Global ETD Search

281	Host B cells produce IL-10 following TBI and attenuate acute GVHD after allogeneic bone marrow transplantation Rowe, Vanessa Robyn January 2008 (has links) Host antigen presenting cells (APC) are known to be critical for the induction of graft versus host disease (GVHD) after allogeneic bone marrow transplantation (BMT) but the relative contribution of specific APC subsets remains unclear. We have studied the role of host B cells in GVHD by using B cell deficient (ìMT) mice as bone marrow transplant recipients in a model of CD4 T cell-dependent GVHD to major histocompatibility antigens. We demonstrated that acute GVHD is initially augmented in ìMT recipients relative to wild-type (WT) recipients (mortality: 85% v 44%, P<0.01) and that this was the result of an increase in donor T cell proliferation, expansion and inflammatory cytokine production early after BMT. Recipient B cells were depleted 28-fold at the time of BMT by total body irradiation (TBI) administered 24 hours earlier and we demonstrated that TBI rapidly induced sustained IL-10 generation from B cells but not dendritic cells (DC) or other cellular populations within the spleen. Finally, recipient mice in which B cells were unable to produce IL-10 due to homologous gene deletion developed more severe acute GVHD than recipient mice in which B cells are WT. Thus the induction of interlukin-10 (IL-10) in host B cells during TBI attenuates experimental acute GVHD.
282	Pathophysiological role and clinical relevance of cytokines in hypertensive heart failure : a combined clinical and experimental study / Haugen, Espen, January 2007 (has links) Diss. (sammanfattning) Göteborg : Göteborgs universitet, 2007. / Härtill 4 uppsatser.
283	Molecular mechanisms governing contraction-induced metabolic responses and skeletal muscle reprogramming / Glund, Stephan, January 2007 (has links) Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007. / Härtill 5 uppsatser.
284	Cytokines in metabolic functions / Benrick, Anna, January 2008 (has links) Diss. (sammanfattning) Göteborg : Göteborgs universitet, 2008. / Härtill 4 uppsatser.
285	Osteotropic cytokines : expression in human gingival fibroblasts and effects on bone / Palmqvist, Py, January 2006 (has links) Diss. (sammanfattning) Umeå : Umeå universitet, 2007. / Härtill 4 uppsatser.
286	T-cell competition as a mechanism for immunodominance and the role for IL-12 in CTL responses / Grufman, Per, January 2002 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2002. / Härtill 5 uppsatser.
287	Disease activity in rheumatoid arthritis : studies on interleukin-6, tumour necrosis factor alpha, monocyte activity, acute phase markers, glucocorticoids, and disability / Arvidson, Nils Gunnar, January 2003 (has links) Diss. (sammanfattning) Uppsala : Univ., 2003. / Härtill 6 uppsatser.
288	Regulation of interleukin-1[Beta] and tumor necrosis factor[alpha] synthesis by fatty acids and eicosanoids / Caughey, Gillian Elizabeth. January 1998 (has links) (PDF) Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1998? / Bibliography: leaves 267-345.
289	Characterization of hippocampal slice cultures as model systems for neurodegenerative processes in Alzheimer's disease / Johansson, Sara, January 2005 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2005. / Härtill 4 uppsatser.
290	Structural analysis of the Ser/Thr kinase IRAK4 and a phosphorylation mimic of eIF4E Sun, Yue, January 1900 (has links) Thesis (M.Sc.). / Written for the Dept. of Biochemistry. Title from title page of PDF (viewed 2008/05/29). Includes bibliographical references.

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