Interactions between serum lipoproteins and human cells in the secretion of glycosaminoglycans (GAG) were investigated in cultures of arterial smooth muscle cells (SMC) and fibroblasts. Lipoprotein free serum (LFS) supported cell proliferation but caused a dose-dependent decrease in GAG secretion and cell cholesterol. Addition of low density lipoproteins (LDL) to 10% LFS in the medium caused increases in GAG secretion and cell cholesterol but a net decrease in cell population. LDL effects were positively correlated with the rate of cell proliferation independent of serum concentration. High density lipoproteins (HDL) decreased GAG secretion in slowly but not in actively proliferating cultures; however in the latter, it reduced all LDL-induced changes. Cells from non insulin-dependent diabetics had an increased GAG response to LDL. Low concentrations of platelet factors enhanced GAG secretion. The addition of a GAG mixture inhibited all LDL effects. On the basis of these observations, a hypothetical model is presented indicating that GAGs play a significant role in the development of atherosclerosis.

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Includes bibliographical references (leaves [138]-186) / xiii, 186 leaves : ill. (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Describes the kinetics of the hepatic lipase mediated hydrolysis of phospholipids and triacylglycerol in spherical, apolipoprotein-specific reconstituted high density lipoproteins. The results show that apolipoproteins have a major impact on these processes. / Thesis (Ph.D.)--Adelaide University, Dept. of Medicine, 2001

"March 2003" / Corrections inside front cover. / Includes bibliographical references (leaves 111-167) / x, 167 leaves : ill. (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 2003

Thesis (Ph. D.)--University of Adelaide, Dept. of Animal Sciences, Waite Agricultural Research Institute, 1987. / Includes bibliographical references (leaves 198-223).

Thesis (Ph. D.)--University of Hong Kong, 2007. / Also available online.

Thesis (Ph. D.)--University of Adelaide, Dept. of Medicine, 2004. / "February 2004." Includes bibliographical references (leaves 150-168).

Thesis (M.S.)--Northern Michigan University, 2006. / Bibliography: leaves 70-72.

Thesis (Ph. D.)--University of Hong Kong, 2007. / Title proper from title frame. Also available in printed format.

Thesis (Ph. D.)--University of Hong Kong, 1998. / Includes bibliographical references.