Global ETD Search

1	Regulation of Nucleoporins in Mitosis Chakraborty, Papia 27 June 2007 (has links) Nucleoporins mediate nucleocytoplasmic trafficking in interphase. In mitosis, upon nuclear envelope breakdown, the role and regulation of Nups remain to be elucidated. An important subcomplex of nucleoporins is the Nup107-160 complex, which, in mitosis, is involved in spindle assembly and nuclear pore re-assembly. Here we show that the level of a key constituent of the Nup107-160 complex- Nup96 is cell cycle regulated. We found that the mechanism involved in regulating Nup96 levels in mitosis is proteolysis by the anaphase-promoting complex (APC). Nup96 interacts with the APC, and its proteolysis can be regulated by Cdc20 and Cdh1. Like the Nup107-160 complex, the APC is localized at kinetochores, centrosomes, and spindles. Disruption of Nup96 levels led to an acceleration of prophase to prometaphase transition and, most importantly, resulted in a delay of G1 progression. Thus, regulation of Nup96 proteolysis in mitosis sets the stage for proper G1 progression. Additionally, we have observed differential regulation of members of the Nup107-160 complex during mitosis and have identified interacting partners of Nup96 at the centrosome which reveal a novel role of nucleoporins in regulating microtubule nucleation.
2	Biochemical characterization of the Nup62⋅58⋅54 nucleoporin complex and mutational analysis of the exportin CRM1 Chug, Hema 28 October 2013 (has links) No description available. 572 Nucleoporins X-ray Crystallography Biologie (PPN619462639)
3	Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-binding Sites Involved in Nucleocytoplasmic Transport Port, Sarah A. 27 April 2015 (has links) No description available. 572 nuclear transport transport receptors nuclear pore complex nucleoporins CRM1 Nup214 Biologie (PPN619462639)
4	Molecular Size and Charge Effects on Nucleocytoplasmic Transport Studied By Single-Molecule Microscopy Goryaynov, Alexander G. 03 April 2013 (has links) No description available. Biophysics 3D imaging nucleoporins nuclear pore complex single-molecule fluorescence super-resolution microscopy
5	The function of Nup358 in nucleocytoplasmic transport / Die Funktion von Nup358 im nukleocytoplasmatischen Transport Wälde, Sarah 23 August 2010 (has links) No description available. 570 Biowissenschaften, Biologie Mathematics and Computer Science Kernporenkomplex Nukleoporine Nup358 Nukleocytoplasmatischer Transport Importine DBC-1 nuclear pore complex nucleoporins Nup358 nucleocytoplasmic transport importins DBC-1 42.15 W

1

Page generated in 0.4166 seconds