Global ETD Search

1	Efeito do interferon-gama em células dendríticas de pacientes com defeitos no CD40L. / Effect of interferon-gamma on dendritic cells of patients with CD40L defects. Lambert, Christiane Guedes 13 April 2017 (has links) Mutações no gene CD40LG estão associadas à Síndrome de Hiper-IgM, relacionada ao cromossomo X, que é uma Imunodeficiência Primária. A ausência da interação CD40L/CD40 (linfócitos-DCs) acarreta um aumento da suscetibilidade às infecções fúngicas. Os efeitos do tratamento in vitro com interferon-gama em células dendríticas de pacientes com mutações no CD40L demonstraram potencial sobre a imunologia das DCs e nos remete a fundamentar possíveis ensaios clínicos futuros, que tenham por tema a prevenção e o tratamento de infecções oportunistas. / Mutations in the CD40LG gene are associated with the X-linked Hyper-IgM Syndrome, which is a Primary Immunodeficiency. The absence of the CD40L / CD40 interaction (lymphocytes-DCs) leads to increased susceptibility to fungal infections. The effects of in vitro gamma-interferon treatment on dendritic cells from patients with CD40L mutations have demonstrated potential for DC immunology and suggest that future clinical trials should address the prevention and treatment of opportunistic infections. C. albicans C. albicans CD40L CD40L Células dendríticas Dendritic cells Hyper IgM syndrome Interferon-gama Interferon-gamma Síndrome de hiper IgM
2	Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination / AIDのC末端変異体は特異的共役因子を枯渇させるため、クラススイッチ組換えにドミナントネガティブ効果を及ぼす Al, Ismail Azza Darwish 26 March 2018 (has links) 京都大学 / 0048 / 新制・課程博士 / 博士(医科学) / 甲第21030号 / 医科博第91号 / 新制\|\|医科\|\|6(附属図書館) / 京都大学大学院医学研究科医科学専攻 / (主査)教授生田宏一, 教授清水章, 教授竹内理 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM Heterogeneous nuclear ribonucleoproteins Hyper IgM syndrome CRISPR/Cas9 mutagenesis CH12F3-2A B cell AID-deficient spleen cells 491

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Efeito do interferon-gama em células dendríticas de pacientes com defeitos no CD40L. / Effect of interferon-gamma on dendritic cells of patients with CD40L defects.