A perda de energia de íons na matéria é um tópico de grande interesse não apenas por suas aplicações diretas em técnicas de análises de materiais bem como nos estudos teóricos das interações íon-átomo. No entanto, o poder de freamento de sólidos para íons pesados é ainda pouco compreendido especialmente para baixas velocidades devido principalmente a complicada dependência nos números atômicos do meio freador e do íon incidente. Neste trabalho são apresentados os dados experimentais para o freamento de Cu em Au na região de velocidades de 2 - 4% da velocidade da luz. Os dados experimentais foram obtidos com uso da técnica de espalhamento elástico, onde um feixe primário de 16O e 28Si, com energias entre 35 - 52 MeV e 49 - 79 MeV respectivamente, foram tilizados para produzir íons de Cu em recuo a partir de um alvo fino ( 160 g/cm2). O feixe primário espalhado é detectado a 60o por um detector de Si, produzindo átomos de Cu do alvo recuando em um ângulo denido pela cinemática da colisão elástica. Os íons em recuo medidos em coincidência temporal com o feixe primário espalhado compõe o feixe secundário de interesse. A perda de energia, em uma folha de Au com espessura em torno de 530 g/cm2, foi obtida medindo-se a energia do feixe secundário com um detector de Si, com e sem a folha de Au interceptando os íons em recuo. Os dados experimentais foram comparados com teorias e modelos semi-empíricos aplicáveis a esse caso. Bom acordo entre a previsão da Aproximação de Convolução Unitária e nossos dados experimentais é observado. / The energy loss of ions in materials is an important issue not only because of its direct applications in analytic techniques of materials but also for studying the basics of ion-atom interactions. Nevertheless, the Stopping Power of heavy ions in solids is still poorly understood which is especially true at low velocities mainly due to the complicated dependence on the atomic numbers of the stopper medium and of the stopping ion. In this work we present new experimental data for Copper ions slowing down in Gold foil in the velocity range of 2 to 4% of the velocity of light. Experimental data were obtained using the elastic scattering technique, where primary beams of 16O and 28Si, with energies from 35 to 52 MeV and 49 to 79 MeV respectively, were used to scatter Cu íons from a thin target ( 160 g/cm2). The scattered primary beam is detected at 60 with a Si detector, producing recoiling atoms of the target in an angle given by the elastic scattering kinematics. The recoiling ions in temporal coincidence with the scattered primary beam will compose the secondary beam. The energy loss, in a gold foil with thickness about 530 g/cm2, was obtained by measuring the energy of the secondary beam with a Si detector, with and without the Au foil intercepting the recoiling ions. Experimental results were compared with theories and semi-empirical models applied to this case. Good agreement between Unitary Convolution Approximation (UCA) prediction and our data is observed.

A perda de energia de íons na matéria é um tópico de grande interesse não apenas por suas aplicações diretas em técnicas de análises de materiais bem como nos estudos teóricos das interações íon-átomo. No entanto, o poder de freamento de sólidos para íons pesados é ainda pouco compreendido especialmente para baixas velocidades devido principalmente a complicada dependência nos números atômicos do meio freador e do íon incidente. Neste trabalho são apresentados os dados experimentais para o freamento de Cu em Au na região de velocidades de 2 - 4% da velocidade da luz. Os dados experimentais foram obtidos com uso da técnica de espalhamento elástico, onde um feixe primário de 16O e 28Si, com energias entre 35 - 52 MeV e 49 - 79 MeV respectivamente, foram tilizados para produzir íons de Cu em recuo a partir de um alvo fino ( 160 g/cm2). O feixe primário espalhado é detectado a 60o por um detector de Si, produzindo átomos de Cu do alvo recuando em um ângulo denido pela cinemática da colisão elástica. Os íons em recuo medidos em coincidência temporal com o feixe primário espalhado compõe o feixe secundário de interesse. A perda de energia, em uma folha de Au com espessura em torno de 530 g/cm2, foi obtida medindo-se a energia do feixe secundário com um detector de Si, com e sem a folha de