NDLTD Global ETD Search
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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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1

Design, synthesis and study of myeloperoxidase inhibitors in the series of 3-alkylindole

Soubhye, Jalal 09 October 2013 (has links)
The deleterious effects of MPO make it a new target for medicinal research. The aim of our study is to find promising inhibitors of MPO for using them as starting point of new anti-inflammatory drugs. Depending on previous researches on MPO inhibitors, we selected 5-fluorotryptamine as starting compounds. Using docking experiments, we designed a series of compounds derived from 5-fluorotryptamine. Two modifications were proposed: <p>& / Doctorat en Sciences biomédicales et pharmaceutiques / info:eu-repo/semantics/nonPublished
Sciences pharmaceutiques
Serotonin
Chemical inhibitors
Low density lipoproteins
Anti-inflammatory agents
Serotonin
Inhibiteurs
Lipoprotéines de basse densité
Antiinflammatoires
3-alkylindole
docking
medicinal chemistry
LDL
atherosclerosis
MPO
Myeloperoxidase
serotonine
HDL
inflemmation
anti inflammatory drugs
depression

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