The human motor system is constantly faced with decisions about how to choose a path when navigating our environment. These types of decisions occur rapidly and constantly, from initial movement planning, through movement execution, to completion. With infinite ways to complete any given task, the central nervous system generally, and motor control systems specifically, must somehow “decide” the best way to do this while taking into account physiological and environmental constraints. In addition, these movement choices must consider the feasibility and efficiency of all movement alternatives. For example, when deciding between paths that vary in reach distance and walking distance, the path with the shorter reach distance is more likely to be chosen, as reaching is deemed to be ~10x more costly than walking a given distance (Rosenbaum et al., 2011; Rosenbaum, 2012). It is not clear, however, how much more costly the non-chosen path is, compared to the chosen path, and what factors are mediating these decisions. Thus, the purpose of this thesis was to investigate potential underlying non-cognitive mediators of behavioural decisions involved with posture selection during tasks that occur within a constrained task environment, by quantifying the biomechanical mechanisms that may be driving these decisions. Chapter 2 replicated and extended upon the work of Rosenbaum et al. (2011) by recording whole-body motion capture during a bucket transfer task. This study was the first to look at the loading of the shoulder joint and trunk during the reaching and walking decision paradigm, comparing joint loading in the chosen versus unchosen paths. In Chapter 3, participants made decisions between movements with seemingly similar functional distances, in a four-choice reaching and walking paradigm. Behavioural outcomes suggest that the decision-making process reflects spatial coding of the movement goal that is backwards planned from the task sub-goal. Chapter 4 explored how perceived costs of multiple task variables are prioritized and integrated into action planning. Here, participants prioritized decreased reach distance over bearing an increased load. Collectively, this thesis provides evidence that bottom-up processes, namely the biomechanics of the shoulder and trunk, exert influence on cognitive decision-making and action planning, as reflected in decreased joint loading in chosen versus unchosen paths. / Dissertation / Doctor of Philosophy (PhD)

Yes / We investigated the role of the human right Supra-Marginal Gyrus (SMG) in the generation of learned eye movement sequences. Using MRI-guided transcranial magnetic stimulation (TMS) we disrupted neural activity in the SMG whilst human observers performed saccadic eye movements to multiple presentations of either predictable or random target sequences. For the predictable sequences we observed shorter saccadic latencies from the second presentation of the sequence. However, these anticipatory improvements in performance were significantly reduced when TMS was delivered to the right SMG during the inter-trial retention periods. No deficits were induced when TMS was delivered concurrently with the onset of the target visual stimuli. For the random version of the task, neither delivery of TMS to the SMG during the inter-trial period nor during the presentation of the target visual stimuli produced any deficit in performance that was significantly different from the no-TMS or control conditions. These findings demonstrate that neural activity within the right SMG is causally linked to the ability to perform short latency predictive saccades resulting from sequence learning. We conclude that neural activity in rSMG constitutes an instruction set with spatial and temporal directives that are retained and subsequently released for predictive motor planning and responses.

