The "Guayacundo" Ethnos in the Highland of PiuraThe Guayacundo were an atuncuracazgo, or macroethnia, during the Late Intermediate Period and Late Horizon. Their location corresponds to the space occupied by the counties of Ayabaca and Huancabamba, in Piura. Their culture was greatly influenced by peoples from the forest, such as the Paltas, Caluas and Malacatos, located to the north and the northeast. Guayacundo was a chiefdom of sedentary towns, dedicated to agriculture and diverse crafts, organized in a politically structured space with permanent contact with both the coast and the tropical forest. The Guayacundo were conquered by Tupac Yupanqui who, among other things, founded the urban establishment of Caxas, in the lands of Coyayca. The guayacundos became part of the Tahuantinsuyo in capacity of loyal servants of the Inca, who trusted them with positions of responsibility in the service of the state. / Los guayacundo formaron un atuncuracazgo o macroetnia durante el Periodo Intermedio Tardío y el Horizonte Tardío. Su ubicación corresponde al espacio actualmente ocupado por las provincias de Ayabaca y Huancabamba, en el departamento de Piura. Su cultura tuvo una gran influencia selvática, al igual que los paltas, caluas y malacatos, localizados al norte y al noreste. Guayacundo fue un señorío de pueblos sedentarios, dedicados a la agricultura y a diversas artesanías, organizados en un espacio políticamente estructurado y con permanente contacto con costa y selva. Fueron conquistados por Túpac Yupanqui, quien, entre otras cosas, fundó el asentamiento urbano de Caxas, en las tierras de Coyayca. Los guayacundos pasaron a formar parte del Tahuantinsuyo en calidad de leales servidores de los incas, los que les confiaron cargos de responsabilidad a favor del Estado.

Made available in DSpace on 2014-06-11T19:26:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-10-06Bitstream added on 2014-06-13T20:14:47Z : No. of bitstreams: 1 elias_fa_me_rcla.pdf: 3769559 bytes, checksum: f01a99ac620f8c79cf85423c0351edbf (MD5) / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / A utilização de dentes isolados, com finalidades taxonômicas, é reconhecida por diversos autores. No Hemisfério Norte investigações desta natureza são freqüentes, versando principalmente sobre micro e macromorfologias dentárias e sua utilização na identificação de grupos taxonômicos, eventualmente a categorias bastante específicas. No Hemisfério Sul, em especial no Brasil, estudos enfocando dentes isolados ainda representam uma parcela bastante sutil de contribuição no âmbito da Paleontologia. Esta contribuição representa o plano de investigação de um conjunto de dentes de amniotas, resgatados em um dos mais ricos e diversificados depósitos fossilíferos cretácicos do Estado do Maranhão: o afloramento Laje do Coringa. Situado na Ilha do Cajual, Município de Alcântara, representa um bone-bed com expressivo registro fossilífero do neo-Albiano/eo-Cenomaniano da Formação Alcântara, Bacia de São Luís- Grajaú. Considerando sua abundância e diversidade morfológica, os dentes fósseis dos depósitos cretácicos no Estado do Maranhão mostram-se potencialmente importantes no âmbito de investigações paleontológicas. A análise de parâmetros morfológicos aplicados à coroa, permitiu a identificação de 19 morfótipos dentários, representando terópodos (Carcharodontosauridae, Spinosauridae e Velociraptorinae), saurópodos (Titanosauria e Diplodocoidea), crocodilomorfos (Pholidosauridae) e pterossauros (Anhangueridae e Ornithocheiridae). A variedade morfológica evidenciada na amostra da Laje do Coringa sugere uma relativa diversidade paleobiológica e paleoecológica durante o neo-Albiano/eo- Cenomaniano do Estado do Maranhão... . / The use of isolated tooth, with taxonomic purposes, is recognized for many authors. In North Hemisphere inquiries of this nature are frequent, mainly treating about dental micro and dental macromorphologies and its use in the identification of taxonomic groups, eventually the very specific categories. In South Hemisphere, in especially Brazil, studies focusing isolated teeth still represent a very subtle parcel of contributions in the scope of Paleontology. This contribution represents the plan of inquiry of a amniotes teeth's set, rescued in one of richest and diversified Cretaceous fossiliferos deposits of the Maranhão State: the Laje do Coringa outcrop. Situated in the Cajual Island, Alcântara Municipality, it represents a bone-bed with expressive fossiliferous record in the late Albian/early Cenomanian of the Alcântara Formation, São Luís-Grajaú Basin. Considering its abundance and morphologic diversity, fossil teeth of the Cretaceous deposits in the Maranhão State reveal potentially important in the scope of paleontological inquiries. The analysis of morphologic parameters applied to the dental crown allowed the identification of 19 dental morphotypes, representing theropods (Carcharodontosauridae, Spinosauridae and Velociraptorinae), sauropods (Titanosauria and Diplodocoidea), crocodilomorphs (Pholidosauridae) and pterosaurs (Anhangueridae and Ornithocheiridae). The morphologic variety evidenced in the sample of the Laje do Coringa outcrop suggests a relative paleobiological and paleoecological diversity during the late Albian/early Cenomanian of the Maranhão State. As evidenced in studies developed for other authors (and confirmed in this inquiry) the paleofaunistical assemblage of the Alcântara Formation probably had a particular similarity with isochronous assemblages of the North of Africa, suggesting that the events of biological particularity in each one of continental... (Complete abstract, click electronic address below).

