No description available.

L'industrie du béton est une source importante d'émissions de gaz CO2 lors de la production de ciment. Une des solutions proposées à l'industrie de la construction est de remplacer le ciment par des matières premières secondaires moins polluantes (ex : filler calcaire, fumée de silice), qui peuvent également améliorer les caractéristiques rhéologiques du liant et accroître la durabilité du béton.Le but principal de cette thèse est donc de : (1) standardiser la formulation de béton issue des différents travaux de recherche publiés tout en assurant une bonne compréhension de ses propriétés rhéologiques; (2) adapter ces principes aux conditions de réalisation (prise en compte des caractéristiques des matériaux locaux utilisés); et (3) vérifier dans le laboratoire ou sur le terrain la viscosité plastique et le seuil d’écoulement des bétons.Outre les moyens expérimentaux classiques nous avons utilisé, dans notre étude, un autre moyen de caractérisation rhéologique : c’est l’écoulement de béton dans un V-Funnel couplé à un canal horizontal en plexiglas. Dans un premier temps nous cherchons à comprendre la corrélation entre la viscosité et les paramètres rhéologiques de béton en se basant sur des modèles proposés dans la littérature. À partir de là, nous cherchons à présenter le modèle qui décrit le comportement de béton. Pour ce faire, nous proposons une corrélation théorique entre la viscosité plastique du béton frais et le temps d’écoulement dans le V-Funnel, puis nous comparons cette solution théorique avec des mesures expérimentales rapportées dans la littérature. / The concrete industry is an important source of carbon dioxide gas emissions during cement production. One of the proposed solutions to the construction industry is to replace the cement by less polluting secondary raw materials (e.g. limestone filler, silica fume), which can also improve the rheological properties of binder and increase the concrete durability.Thus, the development of self-compacting concrete can be seen as an attempt to reduce the environmental impact of the construction. Similarly, the structure optimization also aims at reducing the quantity (in volume) of concrete and is reflected in the use of high performance concrete and ultra performance fiber-reinforced concrete (HPC and UPFRC).The most widely adopted approach to quantify these rheological properties is to experimentally measured the shear stress versus strain rate using a concrete rheometer.In addition to traditional experimental tests such as the V-funnel, spread, sieve stability and L box, in our study we used another test of rheological characterization: it is the flow of concrete in a V-Funnel and then in a horizontal channel Plexiglas.The main purpose of this thesis is to: (1) standardize the concrete formulation outcome of various research works published while ensuring a good understanding of its rheological properties, (2) adapt these principles to the realization conditions (taking into account characteristics of local materials used), and (3) check, in the laboratory or in the field, the plastic viscosity and the flow threshold of concrete.

No description available.

The study investigates whether it is possible to drive sales-oriented marketing for B2C companies in social media through data-driven marketing, and thus increasing the relevance of the ads. The study has had an experimental approach where hypotheses are tested from a company towards a target group of just over 480 000 people in the Småland region. Two separate marketing campaigns were run on Facebook and Instagram where the fundamental difference between the two was the strategic arrangement. The experimental design included a campaign, containing three separate ads, where strategy and target group segmentation were based on the "The purchasing funnel" model. The result of the campaign, as part of the study's experiments, was then compared against the campaign run without strategy or audience segmentation. This showed a final result just over 20 times better than the previous campaign and a ROAS (return of ad spent) of 25.

This essay is a study and analysis of the funnel beaker pottery at Gullarve 1:13 in Väte parish. The purpose of the study is to analyse the chronology of the settlement by determine the distribution, stratigraphic context and the ornamentation of the pottery. Another purpose is to discuss the geographical location of the settlement in the landscape.In this essay a short review of the pottery and the funnel beaker culture as well as a description of the pottery from the archaeological excavation from 1984 at Gullarve 1:13 is presented. Since the documentation of the archaeological excavation from 1984 is missing or is very inadequate, no spatial analysis can be carried out. The distribution of the pottery can’t contribute to the result of the essay, though if possible it probably would have provided some interesting results. A clear stratigraphic difference of pottery with ornamentation and flint is indicated. The earliest radiocarbon date of the settlement is approximately 5000 BC. The funnel beaker pottery is generally dated to 4200 BC, which suggests that the Väte settlements on Gotland are the earliest agriculture settlements in Sweden. This area provide a productive natural resource area around the settlement, including a sweet water lake and sandy soil, which indicates a typical funnel beaker settlement at Gotland. One can easily understand why the inhabitants of the early Neolithic settlement chose to live at Gullarve 7000 years ago.

