The neutrino is, by its nature, an elusive particle that requires massive detectors with small backgrounds to capture a handful of events. Nevertheless, neutrino experiments stand at the heart of the current mysteries of particle physics and astrophysics. These include the origin and size of neutrino mass, the existence of additional types of neutrinos, CP violation and the matter--antimatter asymmetry, the amount of metals in the Sun's core, and the existence of non-nuclear energy sources in the Sun. This dissertation concerns the the use of a novel detector technology, the Raghavan Optical Lattice (ROL), in the Low-Energy Neutrino Spectrometer (LENS) and Neutrino Lattice (NuLat) experiments. LENS will measure the solar neutrino luminosity and the Sun's core metallicity using a ROL with indium-loaded liquid scintillator. NuLat will probe the existence of light sterile neutrinos with masses of $ \sim 1\,\mathrm{eV} $ using a ROL made from $ ^{6}\mathrm{Li} $-loaded plastic scintillator. For LENS we present an overview of the experiment and the present the ROL construction results from the LENS R\andD program. In particular we will present results from the micro- and mini-LENS prototypes. For both LENS and NuLat we present the development of an event reconstruction algorithm for ROLs and we apply these to the expected signals for these experiments. For NuLat we present an overview of the experiment including its theory of operation and its sensitivity to sterile neutrino oscillations. Finally, we present work toward the full-sized NuLat detector through bench-top tests and construction of the NuLat demonstrator. / Ph. D.

Making electricity grids smarter and facilitating them with integration of renewable energy sources (RES) and energy storage are fairly accepted as the necessary steps to achieve a sustainable and secure power industry. To enable Net-zero energy and optimize power management for future homes or buildings, DC electric distribution systems (DC Nano-grid) find feasibility and simplicity for integrating renewable energy sources and energy storage. However, integrating the sources and loads in a simple, robust and smart way is still challenging. High voltage lithium-ion battery should be seriously considered concerning the overcharge/over-discharge risk. Dissipative cell equalization and its performance are studied. Non-dissipative equalization methods are reviewed using an energy flow chart. Typical charging schemes and the related over-charge risk are illustrated. A Lithium-ion battery charging profile based on VCell_Max/Min monitoring is proposed and validated with experimental results in an 8.4kW bidirectional battery charger for DC future home. For the DC future home emulator testbed, a grid interface converter, i.e. energy control center (ECC) converter, is reviewed with functions identification. A PV system with different configurations is compared to further expand the common MPPT region, and a DC-DC converter is designed as the interface between PV panels and DC bus, facilitating maximum power point tracking (MPPT) as well as fulfill the system energy management requirement. An 8.4kW multi-phase bidirectional battery charger with Si IGBT in DCM operation is designed to achieve high efficiency and to be the interface converter between lithium-ion battery and DC bus, enhancing the battery system management as well as increasing the system reliability. To integrate all the sources and loads in a simple, reliable and smart way, this thesis proposes a distributed droop control method and smart energy management strategy to enhance the Net-zero electric energy cost. All of the control strategies are applied to the DC future home with interactions among the energy control center (ECC), renewable energy sources, energy storage and load within a day/24 hours. System level energy management control strategies for Net-zero electric energy cost are examined and illustrated. A 10kW future home emulator testbed is built and introduced for concepts validation. / Master of Science

Over the past 20 years, the detection of neutrino oscillation has reported a lot of important results. The oscillation phenomenon itself has been well proved by various experiments. Some oscillation parameters has been measured and now in the area of precise determination. On the other hand, some new questions like the possibility of the existence of light sterile neutrinos and unexpected 5 MeV bump were raised during the measurement. The Neutrino Lattice Experiment (NuLat) is a detector based on the Raghavan Optical Lattice (ROL). It should be able to offer a compact design of an effective detector with good mobility. It can be extremely useful in the short baseline reactor neutrino oscillation detection community to resolve several confusing issues. In this thesis, we present the calibration results we got from the first active NuLat detector and show what kind of improvements we need for the next version of the NuLat detector based on these results. / Ph. D.