Thesis (PhD (Electrical and Electronic Engineering))--University of Stellenbosch, 2011. / ENGLISH ABSTRACT: The multiphase induction machine drive has been under investigation for the last half century. Although it offers several attractive advantages over the conventional three-phase induction machine drive, it is restricted to highly specialised applications. One aspect of the multiphase induction machine drive is the complexity of the control algorithm for decoupled flux and torque control. The complexity, arising from the required coordinate transformations, increases with increase in the number of phases of the machine. Recently, a method that allows the control of a six-phase induction machine drive without any coordinate transformations was developed and tested. This new control technique allows the control of the machine to be similar to that of dc machines through the use of special trapezoidal-shaped stator current waveforms. These stator phase current waveforms consist of field (flux) and torque current components, with flat-topped amplitudes allowing a stator phase to act alternately in time as either a flux or a torque producing phase. The idea is to have a number of stator phases acting as flux producing phases, whilst the remaining phases act as torque producing phases at each time instance. This dissertation takes a further step in the research on this particular control technique. As the control method relates directly to the brush-dc machine operation, in this dissertation, the control method is defined as a “brush-dc equivalent” (BDCE) control method. First, in this dissertation, a simple analytical method is developed to determine a defined optimal ratio of the number of field to the number of torque phases of a multiphase induction machine that utilises trapezoidal stator current waveforms. The method is applied to induction machines with up to fifteen stator phases. Finite element analysis is used to verify the validity of the developed criterion and to verify the square-like air gap flux density. Secondly, in this dissertation, an analytical method for predicting and evaluating the rotor bar current waveform of a cage multiphase induction machine is proposed. The method is based on the Fourier transform and the winding function theory under linear condition assumptions. The method also allows for the calculation of the electromagnetic torque and rotor bar losses. Skin effect is considered in the calculation of the rotor bar resistance of the machine. Again, finite element analysis is used to verify the analytically calculated results. The developed method can be expanded and used to evaluate the rotor current waveform of any multiphase induction machine supplied with any stator current waveforms. The BDCE control method is implemented on a prototype nine-phase cage-rotor induction machine drive. A nine-phase inverter and control system are developed for supplying the nine-phase induction machine with the trapezoidal stator current waveforms. Rotor current waveform measurements are taken on a specially designed rotor to verify the analytically predicted waveform. The linear relationship of the developed torque and torque current of the proposed BDCE control method is verified through measurements. Through the comparison of analytical calculated results with finite element calculated and measured results, it is shown in this dissertation that the developed analytical techniques can be used in the design and performance analysis of multiphase induction machines. Also, from the results, it is clear that the new control technique works remarkably well even in the flux weakening region. However, outstanding aspects, such as efficiency and generated torque quality of the proposed drive still need to be investigated further. / AFRIKAANSE OPSOMMING: Die multifase induksiemasjien aandryfstelsel word in die laaste halwe eeu al in navorsing ondersoek. Alhoewel dit verskeie aantreklike voordele bied bo die konvensionele driefase induksiemasjien aandryfstelsel, is dit beperk tot hoogs gespesialiseerde aanwendings. Een aspek van die multifase induksiemasjien aandryfstelsel is die kompleksiteit van die beheer algoritme vir ontkoppelde vloed en draaimoment beheer. Die kompleksiteit, wat voortspruit uit die vereiste koördinaat transformasies, neem toe met toename in die aantal fases van die masjien. Onlangs is 'n metode wat die beheer van ’n sesfase induksiemasjien sonder enige koördinaat transformasies doen, ontwikkel en getoets. Hierdie nuwe beheertegniek maak die beheer van die masjien soortgelyk aan dié van GS masjiene deur die gebruik van spesiale trapezium-vormige statorstroom golfvorms. Hierdie stator fasestroom golfvorms bestaan uit veld- (vloed-) en draaimoment-stroom komponente met plat amplitudes, sodat 'n statorfase om die beurt in tyd optree as óf' ’n vloed of 'n draaimoment genereerde fase. Die idee is om 'n aantal statorfases te hê wat as vloed genereerde fases dien, terwyl die oorblywende fases as draaimoment genereerde fases optree op