Alternative means of satisfying the high bandwidth and protected communications requirements for New Construction Naval Surface Ships in the midst of conflicting reduced radar cross section (RCS) requirements were investigated using the systems engineering process. <p>Various antenna, ranging from parabolic dish antennas to Luneberg lens antennas to phased array antennas, and feed and amplifier combinations were considered to provide a dual-band Super High Frequency (SHF) and Extremely High Frequency (EHF) Satellite Communications (SATCOM) Terminal (SEST). <p>Through the design of this hypothetical system, the various stages of the systems engineering process are considered-- definition of need, conceptual design, preliminary system design, production and installation, and utilization and support. Sample tasks are performed at each stage in the process (e.g., a system performance specification is prepared in the advanced system planning stage). <p>The set of technical solutions that remained in the preliminary design phase are compared based on life cycle costs. Two approaches are recommended -- one assuming lowest life cycle cost has highest priority and one assuming that the ability to communicate simultaneously on SHF and EHF has highest priority. / Master of Science

Thesis: M.S., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 1980 / Includes bibliographical references. / by Tarek Mohamed Habashy. / M.S. / M.S. Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science

The aims of this study were to evaluate the influence of an extremely low-frequency electromagnetic field (ELF-EMF) on [3H]glucose uptake in the peripheral tissues and organs of rats. Rats were exposed to ELF-EMF (frequency-10 Hz, induction -1.8-3.8 mT) one hour daily for 14 consecutive days. Control animals were sham exposed. On the 15th day (24 hours after last exposure) rats were injected with D-[3H]-6-glucose 500μCi/kg IP. Fifteen minutes later animals were sacrificed by decapitation and peripheral tissues were excised and examined for radioactivity (desintegrations per minute, DPM/ 100 mg wet tissue weight), which expressed [3H]glucose uptake. In most of the examined tissues and organs, such as liver, kidney, heart muscle, cartilage, connective tissue, tendon and skin, [3H]glucose uptake in ELF-EMF-exposed animals was significantly higher as compared to that in the sham control. Exposure to ELF-EMF did not influence [3H]glucose uptake in the thoracic aorta and the skeletal muscle. It is concluded that ELF-EMF impacts tissue glucose uptake by facilitating glucose transport via cell membranes, dependent and probably also independent of its role in increasing insulin action in insulin-dependent tissues.

京都大学 / 新制・論文博士 / 博士(医学) / 乙第13580号 / 論医博第2302号 / 新制||医||1069(附属図書館) / (主査)教授 平井 豊博, 教授 江木 盛時, 教授 齋藤 潤 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM

No description available.

Sammanfattning Mål: Tidigare studier visar att delar av den fysiska och psykiska tillväxten och utvecklingen hos för tidigt födda barn kan påverkas av den förkortade graviditetsperioden. De odontologiska aspekterna av prematuritet har ännu inte till fullo studerats. Syftet med denna studie är att undersöka om tandmognaden påverkas av för tidig födsel och om enskilda tänder i högre utsträckning är mer påverkade.Material och Metod: I studien deltog 116 barn: 36 extremt för tidigt födda barn (extremely preterm - EPT), 38 mycket för tidigt födda barn (very preterm – VPT) och 42 fullgångna kontroller (controls – C). Panoramaröntgenbilder analyserades av fem kalibrerade observatörer, enligt en metod som utvecklats av Demirjian och Goldstein. Röntgenbilderna avidentifierades och mognadsgraden av de 7 permanenta tänderna i underkäkens vänstra sida (tand 31-37) bedömdes enligt ett 8-stegs system. De 7 bedömningarna adderades sedan till en tandmognadspoäng (maturity score) som motsvarade barnets tandmognadsgrad. Detta möjliggjorde jämförelser på såväl gruppnivå som tandnivå. Observatörernas tillförlitlighet och metodens reproducerbarhet utvärderades genom att 27 slumpvis utvalda röntgenbilder bedömdes ytterligare en gång. Statistiska analyser utfördes av studiens resultat samt av reproducerbarheten.Resultat: Resultatet, med hänsyn till variationer i observatörernas bedömningar, visade att EPT-gruppen hade en genomsnittlig tandmognadspoäng mellan 81.9 och 86.7, VPT 85.2-89.1 och kontrollgruppen 88.1-91.0. Samtliga fem observatörer uppvisade statistiskt signifikanta skillnader mellan EPT-gruppen och kontrollgruppen (p≤0.006). På tandnivå uppvisade alla observatörer en signifikant fördröjning (p≤0.002) av tandmognaden för tand 37 när EPT-gruppen jämfördes mot kontrollgruppen. Signifikanta skillnader mellan ett flertal andra tänder erhölls men konsensus mellan observatörerna saknades. Överensstämmelsen inom varje enskild observatör (intra-observer agreement) beräknades med ett Kappa-test, där resultaten varierade mellan 0.16-1.00. Kappa-beräkningen av reproducerbarheten mellan samtliga observatörer (inter-observer agreement) varierade mellan 0.31-0.71.Slutsats: Resultaten i denna studie tyder på en allmän försening av tandmognaden vid 9 års ålder hos de extremt för tidigt födda barnen (EPT), jämfört med fullgångna barn (C). En förkortad gestationsperiod tycks indikera en fördröjning av tandmognaden jämfört med tandmognaden hos fullgångna barn.