村里基層行政人員是執行政策的主要行動者，其業務執行的判斷與裁量行為將影響民眾的權利，其對民主價值觀的認知，則左右其行政行為態樣。本研究的主要目的是欲探討民主化後的台灣，村里基層行政人員的民主價值，並找出影響因素。同時，探討村里基層行政人員是否因為民主價值的差異，而對於裁量行為有不同偏好。本研究使用2007年國科會計畫『填補「公民參與」研究脫落的環節—基層公務人員對公民參與態度的初探』所收集的量化資料。在分析961位村里基層行政人員所填答的問卷資料後，發現多數村里基層行政人員具中等程度的民主價值，其中村里幹事更達八成以上。主要影響民主價值差異的因素，是村里基層行政人員的年齡與教育程度。在裁量的偏好方面，多數受訪者傾向依法行政，民眾需求居次。主要解釋變異的因素是村里長與村里幹事間職責的差異，導致其偏好不同的裁量原則。因為村里長與村里幹事在民主價值以及裁量類型方面有許多的不同，而村里層級又是民主機制運作的第一線，因此應強化村里基層行政人員的民主價值。本研究建議政府應當建立村里長的培訓課程，以提升其對民主機制的認識與涵養，確保民眾的利益。 / Street-level administrators in Village/Li are the main actors for policy implementation. Their discretionary behaviors will affect the rights of citizens and such behaviors are profoundly influenced by their belief in democracy. The purpose of this thesis is to explore the democratic values of Village/Li Chiefs and Secretaries in Taiwan, and to find out the influential factors of democratic values. Further, this thesis discusses the extent to which their democratic values affect the preference of discretionary behaviors. The data used in this article are from the research sponsored by the National Science Council of the Executive Yuan; which conducted 961 face-to-face interviews with Village/Li Chiefs and Village/Li Secretaries in Taiwan in early 2007. This study finds that the majority of street-level administrators and 80% of Village/Li Secretaries have moderate democratic values. Statistical analysis indicates that age and education have critical influence on democratic values. With regard to their preference of discretionary behaviors, most respondents make decision mainly based on the enactments, and the need of citizens is secondary concern. The crucial factor to explain the variation is the difference on duties between Village/Li Chiefs and Secretaries. Consequently, the preference of their discretionary behaviors is diverse. Because of such divergence and the crucial role of street-level administrators in service delivery and grass-root democracy, this study suggests that the government should provide training programs to enhance the democratic values of Village/Li chiefs in particular and street-level administrators in general.

Four molecular germanates based on salicyl alcoholates, bis(dimethylammonium) tris[2-(oxidomethyl)phenolate(2-)]germanate (1), bis(dimethylammonium) tris[4-methyl-2-(oxidomethyl)phenolate(2-)]germanate (2), bis(dimethylammonium) tris[4-bromo-2-(oxidomethyl)phenolate(2-)]germanate (3) and dimethylammonium bis[2-tert-butyl-4-methyl-6-(oxidomethyl)phenolate(2-)][2-tert-butyl-4-methyl-6-(hydroxymethyl)phenolate(1-)]germanate (4), were synthesized and characterized including single crystal X-ray diffraction analysis. In the solid state, compounds 1 and 2 exhibit one-dimensional hydrogen bonded networks, whereas compound 4 forms separate ion pairs, which are connected by hydrogen bonds between the dimethylammonium and the germanate moieties. The potential of these compounds for thermally induced twin polymerization (TP) was studied. Germanate 1 was converted by TP to give a hybrid material (HM-1) composed of phenolic resin and germanium dioxide. Subsequent reduction with hydrogen provided a microporous composite containing crystalline germanium and carbon (Ge@C – C-1, germanium content ∼20%). Studies on C-1 as an anode material for Li-ion batteries revealed reversible capacities of ∼370 mA h gGe@C−1 at a current density up to 1384 mA g−1 without apparent fading for 500 cycles. / Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.

