Background: Carriers of the APOE epsilon 4 allele are at increased risk of developing Alzheimer's disease (AD), and have been shown to have reduced cerebral metabolic rate of glucose (CMRgl) in the same brain areas frequently affected in AD. These individuals also exhibit reduced plasma levels of apolipoprotein E (apoE) attributed to a specific decrease in the apoE4 isoform as determined by quantification of individual apoE isoforms in APOE epsilon 4 heterozygotes. Whether low plasma apoE levels are associated with structural and functional brain measurements and cognitive performance remains to be investigated. Methods: Using quantitative mass spectrometry we quantified the plasma levels of total apoE and the individual apoE3 and apoE4 isoforms in 128 cognitively normal APOE epsilon 3/epsilon 4 individuals included in the Arizona APOE cohort. All included individuals had undergone extensive neuropsychological testing and 25 had in addition undergone FDG-PET and MRI to determine CMRgl and regional gray matter volume (GMV). Results: Our results demonstrated higher apoE4 levels in females versus males and an age-dependent increase in the apoE3 isoform levels in females only. Importantly, a higher relative ratio of apoE4 over apoE3 was associated with GMV loss in the right posterior cingulate and with reduced CMRgl bilaterally in the anterior cingulate and in the right hippocampal area. Additional exploratory analysis revealed several negative associations between total plasma apoE, individual apoE isoform levels, GMV and CMRgl predominantly in the frontal, occipital and temporal areas. Finally, our results indicated only weak associations between apoE plasma levels and cognitive performance which further appear to be affected by sex. Conclusions: Our study proposes a sex-dependent and age-dependent variation in plasma apoE isoform levels and concludes that peripheral apoE levels are associated with GMV, CMRgl and possibly cognitive performance in cognitively healthy individuals with a genetic predisposition to AD.

This thesis is a selective study of Postmodern literature, focusing on the work of Alasdair Gray and Salman Rushdie. Postmodern literature is an expression of and response to the profound uncertainty that characterises the late-twentieth century. The works of many diverse authors attempt to come to terms with the Postmodern situation, which Jürgen Habermas has described as `the legitimation crisis'. The Enlightenment metanarratives that legitimise Western, industrial societies, have been undermined by Capitalism and events. We no longer accept general metanarratives and this generates profound uncertainty. As Postmodern literature challenges the incomplete certainties of grandnarratives, such as religious and political ideologies, it adopts uncertain forms. Texts create series of debates because these dramatise our conflicting uncertainties and our reluctance to accept, set positions, and answers that erroneously claim to be universal and absolute. By presenting issues in conflict without offering a set conclusion, fiction is able to bring its readers actively into the arguments and find a role for itself within society. The uncertainty of the present has contributed to an impression that we have lost a sense of connection with the past and future and therefore continuous identity. Postmodern novels tend to concentrate upon the struggles of the present in order to free the future from both restrictive traditional visions and the paralysing present. The future finally emerges as the direct product of the past and present, but we can also begin to imagine it as something radically different. Postmodern literature does not create new metanarratives, it legitimises a tense and provisional relationship with society that helps peoples to live in an uncertain world while not surrendering to it.

This study problematizes the criticism Oscar Wilde received for his novel The Picture of Dorian Gray and aims to explore the aesthetic style he employed when writing the novel. The theoretical approach used in this essay is based on the perspectives of New Historicism; Wilde’s life and how people reasoned during his lifetime are brought into focus and different influences on his work are examined, especially evidence of biographical aspects as well as aesthetic elements in the novel. Wilde himself refuted that he had written an immoral story, insisting that morality was not part of Aestheticism. He also made an effort to clarify his aesthetic objectives in later editions by removing some ambiguous sentences and adding a preface.

No description available.

Although critics have studied Oscar Wilde's The Picture of Dorian Gray for nearly one hundred years, no one has examined the author's Irish Celtic heritage in relation to such unanswered questions as the source for the supernatural power that grants Dorian's wish to remain young and creates the central conflict, the purpose of the eleventh chapter, or the apparent "overwriting" or "purple patches" of prose.As a result, the novel has remained elusive, yet fascinating, to both critics and readers. This study asserts that the problem with the traditional approaches critics have taken to solve these questions is that Dorian_ Gray does not entirely belong to mainstream British literary tradition. It also belongs in part to Irish Celtic literature.Consequently, the answers to these unresolved "mysteries" become part of a natural, even inevitable culmination of Irish folklore placed in a Victorian London setting. questions lie in Wilde's Irish background. By looking at the mythology and folklore of Wilde's native Ireland, the “mysteries” become part of a natural, even inevitable culmination of Irish folklore placed in a Victorian London setting.This study's approach to Dorian Gray combines both historical and textual study and builds upon the already substantial number of source studies and biographies available. Moreover, this study examines the almost entirely unexplored background of Wilde's Irish past in the novel which relates to Irish literature. In addition to these components, this paper also offers explanations for the source of the supernatural elements, the problems within the eleventh chapter, and the strategy of the overall structure. Finally this study examines the satirical elements that have their origin in Irish folklore. In many ways, this analysis unifies the other, often conflicting, approaches by explaining these previously misunderstood elements. / Department of English

