Magister Public Health - MPH / Background: South African medical scheme members needlessly purchase high cost originator prescription medicines which attract out of pocket co-payments at pharmacies. This is despite availability of low priced generic medicines that are paid for in full by medical schemes. Co-payments result from misalignment between prices of the dispensed medicine and that of the alternative medicine which appears on the medical scheme's formulary list and for which the scheme is prepared to pay for in full. To establish what factors caused such misalignment, perspectives of medical scheme members and key informants which included pharmacists, regulators and representatives of medical schemes were explored. The study focused on co-payments for prescription medicines dispensed at private sector retail pharmacies in Pretoria, South Africa. Aim: The aim of the study was to explore views about co-payments and identify factors that motivate and influence Pretoria medical scheme members to co-pay when purchasing prescription medicines at pharmacies, despite being insured by medical scheme insurance organizations. Methodology: An exploratory qualitative research study was performed. Semi-structured interviews were conducted among purposefully selected medical scheme members (12) and 9 key informants. Key informants consisted of dispensing pharmacists (6), regulators of health professionals and medical schemes (2) and a senior official (1) with experience in the regulation of medicines and operations within medical scheme organizations. From a total of twelve interviewed medical scheme members, eight were interviewed at preselected retail pharmacies after they had made a co-payment and the other four selected because they did not make a co-payment. To ensure diversity in views about co-payments and related factors, dispensing pharmacists, co-paying and non co-paying medical scheme members were accessed from six pharmacies that are located in two separate locations of different socioeconomic status in Pretoria, that is, the Pretoria East suburban area and Pretoria city centre which is close to Pretoria central station and taxi routes. Three pharmacies were identified from each of the two different geographical locations, one independent and two corporate pharmacies per socioeconomic area. One pharmacist was interviewed from each of the selected pharmacies and medical scheme members were accessed from across the six pharmacies. The remainder of the key informants such as the regulators, were interviewed during office hours at venues of their choice which included areas of work. A pilot study was conducted among medical scheme members and pharmacists to test the applicability of interview tools. All interviews were conducted face-to-face by the researcher and recorded. The electronic record was independently compared with the researcher's enhanced notes for data accuracy. Codes identified during data analysis were derived from the interview notes and recordings and translated into organized text for theme development in a manner that referenced them to each study objective. Themes were arrived at after combining similar codes which were noted as representing a particular description for use during data interpretation and report writing. Ethics: Ethical clearance was sought from the UWC Senate Research Committee and granted. Prior to conducting interviews, written consent was obtained from all participants. Research details were explained and also provided on the participant information sheet wherein voluntary participation was emphasized. Anonymity and confidentiality was maintained throughout. Results: All patients and pharmacists expressed confusion about the medical scheme rules and related co-payments. There were differing co-payment perspectives among scheme members depending on socioeconomic status, with affordability being a key factor among those of lower socio-economic status whilst convenience and lack of comprehensible information about co-payments was prioritised amongst those members of higher socioeconomic status. Key influences on patient's purchasing decisions were health professionals (both doctors and pharmacists), with friends, family members and advertisements less influential. Patients and medical schemes generally preferred to utilise large chain pharmacies and patients, in particular, had a poor perception of the quality of generics. In general, the first prescribed medicine was highly favoured by patients and this influenced medicine preferences during subsequent prescriptions, especially for non communicable disease (NCD) medicines. Pharmacists did not apply the generic substitution policy in a manner that benefited the consumer because the lowest priced generic was frequently not kept as pharmacy stock. Co-payments appeared to create a divide between corporate and independent pharmacies. Some regulators tended to blame patients, pharmacists and medical schemes rather than the lack of adequate enforcement of national policies and regulations. Inadequate monitoring and enforcement of pro-consumer policies were found to be the main factors that contributed to co-payments. Conclusions and Recommendations: The introduction of regulations on minimum requirements for stock available at private sector retail pharmacies should be considered to ensure availability of the lowest priced generic at all times. This would ensure that co-payments are reduced and the desired consumer benefits that should accrue from the existing generic substitution policy are realized and maximized. To prevent perception-based and self-initiated co-payment behavior among consumers, vigorous and continued education about the value and equivalence of generics should be championed at the highest level of government with the execution of this critical responsibility not left to those with profit driven motives. Consumers might benefit from extensive education about the purchasing choices made at pharmacies and, in particular, the negative financial consequences associated with choosing a preferred but highly priced originator versus a low cost generic medicine which is used to treat the same ailment. Enforcement of policies by dedicated government agencies could further protect consumers from preventable high cost of healthcare and of medicines in particular.

This thesis introduces an efficient and robust approach for 3D reconstruction of complete head models with consistent parameterization and personalized shapes from several possible inputs. The system input consists of Cyberware laser-scanned data where we perform scanning task as well as publically available face data where (i) facial expression may or may not exist and (ii) only partial information of head may exist, for instance only front face part without back part of the head. Our method starts with a surface reconstruction approach to either transfer point clouds to a mesh structure or to fill missing points on a triangular mesh. Then, it is followed by a registration process which unifies the representation of all meshes. Afterward, a photo-cloning method is used to extract an adequate set of features in a semi-automatic way on snapshots taken from front and left views of provided range data. We modify Radial Basis Functions (RBFs) deformation so that it would be based on not only distance, but also regional information. Using feature point sets and modified RBFs deformation, a generic mesh can be manipulated in a way that closed eyes and mouth movements like separating upper lip and lower lip can be properly handled. In other word, such mesh modification method makes construction of various facial expressions possible. Moreover, new functions are added where a generic model can be manipulated based on feature point sets to consequently recover missing parts such as ears, back of the head and neck in the input face. After feature-based deformation using modified radial basis functions, a fine mesh modification method based on model points follows to extract the fine details from the available range data. Then, some post refinement procedures employing RBFs deformation and averaging neighboring points are carried out to make the surface of reconstructed 3D head smoother and uniform. Due to existence of flaws and defects on the mesh surface such as flipped triangles, self-intersections or degenerate faces, an automatic repairing approach is leveraged to clean up the entire surface of the mesh. The experiments which are performed on various models show that our method is robust and efficient in terms of accurate full head reconstruction from input data and execution time, respectively. In our method, it is also aimed to use minimum user interaction as much as possible.

