Data Handover est une librairie de fonctions adaptée aux systèmes distribués à grande échelle. Dho offre des routines qui permettent d'acquérir des ressources en lecture ou en écriture de façon cohérente et transparente pour l'utilisateur. Nous avons modélisé le cycle de vie de Dho par un automate d'état fini puis, constaté expérimentalement, que notre approche produit un recouvrement entre le calcul de l'application et le contrôle de la donnée. Les expériences ont été menées en mode simulé en utilisant la libraire GRAS de SimGrid puis, en exploitant un environnement réel sur la plate-forme Grid'5000. Par la théorie des files d'attente, la stabilité du modèle a été démontrée dans un contexte centralisé. L'algorithme distribué d'exclusion mutuelle de Naimi et Tréhel a été enrichi pour offrir les fonctionnalités suivantes: (1) Permettre la connexion et la déconnexion des processus (ADEMLE), (2) admettre les locks partagés (AEMLEP) et enfin (3) associer les deux propriétés dans un algorithme récapitulatif (ADEMLEP). Les propriétés de sûreté et de vivacité ont été démontrées théoriquement. Le système peer-to-peer proposé combine nos algorithmes étendus et le modèle originel Dho. Les gestionnaires de verrou et de ressource opèrent et interagissent mutuellement dans une architecture à trois niveaux. Suite à l'étude expérimentale du système sous-jacent menée sur Grid'5000, et des résultats obtenus, nous avons démontré la performance et la stabilité du modèle Dho face à une multitude de paramètres / Data Handover is a library of functions adapted to large-scale distributed systems. It provides routines that allow acquiring resources in reading or writing in the ways that are coherent and transparent for users. We modelled the life cycle of Dho by a finite state automaton and through experiments; we have found that our approach produced an overlap between the calculation of the application and the control of the data. These experiments were conducted both in simulated mode and in real environment (Grid'5000). We exploited the GRAS library of the SimGrid toolkit. Several clients try to access the resource concurrently according the client-server paradigm. By the theory of queues, the stability of the model was demonstrated in a centralized environment. We improved, the distributed algorithm for mutual exclusion (of Naimi and Trehel), by introducing following features: (1) Allowing the mobility of processes (ADEMLE), (2) introducing shared locks (AEMLEP) and finally (3) merging both properties cited above into an algorithm summarising (ADEMLEP). We proved the properties, safety and liveliness, theoretically for all extended algorithms. The proposed peer-to-peer system combines our extended algorithms and original Data Handover model. Lock and resource managers operate and interact each other in an architecture based on three levels. Following the experimental study of the underlying system on Grid'5000, and the results obtained, we have proved the performance and stability of the model Dho over a multitude of parameters

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<p>A new kind of lipid/polymer composite particle, consisting of a biodegradable polymer matrix with well-defined lipid domains, has been created. The lipid used is the water-swelling lipid monoolein (MO), which forms a reversed bicontinuous cubic diamond structure in aqueous solutions. The polymer is poly(d,l-lactide-co-glycolide) (PLG), which degrades into water-soluble monomers through hydrolysis. This new particle might be a good alternative for encapsulation of active substances intended to be released over a longer period of time, i.e. sustained/retained/controlled release.</p><p>To prepare such particles can be difficult. Suitable phase behaviour and a solvent with the right properties are needed. For this reason, the phase behaviours of several different lipid/polymer/solvent/water systems have been explored. From the phase behaviour of a suitable system (i.e. MO/PLG/ethyl acetate/water), a route for formation of lipid/polymer composite particles has been deduced. Particles have been formed and distinct, water-swelling, lipid domains have been confirmed by characterization by means of confocal laser scanning probe microscopy (CLSM). </p><p>The sample preparation process has been automated and a method based on using a robotic liquid handler has been developed. Phase diagrams have been determined by examination of macroscopic behaviours and the microstructures of the phases have been studied by small- and wide-angle X-ray scattering (L₃, V₂, L_α, L), nuclear magnetic resonance self-diffusion (L, L₃), viscosimetry (L) and rheology (L). Several different theoretical models have been applied for interpretation of the results. For example, the swelling of the reversed bicontinuous cubic phases and the sponge phase have been modelled by applying the theory of infinite periodical minimal surfaces, the sponge phase has been shown to be bicontinuous according to the theory of interconnected rods and the phase behaviour of the polymer has been described by the Flory-Huggins theory. The main focus of this work (4/5) concerns phase studies in multicomponent systems from a physical-chemical point of view.</p>

A new kind of lipid/polymer composite particle, consisting of a biodegradable polymer matrix with well-defined lipid domains, has been created. The lipid used is the water-swelling lipid monoolein (MO), which forms a reversed bicontinuous cubic diamond structure in aqueous solutions. The polymer is poly(d,l-lactide-co-glycolide) (PLG), which degrades into water-soluble monomers through hydrolysis. This new particle might be a good alternative for encapsulation of active substances intended to be released over a longer period of time, i.e. sustained/retained/controlled release. To prepare such particles can be difficult. Suitable phase behaviour and a solvent with the right properties are needed. For this reason, the phase behaviours of several different lipid/polymer/solvent/water systems have been explored. From the phase behaviour of a suitable system (i.e. MO/PLG/ethyl acetate/water), a route for formation of lipid/polymer composite particles has been deduced. Particles have been formed and distinct, water-swelling, lipid domains have been confirmed by characterization by means of confocal laser scanning probe microscopy (CLSM). The sample preparation process has been automated and a method based on using a robotic liquid handler has been developed. Phase diagrams have been determined by examination of macroscopic behaviours and the microstructures of the phases have been studied by small- and wide-angle X-ray scattering (L3, V2, Lα, L), nuclear magnetic resonance self-diffusion (L, L3), viscosimetry (L) and rheology (L). Several different theoretical models have been applied for interpretation of the results. For example, the swelling of the reversed bicontinuous cubic phases and the sponge phase have been modelled by applying the theory of infinite periodical minimal surfaces, the sponge phase has been shown to be bicontinuous according to the theory of interconnected rods and the phase behaviour of the polymer has been described by the Flory-Huggins theory. The main focus of this work (4/5) concerns phase studies in multicomponent systems from a physical-chemical point of view.