Grid connected inverter requires accurate and appropriate sizing which depends on the temperature, inverter operating efficiency, performance ratio, annual system yield and solar radiation characteristics. The aim of this study was to design and size for optimum sizing factor for grid connected inverter. The main component to be considered in any photovoltaic grid connected system is the inverter since the output depends on the inverter sizing ratio, therefore optimal sizing factor was designed by considering factors that affects inverter sizing such as temperature, irradiance and the location. Large and small systems of 50 kW and 5 kW respectively were considered to determine grid connected inverter sizing factors for different climates in Kenya, Sweden, and India using PVsyst simulation. Two different inverter brands of SMA and ABB with 20 kW and 25 kW rating for large system and 4.6 kW, 4 kW inverters for small system. PVsyst simulation result showed that different locations with different orientation angles, the optimum sizing varies hence affects the annual performance of the system. Photovoltaic system inverters are sized based on the rated power of the installed system and this can be achieved when the inverter size is either almost matching or not. In this case the study presents the optimal sizing factor for grid connected inverter for Mandera in Kenya, Norrköping in Sweden and Kerala in India. The determination was done through the use of designing, assessing and analyzing of the relationship between the sizing factor with performance ratio, operational efficiency and annual hourly energy yield. The unique weather profile in Kerala and in Mandera favors the adoption of solar energy technology in the location. Solar radiation for one year was used as a baseline input and the result reveals that Mandera receives yearly radiation of 2.1 MWh/m² while Kerala and Norrköping receives 2 MWh/m² and 1.1 MWh/m² respectively. Design simulation using PVsyst tool made it possible for the determination of the optimal sizing factor for the grid connected system. Considerations such as the losses and the variations within the specific location was done and a graph showing the relationship between the sizing factor in relation to the operational inverter efficiency as well as energy yield and performance ratio was later on compared to see the behavior of the sizing factor. The study concludes that operational efficiency, performance ratio and energy yield affects the array optimum sizing ratio. For the three locations, inverters (SMA and ABB) shows different variations because optimal sizing ratio depends on the location and irradiation. The results reveal that Mandera has an optimal grid connected inverter sizing of the range from 1.1 to 1.4 while in Kerala it has from 1.2 to 1.4 and Norrköping has the range from 1.1 to 1.3. Optimal sizing of grid connected inverters depends on the energy yield and the location therefore the inverter mismatch voltage and its rating values have to be considered while determining the optimal sizing factor. The 25 kW inverters in all the locations had better efficiency and sizing factor and this proves that sizing the photovoltaic inverter will give better performance and efficiency.