enige tydstip. Hierdie tesis neem 'n verdere stap in die navorsing op hierdie spesifieke beheertegniek. Met die beheermetode wat direk verband hou met borsel-GS masjien werking, word in hierdie proefskrif die beheermetode as 'n "borsel-GS ekwivalente" ["brush-DC equivalent" (BDCE)] beheermetode gedefinieer. In die eerste plek word in hierdie proefskrif 'n eenvoudige analitiese metode ontwikkel om ’n gedefinieerde optimale verhouding van die aantal veld tot die aantal draaimoment fases van 'n multifase induksiemasjien te bepaal, wat van trapesoïdale statorstroom golfvorms gebruik maak. Die metode word toegepas op induksiemasjiene met tot vyftien statorfases. Eindige element analise is gebruik om die geldigheid van die ontwikkelde kriterium te verifieer en om die vierkantvormige luggaping vloeddigtheid te verifieer. In die tweede plek word in hierdie proefskrif 'n analitiese metode vir die voorspelling en evaluering van die rotorstaafstroom golfvorm van 'n kourotor multifase induksiemasjien voorgestel. Die metode is gebaseer op die Fourier transform en die wikkelingsfunksie teorie onder lineêre-toestand aannames. Die metode wend hom ook daartoe tot die berekening van die elektromagnetiese draaimoment en rotorstaafverliese. Die huideffek word in ag geneem in die berekening van die rotorstaafweerstand van die masjien. Weereens is eindige element analise gebruik om die analitiese berekende resultate te verifieer. Die ontwikkelde metode kan uitgebrei en gebruik word om die rotorstroom golfvorm van van enige multifase induksiemasjien te evalueer wat gevoer word met enige statorstroom golfvorms. Die BDCE beheermetode is toegepas op 'n prototipe negefase kourotor induksiemasjien. 'n Negefase omsetter en beheerstelsel is ontwikkel vir die toevoer van die trapesoïdale statorstroom golfvorms aan die negefase induksiemasjien. Die rotorstroomgolfvorm metings is geneem op 'n spesiaal ontwerpte rotor om die analitiese voorspelde golfvorm te verifieer. Die lineêre verwantskap tussen die ontwikkelde draaimoment en draaimomentstroom van die voorgestelde BDCE beheermetode is geverifieer deur metings. Deur die analitiese berekende resultate met die eindige element berekende en gemete resultate te vergelyk, wys hierdie proefskrif dat die ontwikkelde analitiese tegnieke gebruik kan word in die ontwerp en werkverrigting analise van ’n multifase induksiemasjien. Vanuit die resultate is dit ook duidelik dat die nuwe beheertegniek besonder goed werk, selfs in die vloedverswakking spoedgebied. Egter, uitstaande aspekte soos effektiwiteit en genereerde draaimoment kwaliteit van die voorgestelde aandryfstelsel moet nog verder ondersoek word.

While motor neuron activity has been studied for many decades, the relative contribution of synaptic and non-synaptic mechanisms underlying this activity during natural behaviors is not well understood. Thus, the goal of this dissertation was to further understand the role of non-synaptic properties of motor neurons during voluntary activity. In particular, I considered three non-synaptic properties: persistent inward currents (PICs) that boost synaptic inputs, spike-threshold accommodation that affects recruitment threshold as excitation rates of rise slow, and spike-frequency adaptation that leads to a decrease in firing rate despite constant excitation levels. Computer simulations were employed to understand the potential effect that these properties could have on firing rate behavior. In particular, the focus was on paired motor unit recordings where a lower threshold motor unit’s firing rate served as a proxy for synaptic drive, and differences in firing rate (ΔF) were compared at a higher threshold unit’s recruitment and derecruitment. While ΔF has been used by others to estimate PIC activation, the simulation results indicated that each of these non-synaptic mechanisms could lead to positive ΔF. Furthermore, by varying contraction speed and duration it seemed possible to determine which property contributes to ΔF in vivo. The results from human experiments indicated that adaptation is most likely the predominant contributor to ΔF during natural behaviors. Additionally, positive ΔF was even observed in the genioglossus muscle of the tongue, where the role of PICs has been debated. These results suggested that ΔF may not the best method to detect PICs during natural behaviors. As such, I also considered whether there might be another metric to infer PIC activation during natural behaviors. Motor unit firing rates tend to plateau, or saturate, despite continued force increase, and one hypothesis is that PICs contribute to this behavior. Indeed, motor unit firing rate saturation was diminished by the addition of inhibition, which should have limited PIC activation. Therefore, this final study provided possible evidence for PIC activation during natural behaviors. Overall, this dissertation highlights that non-synaptic properties of motor neurons are activated during natural behaviors and that they contribute significantly to firing rate output.