No abstract available / Dissertation (LLM)--University of Pretoria, 2012. / gm2014 / Centre for Human Rights / Unrestricted

The standard approach to modelling mechanics of continuum based on bal- ances of mass, momentum, angular momentum and energy is a very powerful tool. However, there is no connection between that and the Hamiltonian mechanics, that superbly describes kinematics of isolated particles. Thus, the two topics are rather isolated. Nevertheless, there is another approach to continuum mechan- ics - a one, whose reversible part is based on Hamiltonian mechanics, while the irreversible is generated by a dissipation potential. This framework, called GENERIC, is thus an interesting bridge between con- tinuous and discrete systems. In this thesis, we present the GENERIC framework applied to a continuous body, derive the governing equations and compare them to the standard theory. Both analytical and numerical solutions to a decent range of model examples are presented and analysed.

Control law design can be an iterative and time-consuming process. The design procedure can often include manual tuning, not uncommonly in the form of trial and error. Modern software tools may alleviate this process but are generally not developed for use within any specific industry. There is therefore an apparent need to develop field-specific tools to facilitate control law design.The main contribution of this thesis is the investigation of a systematic and simplified approach to semi-automatic generation of control law parameters for generic fighter aircraft. The investigated method aims to reduce human workload and time spent on complex decision making in the early stages of aircraft development. The method presented is based on gain scheduled LQI-control with piece-wise linear interpolation. A solution to the automated tuning problem of the associated weighting matrices Q and R is investigated. The method is based on an LQ-optimal eigenstructure assignment. However, the derived method suffers from problem regarding practical implementation, such as the seemingly narrow LQ-optimal root-loci of the linearized aircraft model.Furthermore, the inherent problem of hidden coupling is discussed in relation to gain scheduled controllers based on conventional series expansion linearization. An alternative linearization method is used in order to circumvent this problem. Moreover, the possible benefits and disadvantages of control allocation is addressed in the context of actuator redundancy. It is concluded that one may achieve a somewhat simpler handling of constraints at the expense of some model accuracy due to the inevitable exclusion of servo dynamics.

Event-related potential (ERP)-based brain-computer interfacing (BCI) is an effective method of basic communication. However, collecting calibration data, and classifier training, detracts from the amount of time allocated for online communication. Decreasing calibration time can reduce preparation time thereby allowing for additional online use, potentially lower fatigue, and improved performance. Previous studies, using generic online training models which avoid offline calibration, afford more time for online spelling. Such studies have not examined the direct effects of the model on individual performance, and the training sequence exceeded the time reported here.The first goal of this work is to survey whether one generic model works for all subjects and the second goal is to show the performance of a generic model using an online training strategy when participants could use the generic model. The generic model was derived from 10 participant's data. An additional 11 participants were recruited for the current study. Seven of the participants were able to use the generic model during online training. Moreover, the generic model performed as well as models obtained from participant specific offline data with a mean training time of less than 2. min. However, four of the participants could not use this generic model, which shows that one generic mode is not generic for all subjects. More research on ERPs of subjects with different characteristics should be done, which would be helpful to build generic models for subject groups. This result shows a potential valuable direction for improving the BCI system.

Event-related potential (ERP)-based brain-computer interfacing (BCI) is an effective method of basic communication. However, collecting calibration data, and classifier training, detracts from the amount of time allocated for online communication. Decreasing calibration time can reduce preparation time thereby allowing for additional online use, potentially lower fatigue, and improved performance. Previous studies, using generic online training models which avoid offline calibration, afford more time for online spelling. Such studies have not examined the direct effects of the model on individual performance, and the training sequence exceeded the time reported here.The first goal of this work is to survey whether one generic model works for all subjects and the second goal is to show the performance of a generic model using an online training strategy when participants could use the generic model. The generic model was derived from 10 participant's data. An additional 11 participants were recruited for the current study. Seven of the participants were able to use the generic model during online training. Moreover, the generic model performed as well as models obtained from participant specific offline data with a mean training time of less than 2. min. However, four of the participants could not use this generic model, which shows that one generic mode is not generic for all subjects. More research on ERPs of subjects with different characteristics should be done, which would be helpful to build generic models for subject groups. This result shows a potential valuable direction for improving the BCI system.

No description available.

Despite the recognized importance of Anna Letitia Barbauld, Maria Edgeworth, and Charlotte Smith as commentators on 1790s radicalism, pedagogy, and novel conventions, their writings for children and for adults tend to be studied separately. Indeed, despite each writer's familiarity with the others' work, these figures are rarely discussed together. I argue that studying these authors' cross-generic works using a comparative approach reveals the ways in which novels and children's books have informed and influenced each other, both in their reciprocal developments and as distinct genres. I further argue that even as the juvenile fiction of Barbauld, Edgeworth, and Smith seems rather tamely oriented toward the integration of natural history with conduct lessons, the genre was in fact a vital means by which each writer weighed her own social-welfare and aesthetic priorities within contexts of political upheaval.

No description available.