Desenvolvemos estudo entre trabalhadores de uma destilaria do interior paulista com o objetivo de identificar o perfil de trabalhadores do sexo masculino quanto aos fatores de risco cardiovasculares. O referencial teórico foi o Modelo de “Campo de Saúde" que compõe os elementos de biologia humana, meio ambiente, estilo de vida e organização dos serviços de saúde. A população estudada constituiu-se de 123 trabalhadores, com idade entre 18 e 71 anos, que desenvolviam atividades no setor da indústria. Os dados foram obtidos através da entrevista individual feita pelo pesquisador na própria destilaria onde os mesmos atuavam. Ao término de cada entrevista procedeu-se a verificação da pressão arterial pelo método indireto, em seguida o exame antropométrico que constituiu-se da medida de peso e altura. Os níveis tensionais foram obtidos através de duas medidas com utilização do aparelho oscilométrico da marca Dixtal (modo automático) e manguitos de bolsa de borracha compatíveis com a circunferência braquial do indivíduo. Com relação a biologia humana, 10,6% dos trabalhadores apresentou obesidade grau I, 17,0% obesidade grau II; em 11,4% dos indivíduos identificamos valores de pressão arterial sistólica ³ 140 mmHg e em 12,2% com pressão arterial diastólica ³ 90 mmHg; quanto aos antecedentes familiares, 32,5% referiram história familiar positiva de doença hipertensiva, 26,0% de acidente vascular cerebral e 27,6 de diabetes melitus. Quanto ao meio ambiente, 60,2% possuíam o 1º grau incompleto, 49,6% eram casados e 97,6% tinham o único emprego. No tocante ao estilo de vida, 40,7% referiram realizar algum tipo de atividade física, 16,3% eram fumantes, 65,9% indicaram consumo de bebida alcoólica e 49,6% referiram ingerir alimentos preparados com muito sal. Em relação ao atendimento de saúde todos trabalhadores participantes no estudo possuíam convênio médico, além daquele oferecido pela própria empresa. Os dados revelam existência de hábitos autocriados que podem ser modificados e que se constituem em fatores de risco cardiovascular; realçamos a necessidade de promoção de ações educativas visando à prevenção dessas doenças. / This study was developed among workers of a distillery in the interior of São Paulo State aiming at identifying the profile of male workers with regard to risk factors of cardiovascular diseases. The theoretical framework was based on the “Health Field" Model, which composes the elements of human biology, environment, lifestyle and organization of health services. The studied population consisted of 123 workers aged 18 to 71 years who performed their activities in the factory. Data were obtained by means of individual interviews conducted by the researcher in the facilities of the distillery where the subjects worked. At the end of each interview, each individual’s arterial pressure was measured by means of the indirect method, which was followed by the assessment of their anthropometric measures, namely height and weight. Tension levels were obtained through two measurements with the use of an oscillometric device (automatic mode) manufactured by Dixtal and rubber-bag cuffs which were compatible with the individual’s brachial circumference. With regard to human biology, 10.6% of the workers presented level-1 obesity and 17% had level-2 obesity, 11.4% of the individuals, systolic arterial pressure values were found to be 140mmHG and in 12.2% diastolic arterial pressure values were found to be 90mmHG. Concerning their family history, 32,5% reported a family history with the presence of hypertensive disease consisting of cerebral vascular accidents (26.0%) and diabetes mellitus (27.6%). As to the environment, 60.2% had incomplete elementary school education, 49.6% were married and 97.6% had only one job. Concerning lifestyle, 40.7% reported the habit to perform some type of physical activity, 16.3% were smokers, 65.9% indicated the consumption of alcoholic beverages and 49.6% reported to ingest food prepared with a high amount of salt. As to healthcare, all the workers participating in the study had a medical insurance in addition to that provided by the company. Data showed the existence of self-created habits which consisted in risk factors of cardiovascular diseases. Since such habits can be modified, the need to promote educational action aiming at the prevention of such diseases is emphasized.

