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Deciphering the Role of Aft1p in Chromosome StabilityHamza, Akil 25 January 2012 (has links)
The Saccharomyces cerevisiae iron-responsive transcription factor, Aft1p, has a well established role in regulating iron homeostasis through the transcriptional induction of iron-regulon genes. However, recent studies have implicated Aft1p in other cellular processes independent of iron-regulation such as chromosome stability. In addition, chromosome spreads and two-hybrid data suggest that Aft1p interacts with and co-localizes with kinetochore proteins, however the cellular implications of this have not been established. Here, we demonstrate that Aft1p associates with the kinetochore complex through Iml3p. Furthermore, we show that Aft1p, like Iml3p, is required for the increased association of cohesin with the pericentromere and that aft1Δ cells display sister chromatid cohesion defects in both mitosis and meiosis. Our work defines a new role for Aft1p in the sister chromatid cohesion pathway.
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Significance of MAD2 in mitotic checkpoint control and cisplatin sensitivity of testicular germ cell tumour cells /Fung, Ka-lai. January 2007 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2007. / Also available online.
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Regulation of CDK dephosphorylation in mitotic entry /Lindqvist, Arne, January 2005 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2005. / Härtill 4 uppsatser.
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The ABC of the cell cycle: roles of the mammalian Cdc25 isoforms /Lundgren, Andreas. January 2006 (has links)
Lic.-avh. (sammanfattning) Stockholm : Karol. inst., 2006. / Härtill 3 uppsatser.
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Disassembly and reassembly of the nuclear pore complex /Onischenko, Evgeny, January 2006 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2006. / Härtill 4 uppsatser.
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Significance of MAD2 in mitotic checkpoint control and cisplatin sensitivity of testicular germ cell tumour cellsFung, Ka-lai. January 2007 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2007. / Title proper from title frame. Also available in printed format.
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Progression through the cell cycle is regulated by dynamic chloride dependent changes in cell volumesHabela, Christa Whelan. January 2008 (has links) (PDF)
Thesis (Ph.D.)--University of Alabama at Birmingham, 2008. / Title from first page of PDF file (viewed on June 24, 2009). Includes bibliographical references.
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Chromosome missegregation in Alzheimer's disease caused by presenilin 1 /Boeras, Debrah I. January 2005 (has links)
Dissertation (Ph.D.)--University of South Florida, 2005. / Includes vita. Includes bibliographical references (leaves 164-190). Also available online.
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The Drosophila GW protein, a posttranscriptional gene regulator that influences progression through mitosisSchneider, Mary D. January 2009 (has links)
Thesis (Ph.D.)--University of Alberta, 2009. / A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Doctor of Philosophy, Department of Cell Biology. Title from pdf file main screen (viewed on November 1, 2009). Includes 2 video recordings. Includes bibliographical references.
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The structure and behavior of the nucleus in the life history of Phycomyces nitens (Agardh) Kunze and Rhizopus nigricans EhrbgBaird, Edgar Alan. January 1924 (has links)
Presented as Thesis (Ph. D.)--University of Wisconsin--Madison, 1920. / Cover title. "Reprinted from the Transactions of the Wisconsin Academy of Sciences, Arts, and Letters, Vol. XXI." Includes bibliographical references (p. 376-377).
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