Au interceptando os íons em recuo. Os dados experimentais foram comparados com teorias e modelos semi-empíricos aplicáveis a esse caso. Bom acordo entre a previsão da Aproximação de Convolução Unitária e nossos dados experimentais é observado. / The energy loss of ions in materials is an important issue not only because of its direct applications in analytic techniques of materials but also for studying the basics of ion-atom interactions. Nevertheless, the Stopping Power of heavy ions in solids is still poorly understood which is especially true at low velocities mainly due to the complicated dependence on the atomic numbers of the stopper medium and of the stopping ion. In this work we present new experimental data for Copper ions slowing down in Gold foil in the velocity range of 2 to 4% of the velocity of light. Experimental data were obtained using the elastic scattering technique, where primary beams of 16O and 28Si, with energies from 35 to 52 MeV and 49 to 79 MeV respectively, were used to scatter Cu íons from a thin target ( 160 g/cm2). The scattered primary beam is detected at 60 with a Si detector, producing recoiling atoms of the target in an angle given by the elastic scattering kinematics. The recoiling ions in temporal coincidence with the scattered primary beam will compose the secondary beam. The energy loss, in a gold foil with thickness about 530 g/cm2, was obtained by measuring the energy of the secondary beam with a Si detector, with and without the Au foil intercepting the recoiling ions. Experimental results were compared with theories and semi-empirical models applied to this case. Good agreement between Unitary Convolution Approximation (UCA) prediction and our data is observed.

No description available.

La théorie de la QCD (Quantum ChromoDynamics) prédit l’existence d’une nouvelle phase de la matière nucléaire à très haute température. Cette phase, caractérisée par un déconfinement des quarks au sein des hadrons, est appelée QGP (Quark Gluon Plasma). Le spectromètre à muons de l’expérience ALICE (A Large Ion Collider Experiment) a pour but d’étudier les propriétés du QGP aux densités d’énergie extrêmes atteintes dans les collisions d’ions lourds au LHC (Large Hadron Collider). Le système de déclenchement du spectromètre à muons, appelé MUON TRG est, pour une large part, sous la responsabilité du groupe ALICE de Clermont-Ferrand. Il se compose de quatre plans de détecteurs RPC (Resistive Plate Chamber) d’une superficie totale de 140 m2, de 21k voies de lecture et d’une électronique de décision rapide. Il a été conçu afin de reconstruire ”en ligne” des traces (muons), dans un environnement présentant un important bruit de fond. Une décision de trigger, pour les ”single muons” et les ”dimuons”, est délivrée toutes les 25 ns (40 MHz) avec un temps de latence relatif à l’interaction proche de 800 ns. Les performances, en particulier celles liées à la décision de trigger, obtenues avec des outils de test dédiés, les évènements cosmiques, les premiers faisceaux d’injection dans le LHC ainsi que les premières collisions proton-proton à √s = 900 GeV seront présentés. / The QCD theory (Quantum ChromoDynamics) predicts the presence of a new phase of the nuclear matter at very high temperature. This phase, characterized by a deconfinement of quarks within hadrons, is called QGP (Quark Gluon Plasma). The muon spectrometer of the ALICE experiment (A Large Ion Collider Experiment) aims at investigating the propertiesof the QGP at the extreme energy density reached in heavy ion collisions at LHC (Large Hadron Collider). The trigger system of the Muon Spectrometer, called MUON TRG mainly come under the responsability of the Clermont-Ferrand ALICE team. It consists of four planes of RPC (Resistive Plate Chamber) detectors with a total area of 140 m2 , 21k front-end channels and fast-decision electronics. It is designed to reconstruct (muon) tracks online, in a large background environment. A fast trigger decision, for both single-muons and dimuons, is delivered each 25 ns (40 MHz) with a latency with respect to the interaction of about 800 ns. The performances, especially the ones related to trigger decision, obtained with dedicated test tools, cosmic rays, first LHC injection beams and first proton-proton collisions at √s = 900 GeV will be presented.

