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Aromatic hydroxylation in plantsVaughan, P. F. T. January 1968 (has links)
No description available.
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The biotransformation of adamantane and its derivativesRidyard, C. H. January 1995 (has links)
No description available.
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Development of PCP pincer complexes as catalysts for organic transformations involving the activation of "unreactive" bondsWang, Zhaohui, 1972 January 2005 (has links)
Thesis (Ph. D.)--University of Hawaii at Manoa, 2005. / Includes bibliographical references (leaves 101-111). / Also available by subscription via World Wide Web / xii, 111 leaves, bound ill. 29 cm
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Development of PCP pincer complexes as catalysts for organic transformations involving the activation of "unreactive" bondsWang, Zhaohui, January 2005 (has links)
Thesis (Ph. D.)--University of Hawaii at Manoa, 2005. / Includes bibliographical references (leaves 101-111).
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Hydroxylation of picolinic acid by cell-free extracts of Arthrobacter picolinophilus, n. sp.Tate, Robert L., January 1970 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1970. / Typescript. Vita. Description based on print version record. Includes bibliographical references (leaves 98-106).
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Characterization of chain association in collagen types XII and XIII and other biochemical features of type XIII collagen using baculovirus-directed insect cell expressionSnellman, A. (Anne) 22 August 2000 (has links)
Abstract
Type XII minicollagen chain association was studied using
baculovirus-directed insect cell expression. Since insect cells
contain low endogenous prolyl 4-hydroxylase activity, the mechanism of
the effect of prolyl hydroxylation on trimer formation in this collagen
could be studied directly by adding recombinant baculoviruses directing
the synthesis of prolyl 4-hydroxylase. Prolyl 4-hydroxylase
was shown to be involved in the trimeric assembly process of type
XII collagen through its α subunit, and thus through its
hydroxylase activity.
The transmembrane protein type XIII collagen was also characterized
by means of insect cell expression, for which purpose new antibodies
against its non-collagenous domains NC2 and NC4 were generated,
together with a pan-collagen antibody against collagenous sequences.
Type XIII collagen α chains were found to form disulphide-bonded
homotrimers, and this was enhanced by prolyl 4-hydroxylation. Analysis
of the disulphide-bonding pattern of the eight cysteine residues
of the α1(XIII) chains revealed that some of the cysteines
in the NC1 domain, and possibly the cysteines at the junction of
the COL1 and NC2 domains, are interchain-linked, while the cysteines in
the NC4 domain are intrachain-linked. The three collagenous domains
of type XIII collagen were shown to be in triple-helical conformation
and have different thermal stabilities, i.e. 38±C for the COL1
domain, 49±C for COL2 and 40±C for COL3.
Furthermore, it was shown that type XIII collagen is oriented
in the plasma membrane of insect cells so that its non-collagenous
N-terminus is intracellular and its mostly collagenous C-terminus is
extracellular. Type XIII collagen was also found to be cleaved into
the insect cell culture medium by a furin-like protease.
The expression of various type XIII collagen deletion variants
suggested that chain recognition and the association of type XIII
collagen α chains into trimers occur in the N-terminal
portion of this molecule. An internal in-frame deletion of residues
63-83 immediately adjacent to the transmembrane domain indicated
that this short ectodomain sequence is necessary for the formation of
disulphide-bonded trimers. Since a sequence homologous with these
deleted residues was also found at the same plasmamembrane-adjacent
location in other collagenous transmembrane proteins, this points
to common features in their chain association.
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Non-heme iron(III) complexes catalyzed oxidation of saturated hydrocarbons and cis-dihydroxylation of alkenesChow, Wai-shan., 周慧珊. January 2010 (has links)
published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy
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A study of tyrosine hydroxylase activity in nonadrenergic neurones in the rat brainGraham-Jones, Susanna January 1981 (has links)
This abstract sent to supervisor 5/4/12 Tyrosine hydroxylase is the enzyme which controls the ratelimiting step in the synthesis of noradrenaline. In order to discover whether the activity of tyrosine hydroxylase might serve as an indicator of noradrenergic function in the brain, two preparations for the direct measurement of TH activity in rat brain regions by a tritium-release method were employed: synaptosomal suspensions prepared from pinchedoff nerve terminals, and partially solubilised enzyme preparations prepared from frozen homogenates or synaptosomal suspensions and assayed at saturating concentrations of cofactor and tyrosine. There was evidence of an increase in tyrosine hydroxylase activity in hippocampal synaptosomes of rats killed immediately after a mild electrical footshock. Activation of synaptosomal enzyme activity was also found after single doses of clonidine and parachloroamphetamine, and after repeated handling; and single doses of morphine and of yohimbine appeared to lower tyrosine hydroxylase activity. Repeated administration of drugs such as clonidine, desipramine and 2-deoxyglucose, however, did not affect tyrosine hydroxylation rate. A preliminary finding , suggesting differences in synaptosomal tyrosine hydroxylase activity related to experience with different reinforcement schedules (continuous reward vs. partial reward) in a runway experiment, was not substantiated in later experiments; nor was there any difference between the synaptosomal tyrosine hydroxylase activity of naive controls and rats given repeated daily shocks for a week. The saturated TH assay performed on solubilised enzyme was, as predicted, unresponsive to the short term stimulation effects detected with the synaptosomal assay. However, other changes, such as a reduced maximal hydroxylation rate after repeated desipramine administration, and an increased rate several weeks after a course of electrical stimulation of the septal area, were established with the saturated assay. Although the changes in stimulated rats were associated with increased behavioural tolerance to stress, e.g. resistance to extinction of a running response in a runway, other experiments in which the behavioural stress-tolerance was induced by behavioural methods alone showed no accompanying changes in TH activity. Measures of synaptosomal and saturated soluble TH activity appear to constitute independent indicators of noradrenergic function. It seems that synaptosomal tyrosine hydroxylase activity is not, as anticipated, controlled by the firing rate of locus coeruleus neurones; but it may be subject to local regulation in noradrenergic terminals. The results are discussed in the context of theoretical aspects of the regulation of noradrenaline synthesis in the brain, and the mechanisms underlying physiological responses to stress and behavioural tolerance to stress.
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Systemic oxidant stress and its effects on hepatotoxicity /Wright, Paul F. A. January 1988 (has links) (PDF)
Thesis (Ph. D.)--University of Adelaide, Dept. of Clinical and Experimental Pharmacology, 1989. / Includes bibliographical references (leaves 162-174).
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Activation de la liaison C-H : hydroxylation catalytique des hydrocarbures par de nouveaux complexes alkylperoxidiques du cobalt (III), déshydrogénation sélective et catalytique de cyclo-alcanes en présence d'éponges à hydrogène à base d'uranium métallique /Brazi, Eric, January 1900 (has links)
Th. univ.--Sci. pétrolières, spécialité Chimie--Paris VI et Ecole nationale supérieure du pétrole et des moteurs, 1987. / 1988 d'après la déclaration de dépôt légal. Bibliogr. p. 181-188.
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