O ruído de baixa frequência é um limitador de desempenho em circuitos analógicos, digitais e de radiofrequência, introduzindo ruído de fase em osciladores e reduzindo a estabilidade de células SRAM, por exemplo. Transistores de efeito de campo de metalóxido- semicondutor (MOSFETs) são conhecidos pelos elevados níveis de ruído 1= f e telegráfico, cuja potência pode ser ordens de magnitude maior do que a observada para ruído térmico para frequências de até dezenas de kHz. Além disso, com o avanço da tecnologia, a frequência de corner —isto é, a frequência na qual as contribuições dos ruídos térmico e shot superam a contribuição do ruído 1= f — aumenta, tornando os ruídos 1= f e telegráfico os mecanismos dominantes de ruído na tecnologia CMOS para frequências de até centenas de MHz. Mais ainda, o ruído de baixa frequência em transistores nanométricos pode variar significativamente de dispositivo para dispositivo, o que torna a variabilidade de ruído um aspecto importante para tecnologias MOS modernas. Para assegurar o projeto adequado de circuitos do ponto de vista de ruído, é necessário, portanto, identificar os mecanismos fundamentais responsáveis pelo ruído de baixa frequência em MOSFETs e desenvolver modelos capazes de considerar as dependências do ruído com geometria, polarização e temperatura. Neste trabalho é proposta uma técnica para análise de ruído de baixa frequência baseada na autocorrelação dos espectros de ruído em função de parâmetros como frequência, polarização e temperatura. A metodologia apresentada revela informações importantes sobre os mecanismos responsáveis pelo ruído 1= f que são difíceis de obter de outras formas. As análises de correlação realizadas em três tecnologias CMOS comerciais (140 nm, 65 nm e 45 nm) fornecem evidências contundentes de que o ruído de baixa frequência em transistores MOS tipo-n e tipo-p é composto por um somatório de sinais telegráficos termicamente ativados. / Low-frequency noise (LFN) is a performance limiter for analog, digital and RF circuits, introducing phase noise in oscillators and reducing the stability of SRAM cells, for example. Metal-oxide-semiconductor field-effect-transistors (MOSFETs) are known for their particularly high 1= f and random telegraph noise levels, whose power may be orders of magnitude larger than thermal noise for frequencies up to dozens of kHz. With the technology scaling, the corner frequency — i.e. the frequency at which the contributions of thermal and shot noises to noise power overshadow that of the 1= f noise — is increased, making 1= f and random telegraph signal (RTS) the dominant noise mechanism in CMOS technologies for frequencies up to several MHz. Additionally, the LFN levels from device-to-device can vary several orders of magnitude in deeply-scaled devices, making LFN variability a major concern in advanced MOS technologies. Therefore, to assure proper circuit design in this scenario, it is necessary to identify the fundamental mechanisms responsible for MOSFET LFN, in order to provide accurate LFN models that account not only for the average noise power, but also for its variability and dependences on geometry, bias and temperature. In this work, a new variability-based LFN analysis technique is introduced, employing the autocorrelation of multiple LFN spectra in terms of parameters such as frequency, bias and temperature. This technique reveals information about the mechanisms responsible for the 1= f noise that is difficult to obtain otherwise. The correlation analyses performed on three different commercial mixed-signal CMOS technologies (140-nm, 65-nm and 40-nm) provide strong evidence that the LFN of both n- and p-type MOS transistors is primarily composed of the superposition of thermally activated random telegraph signals (RTS).