Orientador: Luis Cuadrado Martin / Resumo: Introdução: A Doença Renal Crônica é um importante problema de saúde em todo o mundo, com repercussões sistêmicas de evolução progressiva, ocasionada em grande parte dos casos pelos efeitos deletérios renais da hipertensão arterial. É possível destacar o declínio funcional, como o principal ponderador para elevação das taxas de morbidade e mortalidade. Que reporta a necessidade de métodos que visem prevenir, retardar ou minimizar os agravos renais e cardiovasculares. Objetivo: Analisar a associação da albuminúria com o nível de atividades físicas e capacidade funcional em indivíduos portadores de hipertensão arterial. Materiais e métodos: Foi realizado um estudo transversal, com casuística composta por pacientes hipertensos, de todas as unidades de saúde de Itaí, com idade mínima de 18 anos, com algum grau de albuminúria, avaliados através do uso de fita reagente e quantificada pelo exame de urina 24 horas, o nível de atividades físicas foi avaliado com uso do questionário internacional de atividades física IPAQ, a capacidade funcional foi avaliada através da execução do teste de caminhada de seis minutos (TC6), o índice de dispneia pela escala modificada de Borg e a rigidez arterial foi aferida através da velocidade de onda de pulso (VOP). Para análise dos dados os indivíduos foram divididos em três grupos em conformidade ao grau de albuminúria, sendo <10mg/24h, 10mg/24h a <30mg/24h e 30mg/24h ou valores superior. As variáveis categóricas foram expressas por números absoluto... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Introduction: Chronic Kidney Disease is a major health problem worldwide, with systemic and progressive repercussions, due in large part to the deleterious effects of hypertension. Among its repercussions it is possible to highlight the functional decline, as the main weight for raising morbidity and mortality rates. That reports the need for methods that aim to prevent, delay or minimize renal and cardiovascular diseases. Objective: To analyze the association of albuminuria with the level of physical activity and functional capacity in individuals with arterial hypertension. Materials and methods: A cross-sectional study was carried out with a sample of hypertensive patients from all health units of Itaí, with a minimum age of 18 years, with some degree of albuminuria, evaluated using reagent tape and quantified by the examination Of 24-hour urine, the level of physical activity was assessed using the IPAQ international physical activity questionnaire, functional capacity was assessed by performing the six-minute walk test (MWT), dyspnea index using the modified Borg scale And arterial stiffness was measured by pulse wave velocity (PWV). For data analysis, subjects were divided into three groups according to albuminuria, being <10mg / 24h, 10mg / 24h at <30mg / 24h and 30mg / 24h or higher values. Categorical variables were expressed by absolute numbers and percentage and compared by the chi-square test. The continuous and parametric distribution variables were compared by t... (Complete abstract click electronic access below) / Mestre

This thesis presents four studies investigating the phenomenon of post exercise hypotension in the human condition of pre (borderline)-hypertension. Study one investigated the effects of an acute bout of 30-minutes upright cycling on post exercise haemodynamics and compared the results to a non-exercise control condition. 9 pre-hypertensive males, mean arterial pressure (MAP) = 106 ± 5 mmHg (50 ± 10 yr), not on medication, were studied for 6 hours following 30-minutes of cycle exercise at 70% maximal oxygen consumption and following 30-minutes of seated rest. Results demonstrate that moderate intensity exercise exerts a modest fall (~6 mmHg) in arterial pressure with the hypotension sustained for 6-hours post exercise. The fall in arterial pressure equates to a significantly reduced after load when compared to both pre-exercise baseline and non-exercise control data taken at the same time of day. The arterial pressure responses transcended into a sustained reduction (20%) in systemic vascular resistance and reciprocal increase in vascular conductance for up to 2-hours post-exercise. Venous atrial natriuretic peptide (ANP) demonstrated an elevation (44%) following exercise and a significant decline (33%) in the post-exercise period mirroring the haemodynamic response. This research reveals that acute exercise is capable of sustained reductions in arterial pressure and vascular resistance beyond the usual labile fluctuations and that the octapeptide ANP may exert a modulatory influence over the post-exercise response. Increases in 02 tension beyond the physiological range induces complex effects on the circulatory system with a dominant vasoconstriction following hyperoxia. The purpose of study 2 was to assess the effects of hypoxic (16% 02) and hyperoxic (50% 62) exercise on subsequent haemodynamic control when compared with normoxia. 