were used to study the ’flow-type’ of the cavities. Unsteady pressure measurements were used to study the acoustic characteristics of the cavity. The cavity length-to-boundary layer thickness ratios tested were 10, 20 and 40. The Cp distribution on the clean cavities indicated a change in the cavity flowtype with change in the cavity scale. Varying the L/δ from 10 to 40 changed the cavity flow-type from open to transitional. Analysis of the frequency spectra of the cavity revealed an increase in tonal amplitudes and OASPL with increasing L/δ . The PIV measurements indicated that this could be caused by an increase in energy exchange between the freestream and the cavity. The velocity magnitudes inside the cavities were found to increase with increase in L/δ . A comparative study of different passive control methods on the largest cavity showed that leading-edge spoilers were superior in cavity tone suppression. Of these, the effectiveness of a sawtooth spoiler on the three cavities of different scales was tested. The results showed that while the spoiler was effective in eliminating tones and suppression of noise for the smaller cavities, it was unable to eliminate the tones completely for the largest cavity. To find the correct method for scaling the spoilers with the cavity dimensions, different spoiler heights were tested on the three cavities. The results showed that the cavity noise suppression for a given cavity attains saturation level at a particular spoiler height, called the critical spoiler height. An increase in spoiler height beyond the critical spoiler height was found to have no effect on the noise suppression. It is also found that this critical spoiler height can be scaled with the length of the cavity (for given L/D, M and spoiler profile) irrespective of the boundary layer thickness.

Little thought has been given to asyndeton in modern texts, including the translated text. In fact, if manuals on French-to-English translation even mention this troublesome case of punctuation, they almost certainly warn the student translator against replicating it in English, even in literary translation. Writing norms would forbid it, they warn. It would be taken as merely a sloppy case of comma use. Although asyndeton is typically considered a faux pas in English, replicating it may not always be a mistake. Inspired by Québécoise author Catherine Harton’s Traité des peaux (an especially asyndetic collection of short stories published in 2015), this thesis aims to study how asyndeton may be successfully translated from French into English in literary texts. To do so, it adopts Sperber and Wilson’s relevance theory, noting how this theory not only accounts for poetic effects but also provides a principle that can guide translators as they seek to replicate these effects. This thesis then uses relevance theory to analyze cases of asyndeton drawn from three stories in Harton’s collection. The study concludes that there are at least six cases where asyndeton may be effectively translated as asyndeton in literary texts.

Norethynodrel, a common progestin in oral contraceptives, produces in female rats several significant physiological, cytological and biochemical changes at dose levels of 1 mg and 20 mg per kg: 1) a relative increase in liver mass 2) modification of appearance and extent of the endoplasmic reticulum 3) augmentation of the protein content of the liver 4) increase of the level of cytochrome P- 450 in the liver as determined by : a) difference spectroscopy b) increases in biotransformation of aniline and aminopyrine in vitro and c) reduction of sleeping times of rats dosed with phenobarbital The significance of these findings becomes evident when it is realized that norethynodrel affects and is affected by the same enzyme system which oxidizes medicaments in general in the body: induction of cytochrome P-450 by administration of norethynodrel may interfere with the action of other drugs . Ethinyl estradiol alone showed none of the inductive effects. At high dose levels (20 mg per kg) both norethynodrel and ethinyl estradiol caused a marked inhibition of growth of the animals, producing a net loss of body mass over the 30- day experimental period. Electron micrographic evidence implies that there is also a lowering of glycogen content and a chemical change in the lipids of adrenocortical and liver cells accompanying the use of these agents.

Abstract Radiotherapy is used in the treatment of breast cancer in order to reduce local recurrence rate. However, radiation is known to cause both acute and delayed side-effects on normal tissues. A common late complication of radiotherapy is fibrosis of skin and other organs. Fibrosis has been described as excessive accumulation of extracellular matrix components, especially collagens. Collagens are a group of extracellular matrix proteins that provide connective tissues with tensile strength. Type I and III collagens are the major structural proteins in skin. Alterations in collagen synthesis occur in various pathological conditions, during ageing and in association with diverse medical therapies. Collagens are degraded by matrix metalloproteinase enzymes (MMPs). The activity of MMPs is restrained by their specific tissue inhibitors (TIMPs). Elastic fibres constitute about 2–4% of skin dry weight. Despite their low quantity, elastic fibres are responsible for the resilient and elastic properties of skin. Dermal elastic fibres may be affected by intrinsic ageing, by extrinsic reasons such as photodamage and in several connective tissue diseases. The effect of radiotherapy on human skin type I and III collagen synthesis was investigated in a group of women who had been treated for breast cancer surgically and with radiotherapy. The levels of MMP-9, MMP-2/TIMP-2 complex, TIMP-1 and TIMP-2 in irradiated skin were also analysed. The effect of radiotherapy on elastic fibres was analysed using skin samples. The physio-mechanical properties of radiotherapy-treated skin were studied using ultrasound and elastometer devices, and compared with those of non-treated skin. In addition, skin samples were stained for haematoxylin-eosin, tenascin and mast cells. Factor VIII immunostaining was performed to visualize dermal blood vessels. Wound regeneration in irradiated skin was also studied using suction blister as a model. The synthesis of type I and III collagens was markedly increased as a result of radiotherapy. An increased amount of cross-linked type I collagen was detected in irradiated skin, and collagen turnover was also increased in irradiated skin. No difference in the amount or structure of the elastic fibres could be found between radiotherapy-treated and non-treated skin. A slight increase of skin thickness and stiffness was found in irradiated skin compared to non-treated skin. Increased tenascin expression was found in irradiated skin. The number of dermal blood vessels visualized by FVIII immunostaining was slightly higher in irradiated than in control skin. The amount of mast cells positive for tryptase, Kit receptor and chymase was increased in the upper dermis of irradiated skin. No difference in epidermal regeneration was found between irradiated and non-treated skin. The results of this study suggest that alteration of collagen metabolism contributes to dermal side effects of therapeutic irradiation.

The aim of the study is to investigate the impact of exclusion of children on marriage dissolution proceedings and decisions. This investigation takes place in Matatiele, Thotaneng at Tshita administrative area. It further investigate to what extent are children included in the process and if they do receive guidance in the process of the dissolution of a customary marriage. This thesis is aiming at investigating the role of the church could play in improving the situation of children who are caught up in the process of the dissolution of a customary marriage and recommendations thereof. The customary marriage, which is not registered, therefore, the study will investigate the effect of this kind of marriage on the community that practicing it. / Dissertation (MA Theol)--University of Pretoria, 2013. / gm2014 / Practical Theology / unrestricted

Class of 2014 Abstract / Specific Aims: To compare trends in user demographics, clinical effects, and clinical outcomes associated with the use of synthetic cannabinoids and cathinones before and after signing into law the Synthetic Drug Abuse Prevention Act of 2012 on July 9, 2012. Methods: Reports generated by the National Poison and Drug Information Center’s Toxic Exposure Surveillance System were used to isolate calls regarding patients who reportedly used either synthetic cannabinoids or synthetic cathinones from July 2011 to March 2013. Clinical effects, clinical outcomes, and demographic information of patients associated with these calls from July 9, 2011 to July 8, 2012, were compared to that of patients associated with calls from July 9, 2012 to July 8, 2013. Main Results: Pending Conclusion: Pending