O câncer de pele é uma doença com grande incidência mundial. O tratamento tópico do câncer de pele é uma estratégia desejada uma vez que pode diminuir os efeitos adversos graves causados pelo tratamento cirúrgico e quimioterapia sistêmica. No entanto, os tratamentos tópicos atuais são limitados pela baixa efetividade das formulações em carrear o fármaco até as camadas mais profundas da pele. Desta forma, o ultrassom de baixa frequência (LFU) apresenta-se como um método atrativo, mas ainda pouco estudado, para aumentar a permeabilidade da pele. Portanto, o objetivo desse trabalho foi estudar modificações na composição dos meios de acoplamento do LFU visando aumentar as regiões de transporte localizadas (LTRs) da pele e a permeabilidade do quimioterápico doxorrubicina (DOX) para o tratamento tópico do câncer de pele. Para isso, um hidrogel de Poloxamer (nanogel) enriquecido com nanopartículas lipídicas sólidas (NLS) contendo DOX foi preparado e caracterizado; diferentes meios de acoplamento, dentre eles os tradicionais, contendo tensoativo, e os inovadores, contendo as NLS ou hidrogéis com diferentes potenciais zeta e viscosidades semelhantes, foram avaliados associados ao LFU para verificar sua influência na formação das LTRs e penetração cutânea de dois fármacos, calceína e DOX; a penetração cutânea da DOX livre e encapsulada em NLS foi quantificada nas diferentes camadas da pele pré-tratada com LFU; e, finalmente, o pré-tratamento mais promissor, LFU associado ao nanogel, seguido da aplicação passiva da DOX incorporada no nanogel foi avaliada in vivo em tumores cutâneos induzidos em camundongos imunossuprimidos. As NLS apresentaram tamanho e PdI de aproximadamente 200 nm e 0,3 respectivamente, com alto potencial zeta catiônico e pH de 3. A incorporação das NLS no nanogel não alterou o tamanho e PdI, no entanto, diminuiu o potencial zeta da formulação e elevou o pH para 5,5. Verificou-se por difração de raios X a baixo ângulo que as NLS continham fases cristalinas lamelares, enquanto o nanogel, fases cristalinas cúbicas, que foram mantidas quando as formulações foram associadas. O uso das NLS e dos hidrogéis, incluindo o nanogel, como meio de acoplamento do LFU modificou consideravelmente a distribuição e número de LTRs na pele em relação aos meios tradicionais. Tanto o número de LTRs quanto a sua distribuição parecem estar relacionados à tensão interfacial e a viscosidade do meio hidrofílico, sendo que a maior viscosidade dos géis gerou maior área de LTRs. O uso do nanogel originou LTRs em 50% da área da pele tratada, área esta 24 vezes maior do que a área de LTRs formada quando o meio de acoplamento convencional, com lauril sulfato de sódio, foi utilizado. Observou-se que a influência das LTRs na penetração de fármacos aniônicos (calceína) e catiônicos (DOX) depende do potencial zeta do hidrogel usado como meio de acoplamento e da dissociação do fármaco. Desta forma, a permeação cutânea da calceína foi menor quando gel aniônico foi utilizado como meio de acoplamento e o inverso ocorreu para a DOX. A penetração da DOX através do estrato córneo da pele pré-tratada com LFU/nanogel aumentou mais de 4 vezes, mas a encapsulação da DOX nas NLS dificultou a passagem da DOX para as camadas mais profundas da pele após o pré-tratamento da mesma com LFU, sugerindo um recuperação da pele desestruturada pelas partículas lipídicas administradas após o pré-tratamento. Nos estudos in vivo, o pré-tratamento da pele com LFU/nanogel seguido da aplicação diárias do nanogel contendo DOX resultou em diminuição de 6 vezes do volume do tumor após 21 dias de tratamento e apenas 5 aplicações do LFU/nanogel. No entanto, a diminuição do volume do tumor só ocorreu quando a sonda do LFU foi posicionada a 10 mm da superfície do tumor. O posicionamento da sonda a uma distância mais próxima do tumor (5 mm) não diminuiu o tamanho do tumor. Conclui-se que a aplicação de LFU com hidrogéis como meio de acoplamento é uma alternativa simples e efetiva para aumentar a penetração de fármacos na pele. Esta penetração pode ser modulada em função do potencial zeta do meio de acoplamento e da posição da sonda do ultrassom em relação à superfície do tumor. Desta forma, o tratamento tópico do câncer de pele