9 pre-hypertensive males, MAP = 106 ± 5 mmHg (50 ±10 yr), not on medication, performed 30-minutes of cycle exercise at 70% normoxic maximal oxygen consumption in hypoxia (16% O 2 ), hyperoxia (50% O 2) and normoxia(21% O2 ). Hyperoxic exercise blunted post-exercise haemodynamics by significantly attenuating the reductions (from normoxic baseline) in SVR (-45%, PO.05 vs. normoxic & hypoxic exercise immediately post-exercise) that persisted throughout 120-minutes recovery in normoxia (-35% vs. normoxic & hypoxic exercise, during recovery) and elicited a mildly hypertensive effect, with regards to MAP, whereas normoxic and hypoxic exercise elicited a hypotension compared to baseline (P < 0.05). Circulating ANP was decreased in the hyperoxic trial when compared with normoxic and hypoxic exercise [24.3 (13.4) v. 31.5 (16.3) and 29.6 (13.9) pg/ml, respectively; P < 0.05, pooled for state]. Changes in MAP were related to changes in ANP concentration only following hyperoxic exercise (r = 0.50, P < 0.01). These findings indicate that acute modest hyperoxia reflexively induces measurable physiological derangement partly explained by decreased circulating concentrations of ANP. Study three determined the role of free-radical mediated oxidative stress and redox regulation of circulating NO metabolism as a primary modulator of vascular tone following exercise in pre-hypertensive humans. Utilising the same cohort and exercise protocol as in study 1 venous blood was sampled from an antecubital vein. Plasma NO metabolites nitrate (NO" 3 ) and nitrite (NO"2 ) were determined fluorometrically, whilst S-Nitrosothiol (RSNO) concentrations were assayed by the Saville reaction Indirect markers of oxidative stress were determined spectrophotometrically detecting lipid hydroperoxides (LOOH). Exercise led to a delayed increase in LOOH by 60- minutes post-exercise (0.69 ± 0.13 v. 0.86 ± 0.18 umol/1, respectively, P < 0.05), that remained elevated until termination of the trial 6-hours post-exercise. NO'a significantly fell below baseline by 120-minutes post-exercise (10.8 ± 3.3 v. 1.1 ±1.1 u.mol/1, respectively, P < 0.05), remaining attenuated for the remainder of the study.NO'i and RSNO were unmodified in the post-exercise period. In parallel to this finding the data also indicates a significant blunting in the hyperaemic response [SVR decreased from a 31% reduction immediately (within 1-minute) post-exercise to -13 and 8% at 60- and 120-minutes post-exercise, respectively, P < 0.05] and reversal of the hypotension (P < 0.05) over the same time frame as the augmented lipid peroxidation and attenuated circulating NO~3. These results indicate that augmented oxidative stress exerts a deleterious effect on post-exercise haemodynamics and implicates a potential redox regulation pathway of NO as being a mechanism by which free radical-induced oxidative stress blunts the degree of PEH in the recovery period. The final study investigated the potential role of a redox-mediated regulation of circulating NO bioavailability as a modulator of the augmented vasoconstriction following hyperoxic exercise. The same cohort and exercise protocol were employed as in study 2 and venous blood was assayed for NO"3 , NO'a, RSNO, LOOK, & lipid /water-soluble antioxidant concentrations. Similar adverse haemodynamic effects were noted following hyperoxic exercise as reported previously in study 2. RSNO showed a significant increase following hypoxic exercise only (P < Q.Q5, state x time, interaction), whereas NO~3, NO~2 and LOOH failed to differ between conditions (P > 0.05, main effect for state [02] and state x time, interaction effects). Ascorbic acid was mobilised in response to hyperoxic exercise when compared to normoxia (P < 0.05, main effect for state [O2] and state x time, interaction effects) being significantly elevated by 120-minutes post-exercise in hyperoxia compared to normoxia and hypoxia [75.1 (31) v. 39.5 (18.3) v. 46.7 (14.2) |amol/l, respectively, P < 0.05]. This data demonstrates an effective endogenous antioxidant response and argues against a redox regulation pathway of NO metabolism as a primary mediator of blunted vasodilatation in this scenario. This elucidates a more complex regulation of arterial tone, resulting from a metabolic pathway independent of NO in older subjects with pre-hypertension. This work demonstrates that (1) aerobic exercise exerts a hypotensive effect in humans with pre-hypertension, (2) ANP plays a part in the vasodilatation following exercise, (3) Free-radical mediated oxidative stress & subsequent modulation of NO metabolism exerts a deleterious influence on post-exercise haemodynamics (4) Acute hyperoxic exercise induces a sustained vasoconstriction that is mediated via circulating ANP concentration but not by redox regulation of NO metabolism.

