Bakgrund: Karpaltunnelsyndrom är den vanligaste typen av perifera nervinklämningar och orsakas av att medianusnerven blir klämd i karpaltunneln. De symtom som kännetecknar karpaltunnelsyndrom är nattliga domningar och smärta i hand och fingrar.  Syfte: Att undersöka effekt och evidens för nervmobilisering som behandling vid karpaltunnelsyndrom.  Metod: Sökningar genomfördes i databaserna PudMed, PEDro, CINAHL, AMED och Scopus med målet att identifiera randomiserade kontrollerade studier där nervmobilisering som behandling vid karpaltunnelsyndrom undersökts. Inkluderade artiklar kvalitetsgranskades enligt PEDro och de med hög kvalitet evidensgraderades enligt GRADEstud.  Resultat: Nio studier inkluderades i översikten. I alla studier observerades en positiv effekt av nervmobilisering avseende symtom och/eller funktion och en signifikant skillnad sågs mellan grupperna i 7 av 9 studier. Sex av nio studier hade hög kvalitet och tre hade låg kvalitet enligt PEDro-skalan. Evidensgraderingen visade att nervmobilisering som behandling vid karpaltunnelsyndrom har måttligt hög tillförlitlighet (+++). Små studier med få deltagare resulterade i ett poängs avdrag för bristande precision. Slutsats: Nervmobilisering tycks ge positiva effekter på funktion och symtom vid karpaltunnelsyndrom och har enligt GRADEstud måttligt hög tillförlitlighet. Nervmobilisering kan ge effekt även på lång sikt och kan minska behovet av operation men fler större studier med god kvalitet behövs för att kunna bekräfta detta. Nyckelord: Carpal tunnel syndrome, CTS, neural mobilization, nerve gliding / Background: Carpal tunnel syndrome is the most common type of peripheral neuropathy caused by compression of the median nerve in the carpal tunnel. The condition is characterized by night time tingling and pain in the hand and fingers.  Objective: The purpose of this study was to investigate the effects and evidence of neural mobilization as a treatment for carpal tunnel syndrome.  Methods: Searches were made in the databases PubMed, PEDro, CINAHL, AMED and Scopus to try and find randomized controlled trials that investigated neural mobilization as treatment for carpal tunnel syndrome. All of the included articles were appraised by the PEDro-scale and the level of evidence was graded using GRADEstud.  Results: Nine studies were included in this review. In all of the included studies a positive effect could be seen by neural mobilization on symptoms and/or function with a significant difference between groups in seven out of the nine studies. Six out of the nine studies had high quality and three had low quality according to the PEDro-scale. The grading of evidence showed that neural mobilization as treatment for carpal tunnel syndrome has a moderately high level of evidence (+++). Few studies with few participants resulted in one point deduction for lack of precision. Conclusion: Neural mobilization could have positive effects on symptoms and function in patients with carpal tunnel syndrome and has a moderately high level of evidence according to GRADEstud. Neural mobilization may have positive effects long term and could reduce need for surgery but more high quality research is needed to confirm this. Key words: Carpal tunnel syndrome, CTS, neural mobilization, nerve gliding.

京都大学 / 0048 / 新制・課程博士 / 博士(工学) / 甲第19935号 / 工博第4218号 / 新制||工||1652(附属図書館) / 33021 / 京都大学大学院工学研究科マイクロエンジニアリング専攻 / (主査)教授 小寺 秀俊, 教授 中部 主敬, 准教授 横川 隆司 / 学位規則第4条第1項該当 / Doctor of Philosophy (Engineering) / Kyoto University / DGAM

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This dissertation addresses the question, how and why do 'flying' snakes (Chrysopelea) undulate through the air? Instead of deploying paired wings or wing-like surfaces, flying snakes jump, splay their ribs into a bluff-body airfoil, and undulate through the air. Aerial undulation is the dominant feature of snake flight, but its effects on locomotor performance and stability are unknown. Chapter 2 describes a new non-equilibrium framework to analyze gliding animals and how the pitch angle affects their translational motion. Chapter 3 combines flying snake glide experiments and detailed dynamic modeling to address what is aerial undulation and how each kinematic component affects rotational stability and translational performance. Chapter 4 combines the kinematic data of Chapter 3, with elements of the non-equilibrium framework of Chapter 2, to examine the kinematics of snake flight in greater detail. This chapter also tests if our current understanding of flying snake aerodynamics is sufficient to explain the observed center of mass motion. / Ph. D.

