Global ETD Search

1	Behavioural effects of enhanced expression of equilibrative nucleoside transporter 1 or knockout of ecto-5’-nucleotidase in mice Sun, Chao 09 April 2012 (has links) Adenosine is an important neuromodulator. In the present study, we used mice with expression of human ENT1 (hENT1) and deficiency of CD73, respectively, to address the relative importance of intracellular and extracellular pathways in adenosine regulation. [3H]Nitrobenzylthioinosine binding assays were performed and found increased expression of hENT1 with increased gene dose. We performed a series of behavioural experiments with caffeine and ethanol and compared hENT1 heterozygous and homozygous transgenic mice to their wild type littermates. We found that the expression of hENT1 leads to a change in behavioural responses relative to wild type mice, but no sign of a gene dose dependent increase was observed. With CD73 knockout mice, we performed a series of behavioural experiments with caffeine and ethanol that showed a change in adenosine related behaviours. We also performed experiments that tested anxiety-like behaviours and found reduced anxiety-like behaviours with CD73 knockout mice relative to wild type mice. These studies show that mice with enhanced expression of ENT1 or knockout of CD73 have altered extracellular level of adenosine. Adenosine ENT1 CD73 alcohol caffeine anxiety
2	Behavioural effects of enhanced expression of equilibrative nucleoside transporter 1 or knockout of ecto-5’-nucleotidase in mice Sun, Chao 09 April 2012 (has links) Adenosine is an important neuromodulator. In the present study, we used mice with expression of human ENT1 (hENT1) and deficiency of CD73, respectively, to address the relative importance of intracellular and extracellular pathways in adenosine regulation. [3H]Nitrobenzylthioinosine binding assays were performed and found increased expression of hENT1 with increased gene dose. We performed a series of behavioural experiments with caffeine and ethanol and compared hENT1 heterozygous and homozygous transgenic mice to their wild type littermates. We found that the expression of hENT1 leads to a change in behavioural responses relative to wild type mice, but no sign of a gene dose dependent increase was observed. With CD73 knockout mice, we performed a series of behavioural experiments with caffeine and ethanol that showed a change in adenosine related behaviours. We also performed experiments that tested anxiety-like behaviours and found reduced anxiety-like behaviours with CD73 knockout mice relative to wild type mice. These studies show that mice with enhanced expression of ENT1 or knockout of CD73 have altered extracellular level of adenosine. Adenosine ENT1 CD73 alcohol caffeine anxiety
3	Variabilität des Therapieansprechens von Gemcitabin bei Pankreaskarzinom: Identifizierung relevanter Genpolymorphismen / Retrospektive Studie bei Patienten mit Pankreaskarzinom / Variability of therapy response in gemcitabine treated pancreatic carcinoma: Identifying relevant gene polymorphisms / Retrospectiv study in patients with pancreatic carcinoma Schaudinn, Alexander 28 January 2013 (has links) No description available. 610 Klinische Pharmakologie Gemcitabine Gene Polymorphism ENT1 Pancreatic Carcinoma
4	Functional Assessment of Biomarkers in Gemcitabine-Treated Pancreatic Cancer with Specific Focus on Nucleoside Transporter ENT1 Roppel, Sebastian 16 October 2013 (has links) No description available. 610 Gemcitabine SLC29A1 ENT1 Gemcitabine transport Medizin (PPN619874732)
5	Role of OCTN1 (SLC22A4) in the Disposition of Nucleoside Analogs in AML Anderson, Jason T., PharmD January 2019 (has links) No description available. Pharmaceuticals Pharmacy Sciences Pharmacology Transporter Cytarabine Epigenetics Pharmacokinetics OCTN1 ENT1
6	Identifizierung von Biomarkern für die Prognose der Gemcitabin-Therapie beim Pankreaskarzinom: RNA-, DNA- und Immunhistochemische- Analysen / Identification of biomarkers for the prognosis in gemcitabine treated pancreatic cancer: RNA-, DNA- and immunhistochemical- analysis Zimmer, Christian 11 February 2015 (has links) No description available. 610 Gemcitabin Pankreaskarzinom ENT1 genetische Polymorphismen Nukleosid Transporter pankreatic cancer gemcitabin treatment ent1 genetic polymorphisms nucleoside transporter

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