usando LFU/nanogel como pré-tratamento é uma estratégia promissora para o tratamento tópico do câncer de pele. / Skin cancer is a disease with high worldwide incidence. Topical treatment of skin cancer is a desired strategy since it can reduce the serious adverse effects caused by surgery and systemic chemotherapy. However, current topical treatments are limited by low effectiveness of the formulations delivery drug to the deeper layers of the skin. Thus, the low frequency ultrasound (LFU) presents itself as an attractive method, but still little studied, to increase skin permeability. Therefore, the objective of this work was to study changes in the LFU coupling medium composition to increase the transport localized region (LTRs) in the skin and the permeability of chemotherapeutic doxorubicin (DOX) for the topical skin cancer treatment. For this, a Poloxamer hydrogel (nanogel) supplemented with solid lipid nanoparticles (SLN) containing DOX was prepared and characterized; different coupling medium, including traditional, containing surfactant, and innovative, containing the NLS or hydrogels with different viscosities and zeta potential similar, were evaluated associated with the LFU to verify its influence in LTRs formation and skin penetration of two drugs, calcein and DOX; skin penetration of free and encapsulated DOX was quantified in the different layers of the LFU pretreated skin; and finally, the most promising pretreatment, LFU associated with nanogel, followed by the passive application of DOX incorporated into the nanogel was evaluated in vivo, in skin tumors induced in immunosuppressed mice. The NLS showed size and PDI of approximately 200 nm and 0.3, respectively, with high cationic zeta potential and pH 3 value. The incorporation of the NLS into the nanogel did not change the size and PDI, however, decreased the zeta potential of the formulation and increased pH value to 5.5. It was found by low angle X-ray diffraction that NLS-containing lamellar crystalline phase while the nanogel, cubic crystalline phases, which were maintained when the formulations were associated. The use of NLS and hydrogels, including nanogel, as coupling medium of LFU substantially modify the distribution and number of the LTRs in the skin compared to traditional medium. Both, LTRs number and distribution may be related to the interfacial tension and viscosity of the hydrophilic medium, hydrogel with higher viscosity produced greater LTRs area. The use of nanogel as coupling medium resulted in LTRs formation in 50% of treated skin area, this area is 24 times larger than the LTR area LTRs formed when conventional coupling medium sodium lauryl sulfate was used. It was observed that the influence of the LTRs in the penetration of anionic drugs (calcein) and cationic (DOX) depends on the zeta potential of the hydrogel used as coupling medium and drug. Thus, the permeation of calcein was lower when anionic gel was used as the coupling medium and the opposite occurred for DOX. DOX penetration through the stratum corneum of the skin pretreated with LFU / nanogel increased more than 4 times but the encapsulation of DOX in the NLS difficult the passage of DOX to the deeper layers of the skin after pre-treatment with LFU, suggesting the recovery of the skin by lipid particles administered after pretreatment. In the in vivo study, pretreatment of the skin with LFU / nanogel followed by the daily application of nanogel containing DOX resulted in a 6-fold decrease in tumor volume after 21 days of treatment with only 5 applications LFU / nanogel. However, the reduction of tumor volume occurred only when the LFU probe was positioned 10 mm from the tumor surface. The positioning of the probe at distance closer tumor (5 mm) has not decreased tumor size. It is concluded that the application of coupling medium hydrogels with LFU is a simple and effective alternative to enhance drug penetration into the skin. This penetration can be adjusted depending on the zeta potential of the coupling means and ultrasound probe position on the tumor surface. Therefore, topical treatment of skin cancer using LFU / nanogel as pre-treatment is a promising strategy for the topical treatment of skin cancer.

