Postprint attachments without IR clearance. / Ozone was discovered in 1840 by Charles Frederik Schonbein (1), Professer of Chemistry at the University of Basel, Switzerland, who communicated this discovery to the Basel Society for Natural History on April 8, 1840. The discovery appears in several publications during that year (2 - 5) including the British Association Reports, the latter publication being the first on the subject in English (5). [...]

Tne high mortality rate in septic ahock continues to be a clinical problem. Different authors have quoted mortality rates up to seventy per cent. Laboratory study of one type of septic shock is possible in the dog using purified E. coli endotoxin. [...]

The cardiorespiratory alterations accompanying hypoxia in man have been the object of much scientific study since Biot and Guy-Lussac in 1804 first observed an increase in pulse rate as they ascended to 4000 metres in a balloon. They correctly ascribed the phenomenon to oxygen lack. The data accumulated on the subject up to 1959 has been well reviewed by Korner (38) who points out that while it is possible to present a fairly clear picture of the gross circulatory changes accompanying hypoxia, the mechanisms of the control of the cardiorespiratory alterations remain unknown. [...]

Obesity is very common in the United States and Canada today. According to the Society of Actuaries Build and Blood Pressure Study (55), 20% of all males age 20 or over are more than 10% above their ideal weight, and 25% of females in the same age group are more than 10% overweight. 5% of all males and 11% of al1 females in this age group are more than 20% overweight. [...]

For many years, coronary artery disease has been poorly understood. The literature is full of contradictions with regard to cause and effect and there has been no agreement concerning any form of treatment, whether it be medical or surgical (Vineberg, 1964). [...]

The phenomenon and mechanism of tissue and renal homograft rejection is reviewed. Clinical manifestation of the rejection crisis in human renal homotransplantation is described, and problems of accurate diagnosis delineated. A study of daily stained urinary sediment on transplanted patients at the Royal Victoria Hospital showed significant lymphocyturia occurring in 5 out of 5 major rejection crises studied. [...]

The concept of impaired myocardial function in shock has been suspect and a matter of debate for many years. A French surgeon, LeDran as early as 1743, described a severe gunshot wound, postulating that 'spasmodic contraction of the fibers of the heart,' may play a role in the observed syncope, or 'interception of the stream of animal spirits.' [...]

The history of the estrogenic hormones has its start at the turn of the century. In the year 1900, Knauer (1) showed that auto-transplanted ovaries in spayed animals could renew the estrous cycle. From this he concluded that the female gonads played an important part in the regulation of estrus and the production of ova and were thus organs of internal secretion. Thirteen years later, Fellner (2) showed that extracts of human placenta were potent in producing estrus in spayed animals; therefore the placenta was also involved in the metabolism of estrus-producing material. [...]

About 30 years ago, adipose tissue was considered to be metabolically inert. It was thought that its main functions were insulation of the body against heat loss and provision of mechanical support for certain organs. During the past 20 years, a surge of experimental work has changed these concepts radically. At the present time, adipose tissue is known to be the site of an intricate interplay of metabolic processes. [...]

[...] With so many conflicting opinions as to the best management of the shock syndrome, we decided to tackle the biochemical aspect or the problem.With so many conflicting opinions as to the best management of the shock syndrome, we decided to tackle the biochemical aspect or the problem. [...]