Pour la première fois, une étude par spectroscopie infrarouge à transformée de Fourrier et par microsonde ionique des minéraux majeurs de la croûte inférieure et des péridotites mantelliques a été entreprise afin de mieux caractériser les mécanismes d’incorporation et les teneurs en eau de ces minéraux nominalement anhydres, et de déterminer leurs compostions isotopiques en H, O, et Li pour retracer les échanges latéraux et horizontaux de l’eau dans la lithosphère continentale profonde. Les résultats montrent que: (1) Les minéraux nominalement anhydres, comme les pyroxènes et plagioclase, dans les granulites de la croûte inférieure contiennent de l’eau en trace essentiellement sous forme hydroxyles et accessoirement sous forme moléculaire, avec des concentrations (exprimées en poids H2O) allant de 200 à 2330 ppm pour les clinopyroxènes, de 60 à 1875 ppm pour les orthopyroxènes, de 65 à 900 ppm pour les plagioclases. Les teneurs calculées pour chaque roche totale d’après sa composition minéralogique et la teneur en eau des minéraux varient de 155 à 1100 ppm. (2) Les teneurs en H2O des minéraux majeurs et en roche totale de la croûte continentale inférieure sont manifestement plus élevées que celles du manteau lithosphérique sous-jacent, suggérant des variations verticales de la quantité d’H2O dans la lithosphère continentale profonde. Un tel contraste peut affecter de façon notable le comportement rhéologique de la lithosphère continentale. (3) Les rapports isotopiques de l’oxygène des pyroxènes étudiés, et probablement les roches totales, exprimés en [delta]18OSMOW , vont de ~ 4,5 à 12,5‰. Ceci indique la contribution de matériaux recyclés de la croûte continentale durant la pétrogenèse des échantillons ayant un TM18O élevé. (4) Les minéraux de la granulites sont caractérisés par des valeurs de élevées TMD, avec des valeurs de -80~-10‰ exprimées en [delta]DSMOW; les minéraux sont le plus souvent en équilibre les uns avec les autres lorsque l’on considère leurs compositions isotopiques moyennes. (5) Les compositions isotopiques du Lithium mesurée dans les minéraux de nos échantillons de granulites, exprimées en [delta]7Li par rapport à Lsvec, varient de -13 à +4.7 ‰. Ces valeurs sont donc pour la plus part inférieures à celles mesurées sur les MORB (2 – 6‰). La dispersion des valeurs reflètent l’hétérogénéité de la source des granulites, et les valeurs bassent resultent probablement de la perte par diffusion de Li pendant la mise en place des liquides silicatées provenant du manteau dans la croûte inférieure. (6) La grande hétérogénéité des teneurs en eau et en Lithium, et des compositions isotopiques de H-O-Li indique l’absence de circulation de fluide pervasive au travers de la croûte inférieure, qui aurait pour effet de supprimer les hétérogénéités à petite échelle et de les diminuer fortement à grande échelle / For the first time, systematic investigations of water content and H-O-Li isotopic compositions of minerals in lower crustal granulites, as well as water content of minerals in mantle peridotites, from eastern China have been carried out by Fourier transform infrared spectrometer and ion microprobe. The results show that: (1) Nominally anhydrous minerals, such as pyroxenes and plagioclase, in the lower crust generally contain trace amounts of structural water, with their content (H2O by wt.) varying from 200 to 2330 ppm for clinopyroxene, 60 to 1875 ppm for orthopyroxene, 65 to 900 ppm for plagioclase and 155 to 1100 ppm for the estimated bulk compositions. (2) Water contents of minerals in lower crustal granulites from eastern China, and their bulk values, are significantly higher than those in the underlying upper mantle, implying vertical heterogeneities of water distribution in the deep continental lithosphere; the contrast in water content even affect the rheological strength of the lithosphere. (3) The O-isotopic compositions of pyroxenes in the lower crustal granulites from eastern China are highly variable between different localities (~ 4.5 to 12.5‰, expressed in [delta]18OSMOW values), indicating variable influences from recycled crustal materials