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The protein Liquid facets (Lqf) promotes endocytosis at the plasma membrane1. Lqf activity is required for proper Notch signaling, likely through facilitating the endocytosis of Notch ligand by indirectly linking ligand to clathrin. A genetic modifier screen to identify genes that interact with lqf was performed by a previous graduate student. Genes identified in the screen might provide new insights into how Lqf promotes endocytosis or how Notch signaling is regulated. In this work, I performed genetic mapping techniques to identify the genes mutated in each complementation group of the screen. I identified the gene mutated in complementation group 6 as mitochondrial alanyl tRNA synthetase (Aats-ala-m). tRNA synthetases link a tRNA to its cognate amino acid during translation. Mitochondrial tRNA synthetases function in the mitochondria in translation. Aats-ala-m genetically interacts with lqf, suggesting the two genes function in the same pathway. In this work, I also identified chromosomal regions where the genes mutated in complementation groups 1,2, and 9 are located. / text

Made available in DSpace on 2014-06-12T15:54:33Z (GMT). No. of bitstreams: 2 arquivo1977_1.pdf: 1819935 bytes, checksum: 4162d549c75996e549bcc53383212659 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2008 / Software Reuse has been considered a key concept to increase the quality and productivity of the software development by the reuse of existing artifacts, avoiding build new ones from scratch. However, In order to obtain effective benefits from the software reuse is necessary a set of complementary resources such as: education, active management support and the introduction of appropriate process and tools. In fact, resources that provide mechanism to ease the access of reusable components, such as search and retrieval tools, appear as potential instruments in favor of reuse programs adoption in the organizations. One of the challenges of the search and retrieval tools is how to make that existing components returned have a significant relevance. In this sense, the use of the faceted approach rises as a suitable alternative. This approach proposes the creation of a vocabulary supported by attributes, dividing the components into group of classes based on pre-defined keywords, increasing the level of precision and providing a more flexible classification. Thus, this work presents an extension of search and retrieval tool of reusable components, source code in particular, using the faceted classification approach. In addition, also was developed an auxiliary tool to aid the Domain expert to perform his activities using this approach. Finally, an experimental study evaluates the proposed solution

Thesis advisor: Raquel Muñiz / Trust is never more important than during a crisis. For years, researchers have been studying trust in organizations and schools, focusing on the principal and teacher relationship and its impact on school climate. The literature has been less focused, however, on the superintendent and principal relationship—and the role trust plays within that relationship. Moreover, given the recency and continually evolving nature of COVID-19, there is little research about the actions superintendents and principals are taking to lead their school communities through this pandemic and even less research on how this crisis impacts the relational trust between the superintendent and the principal. The purpose of this study, therefore, is to examine how trust impacts the relationship between the superintendent and the principals in their district. Accordingly, this study will address the following research questions: 1) How do principals view their relationship with the superintendent and their schools during a crisis? and 2) What practices influence the role of trust in this relationship? To understand how principals view their relationships with their superintendent, as well as practices that influence trust, I conducted six interviews with five principals and the superintendent, and I observed a School Committee meeting where a principal presented on behalf of all principals in support of the superintendent. Principals highlighted how working for a benevolent, competent, and reliable superintendent over a long period of time helps them build trust in their superior while also leading a school during a time of crisis. Practices that appeared to build and sustain trust during the COVID-19 crisis and that support a trusting relationship between the superintendent and principals include length of time working together; perceived trust from the superintendent in the principals’ competence, which led to reciprocal trust; the ability to advocate for systems-wide change; and acts of benevolence. This research emphasizes that the relationship between principals and the superintendent matters. It is essential that trust is developed between principals and the superintendent to ensure a stable working environment for staff, ultimately leading to greater consistency for students during trying times in school and beyond. / Thesis (EdD) — Boston College, 2022. / Submitted to: Boston College. Lynch School of Education. / Discipline: Educational Leadership and Higher Education.