This thesis describes a series of experiments in human observers using neurophysiological and behavioural approaches to investigate the effects of varying haptic stimuli, attentional demand and age on motor control and perception during haptic sensing (i.e., using the hand to seek sensory information by touch). In Experiments I-IV, transcranial magnetic stimulation (TMS) was used to explore changes in corticomotor excitability when participants were actively engaged in haptic sensing tasks. These studies showed that corticospinal excitability, as reflected in motor evoked potential (MEP) amplitude, was greatly enhanced when participants were engaged in different forms of haptic sensing. Interestingly, this extra corticomotor facilitation was absent when participants performed finger movements without haptic sensing or when attention was diverted away from haptic input by a concurrent cognitive task (Exp I). This provided strong evidence that the observed corticomotor facilitation was likely central in origin and related to haptic attention. Neuroimaging has shown activation of the parieto-frontal network likely subserves this aspect of haptic perception. Further, this haptic-specific corticomotor facilitation was finely modulated depending on whether participants focused attention on identifying material (texture) as opposed to geometric properties of scanned surfaces (Exp II). With regards to aging effects, haptic-related corticomotor facilitation was associated with higher recognition accuracy in seniors (Exp III). In line with this, seniors exhibited similar levels of haptic-related corticomotor facilitation to young adults when task demands were adjusted for age (Exp IV). Interestingly, both young and senior adults also showed substantial corticomotor facilitation in the ‘resting’ hand when the ipsilateral hand was engaged in haptic sensing (Exp IV). Simply touching the stimulus without being required to identify its properties (no attentional task demands) produced no extra corticomotor facilitation in either hand or age group, attesting again to the specificity of the effects with regards to haptic attention. In Experiments V-VI, the ability to recognise 2-D letters by touch was investigated using kinematic and psychophysical measures. In Experiment V, we characterized how age affected contact forces deployed at the fingertip. This investigation showed that older adults exhibited lower normal force and increased letter-to-letter variability in normal force when compared to young adults. This difference in contact force likely contributed to longer contact times and lower recognition accuracy in older adults, suggesting a central contribution to age-related declines in haptic perception. Consistent with this interpretation, Experiment VI showed that haptic letter recognition in older adults was characterized not only by lower recognition accuracy but also by substantial increases in response times and specific patterns of confusion between letters. All in all, these investigations highlight the critical interaction of central factors such as attentional demand with aging effects on motor and perceptual aspects of haptic sensing. Of particular significance is the clear demonstration that corticomotor excitability is greatly enhanced when a haptic sensing component (i.e., attending to specific haptic features) is added to simple finger movements performed at minimal voluntary effort levels (typically <15 % of the maximal effort). These observations underline the therapeutic potential of active sensory training strategies based on haptic sensing tasks for the re-education of motor and perceptual deficits in hand function (e.g., subsequent to a stroke). The importance of adjusting attentional demands and stimuli is highlighted, particularly with regards to special considerations in the aging population.

This thesis assesses the link between action and cognition early in development. Thus the notion of an embodied cognition is investigated by tying together two levels of action control in the context of reaching in infancy: prospective motor control and executive functions. The ability to plan our actions is the inevitable foundation of reaching our goals. Thus actions can be stratified on different levels of control. There is the relatively low level of prospective motor control and the comparatively high level of cognitive control. Prospective motor control is concerned with goal-directed actions on the level of single movements and movement combinations of our body and ensures purposeful, coordinated movements, such as reaching for a cup of coffee. Cognitive control, in the context of this thesis more precisely referred to as executive functions, deals with goal-directed actions on the level of whole actions and action combinations and facilitates directedness towards mid- and long-term goals, such as finishing a doctoral thesis. Whereas prospective motor control and executive functions are well studied in adulthood, the early development of both is not sufficiently understood. This thesis comprises three empirical motion-tracking studies that shed light on prospective motor control and executive functions in infancy. Study I investigated the prospective motor control of current actions by having 14-month-olds lift objects of varying weights. In doing so, multi-cue integration was addressed by comparing the use of visual and non-visual information to non-visual information only. Study II examined the prospective motor control of future actions in action sequences by investigating reach-to-place actions in 14-month-olds. Thus the extent to which Fitts’ law can explain movement duration in infancy was addressed. Study III lifted prospective motor control to a higher that is cognitive level, by investigating it relative to executive functions in 18-months-olds. Main results were that 14-month-olds are able to prospectively control their manual actions based on object weight. In this action planning process, infants use different sources of information. Beyond this ability to prospectively control their current action, 14-month-olds also take future actions into account and plan their actions based on the difficulty of the subsequent action in action sequences. In 18-month-olds, prospective motor control in manual actions, such as reaching, is related to early executive functions, as demonstrated for behavioral prohibition and working memory. These findings are consistent with the idea that executive functions derive from prospective motor control. I suggest that executive functions could be grounded in the development of motor control. In other words, early executive functions should be seen as embodied.

