In the recent years, companies began emphasize the employees¡¦ cognition on happiness and well-being to recruit and retain the talents and human resources. This study is to explore the factors influencing the employee¡¦s well-being cognition and the impacts of attitudes and behaviors from the employees¡¦ well-being. This study adopted the high-performance human resource practice (HPHRP) in organization level as the independent variable and the organizational identification, job involvement and job searching behavior in individual level as dependent variables. The employee¡¦s well-being was a mediator between the independent and dependent variables to examine the mediating effects. This research employed the questionnaire suvey to collect the data. To avoid the common method variance, the questionnaire is divided into two parts, one for the HR professionals, and another on for the general employees. The data was collected from fifty companies. Valid questionnaires from fifty HR professionals and 461 employees are included. The Hierarchical Linear Modeling (HLM) was used in the main hypotheses tests to examine the relationships among the variables. The results showed that the HPHRP of company has significant positive influences on employee¡¦s well-being, organizational identification, and job involvement, and has significant negative influence on job search behavior. Employee¡¦s well-being has positive influences on organizational identification and job involvement. Employee¡¦s well-being is also a mediator between the relationships HPHRP and organizational identification and job involvement of employee. Based on the results, this study proposed some empirical and practical suggestions.