Ganaxolone is a new potencional antiepileptic drug, synthetic analog of allopregnanolone which is a metabolite of progesterone. Preclinical and clinical studies point out its anticonvulsive effect in the treatment of both partial and generalized seizures including refractory epilepsy. The aim of our research was to investigate changes in the motor performance of the immature rats after administration of ganaxolone. We also focused on the relation between motoric impairment and the age of the rats which correlates with the age of children. 90 immature rats of age 12, 18 and 25 days were tested. Rats were divided in three groups injected with doses of 20 mgGNX/kg or 40 mgGNX/kg and the control group. The tests for assessing motor performance were chosen with respect to the maturation of sensorimotor reflexes from the following batery of tests: righting test, bar holding test, wire mesh test, negative geotaxis test and open field test. There were no significant differences before and after injection of the drug and in comparison with the control group not even in comparison of classes of age. We have demonstrated that the dose of ganaxolone effective against epileptic seizures does not markedly affect the motoric performance of the immature rats. Powered by TCPDF (www.tcpdf.org)

ABTRACT Title: Influence of personality to cope with new motoric skills among beginning indoor skydivers. Objectives: The main objective of this work is to determine whether there is a link between the performance of the indoor skydiving for beginners and their personalities, eventually their level of anxiety before this sport. Methods: Literature search, the implementation of a questionnaire survey, observation, analysis and evaluation of data, graphical presentation of results. Results: Extraversion, openness to experience and situational anxiety - only these of observed factors have impact on the performance the indoor skydiving. Extraversion and openness to experience affect performance in direct proportion, to the contrary, situational anxiety affects it inversely proportional. Key words: Motoric learning, indoor skydiving, beginners, personality

The thesis focuses on motor abilities of children from birth to the age of eight years. It outlines the development of gross motor skills, fine motor skills and micromotor skills, and methods how to help children develop these particular areas. The level of motor skills is determined by method of testing in first graders from Stonařov, Pavlov, Třešť and České Budějovice.

Title: Coordination abilities' level of primary school children Author: Petra Vlčková Department: Department of Physical Education Supervisor: Mgr. et Mgr. Zdeňka Engelthalerová Abstract: This thesis is devided into two parts. The theoretical part includes theoretical knowledge, which relates to motoric abilities, especially their definition and structuring in relation to primary school children. There is also a description of coordination abilities and their possibile recognising and development in detail. In the practical part there is a description of testing procedure which finds out the level of space orientation, balance and rhythm coordination abilities by pupils in the forth form at primary school. The tests results are statistically analysed and annotated. Obtained data are compiled in charts and diagrams. There is a supplement to the practical part containing the compendium of activities for coordination development. Key words: coordination abilities, primary school age, motor learning, motor tests

Tittle: Monitoring motorical skills and abilities for girls 8-10 years old in the course of children's recreational aerobics Objective: Method: In order to achieve the aim of the work, the measurement of partial motorical skills and abilities was used based on the Iowa Brace test, the Eurofit test and the Unifit test 6-60. The results were analyzed by using mathematical-statistical methods. Results: Despite the small research set, the result in one test of four, which is quantitatively evaluated, was determined to be statistically significant. The other test results improved or came close to average values relative to the rest of the research population. The results of test exercises evaluating motorical skills, which were evaluated in a qualitative manner, have been positive. All skills have shown an increase in probands who have mastered them. Testing testifies about improving motorical skills and abilities after completing a course of children's recreational aerobics. Keywords: Children's recreational aerobics; motorical abilities; motorical skills; testing; training unit.

