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Vergleichende MR- volumetrische Untersuchung des orbitofrontalen Kortex bei Schizophrenie, bipolarer Störung, Zwangserkrankung und gesunden Kontrollpersonen / Comparative MR- volumetric investigation of the orbitofrontal cortex in schizophrenia, bipolar disorder, obsessive-compulsive disorder and healty control personsMeyer, Kristina 08 February 2011 (has links)
No description available.
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Tractography indicates lateralized differences between trigeminal and olfactory pathwaysThaploo, Divesh, Joshi, Akshita, Georgiopoulos, Charalampos, Warr, Jonathan, Hummel, Thomas C. 18 April 2024 (has links)
Odorous sensations are based on trigeminal and olfactory perceptions. Both trigeminal and olfactory stimuli generate overlapping as well as distinctive activations in the olfactory cortex including the piriform cortex. Orbitofrontal cortex (OFC), an integrative center for all senses, is directly activated in the presence of olfactory stimulations. In contrast, the thalamus, a very important midbrain structure, is not directly activated in the presence of odors, but rather acts as a relay for portions of olfactory information between primary olfactory cortex and higher-order processing centers. The aims of the study were (1) to examine the number of streamlines between the piriform cortex and the OFC and also between the piriform cortex and the thalamus and (2) to explore potential correlations between these streamlines and trigeminal and olfactory chemosensory perceptions. Thirty-eight healthy subjects were recruited for the study and underwent diffusion MRI using a 3T MRI scanner with 67 diffusion directions. ROIs were adapted from two studies looking into olfaction in terms of functional and structural properties of the olfactory system. The “waytotal number” was used which corresponds to number of streamlines between two regions of interests. We found the number of streamlines between the piriform cortex and the thalamus to be higher in the left hemisphere, whereas the number of streamlines between the piriform cortex and the OFC were higher in the right hemisphere. We also found streamlines between the piriform cortex and the thalamus to be positively correlated with the intensity of irritating (trigeminal) odors. On the other hand, streamlines between the piriform cortex and the OFC were correlated with the threshold scores for these trigeminal odors. This is the first studying the correlations between streamlines and olfactory scores using tractography. Results suggest that different chemosensory stimuli are processed through different networks in the chemosensory system involving the thalamus.
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Subtle Differences in Brain Architecture in Patients with Congenital AnosmiaThaploo, Divesh, Georgiopoulos, Charalampos, Haehner, Antje, Hummel, Thomas 18 April 2024 (has links)
People suffering from congenital anosmia show normal brain architecture although they do not have functional sense of smell. Some studies in this regard point to the changes in secondary olfactory cortex, orbitofrontal cortex (OFC), in terms of gray matter volume increase. However, diffusion tensor imaging has not been explored so far. We included 13 congenital anosmia subjects together with 15 controls and looked into various diffusion parameters like FA. Increased FA in bilateral OFC confirms the earlier studies reporting increased gray matter thickness. However, it is quite difficult to interpret FA in terms of gray matter volume. Increased FA has been seen with recovery after traumatic brain injury. Such changes in OFC point to the plastic nature of the brain.
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Decis-State: Einfluss des Sättigungsgrades auf das Entscheidungsverhalten und die funktionelle Interaktion neuronaler Systeme - Eine fMRT-Studie / Decis-State: Influence of satiety on decision making and functional interaction of neuronal systems - An fMRI-studyVieker, Henning 10 July 2012 (has links)
No description available.
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