This thesis investigates the design of a CubeLab Module frame to facilitate biological research aboard the International Space Station (ISS). With the National Laboratory designation of the ISS by the United States Congress the barriers for use of the facility have been lowered for commercial and academic entities, allowing greater volume and diversity in the research that can be done. Researchers in biology and other areas could benefit from development and adoption of a plug-and-play payload containment system for use in the microgravity/space environment of the ISS. This research includes design and analysis of such a system. It also includes production and testing of a prototype. The relevant NASA requirements are documented, and they were considered during the design phase. Results from finite element analyses to predict performance of a proposed design under expected service conditions are reported. Results from functional testing of the prototype are also provided. A discussion of future work needed before the structure outlined in this thesis can become commercially viable is also presented.

The CubeLab is a new payload standard that greatly improves access to the International Space Station (ISS) for small, rapid turn-around microgravity experiments. CubeLabs are small (less than 16”x8”x4” and under 10kg) modular payloads that interface with the NanoRacks Platform aboard the ISS. CubeLabs receive power from the station and transfer data using the standard terrestrial plug-and-play Universal Serial Bus (USB). The Space Plug-and-play Avionics (SPA) architecture is a modular technology for spacecraft that provides an infrastructure for modular satellite components to reduce the time to orbit and development costs for satellites. This paper describes the development of a bus capable of interfacing SPA-1 payloads in the CubeLab form-factor aboard the ISS. This CubeLab also provides the “discover and join” functionality that is necessary for a SPA-1 network of devices. This will ultimately provide persistent SPA capabilities on the ISS which will allow users to send SPA-1 devices to orbit for on-the-fly installation by astronauts.