Doctor of Philosophy / Anindilyakwa is the language spoken by over 1,000 Warnindilyakwa Aborigines on Groote Eylandt, Northern Territory. In the Australian language families, it is placed in the Groote Eylandt Family (Oates 1970:15) or the Andilyaugwan Family (Wurm 1972:117). As Yallop (1982:40) reports, Anindilyakwa and Nunggubuyu "are similiar in grammar and possibly share the distinction of being the most gramatically complex Australian languages. They are diverse in basic vocabularly, however, and are therefore allocated to separate families".

Thesis (Ph.D.)--Boston University / The life and writings of the Blessed John of Ruysbroeck lie at the heart of the Golden Age of Mysticism. The purpose of this study has been to present his life and an interpretation of his writings in the form of a narrative poem, thouroughly documented according to accepted dissertation practice, and to show that his life and writings exerted influence upon Gerhardt Groote and John Tauler. The result of the study indicates that Ruysbroeck had a clear conception and structure for his mystical thought presenting a doctrine of God: Father, Son, and Holy Spirit, a doctrine of man, and a conception of the Church, which, while illuminated in many instances with mystic insight, are still conformale to the spirit and intellect of the fourteenth century. [TRUNCATED]

Background Neuropathic pain (NP), defined as pain caused by a lesion or disease of the somatosensory system, affects 6.9 – 10 % of people worldwide. Pregabalin is currently recommended as a first line drug for NP in South Africa. Methods A cross-sectional retrospective descriptive medicines usage evaluation (MUE) of Pregabalin at Groote Schuur Chronic Pain clinic for the year 2017 was conducted. A MUE using a standardized data collection form was performed on 100 randomly selected folders. Data are summarized using descriptive statistics. Results The majority of cases were women (76) with a mean age of 55.9y (SD12.49). A diagnosis of NP was recorded in 58 folders and a “possible” diagnosis recorded in 7 folders. In 79 cases there was no mention of a tool/method used to diagnose NP. The most common condition diagnosed was chronic post-surgical pain with a neuropathic component (n=16), followed by NP (n=15). The most common initiating and current dose of Pregabalin was 75mg twice daily. In 56 patients, Pregabalin was prescribed in conjunction with a tricyclic antidepressant (TCA) or selective noradrenaline reuptake inhibitor (SNRI). Patient education was documented as having taken place in 76 of cases. Conclusions Based on this MUE we recommend the use of screening tools for the diagnosis of neuropathic pain, and a focus on the initiating dose of Pregabalin. The use of a standardized assessment document and the interdisciplinary team input at this clinic appears to optimize prescribing of Pregabalin in line with practice guidelines.

Diagnosis of infectious pericardial disease has been challenging in the developing world despite improvement of treatment modalities. The diagnostic utility of pH in diagnosing infectious pericardial fluid is unknown, yet this concept is well studied in pleural fluid. This cross-sectional diagnostic study evaluated the diagnostic utility of pH in infectious compared to non-infectious pericardial effusions in a high-burden setting. Methods: Patients of 18 years with moderate to large effusion between the 1st February 2016 and 31st May2018 were enrolled at Groote Schuur Hospital in Cape Town, South Africa. After safe pericardiocentesis, pH was measured with a blood gas analyzer. Mycobacterium tuberculosis culture and/or gene Xpert for TB and/or bacteria culture and/or microscopy served as the reference standard for definite infectious pericardial effusions. We calculated sensitivity, specificity, positive and negative predictive values, negative and positive likelihood ratios for an a priori pH cut off of 7.35. Receiver operating characteristic curve analysis was used for selection of ideal pH cut off. RESULTS Using a set sensitivity of 70% we estimated that we needed to recruit a sample size of 149 subjects for a 95% confidence interval and power of 80%. We screened 200 patients, and excluded 60 because they did not meet the appropriate exclusion criteria. The prevalence of infectious pericarditis was 27.1% (n/N=34/140) as confirmed by the reference standard. We found the median pH (IQR) was 7.30(7.20-7.30) for definite infection, 7.30(7.30-7.35) for probable infection and 7.50(7.40-7.55) for non-infectious effusions p value <0.01 (test for trend). At a cut off or <7.35, the sensitivity was 89.5(95%CI: 75%.5-97.1%) and the specificity was 72.5% (95% CI: 62.8%-80.9%). The ideal ROC- determined cut off for pH that would give maximum sensitivity and specificity was ≤7.30 and the maximum sensitivity and specificity at optimum cut off are 86.8% (95% CI:71.9 - 95.6) and 86.8% (95% CI:71.9 - 95.6), respectively. The area under the curve at this cut-off point is 0.86 (95% CI 0.79 to 0.9), p<0. 001. CONCLUSION: In conclusion, pericardial PH offers diagnostic utility for infectious causes of pericardial effusions using both a PH of 7.35 and an ideal cut-off of 7.30. We recommend that given the simplicity of the test it should be adopted in evaluation of patients with pericardial effusions.