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An investigation is presented into methods of characterising cirrus ice crystals from in-situ light scattering data. A database of scattering patterns from modelled crystals was created using the Ray Tracing with Diffraction on Facets (RTDF) model from the University of Hertfordshire, to which experimental and modelled data was fitted. Experimental data was gathered in the form of scattering patterns from ice analogue crystals with similar optical properties and hexagonal symmetry to ice, yet stable at room temperature. A laboratory rig is described which images scattering patterns from single particles while allowing precise control over the orientation of the particle with respect to the incident beam. Images of scattering patterns were captured and compared to patterns from modelled crystals with similar geometry. Methods for introducing particles en-masse and individually to the Small Ice Detector (SID) instruments are discussed, with particular emphasis on the calibration of the gain of the SID-2 instrument. The variation in gain between detector elements is found to be significant, variable over the life of the detector, and different for different detectors. Fitting was performed by comparison of test scattering patterns (either modelled or experimental) to the reference database. Representation of the two dimensional scattering patterns by asymmetry factor, moment invariants, azimuthal intensity patterns (AIP) and the Fourier transform of the AIP are compared for fitting accuracy. Direct comparison of the AIP is found to be the most accurate method. Increased resolution of the AIP is shown to improve the fitting substantially. Case studies are presented for the fitting of two ice analogue crystals to the modelled database. Fitting accuracy is found to be negatively influenced by small amounts of surface roughness and detail not currently considered by the RTDF model. Fitting of in-situ data gathered by the SID-3 instrument during the HALO 02 campaign at the AIDA cloud chamber in Germany is presented and discussed. Saturation of detector pixels is shown to affect pattern fitting. In-flight operation of the instrument involves the variation of gain of the whole detector (as opposed to individual elements) in order to obtain unsaturated images of both large and small particles.

Cet essai a pour objet le rôle de la notion de fiction dans les domaines de l’art et de la science. Essentiellement, je soutiens que « fiction » dans ce contexte est « a category mistake » (concept versus genre) et je crois que cet essai peut réussir à « cuire du pain philosophique » en dévoilant une dispute verbale. Je suggère donc de clore un débat philosophique dans son intégralité. Je présente un exposé du style de fictionnalisme abordé par Catherine Z. Elgin et Nelson Goodman (que ce soit dans le contexte des arts ou des sciences, nous parvenons à la compréhension grâce à des fictions sous formes de « vérités non littérales ») et j’explore le concept de la fiction. Je soutiens que les représentations (textes descriptifs de toutes sortes, incluant les modèles) sont constituées d’éléments fictionnels et d’éléments facettés (à l’exception de la version idéale possible ou impossible, c’est-à-dire dans l’esprit de Dieu, qui n’inclurait que les facettes.) La compréhension ne peut provenir de la fiction, mais plutôt d’éléments facettés ordonnés de manière à créer une compréhension qui conduit généralement à des prédictions, des explications et des manipulations. Je définis les facettes comme ayant des caractéristiques organisées, alors que les fictions ont des caractéristiques désorganisées. La fiction dans son intégralité est donc, par définition, l’expression du néant (of nothing), ou en matière de langues idéales (mathématiques), l’expression de contradiction. Les fictions et les facettes relèvent des représentations qui sont elles-mêmes primitives. Les textes descriptifs sont donc fictionnels par degré. Les récits qui sont très fictionnels ont une certaine valeur (souvent ludique) mais contiennent toujours au moins une facette. En fin de compte, toutes les activités représentationnelles devraient être considérées irréelles, incomplètes, bien que parfois connectées à la réalité, c’est-à-dire, prises entre une description réaliste facettée et une fiction dans son intégralité. / This essay concerns fiction in art and science. I argue that the term ‘fiction’ used in this manner is a category mistake (concept versus genre) and I believe this essay may succeed in “baking philosophical bread” by recognizing a verbal dispute. I am, therefore, suggesting an entire thread of discussion be re-evaluated. I provide an exposé of Catherine Z. Elgin and Nelson Goodman’s brand of fictionalism (i.e. that we glean understandings in the arts and sciences from fictions in the form of non-literal truth) and concentrate on unpacking the concept of fiction. I argue that representations (narratives of all sorts including models) are made of both fictional elements and faceted elements (with the exception of the possible or impossible ideal version e.g. God’s, which, would include only facets). Understandings are not gleaned from fictions but rather from faceted elements so ordered as to create understanding and usually leading to predictions, explanations, and manipulations. I define facets as ordered features whereas fictions (the genre) are groupings of disordered features. Full fiction is, therefore, by definition the expression of nothing or with respect to ideal languages (mathematics), the expression of contradiction. Representations are primitives and both fictions and facets are parts of them. Narratives are thus fictional by degree. Narratives which are highly fictional are of value (often playful) but they still always contain at least one facet. Ultimately all representational activity should be regarded as irreal i.e. incomplete although sometimes connected to reality and caught between a perfectly faceted realist description and complete fiction.

