The purpose of the study is to investigate the relationship between two phenomena which are much-disputed and whose mechanisms and processes are interlaced with each other: trade and human development. The focus is a specific type of South-South trade; interregional trade in Sub-Saharan Africa, as well as international trade to and from Sub-Saharan Africa.A quantitate method, using a deductive approach, was utilized in this study. The quantitative research data was accessed from the World Bank database and the human development reports of the UNDP. The data was processed in regressions and the level of co-variation (a term used in this paper as the statistical relation between data) between the variables is established and shown through the unit of measurement r².The results tend to indicate that the level of statistical co-variation between interregional trade and international trade in various commodities and human development in Sub-Saharan Africa exist but are varied. Interregional trade does not seem to have a stronger co-variation with human development than general international trade despite the structural viewpoint of the academic field. Interestingly, the commodity traded with does have a varied impact on the level of co-variation with human development.