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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
41

Vascularization of the intervertebral disc in pathological conditions / Robert James Moore.

Moore, R. J. January 1995 (has links)
Bibliography: leaves 148-160. / xix, 160, [40] leaves, [19] leaves of plates : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Investigates the process of neovascularization of intervertebral disc components, with ageing and in disease. Establishes the extent of end plate vascularization in the lumbar discs of young normal sheep, and demonstrates that some components of the disc undergo neovascularization in response to physical trauma, possibly as a part of tissue repair response. / Thesis (Ph.D.)--University of Adelaide, Dept. of Pathology, 1996?
42

Proteomic analysis of human cerebrospinal fluid from patients with painful and non-painful degenerative disc disease

Lim, Tony K. Y., January 1900 (has links)
Thesis (M.Sc.). / Written for the Dept. of Pharmacology and Therapeutics. Title from title page of PDF (viewed 2009/06/29). Includes bibliographical references.
43

Intervertebral disc regeneration using mesenchymal stem cells: a mouse model study

楊帆, Yang, Fan January 2007 (has links)
published_or_final_version / abstract / Orthopaedics and Traumatology / Doctoral / Doctor of Philosophy
44

In vivo study of asporin polymorphic variants in chondrogenesis and degenerative disc disease (DDD)

Lam, To-kam., 林吐金. January 2009 (has links)
published_or_final_version / Biochemistry / Master / Master of Philosophy
45

Monitoring biological functions of cultured tissues using microdialysis

Li, Zhaohui January 2007 (has links)
Continuous monitoring during tissue culture is important for the success of engineered tissue development. It is also challenging due to lack of suitable established monitoring techniques. In this study, microdialysis, a sampling technique for measuring the unbound solute concentrations in the tissues and organs of the living body, was adopted to monitor functional tissue growth in a bioreactor with explanted bovine caudal intervertebral discs (IVD) as the test tissue. Apart from cell metabolic activities, cell and tissue biological functions were investigated for the development of microdialysis for monitoring purposes. Methodologies of microdialysis with large pore size membrane probes for sampling macromolecular bio-functional markers were established. The effects of pumping methods, including 'push', 'pull' or 'push-and-pull', and the effect of the resulting transmembrane pressure on the fluid balance, and the relative recovery of small molecules and of macromolecules (proteins) were experimentally studied. The validity of the internal reference in-situ calibration was examined in detail. It was concluded that a push-and-pull system was the only effective method to eliminate fluid loss or gain. The relative recovery of small solutes was hardly affected by the applied pumping methods; however the relative recovery of macromolecules was significantly influenced by them. The in situ calibration technique using Phenol Red can provide reliable results for small molecules including glucose and lactic acid. Using lOkDa and 70kDa fluorescent dextrans as the internal standard for in situ calibration of large molecules of similar size, it was found that the pull pump system did not work well but that the push-and-pull pumping method did work well. A novel bioreactor system for in vitro IVD culture with static load and microdialysis monitoring was developed. Explanted IVDs were cultured under three different loads for up to 7 days. A single microdialysis probe with 3000 kDa membrane was inserted into each of the IVDs at a defined location. The in situ calibration technique was proved valid in the experiments and membrane fouling was not significant. The tissue metabolism and extracellular matrix turnover during 7 day culture were continuously monitored to investigate the effect of different loads. Microdialysis proved to be a feasible and efficient method for multi-parameter monitoring of tissue culture. Substantial effort was directed towards the identification of functional macromolecular markers in conjunction with microdialysis sampling. Amongst several proteins sampled, chitinase-3-like protein 1 (CHI3L1), a major soluble protein secreted by cultured IVD cells in alginate beads and by cultured IVD explants was identified following its successful isolation. Then it was established as a suitable functional marker. The effect of physico-chemical and mechanical stimuli (e.g. osmolarity, pH, oxygen tension and mechanical load) on secretion of CHI3L1 by cultured IVD cells and chondrocytes in alginate beads and by cultured IVD explant were investigated. CHI3L1 release was sensitive to physico-chemical stimulation. The production of CHI3L1 was directly correlated with the cell metabolism and this could be readily monitored with microdialysis.
46

Three dimensional nonlinear finite element stress analysis of a lumbar intervertebral joint

Shirazi-Adl, Aboulfazl January 1984 (has links)
No description available.
47

Discitis after discography and chemonucleolysis

Fraser, Robert D. (Robert David) January 1986 (has links) (PDF)
Bibliography: leaves 107-109.
48

Uncovering new compounds for treatment of intervertebral disc degeneration by chemical genetics /

Tsui, Yuen-kee. January 2009 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2010. / Includes bibliographical references (leaves 149-163). Also available online.
49

Uncovering new compounds for treatment of intervertebral disc degeneration by chemical genetics

Tsui, Yuen-kee. January 2009 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2010. / Includes bibliographical references (leaves 149-163). Also available in print.
50

Uncovering new compounds for treatment of intervertebral disc degeneration by chemical genetics

Tsui, Yuen-kee., 崔婉琪. January 2009 (has links)
published_or_final_version / Orthopaedics and Traumatology / Doctoral / Doctor of Philosophy

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