Thesis ( MMus (Music))--University of Stellenbosch, 2007. / Steven De Groote (1953-1989) was one of the most successful pianists to have emerged from South Africa. His international reputation rests largely on the fact that he won first prize in the Van Cliburn International Piano Competition in 1977, the only South African to date to have achieved this feat. As such he must be recognized as an important figure in the music history of South Africa. Because the performing musician’s product is transitory in nature and therefore his/her legacy is not tangible in all respects, the introduction to the thesis discusses the specific methodological problems arising from this fact in respect of the writing of a biography. The focus in this biography is on De Groote’s numerous achievements and especially on his career as concert pianist. It includes a discussion of his formative years, his subsequent years of study and the influence of competitions, and more specifically the 1977 Van Cliburn competition on his career. Discussion of his pianistic style, De Groote as teacher and his love for chamber music is also included. De Groote’s contribution to the South African musical scene is highlighted, especially his honorary professorship at the University of Stellenbosch during 1986 and 1987, as are his master classes in this capacity and his regular performances in South Africa. His role as a South African musician abroad is also examined. The biography is concluded with a brief discussion of his airplane accident and the influence this had on his career as a pianist and on his playing.

Thesis (MMus (Music))--University of Stellenbosch, 2009. / Arnold van Wyk was a composer and a pianist. He recorded his largest work for piano, Night Music (1958), on LP in 1963. Steven de Groote performed Night Music on 21 July 1984 at the Cheltenham International Festival of Music. This live performance was broadcast on BBC Radio 3 on 24 September 1984 and a copy of this broadcast exists in the Arnold van Wyk collection in the J.S. Gericke Library at Stellenbosch University. Night Music is a perfect example of Van Wyk’s compositional techniques for the keyboard. It demands a considerable musical imagination and piano technique from the performer. The score of Night Music contains many detailed instructions regarding the different musical parameters and it also encloses unusual terms such as glacial or lugubre. It shows that the composer is extremely concerned to control all aspects of the performance and expects great depth of interpretation of the performer. Analysing the score of Night Music together with a performance by the composer enables one to consider two versions of “authenticated text”. The comparison between Arnold van Wyk’s recording, score and Steven de Groote’s performance allows the researcher to draw conclusions about score fidelity as a condition for “authenticity” in performance. Therefore, the primary aim of this research project is to yield interesting perspectives on notions of authenticity in performance with regard to these two particular performances of Night Music. The main body of this thesis consists of four chapters. In Chapter One a philosophical discussion about authenticity in performance is presented. Chapter Two focuses on the contextualisation of the work under discussion, including the reception and a short analysis of Night Music. It is followed by Chapter Three which compares the pianism of Arnold van Wyk and Steven de Groote. These latter two chapters form the background of the comparative performance analysis of the renditions of Night Music by these two performers which are presented in Chapter Four. Through the careful comparative analysis of Arnold van Wyk’s and Steven de Groote’s performances of Night Music it was possible to observe that a composer can present a version of his work that departs quite radically from the score. As “authenticity in performance” strives to honour the composer’s intentions as notated in the score, this discrepancy illustrates the controversial nature of the discourse on the “authentic” in music.