In this thesis, I chose to identify and evaluate different monitoring methods on surgeon specific outcomes in colorectal surgery. An initial literature search identified different methods that were applied to a cohort of colorectal patients operated on by general surgeons using an electronic hospital database. Surgeon specific complications were validated with a chart review. General surgeons at The Ottawa Hospital were surveyed on their opinions regarding monitoring outcomes. We can conclude that different methods may be needed as they are dependent heavily on specified target limits. With our derived cohort, we had adequate risk adjustment using a modified Escobar model for 30 day mortality and morbidity. These complications were derived from electronic algorithms and had excellent specificity and sensitivity. General surgeons at The Ottawa Hospital have different opinions regarding monitoring their outcomes and surgeon engagement is necessary to make monitoring fruitful for patients, public, hospital administration, and surgeons.

Habilitationsschrift--Universität des Saarlandes, Saarbrücken, 1973/74. / Includes bibliographical references (v. 1, p. 298-320).

Habilitationsschrift--Universität des Saarlandes, Saarbrücken, 1973/74. / Includes bibliographical references (v. 1, p. 298-320).

In this thesis, I chose to identify and evaluate different monitoring methods on surgeon specific outcomes in colorectal surgery. An initial literature search identified different methods that were applied to a cohort of colorectal patients operated on by general surgeons using an electronic hospital database. Surgeon specific complications were validated with a chart review. General surgeons at The Ottawa Hospital were surveyed on their opinions regarding monitoring outcomes. We can conclude that different methods may be needed as they are dependent heavily on specified target limits. With our derived cohort, we had adequate risk adjustment using a modified Escobar model for 30 day mortality and morbidity. These complications were derived from electronic algorithms and had excellent specificity and sensitivity. General surgeons at The Ottawa Hospital have different opinions regarding monitoring their outcomes and surgeon engagement is necessary to make monitoring fruitful for patients, public, hospital administration, and surgeons.

La description des interactions protéine-ligand est d'une importance capitale pour la compréhension de phénomènes biologiques de toutes sortes, et dans le procédé de conception de nouvelles molécules bioactives. Avec l'avènement de nouveaux moyens de calculs numériques, la modélisation des équilibres d'interaction utilisant la dynamique moléculaire est de plus en plus utilisée pour l'étude au niveau microscopique permettant ainsi de guider la conception et l'optimisation de nouveaux inhibiteurs biologiques. Cette thèse est centrée sur l'utilisation de la funnel-métadynamique pour la prédiction d'affinités protéine-ligand et la description des interactions, en corrélation avec des données expérimentales de RMN et de cinétique enzymatique. Sur le modèle biologique des peroxyrédoxines humaines impliquées dans la cascade inflammatoire survenant après un choc ischémique, l'interaction et l'inhibition de composés catéchols ont été étudiées. Les données obtenues par dynamique sur l'interaction de dérivés catéchols ont été utilisées pour guider l'optimisation de cette molécule fragment pour une meilleure affinité et inhibition des peroxyrédoxines humaines. Nos résultats ont montré que la funnel-métadynamique, en plus de permettre la prédiction des affinités protéine-ligand, donnait une description réaliste de l'interaction pouvant mener à l'identification et l'optimisation de nouvelles molécules bioactives dont le potentiel inhibiteur a pu être examiné par cinétique enzymatique. Cette recherche fournit un aperçu des possibilités offertes par les nouvelles méthodes numériques, et leur application en chimie médicinale par exemple / Description of protein-ligand interactions is crucial for the understanding of all biological phenomena, and the drug design process. Thanks to new developments in computational devices, simulation of interaction equilibria using molecular dynamics are becoming state-of-the-art approach for the microscopic study of these molecular interactions. These new methods guide the conception and the optimization of new biological inhibitors. This project is focused on the use of funnel metadynamics for the prediction of protein-ligand affinities, and the description of interactions. Data obtained by metadynamics are correlated with experimental data from NMR and enzymatic assays.On the biological model of human peroxiredoxins, involved in the post ischemic inflammation cascade, interaction an inhibition of catechols derivatives have been studied. Data obtained from simulations have been used in the optimization process of the catechol fragment, to reach a better affinity and inhibition of human peroxiredoxins. Our results have shown that funnel-metadynamics allows the prediction of protein-ligand affinities, and the realistic description of the interaction, that lead to identify and optimize new bioactive molecules. Their inhibitory strengths and mechanisms have been examinated using enzymatic assays.Our research gives an overview of the possibilities brought by new numerical approaches, and their application in medicinal chemistry for example