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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 11 to 13 of 13 (0.026 seconds)Spelling suggestions: "subject:"hms"" "subject:"hmbc""
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Interaktionen von humanen mesenchymalen Stromazellen (hMSC) mit Plattenepithelkarzinomzellen des Oropharynx in indirekter Kokultur / Interactions of human mesenchymal stroma cells (hMSC) with oropharyngeal cancer cells in indirect co-cultureFricke, Martin Dr. 18 May 2011 (has links)
No description available.
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The influence of cell density and culture conditions within 3D hydrogel matrices on mesenchymal stem cells behaviorLourenço, Ana Filipa Henriques Ferreira January 2010 (has links)
Documento confidencial. Não pode ser disponibilizado para consulta / Tese de mestrado. Engenharia Biomédica. Universidade do Porto. Faculdade de Engenharia.. 2010
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Mineralizing Gelatin Microparticles as Cell Carrier and Drug Delivery System for siRNA for Bone Tissue EngineeringHinkelmann, Sandra, Springwald, Alexandra H., Schulze, Sabine, Hempel, Ute, Mitrach, Franziska, Wölk, Christian, Hacker, Michael C., Schulz-Siegmund, Michaela 02 June 2023 (has links)
The local release of complexed siRNA from biomaterials opens precisely targeted therapeutic options. In this study, complexed siRNA was loaded to gelatin microparticles cross-linked (cGM) with an anhydride-containing oligomer (oPNMA). We aggregated these siRNA-loaded cGM with human mesenchymal stem cells (hMSC) to microtissues and stimulated them with osteogenic supplements. An efficient knockdown of chordin, a BMP-2 antagonist, caused a remarkably increased alkaline phosphatase (ALP) activity in the microtissues. cGM, as a component of microtissues, mineralized in a differentiation medium within 8–9 days, both in the presence and in the absence of cells. In order to investigate the effects of our pre-differentiated and chordin-silenced microtissues on bone homeostasis, we simulated in vivo conditions in an unstimulated co-culture system of hMSC and human peripheral blood mononuclear cells (hPBMC). We found enhanced ALP activity and osteoprotegerin (OPG) secretion in the model system compared to control microtissues. Our results suggest osteoanabolic effects of pre-differentiated and chordin-silenced microtissues.
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