Global ETD Search

71	Formation, storage and secretion of prostasomes in benign and malignant cells and their immunogenicity in prostate cancer patients / Sahlén, Göran, January 2007 (has links) Diss. (sammanfattning) Uppsala : Uppsala universitet, 2007. / Härtill 4 uppsatser.
72	Hyposialylation regulates [alpha]4[beta]1 integrin binding to VCAM-1 Woodard-Grice, Alencia V. January 2008 (has links) (PDF) Thesis (Ph.D.)--University of Alabama at Birmingham, 2008. / Title from first page of PDF file (viewed on June 29, 2009). Includes bibliographical references.
73	Protease dysregulation role in neutrophilic inflammation in cystic fibrosis / Gaggar, Amit. January 2007 (has links) (PDF) Thesis (Ph. D.)--University of Alabama at Birmingham, 2007. / Title from first page of PDF file (viewed Feb 17, 2009). Includes bibliographical references.
74	Approches nanotechnologiques et nutraceutiques dans le traitement de la maladie d'Alzheimer Phivilay, Alix 13 April 2018 (has links) La maladie d'Alzheimer (MA) est une maladie neurodégenerative qui risque de toucher plusieurs personnes dans les années à venir. Dans le cadre du projet de recherche, nous approchons le traitement de la MA par deux moyens : un traitement innovateur d'inhibition de la β-sécrétase et l'identification d'un facteur environnemental modifiable. Une stratégie intéressante afin de passer la barrière hémato-encéphalique serait de concevoir un système de transport de médicaments basé sur des immunoliposomes péguylés. En ce qui attrait à la prévention d'un facteur environnemental, nous avons étudié l'effet d'une diète en acides gras trans (AGT) sur un modèle de souris transgénique Alzheimer (3xTg-AD). D'une part, les travaux présentés dans ce mémoire ont porté sur les premières étapes de développement d'une formulation pharmaceutique dans le but d'inhiber la β-sécrétase au cerveau. D'autre part, les diètes en AGT n'ont pas démontré une incidence significative sur les marqueurs neuropathologiques d'un modèle animal Alzheimer Liposomes Excipients Endopeptidases Acides gras trans
75	Subcellular Localization and Partial Purification of Prelamin a Endoprotease: An Enzyme Which Catalyzes the Conversion of Farnesylated Prelamin a to Mature Lamin A Kilic, Fusun, Johnson, D A., Sinensky, M. 30 April 1999 (has links) The nuclear lamina protein, lamin A is produced by proteolytic cleavage of a 74 kDa precursor protein, prelamin A. The conversion of this precursor to mature lamin A is mediated by a specific endoprotease, prelamin A endoprotease. Subnuclear fractionation indicates that the prelamin A endoprotease is localized at the nuclear membrane. The enzyme appears to be an integral membrane protein, as it can only be removed from the nuclear envelope with detergent. It is effectively solubilized by the detergent n-octyl-beta-D-glucopyranoside and can be partially-purified (approximately 1200-fold) by size exclusion and cation exchange (Mono S) chromatography. Prelamin A endoprotease from HeLa cells was eluted from Mono S with 0.3 M sodium chloride as a single peak of activity. SDS-PAGE analysis of this prelamin A endoprotease preparation shows that it contains one major polypeptide at 65 kDa and smaller amounts of a second 68 kDa polypeptide. Inhibition of the enzyme activity in this preparation by specific serine protease inhibitors is consistent with the enzyme being a serine protease. acrylic resins detergents electrophoresis polyacrylamide gel glucosides (metabolism) hela cells (enzymology) humans lamin type a lamins nuclear proteins (metabolism) protein precursors (metabolism) protein prenylation subcellular fractions (enzymology) Biological Sciences
76	Recombinant AAV gene therapy and delivery for Alzheimer's disease Carty, Nikisha Christine. January 2009 (has links) Dissertation (Ph.D.)--University of South Florida, 2009. / Title from PDF of title page. Document formatted into pages; contains 193 pages. Includes vita. Includes bibliographical references.

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