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京都大学 / 新制・課程博士 / 博士(医学) / 甲第24090号 / 医博第4866号 / 新制||医||1059(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 岩田 想, 教授 林 康紀, 教授 松田 道行 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

Thesis (Ph. D.)--University of Washington, 2006. / Vita. Includes bibliographical references (leaves 146-160).

Abstract It appears that "carbohydrate loading" may enhance the performance of resistance training, but studies on CHO supplementation prior to a resistance-training bout are limited and have resulted in conflicting findings. PURPOSE: To investigate the effects of pre-exercise CHO supplementation on high-intensity (>75% 1RM) resistance training performance for resistance-trained women during an acute bout of resistance exercise. METHODS: Thirteen resistance trained female participants (21.9 ± 4.8 yrs; 64.5 ± 3.0 in; 137.0 ± 14.8 lbs) came to the Exercise and Performance Nutrition Laboratory on three separate occasions; the day of the Familiarization Trial (FT) and the two Exercise Testing sessions (ET1 and ET2, respectively) all separated by seven days. Familiarization testing determined each participant's 1RM of the bench press and leg press and then 75% of the bench press 1RM and 85% of the leg press 1RM was determined. The participants were then randomly assigned to either the CHO or P treatment session using a double blind, counterbalanced technique in a cross-over design with each participant consuming 1.0 g CHO/kg body weight or a non-caloric P beverage 60 minutes before beginning the exercise bout for each ET. The total volume of weight lifted during five sets of the bench press, the total volume of the weight lifted during five sets of the leg press, and whole body total lifting volume was analyzed by a two-way repeated measures within subjects ANOVA with significance set at P <.05. RESULTS: There was no statistically significant difference between the CHO and P treatments in the three variables analyzed. Specifically total volume of weight lifted in pounds during five sets of the bench press was 3,200 (± 912) and 3,152 (± 852) (p = 0.655), total volume of weight lifted during five sets of the leg press was 44,004 (± 29,711) and 37,705 (± 19,681) (p = 0.136), and total lifting volume was 47,204 (± 30,399) and 40,857 (± 20,434) for the CHO and P treatment, respectively (p = 0.138). CONCLUSIONS: Pre-exercise CHO supplementation does not improve high-intensity resistance training performance for resistance-trained women during an acute resistance training session. PRACTICAL APPLICATIONS: It is evident that consuming CHO 60 minutes prior to performing resistance training exercises will not increase the number of sets, repetitions, or total work volume completed during acute high-intensity (>75% 1RM) resistance training sessions for women. During lower-intensity resistance training sessions, however, pre-exercise CHO supplementation may provide ergogenic effects and enhance resistance-training performance.

v anglickém jazyce: Thesis abstract: Background and aims: Both obesity and metabolic syndrome form severe health problems in the whole world. Nevertheless the armament of pharmacotherapy for both diseases remains unsatisfactory. We aimed our work to main organs in risk of the mentioned diseases -liver and visceral fat using hepatocytes and visceral adipocytes as model. We detected 3 main metabolic and signalization activities- glycogenolysis, Nitric oxide (NO) production and transcription of inducible NO synthase (iNOS) in hepatocytes, lipolysis, NO production and iNOS transcription rate in adipocytes. We directed our interest to combination of peroxisome proliferation activator receptor γ (PPARγ) agonist, antagonist and β3 adrenergic agonist in the culture of epididymal rat adipocytes in the first part of our work. While in the second part we investigated the influence of β and α adrenergic mimetics, adrenergic blockers in the culture of rat high glycogen content hepatocytes. Methods: NO production was detected under the active agents treatments by detection of NO oxidative products NO2 and NO3 in media. Glycogenolysis was measured as free glucose rise released by hepatocytes into the media. NOS transcription level was extrapolated after comparative polymerase chain reaction with reverse...

v anglickém jazyce: Thesis abstract: Background and aims: Both obesity and metabolic syndrome form severe health problems in the whole world. Nevertheless the armament of pharmacotherapy for both diseases remains unsatisfactory. We aimed our work to main organs in risk of the mentioned diseases -liver and visceral fat using hepatocytes and visceral adipocytes as model. We detected 3 main metabolic and signalization activities- glycogenolysis, Nitric oxide (NO) production and transcription of inducible NO synthase (iNOS) in hepatocytes, lipolysis, NO production and iNOS transcription rate in adipocytes. We directed our interest to combination of peroxisome proliferation activator receptor γ (PPARγ) agonist, antagonist and β3 adrenergic agonist in the culture of epididymal rat adipocytes in the first part of our work. While in the second part we investigated the influence of β and α adrenergic mimetics, adrenergic blockers in the culture of rat high glycogen content hepatocytes. Methods: NO production was detected under the active agents treatments by detection of NO oxidative products NO2 and NO3 in media. Glycogenolysis was measured as free glucose rise released by hepatocytes into the media. NOS transcription level was extrapolated after comparative polymerase chain reaction with reverse...