Many antibiotic resistance genes (ARGs) conferring resistance to a broad range of antibiotics have often been detected in aquatic environments such as untreated and treated wastewater, river and surface water. ARG proliferation in the aquatic environment could depend upon various factors such as geospatial variations, the type of aquatic body, and the type of wastewater (untreated or treated) discharged into these aquatic environments. Likewise, the strong interconnectivity of aquatic systems may accelerate the spread of ARGs through them. Hence a comparative and a holistic study of different aquatic environments is required to appropriately comprehend the problem of antibiotic resistance. Many studies approach this issue using molecular techniques such as metagenomic sequencing and metagenomic data analysis. Such analyses compare the broad spectrum of ARGs in water and wastewater samples, but these studies use comparisons which are limited to similarity/dissimilarity analyses. However, in such analyses, the discriminatory ARGs (associated ARGs driving such similarity/ dissimilarity measures) may not be identified. Consequentially, the reason which drives the dissimilarities among the samples would not be identified and the reason for antibiotic resistance proliferation may not be clearly understood. In this study, an effective methodology, using Extremely Randomized Trees (ET) Algorithm, was formulated and demonstrated to capture such ARG variations and identify discriminatory ARGs among environmentally derived metagenomes. In this study, data were grouped by: geographic location (to understand the spread of ARGs globally), untreated vs. treated wastewater (to see the effectiveness of WWTPs in removing ARGs), and different aquatic habitats (to understand the impact and spread within aquatic habitats). It was observed that there were certain ARGs which were specific to wastewater samples from certain locations suggesting that site-specific factors can have a certain effect in shaping ARG profiles. Comparing untreated and treated wastewater samples from different WWTPs revealed that biological treatments have a definite impact on shaping the ARG profile. While there were several ARGs which got removed after the treatment, there were some ARGs which showed an increase in relative abundance irrespective of location and treatment plant specific variables. On comparing different aquatic environments, the algorithm identified ARGs which were specific to certain environments. The algorithm captured certain ARGs which were specific to hospital discharges when compared with other aquatic environments. It was determined that the proposed method was efficient in identifying the discriminatory ARGs which could classify the samples according to their groups. Further, it was also effective in capturing low-level variations which generally get over-shadowed in the analysis due to highly abundant genes. The results of this study suggest that the proposed method is an effective method for comprehensive analyses and can provide valuable information to better understand antibiotic resistance. / MS / Antibiotic resistance is a natural and primordial process that predates the use of antibiotics in humans for disease treatment and occurs when a bacterium evolves to render the drugs, chemicals, or other agents meant to cure or prevent infections ineffective. Antibiotic resistance genes (ARGs) conferring resistance to a wide range of antibiotics have been widely found in rivers, surface waters, and hospital and farm wastewater discharges. Even treated wastewater from treatment plants is a concern as ARGs have frequently been detected in effluent discharges which poses questions on the effectiveness of treatment plants in removing ARGs. Since, these systems are interconnected there’s a possibility of dissemination and proliferation of ARGs which may pose serious threat to human health. Hence, it is desirable to perform comparative studies among these aquatic habitats. In previous studies, researchers compared different habitats which tells how similar and dissimilar the environments are in terms of ARGs present in these samples. While these analyses are important, it doesn’t tell which ARGs are unique or which ARGs are responsible to create those similarities or dissimilarities. This information is crucial in order to understand the water environments in terms of occurrence and presence of ARGs, the risk posed by them, and in identifying factors responsible for resistance gene proliferation. In this research, a methodology was developed which could capture such ARG variations in the environmental samples, using data analysis algorithms. Further the developed methodology was demonstrated using environmental samples such as wastewater samples from different geographical locations (to understand the spread of ARGs globally), untreated vs treated wastewater (to understand the effectiveness of treatment plants in removing ARGs), and different aquatic habitats (to understand the impact and spread of ARGs within these habitats). It was determined that the proposed method was efficient in differentiating samples and identifying discriminatory ARGs. The comparison between environmental samples showed that the samples from different locations have specific ARGs which were unique to wastewater samples from certain locations suggesting that site-specific factors can have certain effect in shaping the ARG profiles. Comparing untreated and treated samples revealed that treatment plants were able to remove certain ARGs but it was also observed v that some ARGs proliferated after the treatment irrespective of location and treatment plant specific variables. Analyzing different environments, the approach was able to identify certain ARGs which were specific to certain environments. The results of this study suggest that the proposed method is an effective method for comprehensive analyses and can provide valuable information to better understand antibiotic resistance. In essence, it is a valuable addition for improved surveillance of antibiotic resistance pollution and for the framing of best management practices.

