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21	Studium imunopatologických mechanismů autoimunitní uveitidy a definování nových terapeutických možností. / Study of immunopathological mechanisms of autoimmune uveitis and the determination of new therapeutical options. Seidler Štangová, Petra January 2020 (has links) The aim of this work was to gain new knowledge about mechanisms of autoimmune uveitis and to test new therapeutic possibilities that have not yet been studied in uveitis or whose effect is questionable. The main emphasis was placed on the role of microorganisms in the process of uveitis. A mouse model of experimental autoimmune uveitis including a germ-free model was used to achieve the aims and samples of patients' intraocular fluids were analyzed. In the experimental model, the intensity of inflammation was evaluated in vivo clinically and post mortem histologically. The effect of immunomodulatory treatment was evaluated. The intensity of inflammation was compared between groups of germ-free and conventional mice. The therapeutic effect of antibiotics administered to affect microbiome was investigated in conventional mice. In intraocular fluid samples of patients with autoimmune uveitis signs of infection were monitored and levels of cytokines and other factors were evaluated. Evaluation of the effect of immunomodulatory therapy has demonstrated the efficacy of mycophenolate mofetil, which supports its wider use in the treatment of autoimmune posterior uveitis in human medicine. The decrease in bacterial load has led to a decrease in the intensity of inflammation, thereby confirming the importance of...
22	Mechanismy patogeneze experimentální autoimunitní uveitidy a možnosti jejich ovlivnění. / The Mechanism of Pathogenesis of Experimental Autoimmune Uveitis and Possilbilities of Their Regulation Klímová, Aneta January 2016 (has links) Introduction:Uveitis in an ocular inflammation affecting mostly people of working age. Uveitis is responsible for severe visual impairment despite of expanding new therapeutics. The animal models of uveitis were established, because the wide clinical variability of uveitis limits the studies in human medicine. The goal our project was to establish a reproducible model of experimental autoimmune uveitis in Czech Republic, and further on this model to observe the frequency of CD3+ and F4/80+ cells in retina, to assess the influence of microbial environment on intensity of intraocular inflammation and to test the therapeutical possibilities. Material and methods: The C57BL/6J mice were immunized by retinal antigen (IRBP 1-20, interphotoreceptor retinoid binding protein), enhanced by complete Freund's adjuvant and pertussis toxin and mild posterior autoimmune uveitis was induced. The mice were bred in conventional and germ-free (gnotobiotic) conditions. The uveitis intensity was evaluated in vivo biomicroscopically and post mortem histologically on hematoxylin eosin stained sections according to the standard protocol. The histological eye specimen were analyzed also by imunohistochemisty and by flow cytometry. Each experiment was performed for 35 days. The conventional mice with uveitis were treated...
23	Targeting mycophenolate mofetil for graft-versus-host disease prophylaxis after allogenic blood stem cell transplantation / Pharmakokinetisches Targeting von Mycophenolat mofetil zur GvHD - Prophylaxe nach allogener Stammzelltransplantation Häntzschel, Ingmar 01 July 2011 (has links) (PDF) Targeting mycophenolate mofetil for graft-versus-host disease prophylaxis after allogenic blood stem cell transplantation pharmakokinetisches Targeting Mycophenolat mofetil GvHD - Prophylaxe allogene Stammzelltransplantation MPA AUC Targeting mycophenolate mofetil graft-versus-host disease prophylaxis GvHD MPA AUC ddc:615 ddc:610 rvk:XD 2900 rvk:WE 2400 rvk:XD 2904 Mycophenolatmofetil Transplantat-Wirt-Reaktion Transplantation
24	Targeting mycophenolate mofetil for graft-versus-host disease prophylaxis after allogenic blood stem cell transplantation / Pharmakokinetisches Targeting von Mycophenolat mofetil zur GvHD - Prophylaxe nach allogener Stammzelltransplantation Häntzschel, Ingmar 14 December 2010 (has links) Targeting mycophenolate mofetil for graft-versus-host disease prophylaxis after allogenic blood stem cell transplantation:II Deckblatt III Gutachterblatt IV Widmung V Inhaltsverzeichnis VI.1 Publikation VI.2 Original-Artikel VII Abkürzungsverzeichnis VII.1 Selbständigkeitserklärung VII.2 Erklärung über den Eigenanteil bei Erstellung des Manuskriptes VII.3 Lebenslauf VII.4 Danksagung VII.5 Thesen info:eu-repo/classification/ddc/615 ddc:615 info:eu-repo/classification/ddc/610 ddc:610

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