on their protoliths. (4) The H-isotopic compositions of granulite minerals from eastern China, are mostly in the range of -80 to -10‰ expressed in [delta]DSMOW values, and these minerals are usually in equilibrium with their [delta]D values. The relatively high [delta]D of granulite minerals may be related with degassing loss of H during the genesis of granulites. (5) The Li-isotopic compositions of granulite minerals from eastern China are usually in the range of -13 to 4.7‰, mostly lower than those of MORB (2-6‰). They reflect the source heterogeneity and are probably results of high-T Li diffusion during the intrusion of their original melts into the preexisting lower crust. (6) The large dispersion of Li and water contents and of H-O-Li isotopic results indicate the absence of any pervasive fluids in the lower crust

As novas ligas de alumínio que contém lítio são atraentes devido à sua baixa densidade, alto módulo elástico, elevada resistência mecânica e por terem boa resistência à corrosão em comparação com ligas similares que não contém lítio. A degradação do material devido à fadiga e corrosão são os dois principais fatores que contribuem para o envelhecimento de uma aeronave. O objetivo deste trabalho é estudar a resistência à fadiga de uma nova liga de Al-Li, denominada de AA 2050-T84, considerando os estágios de nucleação e de propagação. No primeiro caso são avaliados o efeito da variação do concentrador de tensão (kt) e o efeito da razão de tensões (R), enquanto que no segundo caso são estudados os efeitos da direção de laminação e da razão de tensões (R) na taxa de propagação da trinca por fadiga. Para o estágio de iniciação é possível observar que quanto maior o valor de R, menor é a vida em fadiga. Para um R constante, o concentrador de tensão reduz significantemente a vida em fadiga. Considerando a vida de propagação de trinca por fadiga, observa-se que, independente da direção de laminação, quanto maior o valor de R, para um mesmo ΔK, maior foi a taxa de propagação de trinca. Para um mesmo R, o expoente m da equação de Paris é maior na direção TL indicando maior velocidade de crescimento de trinca. Independentemente da direção tomada, quanto maior o valor de R maior o valor de m. O modelo matemático utilizado previu muito bem o efeito de R na taxa de propagação de trinca. A liga AA 2050 apresenta resistência à fadiga similar ligas das famílias 2XXX e 7XXX e similar a da liga Al-Li AA 2198 T8. / The new Al-Li alloys are very attractive due to its low density, high elastic modulus, increased mechanical strength, as well as good corrosion resistance in comparison with similar alloys that don\'t contain lithium. The material\'s degradation due to fatigue and corrosion are the main factors of aircrafts aging, and it is quite important to take them in account to guarantee the aircraft structural integrity. The aim of this work is to study the fatigue strength of a new Al-Li alloy, denominated as AA 2050 T84, considering both nucleation and propagation fatigue lives. In the first case were evaluated the effect of the variation of the stress concentrator (kt) and the effect of the stress ratio (R), while in the propagation life were considered the effect of the rolling direction and the stress ratio (R). From the initiation life results, it is possible to observe that as higher was R, lower is fatigue life and that the intensity of the stress concentrator reduces fatigue life significantly, independent of the R value. The results from the propagation life shows that in both LT e TL directions and for a constant ΔK, higher R induces larger fatigue crack propagation rates. Considering a constant R, the TL direction presents a larger exponent m of Paris equation, which is an indicative of higher larger crack propagation rate. Also, larger R causes larger m, independently of the rolling direction. The mathematical model used was able to take in account the R effect on the crack propagation rate. Considering the more traditional Al alloys from 2XXX and 7XXX families, and the Ali-Li alloys AA 2198 T8, the AA 2050 presented a quite similar fatigue behavior.

