Orientadores: Lilian Tereza Lavras Costallat, Fernando Cendes / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas / Made available in DSpace on 2018-08-08T06:36:35Z (GMT). No. of bitstreams: 1 Appenzeller_Simone_D.pdf: 2923218 bytes, checksum: ead37b4a881b531bfab95cbff3f95dff (MD5) Previous issue date: 2006 / Resumo: As manifestações do sistema nervoso central (SNC) no Lúpus Eritematoso Sistêmico (LES) são complexas, podendo ser causadas diretamente pela atividade do LES ou serem secundárias a comorbidades. O nosso objetivo foi avaliar as manifestações do SNC no LES e orrelacioná-las às alterações cerebrais estruturais e funcionais à ressonância magnética. Todos os pacientes preenchiam quatro ou mais critérios classificatórios de LES e foram selecionados no ambulatório de Reumatologia da UNICAMP. Observamos que crises epilépticas ocorreram em 11,6% dos pacientes, estando associadas a acidente vascular cerebral e a presença de anticorpos antifosfolípides. A recorrência de crises foi rara, associada somente a presença de anticorpos antifosfolípides. A migrânea ocorreu mais frequentemente no LES que no grupo controle e estava associada a atividade de doença, ao Fenômeno de Raynaud e a presença de anticorpos antifosfolípides. Pacientes com história pregressa de migrânea apresentavam mais dano permanente. Analisando as ressonâncias magnéticas em pacientes com LES, observamos tanto atrofia de substância branca como de substância cinzenta. Embora ambos estivessem associados à presença de manifestações pregressas do SNC e ao maior tempo de doença, somente a atrofia de substância cinzenta esteve associada à dose cumulativa de corticosteróides. Pacientes com distúrbios cognitivos apresentaram mais frequentemente atrofia de corpo caloso e de hipocampo. Observamos também uma disfunção axonal no LES, associada a atividade de doença. De acordo com os nossos resultados, os métodos de neuroimagem estruturais e funcionais são úteis na confirmação do envolvimento do SNC e também na identificação do envolvimento subclínico no LES / Abstract: Central nervous system (CNS) manifestations in systemic lupus erythematosus (SLE) arecomplex. They may be directly caused by SLE disease activity or may be secondary to comorbities. Our objective was to determine CNS manifestations in SLE patients and to determine structural and functional neuroimaging abnormalities associated with its occurrence. Patients with four or more classification criteria for SLE, followed at the Rheumatology Unit of the State University of Campnas were included. We observed 11.6% of epileptic seizures in SLE patients. The occurrence of epileptic seizures was associated with the presence of stroke and antiphospholipid antibodies. Recurrence of seizures was rare and associated only with the presence of antiphospholipid antibodies. Migraine was more frequently observed in SLE patients than controls and was associated with disease activity, Raynaud¿s phenomenon and antiphospholipid antibodies. Pacients with past history of migraine had more frequently organ damage. We observed white and gray matter atrophy in SLE patients. Although both were associated with disease duration and past history of CNS involvement, only gray matter atrophy was associated with the total corticosteroid dose. Patients with cognitive impairment had more frequently corpus callosum and hippocampal atrophy. A transient axonal dysfunction, secondary to disease activity and not to CNS involvement, was observed in SLE. Our results suggest that structural and functional neuroimaging methods are useful in confirming CNS involvement, but also identify subclinical involvement in SLE patients / Doutorado / Clinica Medica / Doutor em Clínica Médica