Desenvolvemos estudo entre trabalhadores de uma destilaria do interior paulista com o objetivo de identificar o perfil de trabalhadores do sexo masculino quanto aos fatores de risco cardiovasculares. O referencial teórico foi o Modelo de “Campo de Saúde” que compõe os elementos de biologia humana, meio ambiente, estilo de vida e organização dos serviços de saúde. A população estudada constituiu-se de 123 trabalhadores, com idade entre 18 e 71 anos, que desenvolviam atividades no setor da indústria. Os dados foram obtidos através da entrevista individual feita pelo pesquisador na própria destilaria onde os mesmos atuavam. Ao término de cada entrevista procedeu-se a verificação da pressão arterial pelo método indireto, em seguida o exame antropométrico que constituiu-se da medida de peso e altura. Os níveis tensionais foram obtidos através de duas medidas com utilização do aparelho oscilométrico da marca Dixtal (modo automático) e manguitos de bolsa de borracha compatíveis com a circunferência braquial do indivíduo. Com relação a biologia humana, 10,6% dos trabalhadores apresentou obesidade grau I, 17,0% obesidade grau II; em 11,4% dos indivíduos identificamos valores de pressão arterial sistólica ³ 140 mmHg e em 12,2% com pressão arterial diastólica ³ 90 mmHg; quanto aos antecedentes familiares, 32,5% referiram história familiar positiva de doença hipertensiva, 26,0% de acidente vascular cerebral e 27,6 de diabetes melitus. Quanto ao meio ambiente, 60,2% possuíam o 1º grau incompleto, 49,6% eram casados e 97,6% tinham o único emprego. No tocante ao estilo de vida, 40,7% referiram realizar algum tipo de atividade física, 16,3% eram fumantes, 65,9% indicaram consumo de bebida alcoólica e 49,6% referiram ingerir alimentos preparados com muito sal. Em relação ao atendimento de saúde todos trabalhadores participantes no estudo possuíam convênio médico, além daquele oferecido pela própria empresa. Os dados revelam existência de hábitos autocriados que podem ser modificados e que se constituem em fatores de risco cardiovascular; realçamos a necessidade de promoção de ações educativas visando à prevenção dessas doenças. / This study was developed among workers of a distillery in the interior of São Paulo State aiming at identifying the profile of male workers with regard to risk factors of cardiovascular diseases. The theoretical framework was based on the “Health Field” Model, which composes the elements of human biology, environment, lifestyle and organization of health services. The studied population consisted of 123 workers aged 18 to 71 years who performed their activities in the factory. Data were obtained by means of individual interviews conducted by the researcher in the facilities of the distillery where the subjects worked. At the end of each interview, each individual’s arterial pressure was measured by means of the indirect method, which was followed by the assessment of their anthropometric measures, namely height and weight. Tension levels were obtained through two measurements with the use of an oscillometric device (automatic mode) manufactured by Dixtal and rubber-bag cuffs which were compatible with the individual’s brachial circumference. With regard to human biology, 10.6% of the workers presented level-1 obesity and 17% had level-2 obesity, 11.4% of the individuals, systolic arterial pressure values were found to be 140mmHG and in 12.2% diastolic arterial pressure values were found to be 90mmHG. Concerning their family history, 32,5% reported a family history with the presence of hypertensive disease consisting of cerebral vascular accidents (26.0%) and diabetes mellitus (27.6%). As to the environment, 60.2% had incomplete elementary school education, 49.6% were married and 97.6% had only one job. Concerning lifestyle, 40.7% reported the habit to perform some type of physical activity, 16.3% were smokers, 65.9% indicated the consumption of alcoholic beverages and 49.6% reported to ingest food prepared with a high amount of salt. As to healthcare, all the workers participating in the study had a medical insurance in addition to that provided by the company. Data showed the existence of self-created habits which consisted in risk factors of cardiovascular diseases. Since such habits can be modified, the need to promote educational action aiming at the prevention of such diseases is emphasized.

