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601	ATM promotes apoptosis and suppresses tumorigenesis in response to Myc Pusapati, Raju V. L. N., 1969- 11 October 2012 (has links) Precancerous lesions from a variety of human tissues display markers of DNA damage suggesting that genetic instability occurs early during the process of carcinogenesis. Consistent with this, several oncogenes can activate ATM and other components of the DNA damage response pathway when expressed in cultured cells. Here we demonstrate that preneoplastic epithelial tissues from four different transgenic mouse models expressing the oncogenes c-myc, SV40 T antigen, human papilloma virus (HPV) E7, or E2F3a display [gamma]-H2AX foci and other markers of DNA damage. Moreover, transgenic expression of these oncogenes leads to increased levels of damaged DNA as measured by the comet assay. In at least the Myc transgenic model, the formation of [gamma]-H2AX foci is dependent on functional ATM. Inactivation of Atm also impairs p53 activation and reduces the level of apoptosis observed in transgenic tissue overexpressing Myc. This correlates with accelerated tumor development in Myc transgenic mice lacking ATM. To understand the mechanism by which oncogenes induce DNA damage, we employed an adenoviral overexpression system. Under conditions in which Myc or E2F3a induced replication is inhibited, we see a reduction in the DNA damage induced by these oncogenes both by comet assay and levels of [gamma]-H2AX. Moreover, Myc and E2F3a induced increased levels of the Cdt1 protein, a replication origin- licensing factor implicated in aberrant DNA replication. Taken together, these findings suggest that deregulated oncogenes induce unscheduled DNA replication leading to DNA damage and activation of the ATM DNA damage response pathway, which is important for the activation of p53, induction of apoptosis and the suppression of tumorigenesis. / text Carcinogenesis Cancer--Genetic aspects Myc oncogenes DNA damage
602	Pathogenesis and progression of malignant B cell neoplasms Au, Wing-yan., 區永仁. January 2005 (has links) published_or_final_version / Medicine / Master / Doctor of Medicine B cells - Tumors. Lymphomas - Genetic aspects. Cytogenetics. Molecular genetics.
603	Characterization of PML/RARA fusion in acute promyelocytic leukemia: molecular cytogenetics study Hui, Koon-chun, Eleanor., 許冠珍. January 2005 (has links) published_or_final_version / Medical Sciences / Master / Master of Medical Sciences Cytogenetics. Molecular genetics.
604	Epigenetic regulation of gene expression of cystatin 6, CST6, in hepatocellular carcinoma Ma, Ka-li, Marcella, 馬嘉莉 January 2005 (has links) published_or_final_version / Medical Sciences / Master / Master of Medical Sciences Liver - Cancer - Genetic aspects. Cysteine proteinases - Inhibitors. Antioncogenes. Genetic regulation.
605	Studies on non-small cell lung cancer with EGFR mutation Tong, Wing-yee., 唐穎儀. January 2005 (has links) published_or_final_version / Medical Sciences / Master / Master of Medical Sciences Mutation (Biology) Epidermal growth factor - Receptors. Adenocarcinoma - Genetic aspects.
606	Expression and functional analysis of a mutant sPDZD2 protein Wong, Yee-man, Kimmi, 黃綺雯 January 2005 (has links) published_or_final_version / Medical Sciences / Master / Master of Medical Sciences Carrier proteins. Gene expression. Prostate - Cancer - Genetic aspects.
607	Functional study of BamH1 a rightward open reading frame 1 (BARF1) expression in nasopharyngeal epithelial cells Hung, Wing-ki., 孔穎祺. January 2006 (has links) published_or_final_version / Medical Sciences / Master / Master of Medical Sciences Nasopharynx - Cancer - Genetic aspects. Epithelial cells. Cytogenetics. Gene expression.
608	Expression of FOXO3a in breast cancer Wu, Lai-han., 胡麗嫻. January 2007 (has links) published_or_final_version / Medical Sciences / Master / Master of Medical Sciences Transcription factors. Gene expression. Breast - Cancer - Genetic aspects.
609	Genetic variants of obesity- and inflammation-related genes in hypertension: genetic association studiesusing candidate gene approach Ong, Kwok-leung, 王國良 January 2010 (has links) published_or_final_version / Medicine / Doctoral / Doctor of Philosophy Hypertension - Genetic aspects. Hypertension - Risk factors. Obesity - Complications. Inflammation - Complications.
610	Genesis, evolution and dissemination of highly pathogenic avian H5N1 influenza A virus in Southern China Wang, Jia, 王嘉 January 2010 (has links) published_or_final_version / Microbiology / Doctoral / Doctor of Philosophy Avian influenza A virus - China. Virus diseases - Genetic aspects.

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