Flexible manufacturing is something that most companies is aiming to accomplish due to the increased demand for variety and a competitive global market. This thesis report includes an introduction to the automation concept and the development towards flexible automation. A general flexible assembly cell is presented and its content and requirements are discussed. The work has been done with focus on an assembly process with dedicated fixtures at VCE (Volvo Construction Equipment). Based on the literature review and the general example, a list of actions to take while planning and implementing a process is developed. The actions roughly include: mapping of the process, defining goals, investigation of automation level, holistic view while planning, definition of the need for flexibility, investment plan, designing and comparing concepts, investigation of possible issues and implementation in small scale. The current manual process at VCE is presented and analysed. Three concepts are designed with product flexibility as an alternative to processes in which traditional dedicated fixtures are used. The designed concepts are a fully automated concept, a hybrid concept with separated workspace and a human-robot collaboration. Finally, the concepts are analysed and compared based on following parameters: productivity, product cost, investment, flexibility, space requirement and setup time. One final comparing summary of the concepts is done. The analysis shows that a fully automated concept is to prefer in this case. However, a human-robot collaboration could be appropriate to use if the process is expected to improve with the human workforce. Examples of when it could be reasonable to use human-robot collaboration despite this are: if the task provides better quality when conducted by human or if the task is complex to automate.

This paper describes recent progress in a continuing program to develop and apply RM³ (recess mounting with monolithic metallization) technologies for heterogeneous integration. Particular emphasis is placed on the applicability of RM³ integration to in-plane geometries for on-chip optical clock and signal distribution and on the suitability of commercially processed IC wafers for use as substrates for rectangular dielectric waveguides. / Singapore-MIT Alliance (SMA)

The genus Rhodotorula includes basidiomycetous oleaginous yeast species. Rhodotorula babjevae can produce compounds of biotechnological interest such as lipids, carotenoids, and biosurfactants from low value substrates such as lignocellulose hydrolysate. High-quality genome assemblies are needed to develop genetic tools and to understand fungal evolution and genetics. Here, we combined short- and long-read sequencing to resolve the genomes of two R. babjevae strains, CBS 7808 (type strain) and DBVPG 8058, at chromosomal level. Both genomes are 21 Mbp in size and have a GC content of 68.2%. Allele frequency analysis indicates that both strains are tetraploid. The genomes consist of a maximum of 21 chromosomes with a size of 0.4 to 2.4 Mbp. In both assemblies, the mitochondrial genome was recovered in a single contig, that shared 97% pairwise identity. Pairwise identity between most chromosomes ranges from 82 to 87%. We also found indications for strain-specific extrachromosomal endogenous DNA. A total of 7591 and 7481 protein-coding genes were annotated in CBS 7808 and DBVPG 8058, respectively. CBS 7808 accumulated a higher number of tandem duplications than DBVPG 8058. We identified large translocation events between putative chromosomes. Genome divergence values between the two strains indicate that they may belong to different species.