Title: Memorandum for thesis about the labour migration to the Soviet union 1917-1939   This memorandum for thesis deals with the international migration to the USSR, principally during the 1920s and 1930s and, though the whole process is described, the Swedish emigrants and Soviet Karelia are subjected to a more attentive exposition. The aim has been to present and evaluate previous research on the migration to USSR and Soviet Karelia to find shortcomings, which can function as a point of departure for further studies. Previous research finds that the migration to the USSR was special, due to the strong political awareness of a not insignificant part of the migrants. Furthermore, an important part of the memorandum, partly as a consequence due to the lack of theoretical perspectives in previous research, was to present a theoretical framework for a feasible thesis. The theoretical approaches to class, gender, ethnicity and generation has consistently been connected to previous research to demonstrate how further studies can be constructed. However, the choice of these theoretical approaches also finds its foundation in the inherent advantages for study of social relations, the capability to categorize people, the inherent relation of power, and the connection to a person’s identity. As a result, I claim that the use of the concepts class, gender, ethnicity, and generation can create a bigger understanding of the migration process, about the migrants in both their countries of departure and the daily life of the migrants in their new home country.

Human C1 inhibitor (C1 INH) belongs to the superfamily of serine protease inhibitors (serpins). It is the only known physiological inhibitor of C1s and C1r, therefore C1 INH plays an essential role as a regulator of complement classical pathway. C1 INH is also one of the major inhibitors of plasma kallikrein and activated factor XII of the kinin system. There is evidence that C1 INH can also inhibit the complement lectin pathway proteases, and the complement alternative pathway (C3b), plasminogen activator, activated factor XI, and kallikrein. A recent report indicated C1 inhibitor was significantly down-regulated in normal breast cells compared to malignant cell line. Thus, the major aim of this project is to study the effect of recombinant C1 inhibitor Ile379-Ala478 on human breast cancer cells. In this study, we constructed plasmid containing DNA fragment for C1 inhibitor C-terminal negion of Ile379-Ala478. Then the constructed plasmid was transferred into E.coli BL21(DE3) for expression. The recombinant protein was purifed by GST-affinity chromatography. Recombinant C1 inhibitor produced by E.coli was used to treat breast cancer cells (MDA MB 435s) to study its effect on cell proliferation and migration. Results showed that recombinant C1 inhibitor Ile379-Ala478 protein inhibited proliferation of MDA MB 435s cells after four, six or eight days, incubation in the presence of recombinant protein (1~100 nM). However, cell migration was inhibited only at 100 nM on 48 hrurs incubation..Our experimental data showed that the recombinant C1 inhibitor Ile379-Ala478 inhibited proliferation and migration of MDA MB 435s cells.

The meandering stream has been well studied in temperate environments but the same level of research has not been achieved for meandering streams in tropical areas. The overall objective of this research was to gain an increased understanding of meandering planform dynamics in humid tropical rivers. The objective was pursued by examining the rate of change of channel pattern and results indicate that migration rate and the range of radius of curvature to width ratio where maximum migration occurs is similar to those reported for humid temperate rivers. In summary, as regards to these aspects, the results suggest that the representative humid tropical river is no more dynamic than its temperate counterparts. A second objective was to document the response and recovery of a humid tropical river system to an extreme flood event. As a result, the trend of shorter recovery times following a major perturbation was demonstrated, and suggests that in the long term, a large flood such as a 100-year event apparently plays a relatively minor role as a formative event in shaping the overall humid tropical landscape. A third objective was to develop an empirical model for predicting bend migration rates in humid tropical rivers, resulting in empirical relationships that indicate that meander migration has a high degree of correlation with the number of bankfull discharge events under all scenarios, and that model correlation can be enhanced when the silt-clay composition of the banks, and the radius of curvature to width ratio are included as independent variables. The resulting equations were tested to predict maximum meander migration distance, and predictions produced very satisfactory results. In addition to increasing basic understanding of meander processes in tropical areas and for developing fluvial geomorphological theory, the results of this research have potentially important benefits to society. Because property and structures are often threatened by channel movement, there is a need for improved predictive capability of deformation of stream channels, and the results can therefore be useful to engineers and other professionals in delineating channel hazard zones.