In dieser Dissertation werden 13 wichtige Werke Giorgio de Chiricos (1888 Volos, Griechenland – 1978 Rom), Filippo de Pisis’ (1896 Ferrara – 1956 Mailand) und Giorgio Morandis (1890 Bologna – 1964 ebenda) eingehend beschrieben und analysiert. Als Ergebnis ergibt sich die zum Teil unerwartete Entdeckung, dass die „noch“ figurative, teilweise als rückgewandt angesehene Kunst der drei untersuchten Künstler eine moderne, immer noch aktuelle Frage nach der besonderen Qualität des Bildes stellt. Ihre Skepsis gegenüber einer festgelegten Art der Wahrnehmung entfaltet sich in einer produktiven Auseinandersetzung mit den Bildern und mit einer Gattung – das Stillleben - einer tradierten Kunsttradition und zeigt Kunst in ihrer Fähigkeit ein besonderes, anderes Sehen anzuregen. Dabei zeigt sich in der Analyse der Bilder die unzertrennliche Beziehung von Sichtbarkeit und Unsichtbarkeit als einen zentralen Moment in der künstleri-schen Produktion. Diese Thematik wird unter anderem in der Verbindung de Chiricos, de Pisis’ und Morandis zu den Schriften Arthur Schopenhauers, Friedrich Nietzsches und Giacomo Leopardis erörtert und speziell mit der Auflösung des klassischen Realitätsbegriffs konfrontiert. Die aus dieser Auflösung resultierende „Krise der Repräsentation“ hat auch die Kunst der Moderne veranlasst, sich kritisch mit dem „Realen“ auseinanderzusetzen und nach neuen Formen der Darstellung, aber auch der Betrachtung zu suchen. Wesentlich ist dabei der Gesichtspunkt, dass die bewusste Reflexion des Sehens und des Wahrnehmens selbst zum Bild werden. Dieser Aspekt wird mithilfe einer phänomenologischen Perspektive und Fragestellung weiter ausgeführt und diskutiert. Der Fokus und die Struktur dieser Dissertation liegen in der konkreten und direkten Auseinandersetzung mit den Werken der drei bildenden Künstler aus denen auch der begriffliche Horizont der Arbeit immanent erschlossen wird. / This study describes and analyses in detail a total of 13 important works by the Italian painters Giorgio de Chirico (1888 Volos, Greece – 1978 Rome), Filippo de Pisis (1896 Ferrara – 1956 Milan) and Giorgio Morandi (1890 Bologna – 1964 Bologna). Its findings include the partially unexpected discovery that the “yet-figurative” aesthetics of these works, which may be valued as backward and even reactionary raise a very modern and relevant question about the special quality of pictures. The works’ scepticism of a fixed kind of perception also emerges in their productive confrontation with canonical, more traditional pictures and in their affirmation of art’s ability to encourage a special, “other” way of seeing. The argument of this study is based on the investigation of the unavoidable relationship between visibility and invisibility as a central moment in de Chirico’s, de Pisis’ and Morandi’s artistic production, and proposes a dialogue with the theories of Arthur Schopenhauer, Friedrich Nietzsche and Giacomo Leopardi, whose influence on the tree painters was of great importance, especially in conjunction with the dissolution of classic concepts of reality. The crisis of representation resulting from this dissolution led in the visual arts to a critical confrontation with the concept of the “Real”. As a consequence of this confrontation news forms of representation and observation emerged. Essential to this transformation is that conscious reflexions about sight and perception became themselves the subjects and objects of pictures. This aspect is also considered from the perspective of phenomenology and its tools of enquiry. The dissertation’s focus and structure derive from the direct confrontation with the pictures, which also informs its conceptual horizon.

