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Synthesis and NMR properties of dihydrogen-hydride complexes of rhodium and iridium /Oldham, Warren James, January 1996 (has links)
Thesis (Ph. D.)--University of Washington, 1996. / Vita. Includes bibliographical references (leaves [114]-123).
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Applications of representation theory and higher-order perturbation theory in NMRSrinivasan, Parthasarathy. Quine, J. R. January 2005 (has links)
Thesis (Ph. D.)--Florida State University, 2005. / Advisor: Dr. John R. Quine, Florida State University, College of Arts and Sciences, Dept. of Mathematics. Title and description from dissertation home page (viewed Sept. 19, 2005). Document formatted into pages; contains x, 69 pages. Includes bibliographical references.
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Models of scientific development and the case of nuclear magnetic resonanceZandvoort, Henk, January 1900 (has links)
Thesis (Ph. D.)--University of Groningen, 1985. / Includes bibliographical references (p. 260-302) and index.
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Deuterium nuclear magnetic resonance spectroscopy and molecular dynamics studies of transmembrane polypeptides /Goodyear, David J., January 2003 (has links)
Thesis (Ph.D.)--Memorial University of Newfoundland, 2004. / Bibliography: leaves 157-167.
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Betaine homocysteine methyltransferase, disease and diet : the use of proton nuclear magnetic resonance on biological methylamines : a thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in the University of Canterbury /Lee, Martin Bryce. January 1900 (has links)
Thesis (Ph. D.)--University of Canterbury, 2006. / Typescript (photocopy). "20-July-2006." Includes bibliographical references. Also available via the World Wide Web.
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Structure and function of RNA modification and transcription regulation factors by NMR /Reichow, Steve L. January 2006 (has links)
Thesis (Ph. D.)--University of Washington, 2006. / Vita. Includes bibliographical references (leaves 159-176).
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Characterizing internal dynamics in nucleic acids by nuclear magnetic resonance spectroscopy : a study of RNA, DNA, and RNA-protein complexes /Shajani, Zahra. January 2007 (has links)
Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (leaves 167-181).
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Magnetic resonance spectroscopy of the in vivo brain with semi-LASERBerrington, Adam January 2016 (has links)
Changes in the metabolic state of the brain can occur, for example, as a result of neuronal activity or in pathologies such as cancer. In these cases, an altered energy demand can lead to changes in neurochemical concentrations detectable using proton magnetic resonance spectroscopy (<sup>1</sup>H-MRS). This thesis explores in vivo <sup>1</sup>H-MRS methods for detection of such changes in the healthy and diseased brain. Specifically, this thesis aims to develop methods with semi-LASER localisation, thereby minimising the negative effects of chemical shift displacement and field inhomogeneity on spectral acquisition. Firstly, a Hadamard-encoded semi-LASER method for simultaneous measurement from two regions was developed at 7 T. Slice profiles, with low chemical shift displacement and small amounts of signal overlap, were revealed in phantom and in vivo. This was then implemented in a study of neurochemical change during positive and negative blood oxygen level-dependent (BOLD) responses. Negative BOLD responses are thought to reflect regions of neuronal suppression. A small decrease in ascorbate, as well as the T2*-induced linebroadening of several spectra, were observed in these regions. Furthermore, increases in glutamate and lactate were detected in positive BOLD regions. These findings suggested that negative BOLD may not be generated by an increase in local GABA concentration. Secondly, an optimised semi-LASER sequence (TE = 110 ms) at 3 T was shown to improve localisation of the oncometabolite 2-hydroxyglutarate (2-HG) - a product of IDH-mutation found in the majority of gliomas. This resulted in improved detection of 2-HG in patients compared to an existing technique. The method was also compared to 7 T, where benefits of an increased spectral resolution resulted in significantly better detection of 2-HG along with associated metabolites. This thesis highlights the importance of robust localisation for performing sensitive in vivo <sup>1</sup>H-MRS neurochemical measurement in the human brain.
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The development of amine-based extractants for separation of base metals in a sulfate mediumMagwa, Nomampondo Penelope January 2015 (has links)
Tridentate benzimidazole-based ligands, bis((1H-benzimidazol-2-yl)methyl)sulfide (BNSN) and bis((1H-benzimidazol-2-yl)methyl)amine (BNNN), along with dinonylnaphthalene sulfonic acid (DNNSA) as a synergist, were investigated as potential selective extractants for Ni2+ from base metals in a solvent extraction system using 2-octanol/Shellsol 2325 (8:2) as diluent and modifier. However, extraction studies show a lack of pH-metric separation of the later 3d metal ions with bis((1-octylbenzimidazol-2-yl)methyl)sulfide (BONSN) and bis((1- decylbenzimidazol-2-yl)methyl)amine (BDNNN) as extractants, but extractions occurred in the low pH range with an opportunity for back extraction. This investigation suggested that tridentate ligands (at least those of the nature investigated here) are not feasible extractants for separation of base metal ions due to their lack of stereochemical “tailor-making.”
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Magnetic Resonance Imaging and Biochemical markers to assess disability in female subjects with Multiple Sclerosis.Herbert, Estelle Penelope January 2016 (has links)
Thesis (M.Sc (Radiography))--Cape Peninsula University of Technology, 2016. / Multiple sclerosis (MS) affects the central nervous system (CNS) and is
characterized by multiple demyelinating lesions. It is in this context that a need arises for
reliable biomarkers such as Magnetic Resonance Imaging (MRI), which could lead to the
early diagnosis and therapeutic intervention when maximum potential impact is possible.
This study examines the impact of MRI as a marker and the sequences that give the best
images to aid in evaluation of disease progression (which can indirectly be seen as disability)
and the early diagnosis of MS which will, in turn, lead to more effective management of the
disease.
METHOD: Sixteen subjects underwent a neurological examination, the Expanded Disability
Status Scale (EDSS), blood tests for iron parameters and a 3Tesla Magnetic Resonance
Imaging (MRI) scan. In a study of MS, 11 had MRI data that could be analysed by using
tract-based spatial statistics (TBSS). Subjects were divided according to the EDSS score (8
of the subjects had an EDSS score of ≤ 3 while 3 subjects had scores of ≥ 6). Diffusion
tensor imaging (DTI), the fused Proton Density and Fluid Attenuation Recovery (FLAIR) was
utilised to compute the lesion numbers and standard laboratory procedures were used to
measure other biochemical markers (serum iron, % transferrin saturation, ferritin,
haemoglobin) in subjects with disability and simultaneously assess the disease process.
RESULTS: The FA of white matter tracts (WMTs) as a parameter of myelin integrity was
lower in subjects with MS only in those who had high EDSS scores. An association between
FA and iron parameters, especially percentage transferrin saturation (% Tf) sat were
observed, which suggests that iron availability to the WM may be a requirement for optimal
myelin functionality.
CONCLUSION: The FA of WMTs as a parameter of myelin integrity was lower only in those
MS subjects who had high EDSS scores. Subjects who had EDSS scores < 3 (i.e. who had a
“benign” disease outcome) had FA values similar to control values and this finding was not
related to their age or disease duration. The association found between FA and iron
parameters, especially % Tf sat, suggests that iron availability to the WM may be a
requirement for optimal myelin functionality. Results also suggest that serum iron
concentration, ferritin and % Tf sat had an effect on myelination. The lack of association
between FA and Hb suggests that the iron in this protein is not available for WM function.
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