Orientador: Mario Carvalho de Matos / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Matematica, Estatistica e Computação Cientifica / Made available in DSpace on 2018-08-04T03:32:54Z (GMT). No. of bitstreams: 1 Favaro_ViniciusVieira_M.pdf: 628930 bytes, checksum: 5fd55816ec18b4b1dbe171a96f69e3ed (MD5) Previous issue date: 2005 / Resumo: Neste trabalho apresentamos um estudo de dois tópicos, principalmente: a teoria básica de tipo e cotipo e a teoria básica dos espaços Lp. Mostramos como estes dois conceitos se relacionam, mais especificamente mostramos que cada espaço Lr; 1 · r < 1; tem tipo min fr; 2g e cotipo max fr; 2g e que nenhum espaço L1 de dimensão infinita pode ter tipo maior que 1 e cotipo menor que 1. Como alicerce para a teoria de tipo e cotipo, detalhamos um estudo sobre as desigualdades de Khintchine e Kahane. Além disso, devotamos um capitulo ao estudo, num contexto mais geral, da desigualdade de Khintchine e dos conceitos de tipo e cotipo, mostrando que estes conceitos não melhoram em nada a teoria já que são equivalentes aos conceitos tradicionais de tipo e cotipo / Abstract: In this work we study two topics: the basic theory of type and cotype and the Lp-spaces theory. We show that each Lr -space, 1 · r < 1; has type min fr; 2g and cotype max fr; 2g. We also prove that no infinite dimensional L1 -space can have type > 1 and cotype < 1. We detail the study of the Khintchine and Kahane inequalities, needed in order to have full understanding of the type, cotype theory. A chapter is dedicated to the study of generalizations of the Khintchine inequality (the classical Rademacher functions are replaced by the so called n-Rademacher functions). It is shown that if we use these n-Rademacher functions to define type and cotype, the new definitions are equivalent to the usual ones / Mestrado / Matematica / Mestre em Matemática

The main study of this thesis is the holomorphic functional calculi for three classes of unbounded operators: sectorial, strip-type and half-plane. The functional calculus for sectorial operators was introduced by McIntosh as an extension of the Riesz-Dunford model for bounded operators. More recently Haase has developed an abstract framework which incorporates analogous constructions for strip-type and half-plane operators. These operators are of interest since they arise naturally as generators of C₀-(semi)groups. The theory of bounded H^&infin;-calculus for sectorial operators is well established and it has been found to have many applications in operator theory and parabolic evolution equations. We survey these known results, first on Hilbert space and then on general Banach space. Our main goal is to fill the gaps in the parallel theory for strip-type operators. Whilst some of this can be deduced by taking exponentials and applying known results for sectorial operators, in general this is insu_cient to obtain our desired results and so we pursue an independent approach. Starting on Hilbert space, we broaden known characterisations of the bounded H^&infin;-calculus for strip-type operators by introducing a notion of absolute calculus which is an analogue to the established notion for the sectorial case. Moving to general Banach space, we build on the work of V&ouml;r&ouml;s, broadening his characterisation for strip-type operators in terms of weak integral estimates by introducing a new, but equivalent, notion of the bounded H^&infin;-calculus, which we call the m-bounded calculus. We also demonstrate that these characterisations fail for half-plane operators and instead present a weaker form of the bounded H-calculus which is more natural for these operators. This allows us to obtain new and simple proofs of well known generation theorems due to Gomilko and Shi-Feng, with extensions to polynomially bounded semigroups. The connection between the bounded H-calculus of semigroup generators and polynomial boundedness of their associated Cayley Transforms is also explored. Finally we present a series of results on sums of operators, in connection with maximal regularity. We also establish stability results for the bounded H^&infin;-calculus for strip-type operators by showing it is preserved under suitable bounded perturbations, which at time requires further assumptions on the underlying Banach space. This relies heavily on intermediate characterisations of the bounded H^&infin;-calculus due to Kalton and Weis.

This study examined the effects of three fixed-duration free operant access conditions on rates of automatically maintained stereotypic behavior and correct task responding during discrete trial training (DTT) with two children diagnosed with autism. Following a functional analysis, confirming automatic function, interviews/observations were conducted to identify behavioral indicators of satiation and an average satiation level. In this endeavor, participants were exposed to a free operant condition to validate satiation of stereotypic responding. Once satiation level was averaged, two durational conditions were computed: Long (75% access) and Short (25% access). A third condition, Deprivation, involved blocking all attempts at the stereotypic response for the average duration till satiation. An alternating treatment design was used to examine the effects of these three conditions on stereotypy and correct responding during subsequent discrete trial tasks. For both, participants correct responding did not seem to be affected by the length of the pre-session access to the stereotypic behavior prior to the DTT session. For Marcus, the Long condition may have acted as an abolishing operation (AO) during DTT. Following the Short condition he engaged in higher rates of the stereotypic behaviors during his DTT sessions compared to the other conditions. For the Sara, it appears that pre-session access to stereotypy had little effect on stereotypic behavior during DTT sessions.