Hexagonales Wolframbronze (HTB)–FeF3·0.33H2O Xerogel und eine HTB– FeF3·0.33H2O/GO Nanoverbindung wurden zunächst durch einen fluorolytischen Sol-Gel Ansatz bei Raumtemperatur in MeOH erhalten und ihre elektrochemischen Eigenschaften bewertet. Operando Mössbauer Spektroskopie und Röntgendiffraktometrie (XRD) wurden verwendet, um den Mechanismus während der Reaktion mit Lithium zu untersuchen. Das Fluorid zeigte ein komplexes Verhalten und den strukturellen Zerfall der HTB Phase sowie eine allmähliche Umwandlung in Fe-F2–Rutil–ähnliche Nanodomänen, welche sich als Hauptkomponente im Verlaufe der Reaktion ausbildeten. Die XRD-Analyse bestätigte die Amorphisierung des elektroaktiven Materials. Die strukturelle Optimierung von HTB-FeF3·0.33H2O wurde durch eine mikrowellenunterstützte, fluorolytische Sol-Gel-Reaktion in Benzylalkohol erreicht. Das Verfahren ermöglichte die Synthese von phasenreinen Nanopartikeln mit einem Durchmesser von rund 30 nm, zusammen mit der Herstellung eines auf reduziertem Graphenoxid (RGO) basierten Nanokomposits bei verminderter Reaktionszeit. Die Abscheidung auf leitfähigem RGO erwies sich als vorteilhaft für die elektrochemische Leistung des Fluorids, das wiederholten Zyklen zu unterschiedlichen C–Raten standhalten konnte und seine volle Kapazität nach mehr als 50 Zyklen aufrecht erhielt im Gegensatz zum reinen HTBFeF3 ·0.33H2O. Für die Herstellung von aktiven Ionenspeichermaterialien zur Verminderung der Sichereitsrisiken (im Vergleich zur Verwendung von Metallanoden) sind Strukturen wie HTBFeF3 ·0.33H2O notwendig. Hierzu wurden Na–enthaltende Hexafluoroferrat-Nanokomposite hergestellt und mit RGO und teilweise oxidierten Ruß (ox–CB) als leitfähigen Kohlenstoff versetzt. Die Art des Kohlenstoffzusatzes beeinflusste die elektrochemische Leistung stark, wobei mit RGO die größten Verbesserungen erzielt werden konnten / Hexagonal tungsten bronze (HTB)-FeF3∙0.33H2O xerogel and HTB-FeF3∙0.33H2O/GO nanocomposite were firstly obtained by a room temperature fluorolytic sol-gel approach in MeOH, and their electrochemical properties evaluated. Operando Mössbauer spectroscopy and X-Ray diffraction were employed to investigate the reaction mechanism during reaction with lithium. The fluoride evidenced a complex behavior, with structural collapse of the HTB phase and gradual transformation into FeF2-rutile-like nanodomains, becoming the predominant component all along the reaction. XRD confirmed the amorphization of the electroactive material. Structural optimization of HTB-FeF3·0.33H2O was then achieved by a microwave-assisted fluorolytic sol-gel in benzyl alcohol. The procedure allowed the synthesis of phase pure nanoparticles of ~30 nm in diameter, along with the production of a reduced graphene oxide (RGO)-based nanocomposite and the reduction of reaction times. Deposition onto conductive RGO resulted beneficial for the electrochemical performance of the fluoride, which was able to sustain repeated cycling at different C-rates and recovered full capacity after more than 50 cycles with respect to the unsupported HTB-FeF3·0.33H2O. Aiming at the production of active ions-holding materials to solve safety issues related to the use of metallic anodes, necessary with structures such as HTB-FeF3·0.33H2O, Na-containing hexafluoroferrate nanocomposites were produced using RGO and partially oxidized carbon black (ox-CB) as conductive carbons. Carbon type greatly affected the electrochemical performance, whose best improvement was obtained using RGO as support