Asperger syndrome and high-functioning autism is a form of pervasive developmental disorder characterized by impaired social interaction and communication and restricted and stereotyped interests. These children are often clumsy and motor uncoordinated. They also performed worse in standardized tests of motor function. In this diploma thesis we used Movement Assessment Battery for Children 2 (MABC-2) for assessment motor skills in children with Asperger syndrome and high-functioning autism aged 7-10 years in comparison with the group of children developing typically. Our study included 9 children with Asperger syndrome, 3 children with high-functioning autism and 64 children with typical development. Evident motor deficit (below 5. percentile) was found in 2 children with Asperger syndrome and 3 children with high-functioning autism. 1 child with Asperger syndrome was in a risk of motor deficit (6.-16. percentile). Children with Asperger syndrome and high-functioning autism performed significantly worse than children developing typically in a total score of this test. Significant difference was found in two components of MABC-2, in Aiming and catching (AC) and Balance (BAL). Better results reached children with typical development. Results of this study indicate that children with Asperger syndrome...

In its theoretical part, the thesis "Postural Function at Early Age and Final Condition of Motor Functions at Preschool Age" summarizes the knowledge of motor abilities and skills, postural control and development, control and development of rough and fine motorics. At the same time, the theoretical part resumes briefly characteristic features of developmental coordination disorders, way of their diagnostics and possible treatment. Furthermore, it presents the most common tests used for motorics assessment and its disorders. Practical part focuses on comparison of results according to developmental kinesiology as an investigation method and MABC-2 test. There have not been found any statistically important relations between the results of the developmental kinesiology test as an investigation method performed in the first and fifth week and in the third month of postnatal development and the results of MABC-2 test performed in the same children at school age. Likewise, there seem to be no statistically important relation between the results of MABC-2 test in children playing sports and those not playing any sport, neither in the results of MABC-2 test in children of sporting parents and non- sporting parents. Key words: Postural function, developmental kinesiology, motor abilities, motor skills,...

The aim of this graduation thesis was to find out the level of motor skills in younger school age children, namely in the group of 7-10 years, using the standardized test battery MABC-2 (Movement Assessment Battery for Children-2nd Edition) at our chosen primary school. 62 children participated in the testing, of which 34 were girls and 28 were boys. We tested three components - gross motor skills, fine motor skills and balance. After evaluating all three components, we compared both sexes with each other. The results showed that all 62 children (100%) did not show any motor difficulties and ranked in the 1st zone. However, in a more detailed examination of the sub-components, we encountered problems with aiming & catching (coarse motoring). There were six children who were diagnosed with the risk of developing motor problems with recommendations for further monitoring (2nd band). In the same component, there were even 9 children who had significant motor difficulties with recommendation for specialized examinations (3rd band).

This master thesis focuses on the influence that artistic gymnastics has on the coordination abilities of young school age girls. The purpose of this thesis was to use motor tests in the field to compare the level of coordination abilities of young school age artistic gymnasts with that of non-sporting girls. The tests results were subsequently statistically evaluated and commented upon. Another aim of the thesis was to compare the coordination abilities of artistic gymnasts aged 6 - 8 years with those of artistic gymnasts aged 9 - 11 years whilst they were undertaking particular tests. From the tests results it can be seen that artistic gymnastics has a positive effect on the level of the childrens coordination abilities. This finding is supported by the fact that in all tests the artistic gymnasts succeeded better than the non-sporting girls. Of the two groups the older girls (9 - 11 years) were more succesful than the younger group (6 - 8 years). The theoretical part of the thesis describes the Child's Motor Development, emphasizing the relationship between coordination abilities and young school age. It discusses the environment of the branch of sport called "women's artistic gymnastics" and the need for the children's sports training.

The aim of this graduation thesis is to find out the level of fine and gross motoric skills amongst children of younger school age in a selected elementary school. In total, we tested 44 children (21 boys and 23 girls) from the 1st to 4th grade from the age of 7 to 10 in January 2018. The level of their motoric skills was measured by a standardized Movement Assessment Battery for Children Second Edition, which includes 8 motor tests suitable for both genders. We compared boys and girls with each other in components and test tasks. The total test results have shown that 100% of children have no motor problems (1st range). In spite of that, there were individuals who fell into the 2nd range (risk of motor problems) in components of manual skills, aiming & catching or 3rd band (major motor problems). Research has convinced us that the fine and gross motor skills of most tested children are at a very good standard.