Submitted by TANI ROBERTO NERES MEIRA null (tani.meira@yahoo.com.br) on 2018-04-09T21:29:57Z No. of bitstreams: 1 MESTRADO PÓS DEFESA.pdf: 803994 bytes, checksum: 5f2313980e254d737ac2088a7c4749dd (MD5) / Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2018-04-10T12:44:29Z (GMT) No. of bitstreams: 1 meira_trn_me_bot.pdf: 803994 bytes, checksum: 5f2313980e254d737ac2088a7c4749dd (MD5) / Made available in DSpace on 2018-04-10T12:44:29Z (GMT). No. of bitstreams: 1 meira_trn_me_bot.pdf: 803994 bytes, checksum: 5f2313980e254d737ac2088a7c4749dd (MD5) Previous issue date: 2018-02-22 / Introdução: A Doença Renal Crônica é um importante problema de saúde em todo o mundo, com repercussões sistêmicas de evolução progressiva, ocasionada em grande parte dos casos pelos efeitos deletérios renais da hipertensão arterial. É possível destacar o declínio funcional, como o principal ponderador para elevação das taxas de morbidade e mortalidade. Que reporta a necessidade de métodos que visem prevenir, retardar ou minimizar os agravos renais e cardiovasculares. Objetivo: Analisar a associação da albuminúria com o nível de atividades físicas e capacidade funcional em indivíduos portadores de hipertensão arterial. Materiais e métodos: Foi realizado um estudo transversal, com casuística composta por pacientes hipertensos, de todas as unidades de saúde de Itaí, com idade mínima de 18 anos, com algum grau de albuminúria, avaliados através do uso de fita reagente e quantificada pelo exame de urina 24 horas, o nível de atividades físicas foi avaliado com uso do questionário internacional de atividades física IPAQ, a capacidade funcional foi avaliada através da execução do teste de caminhada de seis minutos (TC6), o índice de dispneia pela escala modificada de Borg e a rigidez arterial foi aferida através da velocidade de onda de pulso (VOP). Para análise dos dados os indivíduos foram divididos em três grupos em conformidade ao grau de albuminúria, sendo <10mg/24h, 10mg/24h a <30mg/24h e 30mg/24h ou valores superior. As variáveis categóricas foram expressas por números absolutos e porcentagem e comparadas pelo teste do qui-quadrado. As variáveis contínuas e de distribuição paramétrica foram comparadas pela análise de variância de uma via e expressos em média e desvio padrão. As variáveis contínuas e de distribuição não paramétrica foram comparadas pela análise de variância para dados não paramétricos e expressos em mediana e intervalo interquartílico. A significância estatística foi definida ao nível de 0,05. Resultados: Foram analisados 231 pacientes hipertensos, destes 53 apresentavam proteinúria ao exame de urina tipo 1 e 44 concluíram as avaliações propostas. Não foram encontrados valores significantes na associação entre a albuminúria e nível de atividade física, capacidade funcional no TC6 e suas variáveis hemodinâmicas, aos valores antropométricos, ao índice de rigidez arterial, a pressão arterial central, classes de anti-hipertensivos, exames laboratoriais taxa de filtração glomerular. Houve associação entre albuminúria e maior nível da pressão arterial periférica sistólica com valor de p=0,02, bem como índice de dispneia na escala de esforço nos momentos de repouso e posterior ao esforço da execução do TC6 com valores de p=0,02 e p<0,01 respectivamente. Conclusão: Não houve associação do grau de albuminúria com nível de atividade física ou capacidade funcional de pacientes hipertensos. Com isto, é possível crer na hipótese que a execução de atividades físicas não esteja associada ao aumento da albuminúria, assim, a inserção de atividades físicas pode ser um método seguro quanto à albuminúria no manejo da DRC, sendo necessário um estudo prospectivo de intervenção para melhor análise desta informação / Introduction: Chronic Kidney Disease is a major health problem worldwide, with systemic and progressive repercussions, due in large part to the deleterious effects of hypertension. Among its repercussions it is possible to highlight the functional decline, as the main weight for raising morbidity and mortality rates. That reports the need for methods that aim to prevent, delay or minimize renal and cardiovascular diseases. Objective: To analyze the association of albuminuria with the level of physical activity and functional capacity in individuals with arterial hypertension. Materials and methods: A cross-sectional study was carried out with a sample of hypertensive patients from all health units of Itaí, with a minimum age of 18 years, with some degree of albuminuria, evaluated using reagent tape and quantified by the examination Of 24-hour urine, the level of physical activity was assessed using the IPAQ international physical activity questionnaire, functional capacity was assessed by performing the six-minute walk test (MWT), dyspnea index using the modified Borg scale And arterial stiffness was measured by pulse wave velocity (PWV). For data analysis, subjects were divided into three groups according to albuminuria, being <10mg / 24h, 10mg / 24h at <30mg / 24h and 30mg / 24h or higher values. Categorical variables were expressed by absolute numbers and percentage and compared by the chi-square test. The continuous and parametric distribution variables were compared by the analysis of one-way variance for repeated data and expressed in mean and standard deviation. The continuous and non-parametric variables were compared by analysis of variance for non-parametric data and expressed in median and interquartile range. Statistical significance was set at the 0.05 level. Results: A total of 231 hypertensive patients were analyzed, 53 of them had some degree of proteinuria and 44 completed the proposed evaluations. No significant values were found in the association between albuminuria in relation to physical activity level, functional capacity at MWT and its hemodynamic variables, anthropometric values, arterial stiffness index, central arterial pressure, antihypertensive class, laboratory tests And for glomerular filtration rate. Except for the association between albuminuria with a higher systolic peripheral blood pressure level of p = 0,02 and for the dyspnea index in the exertion scale at the moments before and after the MWT with values of p = 0,02 and p <0,01 respectively. Conclusion: There was no association between the degree of albuminuria in hypertensive patients, in response to the level of physical activity and functional capacity of the individuals. Thus, it is possible to believe that physical activity is not associated with increased albuminuria, so possibly physical activity insertion may be an effective method for the management of CKD, and a prospective intervention study is necessary to better analyze this information.