Dans un contexte de données industrielles et numériques, le développement d'un outil sur mesure pour une tâche particulière est couteux par de nombreux aspects. À l'inverse, l'adaptation d'outils génériques l'est également en particularisation (personnalisation, adaptation, extension, …), pour les développeurs comme pour les utilisateurs finaux. Nos approches visent à considérer les différents niveaux d'interactions pour améliorer l'exploitation des données fournies ou générées en collaboration.Les définitions et problématiques liées aux données dépendent le plus souvent des domaines dans lesquelles elles sont traitées. Pour ce travail, nous avons opté pour une approche holistique considérant ensemble des perspectives différentes. Le résultat est une synthèse des concepts émergeant montrant les équivalences d'un domaine à l'autre. La première contribution consiste à améliorer le marquage collaboratif de documents. Deux améliorations sont proposées par notre outil Coviz. (1) L'étiquetage des ressources est propre à chaque utilisateur qui organise ses vocables par une poly-hiérarchie nominative. Chacun peut considérer les concepts des autres par une relation de partage. Le système fournit également du contenu connexe via un moissonnage des archives ouvertes. (2) L'outil applique le concept de facette des données à l'interface puis les combine avec une recherche par mot-clé. Ce dernier point est commun à tous les utilisateurs, le système considère chacune des actions individuelles comme celles d'un groupe.La contribution majeure, confidentielle, est un framework baptisé DIP pour Data Interaction and Presentation. Son but est d'augmenter la liberté d'expression de l'utilisateur sur l'interaction et l'accès aux données. Il diminue les contraintes machines et logicielles en adjoignant une nouvelle voix d'accès direct entre l'utilisateur et les données disponibles, ainsi que des points d'« articulation » génériques. D'un point de vue final, l'utilisateur gagne en expression de filtrage, en partage, en maintien de l'état de sa navigation, en automatisation de ses tâches courantes, etc.Il a été testé en condition réelle de stress, de ressources et d'utilisation avec le logiciel KeePlace. Ce dernier a d'ailleurs été l'initiateur de cette thèse. / In the context of numeric data, the software development costs entail a number of cost factors. In contrast, adapting generic tools has its own set of costs, requiring developer's integration and final user's adaptation. The aim of our approach is to consider the different points of interaction with the data to improve the exploitation of data, whether provided or generated from collaboration.The definitions and problems related to data are dependent upon the domain from which the data come and the treatment that have been applied to them. In this work we have opted for a holistic approach where we consider the range of angles. The result is a summary of the emergent concepts and domain equivalences.The first contribution consists of improving collaborative document mark-up. Two improvements are proposed by out tool – Coviz –. 1) Resource tagging which is unique to each user, who organises their own labels according to their personal poly-hierarchy. Each user may take into consideration other users approaches through sharing of tags. The system supplies additional context through a harvesting of documents in open archives. 2) The tool applies the concept of facets to the interface and then combines them to provide a search by keyword or characteristic selection. This point is shared by all users and the actions of an individual user impact the whole group.The major contribution, which is confidential, is a framework christened DIP for Data Interaction and Presentation. Its goal is to increase the freedom of expression of the user over the interaction and access to data. It reduces the hardware and software constrains by adding a new access point between the user and the raw data as well as generic pivots. From a final point of view the user gains in expression of filtering, in sharing, in state persistence of the navigator, in automation of day-to-day tasks, etc.DIP has been stress tested under real-life conditions of users and limited resources with the software KeePlace. Acknowledgement is given to KeePlace who initiated this thesis.