Le gène TP53 est extrêmement polymorphique avec 85 polymorphismes décrits. Certains de ces polymorphismes sont associés à une augmentation du risque de cancer, par exemple rs10425222 peut moduler les fonctions de p53. Cependant, pour d’autres, comme le rs17878362 qui est le polymorphisme intronique le plus étudié, leur association avec une augmentation du riques au cancer est controversée.Pour analyser l’association entre le polymorphisme rs17878362 et la susceptibilité au cancer, nous avons analysé son rôle dans des contextes de cancers sporadiques et familiaux. Les résultats obtenus pour le polymorphisme rs17878362 sont paradoxaux avec une augmentation des cancers sporadiques associée avec le génotype A2A2 alors que l’allèle A2 est associé avec un effet « protectif » chez les patients atteints du syndrome de Li-Fraumeni porteurs d’une mutation germinale de TP53 situé sur l’haplotype A1. Ces observations suggèrent que des haplotypes spécifiques de TP53 pourraient moduler les capacités suppressives de p53. Une hypothèse possible est que les différents haplotypes de TP53 présenteraienrt des mutations somatiques à des fréquences différentes dans la population.De plus, le gène TP53 exprime différentes isoformes, comme le D40p53, inhibant l’activité suppressive de p53. Le D40p53 peut être produite par le maintien de l’intron 2 par épissage alternatif. Nous avons montré que les G-quadruplexes, des structures tridimensionnelles formées dans des régions riches en G, sont formés dans l’intron 3 et régulent la rétention de l’intron 2 et la formation du transcrit p53I2. Nous avons aussi observé que le polymorphisme rs1652785 (localisé dans l’intron 2) semble réguler la stabilité du p53I2. Ces résultats suggèrent que les polymorphismes de TP53 localisés dans une région de 412 pb située entre l’exon 2 et l’exon 4 régulent l’expression des isoformes de p53 dans une séquence temporelle d’évènements en modulant la formation des pré-ARNm (rs17878362), la stabilité des ARNm (rs1642785) et les fonctions protéiques (rs10425222).L’expression des isoformes de p53 est donc finement régulée par des mécanismes impliquant les polymorphismes de TP53 qui sont aussi associés avec une altération dans la susceptibilité au cancer. / The TP53 gene is a highly polymorphic gene with 85 polymorphisms described. Some of these have been associated with an increase of cancer susceptibility, for example rs10425222 that can modulate certain p53 activities. However for others such as rs17878362, the most studied intronic polymorphism, the association with cancer risk is more controversial. To investigate the influence of rs17878362 on cancer susceptibility, we analysed its role in sporadic and familial contexts. The results are paradoxical with an increase of sporadic cancer associated with the rs17878362 A2A2 genotype whereas the rs17878362 A2 allele is associated with a “protective” effect in the context of Li-Fraumeni patients carrying a TP53 germline mutation on an A1 haplotype. These observations suggest that specific TP53 haplotypes could modulate p53’s tumour suppression capacities. A possible hypothesis to explain this could be that somatic mutations are carried on different haplotypes of TP53 present at different allele frequencies in the population. In addition, TP53 is expressed as several protein isoforms, such as D40p53, which inhibits p53’s suppressive activity. D40p53 can be produced from an alternative spliced transcript that retains intron 2. We have shown that G-quadruplexes, tri-dimensional structures formed in G-rich sequences, are formed in intron 3 and regulate the retention of intron 2 and the formation of the p53I2 transcript. We also observed that rs1642785 (located in intron 2) could regulate p53I2’s stability. These results suggest that the TP53 polymorphisms located in a 412 bp region located between exon 2 and exon 4 regulate the expression of p53 isoforms in a temporal sequence of events by modulating the pre-mRNA formation (rs17878362), mRNA stability (rs1642785) and protein functions (rs1042522).p53 isoforms’ expression is thus finely regulated by mechanisms involving TP53 polymorphisms, which are also associated with altered cancer susceptibility.