Global ETD Search

1	Old-age hippocampal sclerosis in the aged population Hokkanen, Suvi Rosa Kastehelmi January 2018 (has links) Old-age hippocampal sclerosis (HS), characterised by severe neuron loss in hippocampal CA1, is a poorly understood cause of dementia. At present no objective pathological HS criteria exist. In life HS is commonly diagnosed as Alzheimer's disease. HS aetiology is unclear, although it has been associated with both ischaemia and TAR-DNA-binding protein-43 (TDP-43)-related neurodegeneration. Variations in genes GRN, TMEM106B and ABCC9 are proposed as HS risk factors. The aim of this thesis was to investigate epidemiological, clinical, pathological and genetic characteristics of HS in older European populations. 976 brains donated for the Cambridge City over-75s Cohort, the Cognitive Function and Ageing Study and the Finnish Vantaa 85+ study were available for evaluation -including bilateral hippocampi from 302 individuals. A protocol capturing the extent and severity of hippocampal neuron loss was developed, establishing objective HS diagnosis criteria and allowing observation of distinct neuron loss patterns associated with ischaemia and neurodegeneration. 71 HS cases (overall prevalence: 7.3%) were identified. HS was significantly associated with an advanced age at death as well as dementia at the end of life. Neuropsychological and cardiovascular characteristics were similar between HS and AD, except for a longer duration of dementia and more disability in HS. HS was not associated with neurofibrillary tangles, amyloid plaques, or vascular pathologies, but all HS cases evaluated for TDP-43 showed neuronal inclusions in the hippocampal dentate and a high frequency of other glial, neuronal and neurite TDP-43 pathologies. GRN and TMEM106B but not ABCC9 variations were linked to HS. A moderating effect of TDP-43 on this association was detected. HS presented pathologically similarly to frontotemporal dementia cases with TDP-43 (FTLD-TDP) caused by mutations in GRN, but differed from other FTLD-TDP subtypes. Results of this thesis reveal the importance of HS in the oldest old in the population, the key role of TDP-43, as well as providing robust methods to capture HS characteristics for an area that has been under-researched but is clearly vital to understanding dementia in the oldest old.
2	The role of N-truncated Aβ peptides in Alzheimer’s Disease Lopez Noguerola, Jose Socrates 26 June 2018 (has links) No description available. 570 Alzheimer’s disease N-truncated Aβ Pyroglutamate Aβ Neuron loss Intraneuronal Aβ Biologie (PPN619462639)
3	Therapiemöglichkeiten der Alzheimer-Krankheit durch passive Immunisierung mit dem NT4X-Antikörper im Tg4-42hom-Mausmodell / Alzheimer therapy with passive immunization using the antibody NT4X in Tg4-42hom mice Borgers, Henning 04 July 2017 (has links) No description available. 610 Alzheimer Passive Immunisierung NT4X Tg4-42 CA1 Nervenzellverlust Alzheimer passive immunization NT4X Tg4-42 CA1 neuron loss GOK-MEDIZIN
4	Alzheimer-like pathology in murine transgenic models: disease modification by environmental and genetic interventions / Alzheimer-like pathology in murine transgenic models: disease modification by environmental and genetic interventions Hüttenrauch, Melanie 18 May 2016 (has links) No description available. 570 Alzheimer's disease Physical and cognitive activity Environmental enrichment Tg4-42 mouse model 5XFAD mouse model Hippocampal neuron loss Neurodegeneration Biologie (PPN619462639)
5	Analyse neurodegenerativer Prozesse im Gyrus Dentatus im Tg4-42-Mausmodell der Alzheimerdemenz / The analysis of neurodegenerative processes in the dentate gyrus using the Tg4-42 mouse model of Alzheimer's disease Schubert, Nils 05 April 2018 (has links) No description available. 610 Alzheimer's disease abeta 4-42 transgenic mouse model neuron loss hippocampus Tg4-42 neurogenesis gliosis dentate gyrus Psychiatrie (PPN619876344)
6	Quantitative analysis of neuropathological alterations in two transgenic mouse models of Alzheimer's disease Kurdakova, Anastasiia 23 November 2016 (has links) No description available. 610 Alzheimer's disease transgenic mouse model Tg4-42 5XFAD Hippocampal neuron loss Neurodegeneration Amyloid Axonal degeneration Physical and cognitive activity Environmental enrichment Stereology Gene dosage Medizin (PPN619874732)
7	The role of amyloid beta 4-42 in the etiology of Alzheimer's disease Bouter, Yvonne 12 November 2014 (has links) No description available. 610 Alzheimer's disease truncated abeta abeta 4-42 transgenic mouse model neuron loss hippocampus memory deficits intraneuronal abeta Tg4-42 5XFAD next generation sequencing deep sequencing differentially expressed genes DEG Medizin (PPN619874732)
8	Impact of N-terminally truncated Aß4-42 on memory and synaptic plasticity - Tg4-42 a new mouse model of Alzheimer's disease Dietrich, Katharina 17 December 2014 (has links) No description available. 610 Alzheimer's disease Amyloid-beta N-truncated abeta Transgenic mouse model Tg4-42 Morris water maze Fear conditioning Spatial reference memory Associative memory Neuron loss Synaptic transmission Synaptic plasticity Long-term potentiation (LTP) Medizin (PPN619874732)

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