While many investigations have been performed to establish a better understanding of the effects that magnetic fields and nanoparticles have on cells, the fundamental mechanisms behind the interactions are still yet unknown, and investigations on concurrent exposure are quite limited in scope. This study was therefore established to investigate the biological impact of concurrent exposure to magnetic nanoparticles and extremely-low frequency magnetic fields using an in-vitro CHO-K1 cell line model, in an easily reproducible manner to establish grounds for further in-depth mechanistic, proteomic, and genomic studies. Cells were cultured and exposed to 10nm Fe3O4 nanoparticles, and DC or low frequency (0Hz, 50Hz, and 100Hz) 2.0mT magnetic fields produced by a Helmholtz coil pair. The cells were then observed under confocal fluorescence microscopy, and subject to MTT biological assay to determine the synergistic effects of these concurrent exposures. No effects were observed on cell morphology or microtubule network; however, cell viability was observed to decrease more drastically under the combined effects of magnetic field and nanoparticle exposures, as compared to independent exposures alone. It was concluded that no significant difference was observed between the types of magnetic fields, and their effects on the nanoparticle exposed cells, but quite clearly there are deleterious synergistic effects of these concurrent magnetic field and nanoparticle exposure conditions.

This thesis investigates the footfall excitation of higher modes of vibration in low-frequency floor structures. This is motivated by the increased number of floors reportedly failing to meet the required occupants comfort level although being designed in accordance with the current state-of-the-art design guidelines. In particular modern, lightweight, and slender floor structures. The contribution to knowledge of this thesis can be summarised as: quantifying the signal energy of measured walking forces within and above the natural frequency cut-off proposed by the current state-of-the-art design guidelines; quantifying the contribution of higher modes of vibration to the overall response of low-frequency floors to human walking; propose measures to judge the response nature of low-frequency floors, these are the relevant change of the point stiffness and the shape of frequency response functions; proposing a frequency-domain approach that enables designers to include higher modes of vibration in the design against human-induced vibration. It was found that the signal energy of walking forces is distributed well beyond the natural frequency cut-off proposed by the current state-of-the-art design guidelines. Also, the contribution of localised, higher, modes of vibration to the overall response of ultra-lightweight floors was significant. Moreover, it was found that higher modes affect the response of floors of various construction types in one way or another. Hence, it was recommended to consider their contribution in the design of floors against human-induced vibration. Also, it was found that the higher the relative change of the point stiffness the more higher modes contribute to the overall response of floors. Finally, the frequency-domain analysis was found less expensive than time-domain analysis and could result in similarly useful information.

Les générateurs de suites binaires aléatoires constituent la partie primordiale d'un système cryptographique. La vitesse, la qualité des suites générées, la sécurité et la consommation jouent un rôle essentiel dans le choix d'un générateur. La sécurité du système cryptographique augmente si un tel système peut être réalisé dans un seul circuit.Le travail de recherche développé consiste donc en la réalisation d'un générateur de nombres aléatoires fonctionnant en basse consommation, basse vitesse. Le circuit proposé est de type analogique et valide l'ensemble des tests NIST assurant le caractère du signal. Une réalisation sur Silicium en technologie 0,35μm a été implémentée et validée via les tests NIST développés sous Matlab. De ce travail de thèse, un certain nombre de publications ont montré la plus-value recherche des résultats. / Random binary sequences generators constitute the essential part of a system Cryptographic. The speed, quality of generated suites, safety and consumption play an essential role in the selection of a generator. The security of the cryptographic system increases if such a system can be realized in a single circuit.The developed research work consists in the realization of a random number generator running in low power, low speed. The proposed circuit is analog and Valid all NIST tests ensuring the randomness of a signal.A realization on silicon in 0,35μm technology has been implemented and validated through NIST developed tests Matlab. In this thesis, a number of publications have demonstrated the added value search results.

As a promising alternative to laboratory constrained video capture systems in studies of human movement, inertial sensors (accelerometers and gyroscopes) are recently gaining popularity. Secondary quantities such as velocity, displacement and joint angles can be calculated through integration of acceleration and angular velocities. However, it is broadly accepted that this procedure is significantly influenced by cumulative errors due to integration, arising from sensor noise, non-linearities, asymmetries, sensitivity variations and bias drifts. In this study, new methods for improving foot motion from inertial sensors are explored and assessed. / Sensor devices have been developed previously, for example, to detect postural changes that determine potential elderly fallers, and monitor a person’s gait. Recently, a gait variable known as minimum toe clearance (MTC) has been proposed to describe age-related declines in gait with better success as a predictor of falls risk. The MTC is the minimum vertical distance between the lowest point on the shoe and the ground during the mid-swing phase of the gait cycle. It is therefore of our interest to design a cost effective but accurate solution to measure toe clearance data which can then be used to identify the individuals at risk of falling. In this study, hardware, firmware and software features from off-the-shelf inertial sensors and wireless motes are evaluated and their configuration optimized for this application. A strap-down method, which consists of the minimizing of the integration drift due to cumulative errors, is evaluated off-line. Analysis revealed the necessity of band-pass filtering methods to correct systematic sensor errors that dramatically reduce the accuracy in estimating foot motion. / Cumulative errors were studied in the frequency domain, employing content of inertial sensor foot motion evaluated against a ’gold standard’ video-based device, namely the Optotrak Certus NDI. In addition, the effectiveness of applying band-pass filtering to raw inertial sensor data is assessed, under the assumption that sensor drift errors occur in the low frequency spectrum. The normalized correlation coefficient ρ of the Fast Fourier Transform (FFT) spectra corresponding to vertical toe acceleration from inertial sensors and from a video capture system as a function of digital band-pass filter parameters is compared. The Root Mean Square Error (RMSE) of the vertical toe displacement is calculated for 5 healthy subjects over a range of 4 walking speeds. The lowest RMSE and highest cross correlation achieved for the slowest walking speed of 2.5km/h was 3.06cmand 0.871 respectively, and 2.96cm and 0.952 for the fastest speed of 5.5km/h.