Orientador: Jorge Tulio Mujica Ascui / Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Matemática Estatística e Computação Científica / Made available in DSpace on 2018-08-26T17:26:19Z (GMT). No. of bitstreams: 1 Alves_ThiagoRodrigo_D.pdf: 734025 bytes, checksum: 298106a4813934e730d61824cffa0a7b (MD5) Previous issue date: 2015 / Resumo: Seja U um domínio de existência de um espaço localmente convexo. O principal objetivo da tese é estudar o conjunto E(U) constituído pelas funções holomorfas f : U --> C tais que U é o domínio de existência de f. Mais especificamente, é verificado que sob certas condições o conjunto E(U) contém variadas estruturas algébricas. Ressalta-se que a meta não é apenas demonstrar a existência de diferentes estruturas lineares/algébricas inseridas em E(U), mas também constatar que essas estruturas são em certo sentido "grandes''. Num primeiro momento o estudo é centrado nas funções holomorfas definidas em abertos de um espaço de Banach separável. Posteriormente, sairemos do contexto de espaços de Banach para iniciarmos o estudo das funções holomorfas definidas em abertos de espaços DFC, os quais se restringirão àqueles espaços da forma E = F'_c com F espaço de Fréchet separável / Abstract: Let U be a domain of existence of a locally convex space. In this thesis we study the set E(U) of all holomorphic functions f : U --> C such that U is the domain of existence of f. More specifically, we will see that under some hypotheses there are several algebraic structures inside the set E(U). Our goal is not only to prove the existence of distinct linear/algebraic structures in E(U), but also to show that these structures are in some way "large''. First we study the algebra of the holomorphic functions whose domains are open subsets of separable Banach spaces. Next we investigate the algebra of the holomorphic functions whose domains are open subsets of DFC spaces, which are in turn restricted to spaces of the form E = F'_c with F a separable Fréchet space / Doutorado / Matematica / Doutor em Matemática

Orientador: Jorge Tulio Mujica Ascui / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Matemática Estatística e Computação Científica / Made available in DSpace on 2018-08-26T22:14:32Z (GMT). No. of bitstreams: 1 Severiano_OsmarRogerioReis_M.pdf: 981069 bytes, checksum: cf807dcc84e563336dd8ed9933bfcea8 (MD5) Previous issue date: 2015 / Resumo: Seja Y um subespaço fechado de um espaço de Banach X. Um resultado clássico afirma que se Y e X/Y são separáveis então X é separável. Outro resultado clássico afirma que X é reflexivo sempre que Y e X/Y o são. Motivados por estes resultados diremos que uma propriedade P é uma propriedade dos três espaços se X tem a propriedade P sempre que Y e X/Y tem a propriedade P. Assim, separabilidade e reflexividade são propriedades dos três espaços. O objetivo deste projeto é o estudo de diversas propriedades dos três espaços / Abstract: Let Y a closed subspace of X Banach space. One classic result states that if Y and X/Y are separable then X is separable. Another classic result states that X is reflexive whenever Y and X/Y are. Motivated by these results we will say that a property P is a three space property if X has property P whenever Y and X/Y has property P. Thereby separability and reflexivity are three space properties. The aim of this project is the stydy of various three space property / Mestrado / Matematica / Mestre em Matemática