The aim of the project was to establish rate and mechanisms of solid state reduction of manganese ores. The project studied carbothermal reduction of manganese oxide MnO, two Groote Eylandt (Australian) and Wessels (South African) manganese ores in hydrogen, helium and argon atmospheres at temperatures up to 1400C for MnO and 1200C for manganese ores. Experiments were conducted in the fixed bed reactor with on-line off-gas analysis. The major findings are as follows. ?? Rate and degree of reduction of MnO and ores increased with increasing temperature. ?? Reduction of MnO and manganese ores at temperatures up to 1200C was faster in helium than in argon, and much faster in hydrogen than in helium. The difference in MnO reduction in hydrogen and helium decreased with increasing temperature to 1400C. ?? Addition of up to 7 vol% of carbon monoxide to hydrogen had no effect on MnO reduction at 1200C. ?? In the process of carbothermal reduction of ores in hydrogen at 1200C, silica was reduced. ?? Reduction of both GE ores was slower than of Wessels ore. This was attributed to high content of iron oxide in the Wessels ore. ?? Carbon content in the graphite-ore mixture had a strong effect on phases formed in the process of reduction; thus, in the reduction of Wessels ore with 12-16 wt% C, a-Mn and Mn23C6 were formed; when carbon content was above 20 wt%, oxides were reduced to carbide (Mn,Fe)7C3. ?? Kinetic analysis showed that mass transfer of intermediate CO2 from oxide to graphite in carbothermal reduction in inert atmosphere was a contributing factor in the rate control. ?? High rate of reduction of manganese oxide in hydrogen was attributed to formation of methane which facilitated mass transfer of carbon from graphite to oxide. Hydrogen was also directly involved in reduction of manganese ore reducing iron oxides to metallic iron and higher manganese oxides to MnO. Reduction of Wessels and Groote Eyland Premium Fines ores in the solid state is feasible at temperatures up to 1200C; while temperature for solid state reduction of Groote Eyland Premium Sands is limited by 1100C.

The aim of the project was to establish rate and mechanisms of solid state reduction of manganese ores. The project studied carbothermal reduction of manganese oxide MnO, two Groote Eylandt (Australian) and Wessels (South African) manganese ores in hydrogen, helium and argon atmospheres at temperatures up to 1400C for MnO and 1200C for manganese ores. Experiments were conducted in the fixed bed reactor with on-line off-gas analysis. The major findings are as follows. ?? Rate and degree of reduction of MnO and ores increased with increasing temperature. ?? Reduction of MnO and manganese ores at temperatures up to 1200C was faster in helium than in argon, and much faster in hydrogen than in helium. The difference in MnO reduction in hydrogen and helium decreased with increasing temperature to 1400C. ?? Addition of up to 7 vol% of carbon monoxide to hydrogen had no effect on MnO reduction at 1200C. ?? In the process of carbothermal reduction of ores in hydrogen at 1200C, silica was reduced. ?? Reduction of both GE ores was slower than of Wessels ore. This was attributed to high content of iron oxide in the Wessels ore. ?? Carbon content in the graphite-ore mixture had a strong effect on phases formed in the process of reduction; thus, in the reduction of Wessels ore with 12-16 wt% C, a-Mn and Mn23C6 were formed; when carbon content was above 20 wt%, oxides were reduced to carbide (Mn,Fe)7C3. ?? Kinetic analysis showed that mass transfer of intermediate CO2 from oxide to graphite in carbothermal reduction in inert atmosphere was a contributing factor in the rate control. ?? High rate of reduction of manganese oxide in hydrogen was attributed to formation of methane which facilitated mass transfer of carbon from graphite to oxide. Hydrogen was also directly involved in reduction of manganese ore reducing iron oxides to metallic iron and higher manganese oxides to MnO. Reduction of Wessels and Groote Eyland Premium Fines ores in the solid state is feasible at temperatures up to 1200C; while temperature for solid state reduction of Groote Eyland Premium Sands is limited by 1100C.