Efeitos de radiação em dispositivos eletrônicos são uma preocupação em diversas áreas, como em missões espaciais, aceleradores de partículas de alta energia, entre outras. Entre os efeitos de radiação induzidos por íons pesados estão os chamados de Efeitos de Eventos Isolados (Single Event Effects - SEE), nos quais o impacto de um único íon pode ser capaz de gerar um efeito observável. Estes efeitos nunca haviam sido estudados no Brasil e seu estudo requer um acelerador de partículas capaz de prover feixes de íons pesados com baixo fluxo. A caracterização de dispositivos é feita medindo-se o número de eventos induzidos por radiação em função da transferência de energia por unidade de comprimento (Linear Energy Transfer - LET) do íon na camada sensível do dispositivo. Neste trabalho desenvolvemos um sistema para produção de feixes pesados para estudar SEE no Acelerador Pelletron 8UD, utilizando espalhamento Rutherford. A montagem permite obter feixes iônicos com valores de LET na superfície de silício na faixa de 1 a 40 MeV/mg/2. O valor de LET na camada sensível do dispositivo depende da espessura de sua camada de passivação. Feixes pesados até 48 podem ser utilizados para irradiações com feixe externo, isto é, fora da câmara de vácuo, e até 107 em vácuo, com uniformidade em intensidade acima de 90%. A caracterização do MOSFET 3N163 foi a primeira medida bem-sucedida de SEE no Brasil, e foi possível correlacionar o LET dos íons com a amplitude do sinal gerado no dispositivo sob teste. A curva de seção de choque de SEE foi obtida, e para o dispositivo estudado os valores obtidos de seção de choque de saturação e LET de limiar foram de 2,94(10)105 2 e 2,35(36)MeV/mg/2 respectivamente. / Radiation effects on electronic devices are a main concern for many situations, such as space applications, high-energy particle accelerators, nuclear medicine, among others. A group of radiation effects induced by heavy-ions are called Single Event Effects, because a strike of a single ion can be enough to generate a damage on electronic devices. So far, SEE were not studied in Brazil due to the need of a high-energy, lowflux particle accelerator. Device characterization is done by measuring the number of events as a function of Linear Energy Transfer of the ion beam on the sensitive layer of the device under test (DUT). In this work we developed a Rutherford scattering setup for studying SEE at Sao Paulo 8UD Pelletron Accelerator. The setup can provide ion beams with Linear Energy Transfer values on the silicon surface ranging from 1 to 40 MeV/mg/2. The values on the active layer of the device depend upon the thickness of the dead-layer of the device. Ion beams up to 48 can be used for irradiation of devices outside the vacuum chamber and up to 107 inside the vacuum chamber, with a uniformity better than 90%. The characterization of the MOSFET 3N163 was the first successful measurement of heavy-ion induced SEE in Brazil, and it was possible to correlate ion LET with signal amplitude generated by the DUT. A complete SEE cross-section curve was obtained, and for the device studied the values of saturation cross-section and threshold LET are 2.94(10).105 2 and 2.35(36) MeV/mg/2,respectively

Indium phosphide (InP) is an important III-V compound, with a variety of applications, for example, in light emitting diodes (LED), InP based photonic crystals and in semiconductor lasers, heterojunction bipolar transistors in integrated circuit applications and in transistors for microwave and millimeter-wave systems. The optical and electrical properties of this compound can be further tailored by ion implantation or prospectively by swift heavy ion beams. ¶ Thus knowledge of ion-induced disorder in this material is of important fundamental and practical interest. However, the disorder produced during heavy ion irradiation and the subsequent damage accumulation and recovery in InP is far from being completely understood. In terms of the damage accumulation mechanisms, the conclusions drawn in the numerous studies performed have often been in conflict with one another. A factor contributing to the uncertainties associated