Le Centre-Ouest de la France est une région clef pour l’appréhension des variations culturelles du Magdalénien moyen ancien (19-17 500 cal. BP). Elle apparaît, à travers de riches productions artistiques (art pariétal et mobilier, parure) et osseuses (pointes de projectiles, navettes), comme un carrefour culturel. Deux faciès sont identifiés : le Magdalénien à pointe de Lussac-Angles et le Magdalénien à navettes. À travers l’étude des sites de la Marche (Lussac-Angles) et de la grotte Blanchard à la Garenne (navettes), nous avons cherché à restituer les comportements techniques liés à la production et à l’utilisation de l’outillage de ces deux grands faciès. À la suite d’une approche systémique combinant analyse technologique et fonctionnelle des productions lithiques, nous montrons qu’il existe un partage de fonds technique commun et une perméabilité entre ces faciès, à travers les modalités de production des lames et des lamelles, les relations entre forme et fonction et les stratégies de gestion de l’outillage (utilisations multiples, réutilisations, ravivages, raffûtages, multiplication des outils doubles). En revanche, des variations en termes de gestes voire de procédés techniques liés à l’utilisation des grattoirs et des lamelles à dos sont perceptibles. Ces éléments révèlent des spécificités propres aux comportements techniques sur chacun des sites. / West-central France is a key region to apprehend cultural variations of the Early Middle Magdalenian (19-17 500 cal. BP). This region appears to be at a cultural crossroad of several traditions visible through rich art (cave art, portable art, ornaments) and bone industry traditions (projectile points, navettes). Two facies are identified: the Lussac-Angles Magdalenian and the navettes Magdalenian. By focusing on the sites of la Marche (Lussac-Angles) and the Blanchard cave on the hillside of la Garenne (navettes), we seeked to approach technical behaviours related to use and production of the tools of these two facies. With a systemic approach that combines technological and functional analyses of lithic production, we show the existence of a shared technical background and a permeability between facies. This is evidenced through modalities of production of blades and bladelets, relations between form and function and tools management strategies (multiple uses, reuses, sharpenings, multiplication of double tools). On the other hand, variations in terms of gestures or technical processes related to the use of endscrapers and backed bladelets are perceptible. These elements reveal specificities of the technical behaviours on each site.

Both complex dynamics and the theory of reproducing kernel Hilbert spaces have found widespread application over the last few decades. Although complex dynamics started over a century ago, the gravity of it's importance was only recently realized due to B.B. Mandelbrot's work in the 1980's. B.B. Mandelbrot demonstrated to the world that fractals, which are chaotic patterns containing a high degree of self-similarity, often times serve as better models to nature than conventional smooth models. The theory of reproducing kernel Hilbert spaces also having started over a century ago, didn't pick up until N. Aronszajn's classic was written in 1950. Since then, the theory has found widespread application to fields including machine learning, quantum mechanics, and harmonic analysis. In the paper, Infinite Product Representations of Kernel Functions and Iterated Function Systems, the authors, D. Alpay, P. Jorgensen, I. Lewkowicz, and I. Martiziano, show how a kernel function can be constructed on an attracting set of an iterated function system. Furthermore, they show that when certain conditions are met, one can construct an orthonormal basis of the associated Hilbert space via certain pull-back and multiplier operators. In this thesis we take for our iterated function system, the family of iterates of a given rational map. Thus we investigate for which rational maps their kernel construction holds as well as their orthornormal basis construction. We are able to show that the kernel construction applies to any rational map conjugate to a polynomial with an attracting fixed point at 0. Within such rational maps, we are able to find a family of polynomials for which the orthonormal basis construction holds. It is then natural to ask how the orthonormal basis changes as the polynomial within a given family varies. We are able to determine for certain families of polynomials, that the dynamics of the corresponding orthonormal basis is well behaved. Finally, we conclude with some possible avenues of future investigation.

This document contains a proof that Bieberbach groups with finite abelianization are not connective (an E-theoretic property) and then uses this result to provide a characterization of connectivity in the case of Bieberbach groups.

Functional analysis is considered best practice for behavior analysts who work with people who have intellectual and developmental disabilities and engage in problem behavior. Unfortunately, a majority of practitioners do not complete functional analyses. The purpose of the present study was to train 10 practitioners to implement a practical functional assessment (PFA) decision making model and to evaluate the ecological validity of the model. Pre- and Post-training overall test scores increased, on average, by 38.18%. Testing subsections increased by 60.0% for foundations and concepts, 5.0% for graphical interpretations, and 40.0% for decision making. A job needs survey showed the greatest gains in reports of antecedent environmental supports, behavior supports in the environment, and antecedents related to the behavior repertoire. A post-training survey indicated that 8 of 8 trainees would recommend the training to others. Finally, at the conclusion of follow-up progress data collection, 3 of the 5 locations were progressing through the PFA model in their regular job duties whereas the other 2 locations experienced professional staffing issues that interfered with their workloads. These results indicate that the training was effective at increasing testing responses related to foundations and concepts as well as decision making. Additionally, when professional staffing was stable, participants reported using the PFA model effectively, suggesting that the model had ecological fit under these conditions.