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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany and Ecology Candidate: Jana Puzyrevská Supervisor: PharmDr. Anna Hošťálková, Ph.D. Title of Thesis: Biological activity of plant metabolites XXXIV. Alkaloids from the herb of Glaucium flavum CRANTZ and their impact on human cholinesterases. Key words: Glaucium flavum Crantz, cataline, N-methyllaurotetanine, norchelidonine, protopine, AChE, BuChE. Alzheimer's disease, the most widespread neurodegenerative disease, causes decrease of cognitive functions and dementia. The most effective therapeutic approach is the application of central cholinesterase inhibitors, which alleviate cholinergic deficit in brain and thus improve memory. Currently, intensive investigation of new active compounds including natural substances is carried on. Within the preliminary testing, alkaloid extract from Glaucium flavum Crantz herb showed promising inhibition of human cholinesterases, so it was selected for further examination. The primary alkaloid extract was acquired from dried flowering herb by extraction with ethanol and subsequent liquid extraction at different pH. This extract was treated by preparative thin layer chromatography. The structure of alkaloids was determined by spectrometric methods (MS, NMR) and their optical...

The target of this dissertation work is the process of analysis of recruitment and selection of employees for a manufacturing company. The strength and weakness of this process depends on acquired information and knowledge. The contribution of this work consists of specific improvements and recommendations in this domain which can help increase the effectiveness in recruitment and selection of employees. The basis for the empirical part of this work consists of consultations with employees of the HR department and the analysis of internal materials. This system is compared with theoretical and generally valid principles. Questionnaire enquiry, with cooperation of new employees and employees of HR department, are used in the second phase. Respondents are asked about the satisfaction of the processes applied in hiring. Employees of HR department are questioned regarding the procedure used in hiring of new employees.

This master thesis is focused on a position and functions of personnel department in the company adidas ČR s.r.o. The important part of the thesis is analysis of the employees perception of the personnel department in the company and the analysis of feedback on personnel activities. The theoretical part describes the findings about evolution of personnel work and personnel functions, it also provides the knowledge and instructions how to change the role of human resource professionals in organizations in order to meet the competitive challenges of today and tomorrow. The practical part is dealing with the topic of perception of human resources department and it works with the output from feedback on personnel activities in the company. In the thesis, there were used methods of personal interviews with the company managers and on-line questionnaire for the employees. As an output of the thesis, there were identified the opportunities for the improvement of the current perception of the human resources department and its functions together with some recommendations and guidelines for potential changes and improvements.

One of the biggest and prolonged capital assets of society is investment in staff. If they are managed in the right way, these investments can be the source of innovation and growth, competitive advantage and previsions of leading position in the market. Viz.[7] This Diploma thesis is aimed on the analyses of the human resources management, structure and demands on the personal information system, which solves this area as a whole. Described systems and solutions are generalization of the author's theoretical and practical experiences with particular human resources information system. There are defined the demands on common concept of HR IS. In this diploma thesis you can find the description

Human resourses are more and more frequently regarded as the most precious company treasure. Any organisation is not able to achieve its goals without capable and educated employees. Recruitments have to be doing with all due carefulness in order to reckruite the best possible employee. Acquisition of new people has to be well planned and done because capable employees are one of the most important competitive advantages.

Člověk je jedním z nejdůležitějších faktorů ve společnosti, který dále vytváří hodnoty. Spokojení zaměstnanci jsou proto jedním z prvků, který odráží celkové fungování organizace. V soukromé sféře plynou do oblasti péče o zaměstnance nemalé peníze, zjištění zda je tomu tak i ve sféře státní je obsahem této práce, která je zaměřena na analýzu pracovní spokojenosti zaměstnanců ve veřejné správě. Práce obsahuje teoretické vymezení problematiky pracovní spokojenosti, postup výzkumu od přípravy, průběhu až po následného zpracování a interpretaci získaných informací. Závěrečná část se věnuje návrhům řešení problémových oblastí.

Diploma thesis is dealing with the relation of financial and economical crises 2008/2009 and human resources. The first part is focused on the causes of crises that we can find in human resource management and employees. Second part describes changes on the Czech labour market, and give a recomendations how the HR department can dealt with it. It also includes the steps that can prevent the future crises.