The objective of this thesis is to successfully design, fabricate, and characterize an optimum metal-insulator-metal diode that can be used as a fast switching diode in various applications such as solar energy conversion. The improvements of this type of diode will result in rectification of a wider spectrum of AC signals to usable electricity. In this project, several proposed designs of MIM diodes were successfully fabricated and characterized. Pt-Al2O3-Al metal-insulator-metal diode was fabricated to have high asymmetry in I-V curve. Additionally, in an attempt to study the effect of material properties on MIM diode???s performance, four different combinations of MIIIIM diode were compared and discussed. Many processes were involved in the fabrication of these diodes such as E-beam evaporation, photolithography, reactive ion etching RIE, and Atomic Layer Deposition (ALD) technique. The fabricated tunneling diodes are intended to operate in the GHz regime and can also operate at higher frequencies (THz) by changing and scaling the dimensions. In addition to MIM diode work, this project attempted to engineer the contrast curve of polystyrene as a negative resist used for E-beam lithography using multi layer resist stack. If the resist stack has a very high contrast and its sensitivity differs between the various layers, it can be ideal for the fabrication of multi-level zone-plate/Fresnel lens.

While the impact of top-down and bottom-up drivers of ecosystem functions has been given considerable argument, here the mid-trophic level is given focus. In marine systems the influence of mid-trophic level species operates in a ‘wasp-waisted’ structure, where they exert regulatory control by acting as a valve to energy flow between large seasonal pulses of primary production and upper level species. In this study I examine the impact of foraging eastern Pacific gray whales (Eschrichtius robustus) on mysid species at the ‘wasp-waist’ (Order Mysidacea), and vice versa, at feeding sites in Clayoquot Sound off the west coast of Vancouver Island. I appraise previously unknown aspects of the ‘prey-scape’, and further explore life-history traits that allow prey populations to persist in a given species array. The set of problems that I examine are all based on the whales’ top-down forcing in a localized area, and the prey response. I use several scales of observation as dictated by the nature of each question. I examine top down forcing and subsequent prey switching over a 25-year period, the variation in foraging intensity over a 15 year period, the differential prey species’ response to persistent predatory pulses that creates dominance and diversity among the mysid species flock, and whales’ within-season response to possible satiation. Each of these studies is linked by the common goal of illuminating the intimate relationship between predator and prey. Gray whale foraging has decimated amphipod prey resources in the study area past the point of recovery over the last 25 years, and the prey resource is no longer a viable energy source. This has led to the abandonment of benthic-feeding by gray whales in the area, and a switch to mysids as a primary prey source. It is in investigating these mysid species’ ability to rebound following severe foraging pressure that I uncovered two principal life history strategies, one held by the single dominant mysid species, and another used by 9 or 10 others consistently sampled. The capacity for renewal of mysid swarms is imperative if Clayoquot Sound is to persist as a productive foraging area for gray whales. The pattern of this relationship that I present, based on a 15 year span, was previously unknown. Intense foraging of mysids by gray whales during a summer affects the reserves for the following season, leading to a biennial fluctuation in the number of whales the area can sustain, although some of the heaviest foraging seasons require several years to show mysid recovery. I state 9 or 10 other species, as through the intense examination of mysids here, there may be a new species designated. The data gathered by myself and colleagues over the past 25 years that whales have been studied in Clayoquot Sound, clearly shows that predation by baleen whales can affect the future quality of their foraging areas, as well as influencing the population, life-stage and diversity of prey species. My work furthers knowledge in life history characteristics of the mysid species present in the study area, particularly growth and reproduction, and ability to capitalize on a release of predation pressure over winter to recover. That, in turn creates a series of following questions about how different life history strategies make use of a variety of possible energy pathways to stabilize ecosystems at least at discrete spatial scales. / Graduate

Thesis (M.S.)--Virginia Polytechnic Institute and State University, 1993. / Vita. Abstract. Includes bibliographical references (leaves 76-82). Also available via the Internet.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1962. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 274-286).

Thesis (Ph. D. in Psychology)--Vanderbilt University, Dec. 2009. / Title from title screen. Includes bibliographical references.