Orientador: Reinaldo José Bertini / Banca: Paulo Milton Barbosa Landim / Banca: Dilce de Fátima Rossetti / Resumo: A utilização de dentes isolados, com finalidades taxonômicas, é reconhecida por diversos autores. No Hemisfério Norte investigações desta natureza são freqüentes, versando principalmente sobre micro e macromorfologias dentárias e sua utilização na identificação de grupos taxonômicos, eventualmente a categorias bastante específicas. No Hemisfério Sul, em especial no Brasil, estudos enfocando dentes isolados ainda representam uma parcela bastante sutil de contribuição no âmbito da Paleontologia. Esta contribuição representa o plano de investigação de um conjunto de dentes de amniotas, resgatados em um dos mais ricos e diversificados depósitos fossilíferos cretácicos do Estado do Maranhão: o afloramento Laje do Coringa. Situado na Ilha do Cajual, Município de Alcântara, representa um bone-bed com expressivo registro fossilífero do neo-Albiano/eo-Cenomaniano da Formação Alcântara, Bacia de São Luís- Grajaú. Considerando sua abundância e diversidade morfológica, os dentes fósseis dos depósitos cretácicos no Estado do Maranhão mostram-se potencialmente importantes no âmbito de investigações paleontológicas. A análise de parâmetros morfológicos aplicados à coroa, permitiu a identificação de 19 morfótipos dentários, representando terópodos (Carcharodontosauridae, Spinosauridae e Velociraptorinae), saurópodos (Titanosauria e Diplodocoidea), crocodilomorfos (Pholidosauridae) e pterossauros (Anhangueridae e Ornithocheiridae). A variedade morfológica evidenciada na amostra da Laje do Coringa sugere uma relativa diversidade paleobiológica e paleoecológica durante o neo-Albiano/eo- Cenomaniano do Estado do Maranhão... (Resumo completo, clicar acesso eletrônico abaixo). / Abstract: The use of isolated tooth, with taxonomic purposes, is recognized for many authors. In North Hemisphere inquiries of this nature are frequent, mainly treating about dental micro and dental macromorphologies and its use in the identification of taxonomic groups, eventually the very specific categories. In South Hemisphere, in especially Brazil, studies focusing isolated teeth still represent a very subtle parcel of contributions in the scope of Paleontology. This contribution represents the plan of inquiry of a amniotes teeth's set, rescued in one of richest and diversified Cretaceous fossiliferos deposits of the Maranhão State: the Laje do Coringa outcrop. Situated in the Cajual Island, Alcântara Municipality, it represents a bone-bed with expressive fossiliferous record in the late Albian/early Cenomanian of the Alcântara Formation, São Luís-Grajaú Basin. Considering its abundance and morphologic diversity, fossil teeth of the Cretaceous deposits in the Maranhão State reveal potentially important in the scope of paleontological inquiries. The analysis of morphologic parameters applied to the dental crown allowed the identification of 19 dental morphotypes, representing theropods (Carcharodontosauridae, Spinosauridae and Velociraptorinae), sauropods (Titanosauria and Diplodocoidea), crocodilomorphs (Pholidosauridae) and pterosaurs (Anhangueridae and Ornithocheiridae). The morphologic variety evidenced in the sample of the Laje do Coringa outcrop suggests a relative paleobiological and paleoecological diversity during the late Albian/early Cenomanian of the Maranhão State. As evidenced in studies developed for other authors (and confirmed in this inquiry) the paleofaunistical assemblage of the Alcântara Formation probably had a particular similarity with isochronous assemblages of the North of Africa, suggesting that the events of biological particularity in each one of continental... (Complete abstract, click electronic address below). / Mestre

