Made available in DSpace on 2014-06-11T19:23:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2001Bitstream added on 2014-06-13T20:30:33Z : No. of bitstreams: 1 motta_dcp_me_botfm.pdf: 1151223 bytes, checksum: 1d7fefba88005a4773d3d06cae669504 (MD5) / Em 40 coelhos machos foram realizados estudos eletromanométricos do esôfago segundo a técnica de puxada intermitente da sonda e infusão contínua dos catéteres com água destilada. Estes estudos permitiram a análise de dois parâmetros: amplitude da pressão no EIE (mmHg) e comprimento do EIE em condições basais (momento 1). Neste momento foi também realizada avaliação do peso corpóreo dos animais. Os 40 animais foram divididos em quatro grupo de 10, na dependência do procedimento cirúrgico realizado: Grupo 1: Fundoplicatura total laparotômica Grupo2 : Laparotomia mediana e dissecção da transição gastroesofágica Grupo 3: Fundoplicatura total laparoscópica Grupo 4: Pneumoperitôneo e dissecção da transição gastroesofágica No momento 2 (uma semana após os procedimentos cirúrgicos) foram realizados estudos eletromanométricos do esôfago e avaliação ponderal em todos os animais. Nos animais do grupo 1 (fundoplicatura laparotômica) foi observado aumento da amplitude da pressão e do comprimento do EIE (p<0,05). Naqueles do grupo 2 não foi observada alteração da amplitude e do comprimento do EIE (p>0,05). Nos coelhos do grupo 3 houve aumento da amplitude da pressão e do comprimento do EIE (p<0,05). Nos animais do grupo 4 não foi observada alteração dos parâmetros acima citados (p>0,01). Com relação ao peso corpóreo, foi observada redução do mesmo (p<0,05) apenas nos coelhos submetidos a fundoplicatura laparotômica (Grupo 1). Nos demais animais (Grupos 2, 3 e 4) não houve qualquer alteração do peso corpóreo na avaliação realizada uma semana após os procedimentos cirúrgicos (momento 2) / Electromanometric studies of the esophagus were registered in 40 male rabbits, through the pull through technique and continuous infusion of the catheters with distilled water. These exams allowed us to measure the pressure width (mmHg) and the length (cm) of the lower esophageal sphincter (LES) in basal conditions (moment 1). The 40 animals were divided into four groups of 10, according to surgical procedure: Group 1: open total fundoplication Group 2: Median laparotomy and dissection of the gastroesophageal junction Group 3: laparoscopic total fundoplication Group 4: pneumoperitonium and dissection of the gastroesophageal junction. In moment two (one week after surgery) electromanometric studies of the esophagus and weight evaluation were performed in every animals. In group 1 (open fundoplication) an increase of pressure width and of LES was observed (p<0,05). In group 2, the pressure width and length of LES didn’t present any alteration (p>0,05). In group 3 an increase of pressure width and length of LES was observed (p<0,05). In group 4, the pressure width and length LES didn’t present any alteration (p>0,05). In respect to the weight evaluation, a decrease was observed in rabbits submitted to open fundoplication (p<0,05). In other animals (groups 2, 3 and 4) the weight didn’t present any alteration in evaluation performed one week after surgery (moment 2)

The aim of this study was to investigate the viability of laparoscopic testicular artery ligation as an alternative to the more conventional castration methods in equids. Twelve intact male donkeys varying in age from 5 months to 13 years were used in this study. Two of these donkeys were castrated by means of an open technique. The remaining donkeys underwent testicular artery ligation under laparoscopic guidance. Ligation of the testicular artery was achieved by application of Filshie clips under laparoscopic visualisation. This was performed with the donkeys standing in stocks and sedated with a combination of detomidine hydrochloride and butorphanol tartrate. The ten donkeys which underwent testicular artery ligation were unilaterally castrated using an acceptable open castration technique on two separate occasions. The first testes were removed at a specific time period after testicular artery ligation, while the second testes were all removed on the same day 9 months after the first group of donkeys underwent laparoscopic assisted testicular artery ligation. The remaining two donkeys which acted as controls underwent a standard open bilateral castration procedure both testes being removed on the same day. All the testes removed, excluding one testis lost to the study, were evaluated histologically. Four testes were used as controls. Thirteen testes showed histological signs of ischaemic necrosis, degeneration and/or atrophy. Three testes showed histological tubular degeneration and atrophy as well as the presence of some normal tissue. The remaining three testes were histologically unchanged. One of the testes was accidentally misplaced at post mortem due to human error. Avascular necrosis of the testicular tissue was not successful in all the subjects. This technique shows promise but further research is required. / Dissertation (MMedVet)--University of Pretoria, 2008. / Companion Animal Clinical Studies / unrestricted

