Made available in DSpace on 2016-04-28T20:18:29Z (GMT). No. of bitstreams: 1 2008 - Michel Jose Sales Abdalla Helayel.pdf: 2764990 bytes, checksum: 2ef0f5307007bc87483b82ee19e1b257 (MD5) Previous issue date: 2008-09-17 / Natural poisoning by Pseudocalymma elegans is described in a cow in the county of Rio Bonito, RJ. Also decribed is the experimental reproduction of this poisoning in three calves (1.0, 0.5 and 0.25 g/kg of the fresh plant) and in five rabbits (0.5 0.25 0.125 0.0625 and 0.0312 g/kg of the dried and ground plant) with the plant collected in the area where the deaths had occurred. Post-mortem and histopathological examinations of the natural case in the cow did not reveal significant alterations. Oral administration of 1g/kg of the sprouts of P. elegans caused death of the calf 5hours and 30 minutes after beginning of the administration of the plant. The dose of 0.5 g/kg caused death of the animal after 76 hours and 36 minutes. The 0.25g/kg dose caused only clinical signs which consisted of heart palpitation and arrhythmia, increase of breathing frequency, reluctance in moving, positive vein pulse, ingurgitated jugular veins, mooing, falling down, peddling movements followed by death. At post-mortem examination the lesions were those of acute heart insufficiency, and histopatologic examination revealed the typical kidney lesion (hydropic degeneration in the distal convoluted tubules) seen in the poisoning by plants that cause "sudden death". In the experimentally poisoned rabbits the clinical course was from less than one to two minutes. The histopatological examination of the kidney of two rabbits also revealed that characteristic microscopic kidney lesion. This is the first description of a natural case of P. elegans poisoning in cattle with post-mortem and histopatological description. The occurrence of the plant in the county of Rio Bonito had not been known by the veterinarians. It is conluded that the plant has a higher toxicity as described before. / Descreve-se a intoxica??o natural por Pseudocalymma elegans em pelo menos um bovino em Rio Bonito, RJ e a reprodu??o experimental dessa intoxica??o em tr?s bovinos (1, 0,5 e 0,25 g/kg da planta fresca) e em 5 coelhos (0,5 - 0,25 - 0,125- 0,0625 e 0,0312 g/kg da planta dessecada e mo?da) com exemplares dessa planta colhida no local onde ocorreu o ?bito. A necropsia e a histopatologia do bovino intoxicado naturalmente, n?o revelaram altera??es significativas. A administra??o, por via oral, de 1g/kg da brota??o da planta causou o ?bito do bovino dentro de 5h e 30 minutos ap?s o in?cio da administra??o da planta, j? pela administra??o de 0,5 g/kg, o ?bito do animal ocorreu ap?s 76 horas e 36 minutos. A dose de 0,25g/kg foi capaz de causar sintomas, mas n?o levou ao ?bito. Os sintomas apresentados foram arritmia card?aca, taquicardia, aumento da freq??ncia respirat?ria, relut?ncia em se mover, pulso venoso positivo, jugulares e grandes vasos ingurgitados, mugidos, queda ao solo, movimentos de pedalagem seguido de ?bito. ? necropsia foram verificadas altera??es compat?veis com ?s observadas na insufici?ncia card?aca aguda, e o exame histopatol?gico revelou a les?o renal t?pica (degenera??o hidr?pica em t?bulos contornados distais) de intoxica??o por plantas que causam morte s?bita . Nos coelhos intoxicados experimentalmente a evolu??o variou entre menos de um minuto a dois minutos. O exame histopatol?gico do rim de dois coelhos tamb?m revelou a les?o microsc?pica caracter?stica. Trata-se do primeiro registro, com necropsia e histopatologia, de intoxica??o natural por P. elegans em bovinos. Essa planta ainda n?o havia sido mapeada nessa ?rea do Estado do Rio de Janeiro. Conclui-se que a planta pode ser mais t?xica do que anteriormente descrito.