Myxococcus xanthus, referred to as a 'social bacterium', demonstrates unique behaviors such as coordinated motility, cooperative feeding, and multicellular structure formation. Its complex social behaviors and developmental processes make M. xanthus a model organism for studying bacterial social behaviors and their underlying mechanisms. Much of the social behavior of M. xanthus hinges on coordination of cell motility among bacteria in close proximity. M. xanthus moves on moist solid surfaces, using its Adventurous (A)-motility and Social (S)-motility systems. A striking feature of M. xanthus motility is the periodic reversal of its direction of movement. The reversal frequency is influenced by chemical and mechanical cues in the surrounding environment. The modulation of the reversal frequency upon physical contact between cells is believed to be a key factor in the bacterium's social behaviors, especially in the formation of complex patterns and structures within the cell population. Here I utilized mathematical modeling to study the motility regulation in M. xanthus, focusing on contact-dependent reversal control, mechanosensing response and impact of motility regulation in solitary (single-cell) predation. My goal is to provide experiment-guiding theories and hypotheses for M. xanthus motility regulation, which is essential to fully understand the social behaviors in this bacterium. In Chapter 2, I developed a single-cell model based on a hypothesis that the motility regulation in M. xanthus is mediated by the interplay between the cell polarity regulation pathway and the A-motility machinery. The aim of this model is to elucidate the cellular mechanism governing contact-dependent motility coordination among cells and to understand how contact-dependent responses at the single-cell level contribute to population-level patterns. This model suggests that the A-motility machinery of M. xanthus potentially serves as a 'mechanosensor' that transduces mechanical cues in the environment into a reversal modulation signal. Chapter 3 addresses a puzzling observation: cells with A-motility alone (A+S−) show a dependence of reversal frequency on substrate stiffness that is opposite to what is observed in wild-type cells that possess both motility systems. Specifically, A+S− cells reverse less frequently on harder substrates, whereas wild-type cells reverse more frequently. To elucidate this perplexing phenomenon, I refined the single-cell model developed in Chapter 2 to study the mechanosensing behaviors with or without S-motility. The base model was sufficient to explain the mechanosensing response in A+S− cells. I then proposed possible interactions between the A-motility and S-motility systems that could explain the contrasting responses to substrate stiffness when S-motility is present or absent. This provides a testable prediction for future experimental investigations. The model suggests that the A-motility system in M. xanthus functions as a central hub of mechanosensing-based reversal control, modulating cell reversal in response to environmental mechanical cues. In Chapter 4, I constructed an agent-based model to investigate the optimal motility strategies for nutrient consumption by M. xanthus during its solitary predation. For different nutrient source types and their uptake latencies, the model identifies 'explore', 'inch', and 'fast explore' as the three most effective motility strategies. Variability in velocity and cell reversal period changes the optimal strategies from 'explore' mode to 'revisit' mode and to 'speed-controlled explore' mode, respectively, for massive remains of prey nutrient sources with moderate uptake latency. The experimental observation that solitary M. xanthus cells combined the 'revisit' and 'inch' mode—as predicted by the model for nutrient acquisition respectively from prey remains and macromolecules—suggests that some of the dead preys may not release its cellular contents immediately and that release of molecular nutrients may require multiple digestion cycles. This model provides insights into the functional role of complex motility regulation in M. xanthus during solitary predation. / Doctor of Philosophy / A fundamental question in biology is how a cell responds to physical, chemical and biological stimuli. Such responses are usually mediated by complex coupling between multiple cellular processes. Bacterial motility and its regulation present many excellent examples of this kind. This dissertation focuses on Myxococcus xanthus, a model organism for bacterial social behavior due to the highly coordinated motility of cells in M. xanthus colonies and their functional cooperation. In this dissertation, I built theoretical models to study the motility regulation in M. xanthus, which is essential for understanding the social behaviors and survival in this bacterium. The specific focuses are to comprehend how environmental mechanical cues regulate M. xanthus's motility, and how the observed motility regulation in M. xanthus facilitates its predatory behavior at the single-cell level. The key aspect of this work is to construct a modeling framework to provide coherent explanations for the experimental observations. It is anticipated that the hypotheses generated through modeling will guide new experiments in the field of myxobacterial biology. The findings offer general insights into how bacterial cells sense, respond, and adapt to the chemical, physical, and biological cues.

Flight is a vital component of butterfly natural history, and flight-associated morphology is thought to be under strong selection for the performance of critical behaviors such as patrolling, courtship and oviposition. However, while different behaviors require different proportions of flapping versus gliding flight, few studies actually quantify butterfly flight behavior. Moreover, as butterfly flight is anteromotoric, no prior study has measured the role of hind wing allometry in flight. Using high-speed videography, this study compares the flight of two species of Haeterini (Nymphalidae) that regularly employ gliding flight. We also employ stereo videography and experimental hind wing area reduction to measure the effects of hind wing allometry on flight. Results suggest that although the forewings are reliable predictors of flight in these two species, relative hind wing area can significantly affect gliding flight performance, and should be considered as a factor in future investigations on flight-associated morphology in butterflies.

The thesis is focused on increasing the surface tension of polyethylen, using plasma. A gliding arc was chosen for this surface modi cation. The theoretical part includes an overview of gas discharges, their classi cation, properties and technical applications, and deals with an in uence of surface tension on surface modi cations of materials. The experiment is explained in the practical part, a jet analysis carried out before the experiment is described. Results of the experiment are presented.

This thesis contains a brief summary of the theoretical applications of plasma discharges, and a description of the principle Gliding Arc plasma source. The practical part is focused on the research of the influence ofcereal seed treatment using plasma discharge on their nutritional value (dry matter, ash, protein and fiber). In the conclusion of this thesis is evaluation of the whole experiment.