Priests and Weavers in the Inka Province of PachacamacBy following the principle that offerings, accompanying the dead, can be used effectively to determine the former occupation the deceased, we can extend our knowledge of the social organisation of the Province of  Pachacamac. The meaning of offerings in terms of level of social status and occupation is interpreted by artifacts which probably belonged the deceased, including those which would include personal items and the tools of the trade, both of which would confirm what kind of social status the deceased enjoyed and what trade he or she pursued. This suits particularly well if the tools and other instruments for specific tasks show signs of wear and if there are half-finished products, such as textiles or nets. In this article I want to identify aspects concerning two specialists groups: the priests and weavers. / Investigaciones arqueológicas han comprobado que, durante el Periodo Intermedio Tardío y el Horizonte Tardío, algunos contextos funerarios son diagnósticos en la identificación de especialidades u oficios laborales. Esto puede demostrarse en la provincia inka de Pachacamac y en este artículo se intenta caracterizar algunos aspectos de dos grupos de especialistas identificados por el análisis arqueológico, apoyado por importantes y reveladoras informaciones etnohistóricas. Es interés del autor mostrar los resultados de sus investigaciones respecto a los sacerdotes y tejedores andinos.

The mysterious Sea Peoples are groups thought to have entered the Orient towards the end of the Late Bronze Age time period. Their impact on the region was seemingly influential and one of the contributing factors leading to the decline of the societal status quo in the region leading up to 1200 BCE. Their origins, cultural identity and long term impact on the area are all factors which have been difficult and complex to research. The challenges with regard to these peoples and any research concentrated upon them include a definitive lack of physical evidence of their material culture, specifically in the northern regions thought to have been inhabited by them. Further south the situation differs slightly as the Philistines (thought to be a Sea Peoples group) did settle into a sophisticated society with material remains to prove it. In the north however, Sea Peoples are known to have settled but their impact is less clear but not necessarily non-existent in all regards. The Phoenicians as an Iron Age civilisation date back to the transitional period of 1200 BCE (Late Bronze Age to Early Iron Age) and have often been regarded as simply the cultural descendants of the Late Bronze Age Canaanites. This is true in many ways but in certain instances the Phoenicians achieved feats and undertook cultural practices that may diverge from this idea of complete continuity. In terms of maritime activity, the Phoenicians were able to accomplish feats never before seen in the region. The time period in which these maritime activities started to take place on such an expansive level corresponds with the settlement of northern Sea Peoples in Phoenicia and just outside its southern borders. Although the physical evidence regarding these Sea Peoples is by no means available in abundance, perhaps one can find their impact in the cultural makeup and actions of the Phoenicians. It may be plausible that groups of people that had such a significant influence on an area through their migrations, as the Sea Peoples did, could have had more long term influences on the occupants of the area than has been credited to them before. One possible manifestation of this influence may be the unique maritime character of the Phoenicians which can be compared with the Sea Peoples, who have not been given their name coincidentally. Their affinity to the sea is well known through textual and pictographic records and can in some instances be favourably paralleled with the Phoenicians. Ship design alterations going into the Phoenician age is possibly, at least in part, due to Sea Peoples influence. Furthermore the actual undertaking of Phoenician expansion across the sea and following early forms of maritime expansion which was, to a degree, unknown in the area before seems to have started in a time period contemporaneous with Sea Peoples settling in Canaan. Apart from the settlement in itself, these peoples did so after migrating en masse across the Mediterranean and this must surely be worthy of additional attention. The Sea Peoples’ constant affiliation with all things ship and sea orientated must add some impetus 9 to this argument. Any other similarities between the Sea Peoples and Phoenicians can also be used as an indicator of cultural mergence. Cultural and societal divergences uncovered between the Late Bronze Age and Early Iron Age inhabitants also may illuminate ideas of decisive outside influences after 1200 BCE. The primary thread of this research is dedicated to dealing with the possibilities mentioned and perhaps presenting alternative theories to those currently accepted. / Dissertation (MA)--University of Pretoria, 2014. / gm2014 / Ancient Languages / unrestricted