[pt] Nos últimos anos, as bandas de frequências nas comunicações sem fio estão começando a saturar devido ao incremento do tráfego e o aumento dos usuários, é devido a isso que, é necessário estudar as bandas de frequências que não estão sendo utilizadas nas áreas das comunicações como a banda milimétrica e sub-milimétrica. A transmissão de dados na banda EHF o banda milimétrica constitui uma possível solução para conseguir transmitir maiores quantidades de informação a altas velocidades de transmissão aliviando as bandas de frequências atuais. Neste trabalho se estuda a transmissão de dados em frequências de 100, 200, 300 e 400 GHz, empregando a modulação Quadrature Phase-Shift Keying (QPSK) mediante uma arquitetura baseada no batimento de dois lasers, cujas frequências são combinadas em um Beam Splitter, para que a corrente resultante da soma dos campos elétricos dos dois lasers seja convertida em um sinal de alta frequência por meio de uma antena fotocondutora. O batimento dos dois lasers, com diferentes comprimentos de onda e com a mesma potência, ao interagir com uma antena fotocondutora dá como resultado uma frequência na ordem de Gigahertz. No experimento utilizaram-se dois tipos de diodos receptores, um de banda larga (menor que 4 GHz) e outro de banda estreita (menor que 1 MHz). As duas antenas foram testadas em diferentes distâncias e com diferentes frequências de portadora para verificar qual delas tinha o melhor desempenho na banda EHF para poder realizar a transmissão de dados. / [en] In recent years, the frequency bands in wireless communications are beginning to saturate due to the increase of traffic and the increase of users, and it for that reason that is necessary to study the frequency bands that are not begin used in the communication areas like millimeter and sub-millimeters bands. Data transmission in the EHF band is a possible solution to be able to transmit large amounts of information at high transmission speeds, alleviating current frequency bands. In this work, the transmission of data in frequencies of 100, 200, 300 and 400 Gigahertz is studied, using Quadrature phase-shift keying (QPSK) modulation with an architecture based on the beat of two lasers, whos frequencies are combined by means of Beam Splitter, so that result of the electric fields of two lasers is converted into a high frequency signal with the aid of a photoconductor antenna. The.beating of the two lasers, with different wavelengths and with the same power, when interacting with a photoconductor antenna results in a frequency in the order of Gigahertz. In the experiment, two types of receiver diodes were used, one Broadband (less than 4 GHz) and the other of narrowband (less than 1 MHz). The two antennas were tested at different distances and with different carrier frequencies to verify which one had the best performance in the EHF band in order to perform the data transmission.