with these conflicting results is a lack of information and direct observation of the “building blocks” leading to the ultimate damage created at high ion fluences as an amorphous layer. These building blocks formed at lower fluence regimes by single ion impacts can be directly observed as isolated disordered zones and ion tracks for low energy and swift heavy ion irradiation, respectively. ¶ The primary aim of this work has thus been to obtain a better understanding of the disorder in this material through direct observations and investigation of disorder produced by individual heavy ions in both energy regimes (i.e. elastic and inelastic energy deposition regimes) especially with low ion fluence irradiations. In this thesis the heavy ion induced disorder introduced by low energy Au ions (100 keV Au+) and high energy Au (200 MeV Au+16) ion irradiation in InP were investigated using Transmission Electron Microscopy (TEM), Rutherford Backscattering Spectrometry (RBS/C) and Atomic Force Microscopy (AFM). ¶ The accumulation of damage due to disordered zones and ion tracks is described and discussed for both low energy and swift ion irradiation respectively. ¶ The in-situ TEM annealing of disordered zones created by 100 keV Au+ ion irradiation shows that these zones are sensitive to electron beam irradiation and anneal under electron energies not sufficient to elastically displace lattice atoms, i.e. subthreshold energies for both constituent atoms In and P. ¶ Ion tracks due to swift heavy ion irradiation were observed in this material and the interesting track morphology was described and discussed. The surface nanotopographical changes due to increasing fluence of swift heavy ions were observed by AFM where the onset of large increase in surface roughness for fluences sufficient to cause complete surface amorphization was observed. ¶ In addition to InP, the principle material of this project, a limited amount of TEM observation work has been performed on several other important compounds (apatite and monazite) irradiated by 200 MeV Au+ ions for comparative purposes. Again the observed segmental morphology of ion tracks were shown and possible track formation scenario and structure were discussed and similarities were drawn to the previously observed C60 cluster ion tracks in CaF2 as more knowledge and data base exist about defect dynamics and formation in that material.

Glioblastoma multiforme (GBM) ist der nach WHO am gefährlichsten eingestufte Hirntumor astrozytären Ursprungs. Patienten versterben ohne Behandlung etwa drei bis sechs Monaten nach Diagnose, die derzeitig modernste Behandlung mit Chemo-Radiotherapie verlängert das mediane Überleben auf 12-15 Monate. Trotz intensiver Forschung gibt es zurzeit keine realistische Heilungschance. Bislang erfolgt der Großteil der Forschung an Zellkulturen oder mit Hilfe von Tiermodellen, bei denen ein Tumor künstlich erzeugt wird. Dabei ergeben sich Probleme für die Übertragung der Ergebnisse auf den Menschen. Zellkulturen werden z.B. als sogenannte Monolayer-Kulturen gehalten, was bedeutet, dass ihnen der natürliche Gewebeverband und die für Signalling-Wege wichtige extrazelluläre Matrix fehlen. Außerdem werden solche Langzeitkulturen häufig subkultiviert und mutieren dadurch in Richtung einer klonalen Linie, was zwar Ergebnisse leichter reproduzierbar macht, aber nicht die Situation im Patienten widerspiegelt. Tierversuche implizieren zwar den Gewebeverband im Körper, jedoch müssen die dafür verwendeten Nager immunsupprimiert sein, so dass sie den induzierten Tumor nicht abstoßen. Dies erzeugt wiederum ein künstliches Umfeld. In diesem Projekt wird untersucht, ob sich humane GBM-Gewebe als sogenannte Slice-Kultur halten lassen und als Testsysteme zur Untersuchung der Wirkung von Chemotherapeutika sowie Bestrahlung geeignet sind. Bei dieser Kultivierungsmethode wird das Gewebe in Scheiben (Slices) geschnitten, wobei alle Zellen im Verband sowie die 3D-Struktur erhalten bleiben. Wegen des humanen Ursprungs entfällt das Problem des Speziesunterschiedes. Das Gewebe wird direkt aus dem Operationssaal ins Labor transferiert und weiterverarbeitet. Wir