<p>Uvod. Kardiovaskularne bolesti kao deo grupe hroničnih nezaraznih bolesti predstavljale su i predstavljaju vodeći uzrok obolevanja i umiranja u svetu. Brojni naučni dokazi potvrđuju da je arterijska hipertenzija glavni kardiovaskularni faktor rizika, a da postignute vrednosti krvnog pritiska niže od 140/90mmHg značajno smanjuju kardiovaskularni rizik, odnosno pojavu kardiovaskularnih događaja, prvenstveno infarkta miokarda i moždanog udara. Arterijska hipertenzija je najzastupljenije stanje koje se viđa u ustanovama primarne zdravstvene za&scaron;tite, a mere prevencije, rano dijagnostikovanje, lečenje i kontrola arterijske hipertenzije predstavljaju javno-zdravstveni izazov u svim zemljama sveta. Ciljevi. Ciljevi istraživanja su utvrđivanje prevalencije arterijske hipertenzije koja je pod kontrolom; utvrđivanje prevalencije i povezanosti metaboličkih faktora sa ishodom u kontroli krvnog pritiska; utvrđivanje prevalencije i povezanosti nezdravih stilova života sa ishodom u kontroli krvnog pritiska; utvrđivanje prediktora lo&scaron;e kontrole krvnog pritiska i izračunavanje 10-godi&scaron;enjeg kardivaskularnog rizika. Metode. U studiju preseka (prevalencije) uključeno je 373 ispitanika oba pola starosti od 45 do 75 godina sa dijagnozom arterijske hipertenzije u kartonu koji su u periodu od oktobra 2015. godine do februara 2016. godine dolazili kod svog izabranog lekara. Prikupljanje podataka obavljeno je merenjem krvnog pritiska, antropometrijskim merenjima, biohemijskim analizama i anketiranjem popunjavanjem upitnika. Rezultati. Uzorak ispitanika je činilo 55% žena i 45% mu&scaron;karaca prosečne starosti 59&plusmn;6,3 godine. Utvrđena je niska učestalost arterijske hipertenzije pod kontrolom od 39,1%, a visoka učestalost metaboličkih faktora (44,5% predgojaznosti, 34% gojaznosti, 29% &scaron;ećerne bolesti, 88,2% povi&scaron;enih masnoća i 41,8% metaboličkog sindroma) kao i njihova povezanost sa ishodom u kontroli krvnog pritiska jer su ispitanici sa nekontrolisanim krvnim pritiskom najče&scaron;će imali dva faktora rizika (40,5%), dok su ispitanici sa kontrolisanim krvnim pritiskom najče&scaron;će imali jedan faktor rizika (45,9%). Utvrđeno je da su prosečne vrednosti sistolnog, dijastolnog pritiska i pulsa bile značajno (p&lt;0,001) niže u grupi sa kontrolisanim pritiskom kao i da su ispitanici sa nekontrolisanim pritiskom imali značajno veći obim struka (p=0,006), metabolički sindrom (p&lt;0,001) i značajno če&scaron;će pili veći broj lekova (p&lt;0,001). Utvrđena je visoka učestalost pu&scaron;enja (26,3%) i visoka učestalost sedentarnog načina života (76,7%) kao i da znanja, stavovi i pona&scaron;anja ispitanika u vezi faktora rizika (pu&scaron;enja, konzumiranja alkohola, fizičke neaktvnosti i prekomerne upotrebe soli) nisu na zadovoljavajućem nivou. Kao nezavisni prediktori arterijske hipertenzije koja nije pod kontrolom dobijeni su obim struka, telesna masa, indeks telesne mase, starost, vrednost pulsa, broj lekova koje ispitanici piju, pasivno pu&scaron;enje, nesvesnost o postojanju arterijske hipertenzije, neznanje o &scaron;tetnosti konzumiranja prekomerne količine alkohola, nepreležan infarkt miokarda i moždani udar. Izračunato je da je u visokom i veoma visokom riziku od neželjenih kardiovaskularnih događaja u desetogodi&scaron;njem periodu 2,7% ispitanika sa arterijskom hipertenzijom bez dijabetesa i 22,2% hipertenzivnih ispitanika sa dijabetesom. Zaključak. Potrebno je sprovođenje javno-zdravstveno vaspitnih i promotivnih aktivnosti u cilju povećanja znanja, promene stavova i pona&scaron;anja kod populacije sa arterijskom hipertenzijom usled lo&scaron;e kontrole krvnog pritiska i prisustva visoke učestalosti pridruženih faktora rizika koji utiču na njegovu kontrolu.