Background: Opioid abuse has become a serious public health issue. While adequate pain management is an ethical responsibility for health care providers, responsible stewardship of controlled substances is of equal concern. Opioids are often prescribed for treatment of acute pain post-operatively. The purpose of this study is to examine opioid prescription practices and use of opioids after laparoscopic cholecystectomy. Methods: A convenience sample of 42 patients scheduled for laparoscopic cholecystectomy were enrolled in the study. Using a descriptive study design, patients were interviewed by phone 6-10 days post-operatively using a scripted questionnaire. The average number of excess prescribed opioid medication pills, patient perception of prescribed quantity, duration of opioid use, and average pain score with and without activity on the date of contact was determined. Participants were also asked about any instruction received regarding proper medication disposal. Results: A final sample of 34 patients met inclusion criteria and completed the phone questionnaire. Average number of excess pills ranged from 0-42 (M:14; SD 11.7). Nearly half of patients (47%) perceived the prescribed quantity as 'too many', 41% indicated the prescription quantity was 'just right' but many had left-over pills, and 11.8% believed the prescribed quantity to be 'too few'. The average number of days of opioid use following surgery was 4.2 days with 71% of patients using opioids for five or fewer days. The average pain score at the time of the interview was 2.0 without activity, and 4.1 with activity. Almost all (88%) patients did not recall any instruction or knowledge of appropriate medication disposal. A few participants volunteered plans to dispose of unused medications by various means, while others indicated they planned to keep excess pills. Conclusion: Pain management experts advise using around-the-clock regimens of over-thecounter analgesics (i.e. acetaminophen or non-steroidal anti-inflammatory medication (NSAID)) and using opioids sparingly as an adjunct therapy following uncomplicated laparoscopic cholecystectomy. The data in this study indicated currently prescribed opioid quantities after laparoscopic cholecystectomy are more than adequate and could be decreased without affecting adequate pain management. In addition, the data show a large majority of patients are not provided with personalized instruction on proper medication disposal procedures.

Massive bilateral adrenal hemorrhage occurring in the postoperative period is an unusual but potentially life-threatening complication of any abdominal operation. The diagnosis is often difficult due to the nonspecific nature of the clinical presentation, which is easily attributable to other more common postoperative conditions. We report a case of bilateral adrenal hemorrhage resulting in acute primary adrenal insufficiency following an otherwise-uncomplicated laparoscopic cholecystectomy, which has not previously been described. An awareness of the possibility of this uncommon condition complicating laparoscopic cholecystectomy may lead to a higher index of suspicion, which is important in timely diagnosis and prompt treatment.

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A quantitative descriptive study was conducted to establish professional nurses’ and patients’ knowledge and understanding of laparoscopic surgery and to determine whether nurses are sufficiently knowledgeable to disseminate adequate information about laparoscopic surgery to patients. Two state hospitals based in KwaZulu-Natal where laparoscopic surgery is done were selected and the respondents were selected through convenience sampling. Data were collected by administering questionnaires to theatre nurses (n=39), ward nurses (n=87) and patients (n=42) scheduled for laparoscopic surgery. The SPSS version 15 for Windows was used to compute the results. The findings revealed that the professional nurses were not sufficiently knowledgeable about laparoscopic surgery to give adequate information to patients and the patients themselves were not fully informed about all aspects of laparoscopic surgery including the possibility of conversion to open surgery, complications and advantages and after care. There is therefore a dire need for improvement of patient education to assist patients gaining optimal recovery / Health Studies / M.A. (Health Studies)

A quantitative descriptive study was conducted to establish professional nurses’ and patients’ knowledge and understanding of laparoscopic surgery and to determine whether nurses are sufficiently knowledgeable to disseminate adequate information about laparoscopic surgery to patients. Two state hospitals based in KwaZulu-Natal where laparoscopic surgery is done were selected and the respondents were selected through convenience sampling. Data were collected by administering questionnaires to theatre nurses (n=39), ward nurses (n=87) and patients (n=42) scheduled for laparoscopic surgery. The SPSS version 15 for Windows was used to compute the results. The findings revealed that the professional nurses were not sufficiently knowledgeable about laparoscopic surgery to give adequate information to patients and the patients themselves were not fully informed about all aspects of laparoscopic surgery including the possibility of conversion to open surgery, complications and advantages and after care. There is therefore a dire need for improvement of patient education to assist patients gaining optimal recovery / Health Studies / M.A. (Health Studies)

Author of this dissertation presentation discuss in the begining definition and historical consequences of origin and consecutive evolution of the method of percutaneous electrogastrography. Intimately is described physiology, anatomy, embryology and function of gastrointestinal tract with special interest on construction and function of the stomach. Next to this author analyses current knowledge about location and function of the gastric pace setter. The technique of used perctutaneous electrogastrography equipmentt is described. In the second part results of original studies monitoring restoration of peristalsis in perioperative period at patients after open and laparoscopic cholecystectomy and laparoscopic non-adjustable gastric banding are discussed. Furthermore results of EGG measurement of patients with mechanic, vascular and paralytic intestinal obstruction are presented in correlation with plasma levels of interleukin 1β, interleukin-6, procalcitonin and C-reactive protein. Key words: Percutanous electrogastrography, laparoscopic cholecystectomy, laparoscopic gastric bandage, inflammatory mediators, intestinal obstruction.

Author of this dissertation presentation discuss in the begining definition and historical consequences of origin and consecutive evolution of the method of percutaneous electrogastrography. Intimately is described physiology, anatomy, embryology and function of gastrointestinal tract with special interest on construction and function of the stomach. Next to this author analyses current knowledge about location and function of the gastric pace setter. The technique of used perctutaneous electrogastrography equipmentt is described. In the second part results of original studies monitoring restoration of peristalsis in perioperative period at patients after open and laparoscopic cholecystectomy and laparoscopic non-adjustable gastric banding are discussed. Furthermore results of EGG measurement of patients with mechanic, vascular and paralytic intestinal obstruction are presented in correlation with plasma levels of interleukin 1β, interleukin-6, procalcitonin and C-reactive protein. Key words: Percutanous electrogastrography, laparoscopic cholecystectomy, laparoscopic gastric bandage, inflammatory mediators, intestinal obstruction.