Exponering av det lågfrekventa ELF (Extremely low frequency) magnetfältet som genereras vid dagens elnät är något som är relativt nytt för människokroppen och den ökar ständigt i och med den tekniska utvecklingen. Eftersom det inte finns ett klart svar på hur fältet påverkar kroppen så tillämpas försiktighet för att hålla exponeringsnivåerna nere och försäkra sig om att ingen skada sker. Med hjälp av tidigare forskning inom området och uppmätta värden från olika anläggningar samt överslagsberäkningar har ett verktyg i Excel tagits fram för att kunna uppskatta magnituden av magnetfältet. Verktyget innehåller information om styrkan på magnetfältet från transformatorer, ställverk, elcentraler, kraftledningar och kanalskenor. Användaren skriver in ett antal parametrar för att få utdata om hur starkt magnetfältet är på olika avstånd ifrån källan. Detta presenteras i form av en tabell och en graf för respektive utrustning. Eftersom magnetfält alstras beroende på strömmens riktning, påverkar själva geometrin i olika elanläggningar magnetfältets styrka. För att beräkna exakta värden krävs då avancerade simuleringsprogram. Med detta verktyg kan projektörer redan vid ett tidigt skede uppskatta magnetfältet. / The exposure of ELF (Extremely low frequency) magnetic field generated by today’s electrical power system, is something that is relatively new to the human body and it is constantly increasing as more technology is developed. As there is no clear answer on how the field actually affects the body, a measure of caution is applied to ensure that the exposure levels are kept down to make sure no harm is done. With the help of previous research in the field, measured values from different locations and approximate calculations, a tool was developed in Excel to estimate the magnitude of the magnetic fields. The tool provides information about the magnitude of magnetic fields from transformers, switchgears, switchboards, powerlines and busbars. The user enters a number of parameters and the tool provides output data with the magnitude of the magnetic field at different distances from the source. This is presented in the form of a table and a graph for each equipment. Since the magnetic field is generated depending on the currents direction, the actual geometry of the electrical system needs to be taken in consideration when calculating the exact magnetic field. This requires an advanced simulation software to be accurate. With this tool, designers have the opportunity to estimate the magnetic fields at an early stage of development.

Exponering av det lågfrekventa ELF (Extremely low frequency) magnetfältet som genereras vid dagens elnät är något som är relativt nytt för människokroppen och den ökar ständigt i och med den tekniska utvecklingen. Eftersom det inte finns ett klart svar på hur fältet påverkar kroppen så tillämpas försiktighet för att hålla exponeringsnivåerna nere och försäkra sig om att ingen skada sker. Med hjälp av tidigare forskning inom området och uppmätta värden från olika anläggningar samt överslagsberäkningar har ett verktyg i Excel tagits fram för att kunna uppskatta magnituden av magnetfältet. Verktyget innehåller information om styrkan på magnetfältet från transformatorer, ställverk, elcentraler, kraftledningar och kanalskenor. Användaren skriver in ett antal parametrar för att få utdata om hur starkt magnetfältet är på olika avstånd ifrån källan. Detta presenteras i form av en tabell och en graf för respektive utrustning. Eftersom magnetfält alstras beroende på strömmens riktning, påverkar själva geometrin i olika elanläggningar magnetfältets styrka. För att beräkna exakta värden krävs då avancerade simuleringsprogram. Med detta verktyg kan projektörer redan vid ett tidigt skede uppskatta magnetfältet. / The exposure of ELF (Extremely low frequency) magnetic field generated by today’s electrical power system, is something that is relatively new to the human body and it is constantly increasing as more technology is developed. As there is no clear answer on how the field actually affects the body, a measure of caution is applied to ensure that the exposure levels are kept down to make sure no harm is done. With the help of previous research in the field, measured values from different locations and approximate calculations, a tool was developed in Excel to estimate the magnitude of the magnetic fields. The tool provides information about the magnitude of magnetic fields from transformers, switchgears, switchboards, powerlines and busbars. The user enters a number of parameters and the tool provides output data with the magnitude of the magnetic field at different distances from the source. This is presented in the form of a table and a graph for each equipment. Since the magnetic field is generated depending on the currents direction, the actual geometry of the electrical system needs to be taken in consideration when calculating the exact magnetic field. This requires an advanced simulation software to be accurate. With this tool, designers have the opportunity to estimate the magnetic fields at an early stage of development.