konnten bislang zeigen, dass Slice-Kulturen von humanem GBM über mindestens zwei Wochen in Kultur vital bleiben und ihre ursprüngliche charakteristische Morphologie beibehalten. Etablierte Behandlungsmethoden wie die Gabe von Temozolomid oder Röntgenbestrahlung zeigen auch in kultivierten Slices bekannte Effekte wie Induktion von DNA-Doppelstrangbrüchen, Reduktion von Proliferation und Aktivierung des Apoptose-Enzyms Caspase 3. Eine neue Therapieoption besteht seit einigen Jahren in der Bestrahlung mit Kohlenstoffionen (12C), die an der GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt entwickelt und getestet wurde. Derzeit wird diese Therapie sehr erfolgreich an soliden Tumoren im Kopf- und Halsbereich angewendet und soll nun auf weitere Tumorarten ausgedehnt werden. Eine Kooperation mit der dortigen Biophysik-Gruppe wurde initiiert, um humane GBM-Slices mit 12C zu bestrahlen. Bislang wurde das entsprechende Setup etabliert und erste Experimente durchgeführt. Die ersten Ergebnisse wurden kürzlich publiziert. Weiterhin soll nun geprüft werden, ob das Ansprechen der GBM Slice-Kulturen mit dem Überleben der Patienten korreliert bzw. ob resistente Kulturen aus Patienten stammten, die schlecht auf die Therapie reagierten. Außerdem sollen überlebende Zellen in den Slices nach Behandlung auf ihre molekularen Eigenschaften geprüft werden, um Hinweise auf die Mechanismen der Tumorresistenz zu erhalten. Langfristig könnten diese Slice-Kulturen genutzt werden, um neuartige Wirkstoffe in der Vorklinik zu prüfen oder eine optimierte, personalisierte Therapie für Patienten zu ermitteln.

La matière nucléaire, constituant le noyau des atomes, est formée de quarks et de gluons, dont l’interaction est décrite par la théorie de la chromodynamique quantique (QCD). Dans des conditions normales, quarks et gluons ne peuvent être observés de façon isolée et sont confinés dans des hadrons tels que les protons et les neutrons. Le Plasma de Quarks et de Gluons (PQG) est un état de la matière nucléaire prédit par la QCD pour lequel ces quarks et gluons sont déconfinés. Expérimentalement, le PQG peut être créé dans des collisions d’ions lourds ultra-relativistes, telles que les collisions d’ions lourds effectuées au LHC, correspondant à des vitesses proche de celle de la lumière. Il est possible d’obtenir des informations sur le PQG en mesurant un large nombre d’observables. En particulier, la production de charmonium tels que le J/ψ et le ψ(2S), particules lourdes constituées d’une paire de quarks charme et anti-charme () est mesurée pour étudier le plasma. En effet, la présence d’un PQG est censée modifier les taux de production des charmonia, à cause d’un équilibre entre un mécanisme d’écrantage de couleur du potentiel des quarks charme et un mécanisme dit de recombinaison. La position de cet équilibre dépend de l’énergie de collision, la température du plasma, et la nature de la particule considérée, et plus spécifiquement, il est attendu que le ψ(2S) soit plus supprimé que le J/ψ. Dans cette thèse, la production inclusive de ψ(2S) en collisions Pb − Pb à une énergie par collision nucléon-nucléon dans le référentiel du centre de masse de TeV est mesurée dans le canal de décroissance de dimuon avec le Spectromètre à Muons d’ALICE. L’analyse est basée sur les données collectées dans ALICE (A Large Ion Coliider Experiment) au LHC en 2015 correspondant à une luminosité intégrée de 225 μb−1. Le facteur de modification nucléaire RAA est étudié en fonction de la centralité des collisions, correspondant à la distance transverse entre les centre des noyaux de plomb. Le rapport des RAA du ψ(2S) et du J/ψ est également mesuré et montre que le ψ(2S) est plus supprimé que le J/ψ pour des collisions mi-centrales et centrales. Comparées aux prédictions théoriques, les mesures sont compatibles avec les modèles dans la limite des incertitudes. L’amélioration du Muon Trigger, le MID, est également étudié, en particulier le débit de données attendu pour des fréquences de collision de 100 kHz. Basée sur les données en collisions Pb − Pb à une énergie de TeV, les estimations prédisent que la technologie qui sera implémentée sur le