Global ETD Search

1	Comparison between therapeutic efficiency of bone marrow derived mononuclear and mesenchymal stem cells in chronic myocardial infarction Mathieu, Myrielle 05 May 2009 (has links) Background: Stem cell therapy can facilitate cardiac repair after healed myocardial infarction but the optimal cell type remains uncertain. Aims: To investigate the pathophysiology of heart failure in a canine model of healed myocardial infarction and to compare the efficacy and the safety of autologous bone marrow mononuclear cell (BMNC) transfer and mesenchymal stem cell (MSC) transfer in this model. It was a blind, randomized and placebo control study. Methods: Eleven weeks after coronary ligation, 24 dogs received intramyocardial injections of BMNC, MSC or Placebo (n = 8 per groups). Echocardiography, conductance method, magnetic resonance imaging, serum neurohormones, holter monitoring, macromorphometry, histology and real time quantitative polymerase chain reaction were used to assess cardiac performance, safety and remodelling in healthy animals, before cell transplantation and up to 16 weeks’ follow-up. Results: The model was characterized by decreased left ventricular end-systolic elastance and ventricular-arterial uncoupling without alteration of compliance. Four months after BMNC transfer, the regional systolic function measured at echocardiographic showed a sustained improvement. This improvement was associated with an improved left ventricular end-systolic elastance and a decreased infarct size. Although the left ventricular ejection fraction stayed unchanged, the serum level of N-terminal B-type natriuretic propeptide level decreased. Mononuclear cell transfer was also associated with increased left ventricular relative wall area, increased vascular density, intramyocardial vascular remodelling and upregulation of angiogenic factors gene expression. Mesenchymal stem cell transfer only improved lately and moderately the regional systolic function, without improvement of cardiac contractility or decreased infarct size. Conclusions: In a canine model of chronic myocardial infarction, BMNC transfer is superior to MSC transfer in improvement of cardiac contractility and regional systolic function, and to reduce the infarct size and plasma N-terminal B-type natriuretic propeptide level. Functional improvement is associated with a favourable angiogenic environment and neovascularization. bone marrow derived stem cells mesenchymal cells conductance catheterstem cell therapy ventricular-arterial coupling systolic function diastolic function healed myocardial infarction Heart failure
2	Comparison between therapeutic efficiency of bone marrow derived mononuclear and mesenchymal stem cells in chronic myocardial infarction Mathieu, Myrielle 05 May 2009 (has links) <p>Background: Stem cell therapy can facilitate cardiac repair after healed myocardial infarction but the optimal cell type remains uncertain. <p>Aims: To investigate the pathophysiology of heart failure in a canine model of healed myocardial infarction and to compare the efficacy and the safety of autologous bone marrow mononuclear cell (BMNC) transfer and mesenchymal stem cell (MSC) transfer in this model. It was a blind, randomized and placebo control study.<p>Methods: Eleven weeks after coronary ligation, 24 dogs received intramyocardial injections of BMNC, MSC or Placebo (n = 8 per groups). Echocardiography, conductance method, magnetic resonance imaging, serum neurohormones, holter monitoring, macromorphometry, histology and real time quantitative polymerase chain reaction were used to assess cardiac performance, safety and remodelling in healthy animals, before cell transplantation and up to 16 weeks’ follow-up. <p>Results: The model was characterized by decreased left ventricular end-systolic elastance and ventricular-arterial uncoupling without alteration of compliance. <p>Four months after BMNC transfer, the regional systolic function measured at echocardiographic showed a sustained improvement. This improvement was associated with an improved left ventricular end-systolic elastance and a decreased infarct size. Although the left ventricular ejection fraction stayed unchanged, the serum level of N-terminal B-type natriuretic propeptide level decreased. Mononuclear cell transfer was also associated with increased left ventricular relative wall area, increased vascular density, intramyocardial vascular remodelling and upregulation of angiogenic factors gene expression. Mesenchymal stem cell transfer only improved lately and moderately the regional systolic function, without improvement of cardiac contractility or decreased infarct size. <p>Conclusions: In a canine model of chronic myocardial infarction, BMNC transfer is superior to MSC transfer in improvement of cardiac contractility and regional systolic function, and to reduce the infarct size and plasma N-terminal B-type natriuretic propeptide level. Functional improvement is associated with a favourable angiogenic environment and neovascularization. <p> / Doctorat en Sciences biomédicales et pharmaceutiques / info:eu-repo/semantics/nonPublished Disciplines biomédicales diverses Médecine pathologie humaine Heart failure Myocardial infarction Stem cells Insuffisance cardiaque Myocarde -- Infarctus Cellules souches bone marrow derived stem cells mesenchymal cells conductance catheterstem cell therapy ventricular-arterial coupling systolic function diastolic function healed myocardial infarction
3	Le geste martial comme expérience : esthétique de l’« être-là »-ninja / The martial gesture as experience : aesthetics of "being-here"-ninja Hmida, Salah 29 September 2018 (has links) Il s’agit, dans ce travail, de trouver le geste qui renouvelle l’identité cicatrisée que le «guerrier » en nous recherche, à travers la pratique martiale définie comme habitation holiste d’un corps-soit, ce que Varela appelle « l’inscription corporelle de l’esprit ».Un être, par l’effet d’un art et par la compréhension de « l’expérience de l’expérience » que constitue la performativité du geste en général, peut-il jamais faire Un avec les choses qui l’entourent et qui l’enveloppent ? Il y a à parier que s’il y arrivait, il lui serait donné de saisir à la fois le caractère mythique des choses en tant qu’il est immanent à leur présence et cette présence en tant qu’oeuvre existentielle. L’art martial ninja constitue une telle réussite. Cette thèse en interroge les effets … / This work consists in finding the gesture that renovates the healed identity, a “worrior” withinus is looking for, through a martial practice defined as a holistic dwelling of a body-being.This is what Varela calls “the corporeal inscription of the spirit”.Is a being able to make one with the things surrounding and covering it, through the effect ofart and the comprehension of “the experience of the experience”, that the performativity of thegesture generally constitutes? It would bet, if possible, that it would be able of creating, at thesame time, the mythic aspect of things, having been inherent to their presence, and creatingthis presence as an existential art-workNinja martial art builds such a success, the effects of which are questioned by this thesis... La mythologie L’identité cicatrisée L’expérience La cicatrice La cicatrisation L’intelligence corporelle La martialité Les stratégies La ruse Les tactiques Les ninjas La magie La facitivité La corporéité Le geste La présence L’inexpérience Mythology Healed identity Experience Thes scar Wound healing Corporeal intelligence Martiality Strategies Cunning Tactics Ninjas Magic Facticity Corporeality The gesture The presence The inexperience

1

Page generated in 0.0221 seconds