Les cellules de mélanome humain expriment différents antigènes tumoraux qui sont reconnus par les lymphocytes T cytotoxiques CD8 + (CTL) induisant des réponses spécifiques de la tumeur in vivo. Cependant, chez les patients atteints de mélanome l'efficacité de la réponse naturelle des CTL ou stimulée par thérapie est limitée. Les mécanismes sous-jacents de l'échec de la phase effectrice des CTL contre les mélanomes sont encore largement méconnus. Notre hypothèse est que l'efficacité limitée des CTL dans leur combat contre les tumeurs est le résultat d'une balance défavorable entre la capacité des CTL à tuer les tumeurs et une résistance tumorale intrinsèque à l'activité cytolytique des CTL. Au cours de ma thèse je me suis concentrée sur la dynamique moléculaire qui se produit à la synapse lytique afin de pouvoir identifier un mécanisme précoce mis en place par les cellules de mélanome face à l'attaque des CTL. En combinant l'utilisation d'approches de microscopie de pointe et des outils moléculaires, j'ai pu montrer que, lors de l'interaction avec les CTL, les cellules de mélanome humain subissent une activation de leur trafic vésiculaire endosomal et lysosomal, lequel est intensifié à la synapse lytique et corrèle avec la dégradation par la cathepsine de la perforine et un défaut de pénétration d'entrée du granzyme B. De plus, j'ai démontré que le blocage du trafic lysosomal dépendant de SNAP23, la modification du pH (intra-vésiculaire) et l'inhibition de l'activité lysosomale protéotlytique des cellules de mélanome permet de restaurer leur sensibilité à l'attaque des CTL. Nos résultats révèlent une stratégie sans précédent d' " auto-défense " des cellules de mélanome à la synapse immunologique basée sur une sécrétion lysosomale massive et sur la dégradation de la perforine sécrétée par les CTL. Ainsi pouvoir interférer avec cette stratégie synaptique d'auto-défense des cellules de mélanome pourrait contribuer à potentialiser les réponses des CTL et les immunothérapies chez les patients atteints de mélanome. / Human melanoma cells express various tumor antigens that are recognized by CD8+ cytotoxic T lymphocytes (CTL) and elicit tumor-specific responses in vivo. However, natural and therapeutically enhanced CTL responses in melanoma patients are of limited efficacy. The mechanisms underlying the failure of CTL effector phase against melanomas are still largely elusive. Our hypothesis is that the limited efficacy of CTL in their fight against tumors is the result of an unfavorable balance between CTL ability to kill tumors and an intrinsic tumor resistance to CTL cytolytic activity. During my thesis I focused on the molecular dynamics occurring at the lytic synapse in order to identify possible "early response-mechanism" of melanoma cells to CTL attack. Using a combination of cutting edge microscopy approaches and molecular tools, I showed that upon conjugation with CTL, human melanoma cells undergo an exacerbated late endosome/lysosome trafficking, which is intensified at the lytic synapse and is paralleled by cathepsin-mediated perforin degradation and deficient granzyme B penetration. Abortion of SNAP-23-dependent lysosomal trafficking, pH perturbation or impairment of lysosomal proteolytic activity restores susceptibility to CTL attack. Our results reveal an unprecedented strategy of melanoma cell "self-defense" at the immunologic synapse based on a lysosome secretory burst and perforin degradation at the lytic synapse. Interfering with this synaptic self-defense strategy might be instrumental to potentiate CTL-mediated therapies in melanoma patients.