MID possède une bande passante suffisante. / The nuclear matter, which constitues the atomic nuclei, is composed of quarks and gluons and interactions between them are described by quantum chromo-dynamics (QCD). Under ordinary conditions, quarks and gluons cannot be observed isolated and are confined inside hadrons such as protons and neutrons. The Quark-Gluon Plasma (QGP) is a state of nuclear matter predicted by QCD where quarks and gluons are deconfined. Experimentally, a QGP can be created in ultra-relativistic heavy ion collisions such as the lead-lead collisions delivered at the LHC, corresponding to speeds close to the speed of light. It is possible to obtain information on the characteris- tics of the QGP by measuring a large number of observables. In particular, the production of charmonium states such as the J/ψ and the ψ(2S), heavy particles composed of a charm and anti-charm pair (), is studied to investigate the plasma. Indeed, the presence of QGP is expected to modify the charmonium production yields, due to a balance between the mechanism of color screening of the charm quark potential and a mechanism called recombination. This balance depends on the collision energy, the temperature of the plasma and nature on the considered particle, in particular one expects the ψ(2S) to be more suppressed than the J/ψ. In this thesis the inclusive production of ψ(2S) in Pb − Pb collisions at an energy per nucleon-nucleon collision in the center of mass frame of TeV is measured in the dimuon-decay channel, using the ALICE Muon Spectrometer. The analysis is based on the data collected in ALICE (A Large Ion Collider Experiment) at the LHC in 2015 with an integrated luminosity of 225 μb−1. The nuclear modification factor RAA is studied as a function of centrality. The ratio of the ψ(2S) and J/ψ RAA is also evaluated and shows that the ψ(2S) is more suppressed than the J/ψ for mid-central and central events. Compared with theoretical predictions, the measurements are, within uncertainty, in agreement with theoretical model. The upgrade of the Muon Trigger, the MID (Muon Identifier), is also studied, in particular the expected data flow at a collisions rate of 100 kHz. Based on the Pb − Pb data at a collision energy of TeV, the estimations predict that the technology that will be implemented in the MID provides a sufficient bandwidth to sustain the data flow.

Efeitos de radiação em dispositivos eletrônicos são uma preocupação em diversas áreas, como em missões espaciais, aceleradores de partículas de alta energia, entre outras. Entre os efeitos de radiação induzidos por íons pesados estão os chamados de Efeitos de Eventos Isolados (Single Event Effects - SEE), nos quais o impacto de um único íon pode ser capaz de gerar um efeito observável. Estes efeitos nunca haviam sido estudados no Brasil e seu estudo requer um acelerador de partículas capaz de prover feixes de íons pesados com baixo fluxo. A caracterização de dispositivos é feita medindo-se o número de eventos induzidos por radiação em função da transferência de energia por unidade de comprimento (Linear Energy Transfer - LET) do íon na camada sensível do dispositivo. Neste trabalho desenvolvemos um sistema para produção de feixes pesados para estudar SEE no Acelerador Pelletron 8UD, utilizando espalhamento Rutherford. A montagem permite obter feixes iônicos com valores de LET na superfície de silício na faixa de 1 a 40 MeV/mg/2. O valor de LET na camada sensível do dispositivo depende da espessura de sua camada de passivação. Feixes pesados até 48 podem ser utilizados para irradiações com feixe externo, isto é, fora da câmara de vácuo, e até 107 em vácuo, com uniformidade em intensidade acima de 90%. A caracterização do MOSFET 3N163 foi a primeira medida bem-sucedida de SEE no Brasil, e foi possível correlacionar o LET dos íons com a amplitude do sinal gerado no dispositivo sob teste. A curva de seção de choque de SEE foi obtida, e para o dispositivo estudado os valores obtidos de seção de choque de saturação e LET de limiar foram de 2,94(10)105 2 e 2,35(36)MeV/mg/2 respectivamente. / Radiation effects on electronic devices are a main