Approved for public release; distribution is unlimited / This thesis explores the hardware requirements of a local area network and then constructs a multiuser software library package for Turkish Battleships. The software implementation is designed as an expandable package so that future requirements can be met. The software package consists of three major parts. These are Personnel Eval­uations, Combat Information Center and Damage Control. Listings of the programs developed are presented, as well as instructions for their effective use. It is concluded that a PC Local Area network with the proper library programs is feasible for Turkish Battle Ships' computing requirements. / http://archive.org/details/microcomputerapp00gule / Lieutenant Junior Grade, Turkish Navy

The The Diploma Thesis deals with the institute of Catholic marriage, also called matrimony, and aims to provide detailed analyses on nullity of matrimony due to invalidity of matrimonial consent and its declaration. Firstly, the Thesis states a definition of matrimony with respect to Sacrament of Marriage being governed by the divine law, the canonical law, and, in regards to certain effects, the civil law. Pursuant to Code of Canon Law [CIC], 1983, canon 1055, §1, the matrimonial covenant, by which a man and a woman establish between themselves a communion of the whole life, is by its nature ordered toward the good of the spouses and procreation and education of offspring. Hence, marriage is a contract by which a man and a woman become irrevocably united, the Code of Canonic Law set up essential properties of marriage obligationes matrimonii essentialis, which are not to be excluded by either contractants. The Thesis further provides commentary on the grounds for the invalidity of the matrimonial consent, by descripting the reasons for nullity of matrimony which are defined by the Code of Canon Law, and can be grouped under these main causes: serious mental incapacity, incapacity to assume obligations, ignorance, error of person,simple error, fraud, simulation, conditional marriage, force and...

The aim of this study was to use the finite element method to model crack, corrosion, and Crack-in-Corrosion defects in a pipeline. The pipe material under investigation for this study was API 5L X60, 508 mm diameter with a wall thickness of 5.7 mm. The pipe material was evaluated using Tensile, Charpy, and J testing in order to model the defects and to establish the numerical failure criteria. Corrosion defects were modeled as flat-bottomed grooves. The collapse pressure was predicted when the deepest point in the bottom of the defect reached a critical stress. Based on this criterion, the FE corrosion failure pressure predictions were conservative compared to the experimental failure pressures, conducted by Hosseini [9], with an average error of 10.13%. For crack modeling, the failure criteria were established considering the plastic collapse limit and the fracture limit. Both the Von Mises stress in the crack ligament and the J-integral values around the crack were monitored to predict the failure pressure of the model. The crack modeling was done based on two approaches, the uniform depth profile and the semi-elliptical profile. The crack with uniform depth profile was done because the uniform shape is the logical equivalent shape for a colony of cracks. The crack with the semi-elliptical profile was done to have a less conservative results and because the experiments were done with semi-elliptical cracks. The FE crack modeling results were conservative compared to the experimental collapse pressure with an average error of 19.64% for the uniform depth profile and 5.35% for the semi-elliptical profile. In crack-in-corrosion (CIC) defect modeling, the crack was modeled with uniform depth because it was very difficult to model the semi-elliptical crack profile when the crack defect is coincident with a corrosion defect. The results were conservative compared to the experimental results with an average error of 22.18%. In general, the FE modeling provides the least conservative failure pressure prediction over the existing analytical solutions for pipe with longitudinal corrosion, crack, and CIC defects.

The aim of this study was to use the finite element method to model crack, corrosion, and Crack-in-Corrosion defects in a pipeline. The pipe material under investigation for this study was API 5L X60, 508 mm diameter with a wall thickness of 5.7 mm. The pipe material was evaluated using Tensile, Charpy, and J testing in order to model the defects and to establish the numerical failure criteria. Corrosion defects were modeled as flat-bottomed grooves. The collapse pressure was predicted when the deepest point in the bottom of the defect reached a critical stress. Based on this criterion, the FE corrosion failure pressure predictions were conservative compared to the experimental failure pressures, conducted by Hosseini [9], with an average error of 10.13%. For crack modeling, the failure criteria were established considering the plastic collapse limit and the fracture limit. Both the Von Mises stress in the crack ligament and the J-integral values around the crack were monitored to predict the failure pressure of the model. The crack modeling was done based on two approaches, the uniform depth profile and the semi-elliptical profile. The crack with uniform depth profile was done because the uniform shape is the logical equivalent shape for a colony of cracks. The crack with the semi-elliptical profile was done to have a less conservative results and because the experiments were done with semi-elliptical cracks. The FE crack modeling results were conservative compared to the experimental collapse pressure with an average error of 19.64% for the uniform depth profile and 5.35% for the semi-elliptical profile. In crack-in-corrosion (CIC) defect modeling, the crack was modeled with uniform depth because it was very difficult to model the semi-elliptical crack profile when the crack defect is coincident with a corrosion defect. The results were conservative compared to the experimental results with an average error of 22.18%. In general, the FE modeling provides the least conservative failure pressure prediction over the existing analytical solutions for pipe with longitudinal corrosion, crack, and CIC defects.