All trunk muscles are important contributors to spine stability. However, the deepest abdominal muscle, transversus abdominis (TrA), with its characteristically horizontal fibre orientation seems to serve a unique function in trunk motor control. The main mechanical role of TrA is believed to be to contribute to vertebral alignment during imposed moments on the trunk, executed mainly via either regulating the pressure level within the abdominal cavity and/or transmit forces to the spine via the thoracolumbar fascia. However, the complete function of TrA and what factors affect its activation are still not fully understood. The purpose of the present thesis was to investigate the role of TrA in trunk motor control, specifically in relation to the presence or absence of postural demand on the trunk. The timing and magnitude of TrA activation were investigated, in relation to other trunk muscles, with intramuscular fine-wire electrodes in different loading situations and body positions with varying postural demand. In a side-lying position, with no postural demand of keeping the trunk upright, the activation of TrA was delayed relative the superficial abdominal muscles compared to previous experiments performed in a standing position. The timing and magnitude of activation of TrA did not depend upon the direction of perturbation. In the standing position, different static arm positions revealed that the activation of TrA co-varied with variations in the degree of postural demand on the trunk and also the imposed moments, regardless of moment direction. Finally, a study on rapid arm flexion movements confirmed that TrA is part of the pre-programmed anticipatory response in advance of known perturbations. The activation magnitude of TrA was the same regardless if the arm movement induced flexion or extension  moments on the trunk. In conclusion, the activation of TrA is associated with the upright postural demand on the trunk and with balancing imposed moments acting on the spine, regardless their direction. The findings are in support of the beliefs that TrA act as a general, direction non specific, stabilizer of the lumbar spine.

Plusieurs champs de recherche ont été combinés - mettant en évidence l'utilité de l'analyse cinématique, non seulement afin d'évaluer le comportement moteur, mais aussi afin de contribuer à la compréhension de la récupération motrice post-AVC. Au travers d'analyses cinématiques, les mouvements du membre supérieur hémiplégique ont été décomposés dans le temps et l'espace, afin d'en extraire l'échelle et les composantes structurelles. Cette décomposition systématique, d'abord connue pour son bien-fondé clinique, nous a permis d'identifier les marqueurs les plus pertinents du contrôle du membre supérieur parétique : i.e., la fluidité, la rectitude et la vitesse. Subséquemment, il a été démontré que i) les changements cinématiques se stabilisent au cours de la phase de rééducation, indiquant potentiellement la nécessité de modifier la stratégie thérapeutique; ii) les patient post-AVC sont capables de percevoir la fluidité du mouvement en réalité virtuelle, cette perception étant meilleure lorsque le feedback visuel ne concerne que le point du travail du membre; iii) l'espace de travail post-AVC n'est pas isotrope pour un patient hémiplégique; iv) chez les patients post-AVC, le niveau de ‘bruit neuromoteur' est augmenté; et v) la cinématique reflète la conséquence des stratégies d'adaptation à l'augmentation du bruit, ces stratégies étant basées sur un compromis entre des modes de contrôle d'erreur en feedforward et en feedback des actions motrices. Ainsi, il peut être conclut que la décomposition du mouvement dans le temps et l'espace est un moyen simple et efficace d'appréhender contrôle moteur chez l'Homme en situation normale et âpres AVC. L'enjeu est maintenant d'implémenter ces méthodes d'analyse cinématique dans les protocoles de rééducation post-AVC quotidienne afin de développer de larges bases de données permettant, à l'aide de méthodes de modélisation, de définir des profils de récupération et ainsi personnaliser de façon optimale la rééducation à chaque patient particulier. / Multiple research fields were combined – highlighting the value of kinematic analysis, not only to evaluate motor behaviour, but also to contribute to the understanding of motor recovery post-stroke. By means of kinematics, hemiplegic upper-limb movements were unfolded in time and space, to extract the scaling and structural components of the