concern for many situations, such as space applications, high-energy particle accelerators, nuclear medicine, among others. A group of radiation effects induced by heavy-ions are called Single Event Effects, because a strike of a single ion can be enough to generate a damage on electronic devices. So far, SEE were not studied in Brazil due to the need of a high-energy, lowflux particle accelerator. Device characterization is done by measuring the number of events as a function of Linear Energy Transfer of the ion beam on the sensitive layer of the device under test (DUT). In this work we developed a Rutherford scattering setup for studying SEE at Sao Paulo 8UD Pelletron Accelerator. The setup can provide ion beams with Linear Energy Transfer values on the silicon surface ranging from 1 to 40 MeV/mg/2. The values on the active layer of the device depend upon the thickness of the dead-layer of the device. Ion beams up to 48 can be used for irradiation of devices outside the vacuum chamber and up to 107 inside the vacuum chamber, with a uniformity better than 90%. The characterization of the MOSFET 3N163 was the first successful measurement of heavy-ion induced SEE in Brazil, and it was possible to correlate ion LET with signal amplitude generated by the DUT. A complete SEE cross-section curve was obtained, and for the device studied the values of saturation cross-section and threshold LET are 2.94(10).105 2 and 2.35(36) MeV/mg/2,respectively

Cette thèse porte sur l’étude de la radio-sensibilité de Molécules AromatiquesHétérocycliques (MAH) à basse température exposées à une irradiation avec des ionslourds rapides. La présence de ces molécules dans les météorites carbonées sur Terre estune forte indication pour l’existence de cette catégorie de molécules dans l’espace.L’objectif de ce travail est de simuler l’effet des rayons cosmiques sur des MAH enphase solide et d’estimer leur résistance à l’irradiation. Les lignes de faisceaux deGANIL et de GSI permettent de simuler cet effet. L’évolution des MAH en phase solidea été monitorée par spectroscopie infrarouge à transformée de Fourier. Cela permet dequantifier la destruction des MAH, de déterminer leur section efficace de destruction etde détecter les molécules produites. Les sections efficaces de destruction de l’adénine etde la cytosine suivent une loi puissance en fonction du pouvoir d’arrêt électronique :σd~ Se1.2. Les nouvelles bandes d’absorption observées après l’irradiation des MAH sontprincipalement attribuées à des nitriles (R-C≡N), des isonitriles (R-N≡C) et (R-C≡C).L’évolution de la section efficace en fonction du pouvoir d’arrêt électronique a permisd’estimer la durée de vie de l’adénine dans l’espace : (14×106) années. Ces résultatspermettront de comprendre la stabilité et la chimie de ces molécules complexes dansl’espace. / The thesis concerns the study of the radio sensitivity of aromatic heterocyclic molecules(AHMs) at low temperature (12 K) exposed to swift heavy ion radiation. The presenceof aromatic heterocyclic molecules in carbonaceous meteorites on Earth is a strongindication that this class of molecules exists in outer space.The aim of this work was to study the effects of cosmic ray analogues on solid AHMsand to estimate their survival under radiation. The beam lines of GANIL and GSI allowto simulate the effects of cosmic rays in AHMs. The evolution of the solid AHMs underirradiation was monitored by Fourier transformed infrared absorption spectroscopy; thisallows to quantify the disappearance of AHMs, to determine their apparent destructioncross section and to detect their radioproducts. Furthermore, it was found that adenineand cytosine destruction cross sections (σd) follow a power law with the electronicenergy loss: σd~ Se1.2 .New IR absorption peaks arising from the AHMs degradationswere observed; these peaks can be attributed to nitriles (R-C≡N), isonitriles (R-N≡C),and (R-C≡C).The observed power law allowed the estimation of the lifetime of adeninein space exposed to galactic cosmic rays as (14×106) years. These findings may help tounderstand the stability and chemistry related to complex organic molecules in space.