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1	Molekulární charakterizace nového subtypu dětské Akutní lymfoblastické leukémie s liniovým přesmykem v časné fázi léčby onemocnění / Molecular characterisation of novel subtype of Acute lymphoblastic leukemia with lineage switch during early phase of treatment Dobiášová, Alena January 2014 (has links) Leukemia is the most common malignant disease in children patients. In our laboratory (CLIP) a novel subtype of B-cell precursor Acute Lymphoblastic Leukemia (BCP-ALL) with lineage switch during early phase of treatment towards myeloid lineage (swALL) was recently documented. SwALL incidence is almost 4 % of all BCP-ALLs (Slámová et al., 2014). DNA methylation (presence of 5-methylcytosine) is together with post-translational histone modifications and non- coding RNAs an epigenetic mechanism which regulates gene expression without changes of genetic code. DNA methylation is easily detected by bisulphite conversion and subsequent sequencing. The aim of this work was to compare genome-wide DNA methylation patterns between patients with swALL and control BCP-ALLs. The first step in achieving that was revision and improvement of bioinformatic processing protocol for eRRBS data from massive parallel sequencing. To improve the sequence adapter trimming I tested four bioinformatic tools - FAR, cutadapt, Trimmomatic and fastx_clipper. I implemented the fastest and most effective - Trimmomatic into the processing protocol. As a next step I analysed the data with improved protocol and extended the analysis in R programming environment where the comparison of studied groups was performed. The comparison of...
2	Zirkulierende Nukleinsäuren als molekulare Marker zur Trächtigkeitsbestimmung beim Rind / Circulating nucleic acids as molecular marker for pregnancy detection in cattle Mayer, Jennifer 26 June 2012 (has links) No description available. 570 Biowissenschaften, Biologie WF 200 Biology (incl. Psychology) zirkulierende Nukleinsäuren Trächtigkeit Next Generation Sequencing SAGE Methylierung repetitive Elemente Serum Kuh circulating nucleic acids bovine pregnancy next generation sequencing SAGE methylation patterns repetitive elements serum dairy cows 42.13

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Molekulární charakterizace nového subtypu dětské Akutní lymfoblastické leukémie s liniovým přesmykem v časné fázi léčby onemocnění / Molecular characterisation of novel subtype of Acute lymphoblastic leukemia with lineage switch during early phase of treatment

Zirkulierende Nukleinsäuren als molekulare Marker zur Trächtigkeitsbestimmung beim Rind / Circulating nucleic acids as molecular marker for pregnancy detection in cattle