movement. This systematic decomposition, first proven to have clinical relevance, allowed us to identify the most pertinent markers of paretic upper-limb control: i.e. smoothness, directness and velocity. Subsequently it was shown that i) change in kinematics levels off over rehabilitation, possibly indicating that treatment may profit from change; ii) people post-stroke are able to perceive movement fluency in virtual realities, whereby simple end-point displays facilitate perception; iii) the workspace post-stroke is heterogeneous; iv) stroke patients have increased levels of neuromotor noise; and v) kinematics reflect the outcome of adaptation strategies to the increased noise in relation to the automaticity of error-corrections on the trade-off between feedforward and feedback based motor control. It may thus be concluded that unfolding the movement in space and time, is a simple and powerful way to define human motor control. The challenge is to implement kinematic analysis in daily post-stroke practice to develop a large database enabling the definition of recovery profiles contributing to provide each individual patient with the right therapy at the right time.

Un vaste corpus de recherches computationnelles est consacré à l’analyse du contrôle moteur. Cette approche, qui étudie l’adaptation saccadique comme un modèle d’apprentissage sensori-Moteur, invoque des mécanismes spécialisés dans la calibration de gains internes ou l’optimisation de fonctions de coûts. Cette thèse propose une explication différente de l’apprentissage oculo-Moteur en montrant que les distributions d’amplitudes saccadiques peuventêtre modifiées par leurs conséquences.D’abord, nous avons manipulé la médiane du gain saccadique. Nous avons éliminé l’erreur rétinienne post-Saccadique et présenté des stimulus sonores ou visuels après les saccades répondant à des critères d’amplitude. Ce renforcement opérant a induit des changements de gain similaires à l’adaptation saccadique obtenue par le paradigme conventionnel de double saut. Puis nous avons montré qu’une part de la variabilité peut être contrôlée par un apprentissage opérant. Différents niveaux de variabilité de gain ont été renforcés avec un son. Les changements obtenus suggèrent que la variabilité ne résulte pas uniquement d’un bruit interne. Enfin, dans une tâche de recherche visuelle, la présentation de la cible en guise d’agent renforçateur a aussi permis d’augmenter puis de réduire la variabilité des amplitudes saccadiques. Cela signifie que voir lacible est une conséquence qui contrôle (en partie) les propriétés des saccades.Ces études montrent qu’un processus général d’apprentissage, qui dépend des conséquences fonctionnelles des saccades, peut guider les changements de leur amplitude. Cela pourrait s’avérer crucial pour maintenir la précision des saccades tout au long de la vie. / A large body of computational research has been devoted to understanding motor control.This approach, using saccadic adaptation as an example of sensorimotor learning, postulates specialized mechanisms responsible for a motor calibration or optimization processes of cost functions. This thesis dissertation provides an alternative view of oculomotor learning byshowing that saccadic amplitude distributions can be altered by their own consequences.First we manipulated saccadic gain medians. We eliminated the postsaccadic retinal error (either by extinguishing the target during the saccade or by stabilizing its image on the fovea) and provided auditory or visual consequences after the saccades meeting amplitude criteria. This reinforcement procedure could induce gain changes similar to saccadic adaptation obtained via a conventional double-Step paradigm.Then we showed that part of saccadic amplitude variability may be controlled by operant learning. Saccadic gain distributions were reinforced with a tone depending on variability criteria.Our data suggested that oculomotor variability may not result solely from an internal randomnoise. Finally we designed a new paradigm involving a visual search task in which presenting atarget was effective to reinforce various saccadic amplitude variability levels. This means that in real life, seeing the target is a consequence controlling (at least in part) saccadic properties.These results show that a general operant learning process, depending on the functional consequences of eye movements, can guide changes in saccadic amplitude. This may be critical to maintain saccadic accuracy during the lifespan.