Anthropomorphic Effigy Vases: A Silvermith’s Production during the Late Intermediate Period and Late HorizonAnthropomorphic effigy vases have been classified, without any scientific basis, as belonging to the Chimu Culture. This investigation shows how these kinds of vases are more related in iconography as well as in provenance with the iconography of the central coast of Peru. In a selection of nine vases analysed, we determine different techniques of manufacture, which indicate the high technological complexity achieved by the precolumbian metal smiths during the Late Intermediate period and the Late Horizon. This study seeks to clarify, with the help of historic and ethnographic documentation, the social importance of the silversmith’s workshops that elaborated the effigy vases in question. We hope through the study of these archaeological remains and their comparison with historical texts, to decipher the symbolic and ritual value, as well as possible religious influences in their manufacture along the Peruvian coast. Finally, the possible process used by the coastal metal smiths in the manufacture of the effigy vases was identified by means of electronic microscope and metalographic analysis. / Desde hace mucho tiempo, un tipo especial de objetos rituales —los vasos-efigie antropomorfos de metal— han sido clasificados, sin sustento científico, como pertenecientes a la cultura Chimú. La investigación llevada a cabo por las autoras demuestra cómo este tipo de vasos está más relacionado, tanto en iconografía como en procedencia, con la temática iconográfica de la costa central del Perú. Se trata de un corpus de nueve vasos analizados con el que se determinaron diferentes técnicas de manufactura que muestran la alta complejidad tecnológica lograda por los orfebres tanto en el Periodo Intermedio Tardío como en el Horizonte Tardío. Para la realización de dicha investigación se ha utilizado documentación tanto histórica como etnográfica, las que permitieron explicar la posible importancia social de los talleres de los orfebres o plateros que manufacturaron dichos vasos. Estudios comparativos entre los restos arqueológicos con textos históricos ayudaron a descifrar el valor simbólico o ritual para el que fueron elaborados y su posible influencia religiosa en otros lugares de la costa peruana. Por último, los análisis metalográficos y microscopía electrónica identificaron las posibles formas de manufactura utilizadas en estos vasos por los antiguos orfebres o plateros de la costa.

This diploma thesis deals with the media representation of celebrities, as it is designed within the framework of the adopted American television format of the late-night talk show. In the first part of the thesis, attention is focused on problems of understanding of the phenomenon of celebrities by various authors, as well as on the development of the late-night talk show itself and its characteristic features. The theoretical starting point is the theory of representation (Hall), three levels of representation (Trampota) and social construction of reality (Berger, Luckmann). The method of critical discourse analysis is chosen for the research and the four principles for the analysis are described: commoditization, infotainment, personalization, congeniality. The practical part presents an analysis of the typical representation of celebrities due to the principles mentioned above in selected talk shows which were broadcast in English and Czech languages in 2015-2016, namely American The Tonight Show Starring Jimmy Fallon and Czech Jan Kraus Show. Keywords: Celebrity, Late-night Talk Show, Media Representation, Personalization, Congeniality, Infotainment, Commoditization

The subject of the thesis is the description, analysis and interpretation of rock art. The first, theoretic, part is dedicated to the research strategy, documentation, dating, conservation and presentation of rock art. It also analyses the relation between rock art and landscape, since differences in how different cultures perceived the landscape led rock art creators to different perception of the environment and to different forms of creative expression. The first part of the dissertation presents approaches rock art and methods of its interpretation from the landscape, historic, sociologic, ritual, artistic and aesthetic perspective. The second part of the dissertation discusses African rock art in the Oukaïmeden Valley, set in the central part of the High Atlas in Morocco. The dissertation focuses on particular archaeologic sites, art techniques applied, distinguishing features and other specificities of the local rock art. Special attention is paid to the motifs, development changes and dating of rock art in the Oukaïmeden Valley. Rock art first appeared there in the Late Neolithic and was further developed in the Bronze Age and continued until the Libyan-Berber period. The dissertation also presents interpretation of rock art motifs including analysis of their function and meaning of their positioning...

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