</p> / <p>Introduction. Cardiovascular diseases, as part of a group of chronic noncommunicable diseases, have been and still are the leading cause of morbidity and mortality in the world. Numerous scientific proofs confirm that arterial hypertension is a major cardiovascular risk factor and that the achieved blood pressure values lower than 140/90mmHg significantly reduce cardio-vascular risk, or the appearance of cardio-vascular events, mainly myocardial infarction and stroke. Arterial hypertension is the most common condition that is seen in primary health care institutions and preventive measures, early diagnosis, treatment and control of arterial hypertension are a public health challenge in all countries of the world. Objectives. The objectives of the research were to determine the prevalence of arterial hypertension which is controlled; to determine the prevalence and correlation of the metabolic factors with the outcome in blood pressure control; to determine the prevalence and correlation of unhealthy lifestyles with the outcome in blood pressure control; to determine the predictors of poor blood pressure control and calculate a 10-year cardiovascular risk. Methods. The cross-sectional study (of prevalence) included 373 respondents of both sexes aged 45 to 75 years diagnosed with arterial hypertension who in the period from October 2015 to February 2016 visited their chosen doctor. Data collection was performed by measuring blood pressure, anthropometric measurements, biochemical analyses and surveying by filling out a questionnaire. Results. The sample consisted of 55% women and 45% men, of mean age of 59&plusmn;6.3 years. The results showed low incidence of arterial hypertension under control of 39.1%, and high incidence of metabolic factors (44.5% of overweight, 34% of obesity, 29% of diabetes mellitus, 88.2% of elevated fat and 41.8% of the metabolic syndrome) as well as their association with the outcome in blood pressure control as the respondents with uncontrolled blood pressure usually had two risk factors (40.5%), while the group with controlled blood pressure usually had one risk factor (45.9%). It was found that the average values of systolic, diastolic blood pressure and heart rate were significantly (p&lt;0.001) lower in the group with controlled blood pressure, as well as that the respondents with uncontrolled pressure had a significantly greater waist circumference (p=0.006), the metabolic syndrome (p&lt;0.001) and more often drunk greater number of medicines (p&lt;0.001). There was a high prevalence of smoking (26.3%) and a high incidence of sedentary lifestyle (76.7%) and it was found that knowledge, attitudes, and behaviors of the respondents related to risk factors (smoking, alcohol consumption, physical inactivity and excessive use of salt) were not satisfactory. As independent predictors of arterial hypertension which was not under the control, the study obtained waist circumference, body weight, body mass index, age, heart rate value, the number of medicines that the respondents drunk, second-hand smoking, unawareness of the existence of arterial hypertension, inexperience on the harmful effects of excessive amounts of alcohol, not overcome myocardial infarction and stroke. It was calculated that 22.2% of hypertensive respondents with diabetes and 2.7% of respondents with arterial hypertension without diabetes were in the high and very high risk of adverse&nbsp; Conclusion. It is necessary to implement public-health educational and promotional activities in order to increase the knowledge, changes in the attitudes and behavior of the population with arterial hypertension due to the poor control of blood pressure and the presence of the high incidence of associated risk factors affecting its control.</p>