Le membre fantôme correspond à la persistance de perceptions sensitives et motrices attribuées au membre amputé. Des douleurs chroniques parfois invalidantes ainsi que des capacités d’évocation de mouvements dans le membre absent sont fréquemment rapportées. Très peu connue, cette motricité résiduelle est souvent considérée comme de l’imagerie motrice. Le premier objectif de cette thèse est de réinterroger le statut psychologique des mouvements de membre fantôme. Le second objectif est d’étudier le lien entre le contrôle moteur dans le membre fantôme et les réorganisations corticales dans le cortex moteur du sujet amputé. Au moyen de tests comportementaux et d’examens en Imagerie par Résonnance Magnétique fonctionnelle (IRMf), ces travaux de thèse ont permis de dissocier expérimentalement une forme de perceptions kinesthésiques associée à de l’imagerie motrice et une autre forme associée à de l’exécution motrice dans le membre fantôme. Cette distinction repose à la fois sur des différences de performances et sur le recrutement de régions cérébrales partiellement distinctes. Au-delà de cette distinction physiologique, les résultats obtenus suggèrent que les mouvements de membre fantôme s’apparentent à une forme d’exécution motrice plutôt qu’à de l’imagerie motrice. A travers le modèle du membre fantôme, ce travail aborde donc la question de la nature des informations menant à la perception d’un mouvement comme étant « exécuté ». Les altérations du fonctionnement cortical mises en évidence chez l’amputé peuvent représenter un modèle d’étude intéressant des différents mécanismes physiopathologiques relevés dans des situations de déficiences liées à une forme de plasticité « maladaptative ». Les observations cliniques et les examens en neuroimagerie menés au cours de cette thèse dressent en effet, un modèle relativement cohérent de l’organisation fonctionnelle du cortex après amputation. En particulier, l’existence d’un lien entre les réorganisations fonctionnelles au sein du cortex moteur et la qualité du contrôle moteur résiduel dans le membre fantôme permet de mieux comprendre les mécanismes sur lesquels reposent certaines thérapies antalgiques, comme les thérapies visuomotrices / The phantom limb is a sensory experience that is perceived to originate from the missing part. Amputees report that the phantom limb had certain sensory properties like touch and pain, as well as kinesthetic properties like being able to be moved voluntarily. Phantom limb movements are little-known and generally considered to reflect motor imagery rather than motor execution. The first aim of this thesis is to investigate whether amputees distinguish between executing a movement of the phantom limb and imagining moving the missing limb. The second aim is to examine the link between the quality of the motor control in the phantom limb and cortical reorganizations in the motor cortex of amputees. Behavioral tests and functional Magnetic Resonance Imaging (fMRI) results reveal the ability of amputees to make the distinction between execution and motor imagery in the phantom limb. This distinction is based both on differences in performances associated with the two tasks and the recruitment of partially distinct brain regions. Beyond this physiological distinction, this result suggests that phantom limb movements are similar to executed movements and differ from imagined movements. This raises important questions about the very nature of the processes underlying the awareness of a movement as being executed or imagined. The functional alterations in the motor cortex of amputees are somewhat similar to the pathophysiological mechanisms of maladaptative plasticity. Amputation could be a great model for its study. Indeed, the clinical and neuroimaging examinations conducted during this thesis led to a relatively coherent model of the functional reorganizations in the motor cortex after a limb-amputation and their relationships with behavioral variables. In particular, the relationship between functional reorganizations in the motor cortex and the quality of residual motor control in the phantom limb helps to understand the mechanisms underlying some analgesic therapies, such as the “visuomotor therapy”