<p>The development of integrated circuit technology seen in the last decades has enabled a large variety of battery operated equipment to emerge, such as smallsensors and medical implants. These applications often has low requirements on sampling frequency but require a very low power consumption to achieve a longbattery life.</p><p>This thesis investigates one aspect of implementing a low power and low frequency analog to digital converter (ADC) using a technique called Sigma Delta-modulation.The Sigma Delta-ADC uses few analog components but instead it requires a digital filter to extract the wanted resolution. It is this filter which is under investigation in this work.</p><p>To investigate the power consumption under the presumption that the filter would be a custom circuit implemented on-chip, a simplistic approach has been taken. Based on a high-level algorithmic investigation and the fact that it is popularly used together with Sigma Delta-modulators the Cascaded Integrator Comb (CIC) filter was chosen for implementation.</p><p>The CIC-filter uses only adders and delay elements which is a great advantage when aiming at a low power consumption. The drawback is that this filter has a poor passband which can introduce distortion within the signal band. Using the Spectre simulator provided in the Cadence Virtuoso suite the lowest power consumption achieved was 16 nW, extracting 80 % of the theoretically available resolution.</p>

No description available.

In this study, the basic absorption and scattering characteristics of acoustic scatterers, specifically Schroeder Diffusers, are investigated. Schroeder Diffusers are one of the most widely used acoustic scatterers in which the scattering phenomenon is predictable due to the geometry of the diffuser, based on a particular mathematical sequence. It is shown that it is possible to increase the amount of absorption by modifying the diffuser structure by means of adding perforated panels into the wells or narrowing diffuser wells. In room acoustics applications, diffusers are conventionally mounted to a wall or ceiling assumed to be rigid enough such that sound wave cannot penetrate through. This thesis proposes a new modification on these diffusers where the diffuser is not backed by a rigid surface / it is hung over a space instead. To construct such a configuration, diffuser wells are terminated with micro-perforated panels (MPP). Inclusion of MPP introduces additional losses / hence, higher absorption can be achieved. However, the most significant absorption in this configuration is achieved below the first resonance frequency of the panel-air space system due to the existence of non-rigid backing. This thesis aims to model the absorption and scattering mechanisms enabled with the non-rigid backing by improving a previously introduced mathematical model.

Interconnection of electric power systems is becoming increasingly widespread as part of the power exchange between countries as well as regions within countries in many parts of the world. There are numerous examples of interconnection of remotely separated regions within one country. Such are found in the Nordic countries, Argentina, and Brazil. In cases of long distance AC transmission, as in interconnected power systems, care has to be taken for safeguarding of synchronism as well as stable system voltages, particularly in conjunction with system faults. With series compensation, bulk AC power transmission over very long distances (over 1000 km) is a reality today. These long distance power transfers cause, however, the system low-frequency oscillations to become more lightly damped. As a result, many power network operators are taking steps to add supplementary damping devices in their systems to improve the system security by damping these undesirable oscillations. With the advent of thyristor controlled series compensation, AC power system interconnections can be brought to their fullest benefit by optimizing their power transmission capability, safeguarding system stability under various operating conditions and optimizing the load sharing between parallel circuits at all times. This thesis reports the results of digital time-domain simulation studies that are carried out to investigate the effectiveness of a phase imbalanced hybrid single-phase-Thyristor Controlled Series Capacitor (TCSC) compensation scheme in damping power system oscillations in multi-machine power systems. This scheme which is feasible, technically sound, and has an industrial application potential, is economically attractive when compared with the full three-phase TCSC which has been used for power oscillations damping.<p> Time-domain simulations are conducted on a benchmark model using the ElectroMagnetic Transients program (EMTP-RV). The results of the investigations have demonstrated that the hybrid single-phase-TCSC compensation scheme is very effective in damping power system oscillations at different loading profiles.