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The Global ETD Search service is a free service for researchers
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Showing 21 to 22 of 22 (0.077 seconds)Spelling suggestions: "subject:"home sapiens""
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O Homem espiritual: um estudo do sagrado - a metafísica do desejo e a formação do humanoRighi, Maurício Gonçalves 06 February 2015 (has links)
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Previous issue date: 2015-02-06 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / The great expansion of knowledge in Archaeology of Pre-History has challenged, in the past decades, well established theories about cultural formation. Recent archaeological discoveries are demanding new theoretical approaches for a better understanding of the archaic. Therefore, this work, in religious studies and in philosophy of history, integrates an overarching discussion on cultural and religious formation in archaic contexts.
In the light of recent discoveries, the so-called religious symbolisms have been placed in a prominent position. It has now become impossible to ignore the central role of the religious symbolisms in the making of the archaic institutions. A deep understanding of the religious mindset which generated the most significant mechanisms and structures of the pre-historic past is key to enlighten the generative processes of culture and hominization.
The theory of mimetic desire meets the new archaeological data in order to suggest more accurate formulations on the institutional developments which went through the pre-historical times, creating the structures and practices responsible for the emergence of urban life in highly developed civilizational environments. These processes highlight the sacred as a fundamental historical and anthropological matrix. Therefore, the movements and transformations of the sacred in the interior of the archaic institutions was a key factor for the creation of life modalities and institutions increasingly complex / O avanço da arqueologia e dos conhecimentos em pré-história nas últimas décadas colocou em xeque teorias e formulações que se propunham a elucidar a chamadas estruturas formadoras. Recentes descobertas arqueológicas passaram a exigir novos investimentos teóricos na formulação de modelos explicativos. Portanto, este é um estudo em ciência da religião e em filosofia da história inserido no debate sobre formação cultural e religiosa em contextos arcaicos.
No quadro das mais recentes investigações, as denominadas simbologias religiosas assumem uma posição de destaque. Não há mais como ignorar o papel central dos simbolismos e das dinâmicas religiosas na formação das instituições arcaicas. Um profundo entendimento sobre o psiquismo religioso que gerou, no seio de suas dinâmicas, os mecanismos e as estruturas mais significativos dos universos arcaicos é fundamental para uma precisa caracterização dos processos formadores da cultura e do próprio processo de hominização.
A teoria do desejo mimético vem ao encontro dos novos dados para formulações mais adequadas sobre os processos de desenvolvimento institucional que atravessaram a pré-história e criaram as estruturas responsáveis pelo aparecimento da vida urbana em contextos civilizacionais. Esses processos apontam para o sagrado como matriz histórica e antropológica. A atuação do sagrado no seio das instituições arcaicas foi, portanto, largamente responsável pela geração de modos de vida crescentemente complexos
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SCF cdc4 regulates msn2 and msn4 dependent gene expression to counteract hog1 induced lethalityVendrell Arasa, Alexandre 16 January 2009 (has links)
L'activació sostinguda de Hog1 porta a una inhibició del creixement cel·lular. En aquest treball, hem observat que el fenotip de letalitat causat per l'activació sostinguda de Hog1 és parcialment inhibida per la mutació del complexe SCFCDC4. La inhibició de la mort causada per l'activació sostinguda de Hog1 depèn de la via d'extensió de la vida. Quan Hog1 s'activa de manera sostinguda, la mutació al complexe SCFCDC4 fa que augmenti l'expressió gènica depenent de Msn2 i Msn4 que condueix a una sobreexpressió del gen PNC1 i a una hiperactivació de la deacetilassa Sir2. La hiperactivació de Sir2 és capaç d'inhibir la mort causada per l'activació sostinguda de Hog1. També hem observat que la mort cel·lular causada per l'activació sostinguda de Hog1 és deguda a una inducció d'apoptosi. L'apoptosi induïda per Hog1 és inhibida per la mutació al complexe SCFCDC4. Per tant, la via d'extensió de la vida és capaç de prevenir l'apoptosi a través d'un mecanisme desconegut. / Sustained Hog1 activation leads to an inhibition of cell growth. In this work, we have observed that the lethal phenotype caused by sustained Hog1 activation is prevented by SCFCDC4 mutants. The prevention of Hog1-induced cell death by SCFCDC4 mutation depends on the lifespan extension pathway. Upon sustained Hog1 activation, SCFCDC4 mutation increases Msn2 and Msn4 dependent gene expression that leads to a PNC1 overexpression and a Sir2 deacetylase hyperactivation. Then, hyperactivation of Sir2 is able to prevent cell death caused by sustained Hog1 activation. We have also observed that cell death upon sustained Hog1 activation is due to an induction of apoptosis. The apoptosis induced by Hog1 is decreased by SCFCDC4 mutation. Therefore, lifespan extension pathway is able to prevent apoptosis by an unknown mechanism.
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