<p>Title: Memorandum for thesis about the labour migration to the Soviet union 1917-1939</p><p> </p><p>This memorandum for thesis deals with the international migration to the USSR, principally during the 1920s and 1930s and, though the whole process is described, the Swedish emigrants and Soviet Karelia are subjected to a more attentive exposition. The aim has been to present and evaluate previous research on the migration to USSR and Soviet Karelia to find shortcomings, which can function as a point of departure for further studies. Previous research finds that the migration to the USSR was special, due to the strong political awareness of a not insignificant part of the migrants. Furthermore, an important part of the memorandum, partly as a consequence due to the lack of theoretical perspectives in previous research, was to present a theoretical framework for a feasible thesis. The theoretical approaches to class, gender, ethnicity and generation has consistently been connected to previous research to demonstrate how further studies can be constructed. However, the choice of these theoretical approaches also finds its foundation in the inherent advantages for study of social relations, the capability to categorize people, the inherent relation of power, and the connection to a person’s identity. As a result, I claim that the use of the concepts class, gender, ethnicity, and generation can create a bigger understanding of the migration process, about the migrants in both their countries of departure and the daily life of the migrants in their new home country.</p>

Texte remanié de: Väitöskirja--Maantiede--Helsingin yliopisto, 1987. / Bibliogr. p. 84-87.

Thesis--PlanB (M.S.)--University of Wisconsin--Stout, 2001. / Includes bibliographical references.

Thesis--PlanB (M.S.)--University of Wisconsin--Stout, 2001. / Includes bibliographical references.

A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine. / Members of the ErbB subfamily of receptor tyrosine kinases are critical regulators of normal mammary gland development, and alterations in their signaling have been associated with breast tumorigenesis. ErbB4 expression in breast carcinomas predicts improved patient survival and inversely correlates with tumor grade, metastasis and disease recurrence. When examined in the context of the breast cancer molecular subtypes, ErbB4 expression is rarely expressed in the triple-negative tumor subtype, which is associated with poor prognosis. Recently, our lab discovered a genomic context for the loss of ErbB4 expression in metastatic, refractory triple-negative breast cancer (TNBC) samples by next generation sequencing technology. The goal of this study was to examine the effects of ErbB4 overexpression on the growth and migration of TNBC cell lines. A GFP-containing construct was used to overexpress ErbB4 in the ErbB4-negative TNBC cell lines BT-20, BT-549 and MDA-MB-468. An empty vector construct was used as the control. Expression was confirmed by western blot and fluorescence microscopy to detect expression of ErbB4 or GFP respectively. Cell motility and growth was assessed with a transwell migration assay and a sulforhodamine B assay to measure cell density, respectively. Our data indicates that overexpression of ErbB4 resulted in no significant difference in the migration of BT-549 or MDA-MB-468 cells but resulted in a slight increase in the migration of BT-20 cells. ErbB4 had a growth inhibitory effect on BT-549 and BT-20 cells but showed no difference in the growth of MDA-MB-468 cells. This data suggests that multiple ErbB4-mediated mechanisms occur to alter the growth of TNBC cells. Although the translational significance of ErbB4 loss may be in its ability to predict outcome in patients with TNBC, more work is needed to elucidate the molecular mechanisms mediating its function.

Archaeological research in the San Pedro Valley during the last decade has shed new light on settlement and subsistence activities of prehistoric people in Southeastern Arizona. The Twin Hawks site (AZ BB:6:20[ASM]), located in the upland region of the Lower San Pedro Valley, provides an opportunity to examine social-economic relationships between riverine and upland sites. Ceramic and flotation studies from excavated sites in the northern Tucson Basin and Lower San Pedro Valley, as well as surveyed sites in the vicinity of the Twin Hawks site are used to address these issues.

No description available.