Purpose: The objective of this study was to examine the timing of the age and the magnitude of peak lean tissue mass accrual (peak lean tissue velocity, PLTV) as it relates to the age and magnitude of peak cross sectional area velocity (PCSAV) and section modulus velocity (PZV) of proximal femur in both males and females during adolescence. We hypothesized that the age of PLTV would precede the age of PCSAV and PZV and that there be a positive relationship between the magnitude of PLTV and both PCSAV and PZV in both genders. <p>Methods: 41 males and 42 females aged 8-18 years were selected from the Saskatchewan Pediatric Bone Mineral Accrual Study (1991-2005). Participants total body lean tissue mass was assessed annually for 6 consecutive years using DXA. Narrow neck, intertrochanteric and femoral shaft cross sectional areas (CSA) and section modulus (Z) were determined annually using the hip structural analysis (HSA) program. Participants were aligned by maturational age (years from peak height velocity). Lean tissue mass, CSA, and Z were converted into whole year velocities and the maturational age of peak tissue velocities was determined using a cubic spline curve fitting procedure. A 2x3 (gender x tissue) factorial MANOVA with repeated measures was used to test for differences between age of PLTV and both, the age of PCSAV and PZV between males and females. Multiple regression analyses were used to determine the relationship between PLTV and both PCSAV and PZV.<p>Results: There were no sex differences in the ages at which tissue peaks occurred when aligned by maturational age. There were significant differences between the age of PLTV and both PCSAV and PZV at the narrow neck (p=0.001) and femoral shaft (p=0.03), where the age of PLTV preceded both PCSAV and PZV when pooled by gender. There were no significant differences at the intertrochanteric site (p=0.814). PLTV was a significant predictor of the magnitude of both PCSAV and PZV at all sites (p<0.05). <p> Conclusions: These findings support the hypothesis that the age of PLTV precedes the age of PCSA and PZV at the proximal femur and provides further evidence to support the muscle-bone relationship, suggesting that lean tissue mass accrual influences bone strength development at proximal femur during pubertal growth.

Purpose: The objective of this study was to examine the timing of the age and the magnitude of peak lean tissue mass accrual (peak lean tissue velocity, PLTV) as it relates to the age and magnitude of peak cross sectional area velocity (PCSAV) and section modulus velocity (PZV) of proximal femur in both males and females during adolescence. We hypothesized that the age of PLTV would precede the age of PCSAV and PZV and that there be a positive relationship between the magnitude of PLTV and both PCSAV and PZV in both genders. <p>Methods: 41 males and 42 females aged 8-18 years were selected from the Saskatchewan Pediatric Bone Mineral Accrual Study (1991-2005). Participants total body lean tissue mass was assessed annually for 6 consecutive years using DXA. Narrow neck, intertrochanteric and femoral shaft cross sectional areas (CSA) and section modulus (Z) were determined annually using the hip structural analysis (HSA) program. Participants were aligned by maturational age (years from peak height velocity). Lean tissue mass, CSA, and Z were converted into whole year velocities and the maturational age of peak tissue velocities was determined using a cubic spline curve fitting procedure. A 2x3 (gender x tissue) factorial MANOVA with repeated measures was used to test for differences between age of PLTV and both, the age of PCSAV and PZV between males and females. Multiple regression analyses were used to determine the relationship between PLTV and both PCSAV and PZV.<p>Results: There were no sex differences in the ages at which tissue peaks occurred when aligned by maturational age. There were significant differences between the age of PLTV and both PCSAV and PZV at the narrow neck (p=0.001) and femoral shaft (p=0.03), where the age of PLTV preceded both PCSAV and PZV when pooled by gender. There were no significant differences at the intertrochanteric site (p=0.814). PLTV was a significant predictor of the magnitude of both PCSAV and PZV at all sites (p<0.05). <p> Conclusions: These findings support the hypothesis that the age of PLTV precedes the age of PCSA and PZV at the proximal femur and provides further evidence to support the muscle-bone relationship, suggesting that lean tissue mass accrual influences bone strength development at proximal femur during pubertal growth.

Phosphatidic Acid (PA) is a natural phospholipid compound derived from lecithin which is commonly found in egg yolk, grains, fish, soybeans, peanuts and yeast. It has been suggested that PA is involved in several intracellular processes associated with muscle hypertrophy. Specifically, PA has been reported to activate protein synthesis through the mammalian target of rapamycin (mTOR) signaling pathway and thereby may enhance the anabolic effects of resistance training. To our knowledge, no one has examined the effect of PA supplementation in humans while undergoing a progressive resistance training program. To examine the effect of PA supplementation on lean soft tissue mass (LM) and strength after 8 weeks of resistance training. Fourteen resistance-trained men (mean ± SD; age 22.7 ± 3.3 yrs; height: 1.78 ± 0.10m; weight: 89.3 ± 16.3 kg) volunteered to participate in this randomized, double-blind, placebocontrolled, repeated measures study. The participants were assigned to a PA group (750mg/day; Mediator®, ChemiNutra, MN, n=7) or placebo group (PL; rice flower; n=7), delivered in capsule form that was identical in size, shape and color. Participants were tested for 1RM strength in the bench press (BP) and squat (SQ) exercise. LM was measured using dual-energy X-ray absorptiometry. After base line testing, the participants began supplementing PA or PLfor 8 weeks during a progressive resistance training program intended for muscular hypertrophy. Data was analyzed using magnitude-based inferences on mean changes for BP, SQ and LM. Furthermore, the magnitudes of the interrelationships between changes in total training volume and LM were interpreted using Pearson correlation coefficients, which had uncertainty (90% confidence limits) of approximately +0.25. iv In the PA group, the relationship between changes in training volume and LM was large(r=0.69, +0.27; 90%CL), however, in the PL group the relationship was small (r=0.21, +0.44; 90%CL). PA supplementation was determined to be likely beneficial at improving SQ and LM over PL by 26% and 64%, respectively. The strong relationship between changes in total training volume and LM in the PA group suggest that greater training volume most likely lead to the greater changes in LM, however, no such relationship was found with PL group. For the BP data, the PA group resulted in a 42% greater increase in strength over PL, although the effect was considered unclear. While more research is needed to elucidate mechanism of action; the current findings suggest that in experienced resistance trained men supplementing 750mg PA per day for 8 weeks may likely benefit greater changes in muscle mass and strength compared with resistance training only.