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Diploma thesis deals with design of verification environment for analyzing systems with digital filters. Verification environment is written in SystemVerilog language and it is generated by program, which is also providing generation of input data for system of filters. Matlab environment is used for gaining the reference data. The simulation of the designed involvement with digital filters is performed by program ModelSim. The most watched parameter is functional coverage which indicates how big part of the HDL description has been tested.

Le rein joue un rôle crucial dans de multiples processus biologiques, tels que le maintien de l’homéostasie acide-base et de la balance sodée. Le transport de chlore dans le néphron distal est un élément majeur de ces deux fonctions physiologiques. Au cours de ma thèse, j’ai travaillé sur deux projets relatifs à la physiologie et la physiopathologie du transport de chlore dans le néphron distal. Le premier travail concerne la caractérisation fonctionnelle et moléculaire d’un modèle murin dont le gène Slc4a1 codant pour l’échangeur d’anion de type 1 (AE1) a été modifié, pour introduire une mutation ponctuelle (R589H) dans la séquence protéique. Cette mutation est la plus fréquente des mutations de cette protéine responsable d’acidose tubulaire rénale distale chez l’Homme. Comme les patients, ces souris présentent une acidose tubulaire distale. Nos résultats ont montré que la diminution de l’activité d’échange Cl-/HCO3-, due à la baisse drastique de l’expression d’AE1 dans les cellules -intercalaires du canal collecteur, affecte l’expression et la distribution apicale de la pompe à protons, ce qui altère de ce fait la fonction d’acidification de l’urine. Le second travail porte sur l’étude de la régulation du transport de chlore par le complexe protéique ClC-Kb/Barttin, par phosphorylation de la Barttin. Ce travail démontre que la phosphorylation de la Barttin stimule le transport de chlore du canal ClC-Kb, en augmentant la distribution et la stabilité du complexe ClC-Kb/Barttin à la membrane. Ainsi, la phosphorylation de la Barttin pourrait représenter un mécanisme d’adaptation du transport de chlore en réponse à des variations des apports alimentaires en NaCl. / Kidney plays a major role in several biological fonctions as sodium balance or acid-base homeostasis. Chloride transport in the distal nephron is a key element of these two processes. During my thesis, i have worked on two projects related to physiology and pathophysiology of chloride transport in distal nephron. The first study is the functionnal and molecular characterization of a mouse model bearing the most common dominant dRTA mutation in human AE1, R589H, which corresponds to R607H in the mouse. R607H knock-in mice display incomplete dRTA. Our results showed that reduced basolateral anion exchange activity in type A intercalated cells inhibits trafficking and regulation of V-type ATPase, compromising luminal H+ secretion. In the second study, we investigated the role of a phosphorylation site in the regulation of chloride transport by the ClC-Kb/Barttin channels complex. Our results indicates that Barttin phosphorylation stimulates chloride transport by ClC-Kb channels by increasing the number of active channels in the membrane and hence are involved in the mechanisms of adaptation of renal chloride absorption in response to changes in dietary NaCl intake.

In the skeletal muscle cell membrane, the voltage gated chloride channel, CIC-1, maintains as unusually high resting membrane conductance and thereby prevents myotonic skeletal muscle disease. Protein crystallization experiments with bacterial CIC proteins, provide the information for the three dimensional (3D) structure of CIC chloride channels. / PhD Doctorate

The aim of this thesis is to study the possibilities of spectrum calculations, as well as data transfer via USB 3.0 and data saving to a DDR3 memory via FPGA. The focus is also on design and realization of a spectral analyzer with a record of samples to DDR memory expnaded by a narrowband converter using gate arrays. The work is divided into two sections, the first one dealing with the theoretical background. The second part denotes the realization of the design. The result of this work is a signal analyzer in a FPGA controlled from a computer application via the USB 3.0 interface.