The focus of this study is on South Africa's transition to democracy. It is argued in this thesis, that an analysis of the transition to democracy in South Africa and the transformation of the con ict that prevailed in this divided society could generate new avenues for theorising about transitions to democracy in divided societies amidst con ict. The aim with this thesis is to contribute towards a more comprehensive understanding of the complex nature of the process of transition to democracy, and the relevant theory involved, particularly with regard to transitions in divided societies. One consequence of the deep divisions within South African society has been the increase in violence, which followed liberalisation. The transition to democracy in South Africa, as a result, was characterised by continuing and escalating violence. In South Africa, the authoritarian regime deteriorated mainly because of internal factors, but external factors also played an important role. The analysis of the transition has been guided by the hypothesis that the democratisation of South Africa was accomplished through a compromise that was negotiated between the major political actors and which re ected the intra-, as well as the inter-dynamics in the domains of, state - political society - civil society. Thus, the main theme of this thesis is, that in the analysis of the dynamics of the tran- sition to democracy in South Africa, a basic framework in which the domains of, state - political society - civil society, are the domains where structural variables (such as culture, economic development, class structures, increased education and the international environ- ment) and behavioural variables (such as major political actors, elite factions, organisations from civil society) interact. Thus, in the diachronic analysis of South Africa's transition, an interactive approach, that seeks to relate structural constraints to the shaping of contingent choice, is followed. At the same time, the institutional substitution of a new democratic political dispensation is examined. In conclusion, democracies are complex phenomena, and they are caused by many di er- ent forces and synthesizing the relevant theoretical approaches to political change provides a more cogent and comprehensive explanation of democratic transition in South Africa. / (D. Litt. et Phil. (International Politics))

Text in English / International studies have demonstrated that Implantable Cardioverter Defibrillators (ICDs) can have a significant impact on the Quality of Life (QOL) of patients. This is often due to factors that cause considerable psychological distress and has not been investigated in South Africa before. This research study thus investigated factors that influence QOL in patients with ICDs who are followed up in the Cardiac Clinic at Groote Schuur Hospital. The objectives were to describe demographic, clinical, ICD and patient support characteristics; to determine the prevalence of anxiety and depression; to assess QOL and to establish factors that influence depression, anxiety and QOL. The method involved a quantitative approach and a descriptive, cross-sectional and correlational design. All eligible patients with ICDs from the Cardiac Clinic were invited to participate. Participants completed a Demographic and Clinical Questionnaire, the Hospital Anxiety and Depression Scale (HADS) and the SF-36v2 Health Survey. A descriptive analysis of frequencies and summary statistics were done, followed by a regression, comparison and correlational analyses. A total of 70 patients (57 years mean, 65% male) participated in the study. The HADS mean score for anxiety was 6.50, SD 4.52 and for depression 4.96, SD 3.36. The SF-36v2 QOL Physical Component Summary (PCS) mean score was 43.83, SD 9.43 and the Mental Component Summary (MCS) was 47.81, SD 10.71. Factors associated with depression, anxiety and poor QOL included having more than 5 ICD shocks (appropriate or inappropriate). Patients who felt that the ICD influenced their lifestyle positively, was 10.46 times more like to have mental well-being. This study showed that patients with ICDs managed in the state sector, is a vulnerable population. They often live far from hospital, have a high unemployment rate and a poor income. The HADS revealed that 21.4% of the patients had depressive symptoms and 28.6% fulfilled criteria for anxiety. The SF-36v2 revealed that the QOL of patients with ICDs was significantly lower than the norm, with regard to their physical and mental well-being. The study highlights the need for psychological and social support of patients living with ICDs. Keywords: quality of life; implantable cardioverter defibrillator; sudden cardiac death; arrhythmia; anxiety; depression; HADS; SF36v2. / Psychology / M.A. (Psychology)